• Title/Summary/Keyword: health characteristics

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Effects of Endocrine Disruptors on the Expression of Estrogen Receptors in Ovary and Uterus from Immature Rats (내분비계 장애물질이 미성숙한 흰쥐의 난소와 자궁에서의 에스트로겐 수용체 발현에 미치는 효과)

  • Lee, Kyeung-Yeup;Lee, Sung-Ho
    • Development and Reproduction
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    • v.10 no.4
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    • pp.255-261
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    • 2006
  • Although some phytoes rogens might have beneficiary rather than adverse effects, most endocrine disrupting compounds(EDCs) are considered to be harmful to human and wildlife health through interfering the endocrine system. Previously we found that prepubertal exposure to genistein(GS), a well-known isoflavone phytoestrogen, could activate the reproductive system of immature female rats resulting precocious puberty. Interestingly, di(2-ethyl hexyl) phthalate(DEHP) exposure brought inverse result, a delayed puberty, in the same experimental regimen. In this study, we examined whether prepubertal exposure to GS or DEHP affect the gene expressions of estrogen receptors($ER\;{\alpha}$ and $ER\;{\beta}$) and LH receptor(LHR) which represent the maturational status of ovary and uterus in immature rats. GS (100 mg/kg/day) was administered daily from postnatal day 25 to the day when the first vaginal opening(VO) was observed, and the animals were sacrificed on the next day(day 32). Similarly, DEHP(l00 mg/kg/day) was administered daily from postnatal day 25 through the day when the first V.O. in control group was observed, and the animals were sacrificed on the next day(day 36). To determine the transcriptional changes in the hormone receptors, total RNAs were extracted from ovary and uterus and were applied to semi-quantitative reverse transcription polymerase chain reaction(RT-PCR). In the GS group, the transcriptional activities of $ER\;{\alpha}$, $ER\;{\beta}$ and LHR in uterus and LHR in ovary were significantly increased when compared to those of control group. In the DEHP group, the transcriptional activities of all the hormone receptors measured were significantly lowered when compared to those of control group. These alteration of the reproductive hormone receptor expressions in ovary and uterus might be represent the phenotypic aspects(secondary sexual characteristics) such as tissue weights and reproductive hormone levels during perinatal period in immature female rats.

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Effect of xylobiose-sugar mixture on defecation frequency and symptoms in young women with constipation (자일로바이오스를 함유한 설탕이 젊은 여성의 변비 개선에 미치는 효과)

  • Lee, Jung-Sug;Kim, A-Reum;Nam, Hye-kyoung;Kyung, Myungok;Jo, Sung-Eun;Chang, Moon-Jeong
    • Journal of Nutrition and Health
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    • v.50 no.1
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    • pp.41-52
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    • 2017
  • Purpose: The objective of the study was to investigate the effects of xylobiose-sugar mixture intake on defecation frequency and constipation symptoms in 31 young women with constipation. Methods: Thirty-one subjects were assigned to two groups, and subjects in each group were administered 10 g of a 7% xylobiose-sugar mixture (Experiment 1: XBS, n = 15) or 10 g of a 7% xylobiose-sugar mixture containing coffee mix (Experiment 2: XBS coffee mix, n = 16) twice per day for 6 weeks. During the study, clinical efficacy was assessed by a daily diary record. The subjects recorded their defecation frequency and fecal characteristics. Results: During pretreatment week, mean defecation frequency of XBS subjects was 2.13 times/week, whereas that of XBS coffee mix subjects was 1.56 times/week. The mean defecation frequencies of XBS and XBS coffee mix subjects increased significantly to 3.73 times/week (p < 0.05) and 3.56 times/week by week 6 (p < 0.05), respectively. After treatment with either XBS or XBS coffee mix, patients presented significant improvements in their amounts of stool, feelings of residual stool leftness, and abdominal pain symptoms (p < 0.05). The total constipation scoring system (CSS) for diagnosing constipation symptoms significantly decreased in the XBS group (10.53 score vs 7.22 score) and in the XBS coffee mix group (10.75 score vs 6.51 score) after 6 weeks. Improvement due to intake of 7% xylobiose-containing sugar seemed to last during the experimental period. Conclusion: The addition of approximately 7% xylobiose to commercially available sweeteners has been shown to improve constipation.

Development of User Based Recommender System using Social Network for u-Healthcare (사회 네트워크를 이용한 사용자 기반 유헬스케어 서비스 추천 시스템 개발)

  • Kim, Hyea-Kyeong;Choi, Il-Young;Ha, Ki-Mok;Kim, Jae-Kyeong
    • Journal of Intelligence and Information Systems
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    • v.16 no.3
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    • pp.181-199
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    • 2010
  • As rapid progress of population aging and strong interest in health, the demand for new healthcare service is increasing. Until now healthcare service has provided post treatment by face-to-face manner. But according to related researches, proactive treatment is resulted to be more effective for preventing diseases. Particularly, the existing healthcare services have limitations in preventing and managing metabolic syndrome such a lifestyle disease, because the cause of metabolic syndrome is related to life habit. As the advent of ubiquitous technology, patients with the metabolic syndrome can improve life habit such as poor eating habits and physical inactivity without the constraints of time and space through u-healthcare service. Therefore, lots of researches for u-healthcare service focus on providing the personalized healthcare service for preventing and managing metabolic syndrome. For example, Kim et al.(2010) have proposed a healthcare model for providing the customized calories and rates of nutrition factors by analyzing the user's preference in foods. Lee et al.(2010) have suggested the customized diet recommendation service considering the basic information, vital signs, family history of diseases and food preferences to prevent and manage coronary heart disease. And, Kim and Han(2004) have demonstrated that the web-based nutrition counseling has effects on food intake and lipids of patients with hyperlipidemia. However, the existing researches for u-healthcare service focus on providing the predefined one-way u-healthcare service. Thus, users have a tendency to easily lose interest in improving life habit. To solve such a problem of u-healthcare service, this research suggests a u-healthcare recommender system which is based on collaborative filtering principle and social network. This research follows the principle of collaborative filtering, but preserves local networks (consisting of small group of similar neighbors) for target users to recommend context aware healthcare services. Our research is consisted of the following five steps. In the first step, user profile is created using the usage history data for improvement in life habit. And then, a set of users known as neighbors is formed by the degree of similarity between the users, which is calculated by Pearson correlation coefficient. In the second step, the target user obtains service information from his/her neighbors. In the third step, recommendation list of top-N service is generated for the target user. Making the list, we use the multi-filtering based on user's psychological context information and body mass index (BMI) information for the detailed recommendation. In the fourth step, the personal information, which is the history of the usage service, is updated when the target user uses the recommended service. In the final step, a social network is reformed to continually provide qualified recommendation. For example, the neighbors may be excluded from the social network if the target user doesn't like the recommendation list received from them. That is, this step updates each user's neighbors locally, so maintains the updated local neighbors always to give context aware recommendation in real time. The characteristics of our research as follows. First, we develop the u-healthcare recommender system for improving life habit such as poor eating habits and physical inactivity. Second, the proposed recommender system uses autonomous collaboration, which enables users to prevent dropping and not to lose user's interest in improving life habit. Third, the reformation of the social network is automated to maintain the quality of recommendation. Finally, this research has implemented a mobile prototype system using JAVA and Microsoft Access2007 to recommend the prescribed foods and exercises for chronic disease prevention, which are provided by A university medical center. This research intends to prevent diseases such as chronic illnesses and to improve user's lifestyle through providing context aware and personalized food and exercise services with the help of similar users'experience and knowledge. We expect that the user of this system can improve their life habit with the help of handheld mobile smart phone, because it uses autonomous collaboration to arouse interest in healthcare.

Ultrasonography findings on thyroid nodule with no clinical symptom (임상적 증상이 없는 갑상선 결절에 대한 초음파영상 소견)

  • Kim, Wha-Sun
    • Journal of radiological science and technology
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    • v.28 no.3
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    • pp.211-217
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    • 2005
  • This study obtained the following conclusions by analyzing whether or not thyroid nodule, the number of nodules depending on age and gender, and the developed site of nodule, targeting 838 persons in their 30s-70s who were conducted the thyroid ultrasonography, without clinical symptoms, at the Health Promotion Center. 1. As for the general characteristics of 838 research subjects, men were 368 persons(44%), and women were 470 persons (56%), and the mean age was 51. 2. Among 838 whole subjects, a case, which was diagnosed to be normal, was 590 persons(70%), and persons with nodules findings were 248 persons (30%), thus it was indicated 30% on an average in having the thyroid nodules findings. 3. As for the frequency by age level in thyroid nodule, it was represented men with 10%-14% and women with $20{\sim}29%$ in their $30{\sim}40s$, and men with $27{\sim}33%$ and women with 37-52% in their 50-60s, and men with 46% and women with 50% in their 70s. 4. As a result of obtaining 248 persons, who have thyroid nodules findings, with the solitary nodule and the multiple nodule, it was indicated the solitary nodule of 50.5% with 125 persons and the multiple nodule of 49.5%, thereby representing the almost same ratio. 5. As for the size of thyroid nodule, the majority in all the age levels had the nodule in small size, and the size of $1{\sim}10\;mm$ was largest with 187 persons (75%) among 248 persons with abnormal findings, and it was 45 persons (18%) in $11{\sim}20\;mm$, 14 persons (5.6%) in $21{\sim}30\;mm$, and 2 persons in more than 31 mm. 6. As for the anatomically developed site in nodule, it was indicated the right lobe with 93 persons (38%), the left lobe with 67 persons (27%), both lobes with 75 persons (30%), and isthmus with 13 persons (5.3%), thereby representing the largest frequency in the right lobe, and it was discovered less in isthmus.

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Experimental Study with Respect to Dose Characteristic of Glass Dosimeter for Low-Energy by Using Internal Detector of Piranha 657 (Piranha 657의 Internal Detector를 이용한 저에너지에서 유리선량계의 선량 특성에 관한 연구)

  • Son, Jin-Hyun;Min, Jung-Whan;Kim, Hyun-Soo;Lyu, Kwang-Yeul;Lim, Hyun-Soo;Kim, Jung-Min;Jeong, Hoi-Woun
    • Journal of radiological science and technology
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    • v.35 no.2
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    • pp.119-124
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    • 2012
  • Recently, Glass Dosimeter (GD) with thermoluminescent Dosimeter (TLD) are comprehensively used to measure absorbed dose from diagnostic field to therapy field that means from low energy field to high energy field. However, such studies about dose characteristics of GD, such as reproducibility and energy dependency, are mostly results in high energy field. Because characteristic study for measurement devices of radiation dose and radiation detector is performed using 137Cs and 60Co which emit high energy radiations. Thus, this study was evaluated the linearity according to Piranha dose which measured by changing tube voltage (50kV, 80kV and 100kV which are low energy radiations), reproducibility and reproducibility according to delay time using GD. Measurement of radiation dose is performed using internal detector of Piranha 657 which is multi-function QA device (RTI Electronic, Sweden). Condition of measurement was 25mA, 0.02sec, 2.5mAs, SSD of 100 cm and exposure area with $10{\times}10cm^2$. As above method, GD was exposed to radiation. Sixty GDs were divided into three groups (50kV, 80kV, 100kV), then measured. In this study, GD was indicated the linearity in low energy field as high energy existing reported results. The reproducibility and reproducibility according to delay time were acceptable. In this study, we could know that GD can be used to not only measure the high energy field but also low energy field.

Estimation of the Characteristics for the Dose Distribution in the Polymer Gel by Means of Monte Carlo Simulation (몬테카를로 시뮬레이션을 이용한 양성자 조사에 따른 Polymer Gel 내부의 선량 분포 특성 평가)

  • Park, Min-Seok;Kim, Gi-Sub;Jung, Hai-Jo;Park, Se-Young;Choi, In-Seok;Kim, Hyun-Ji;Yoon, Yong-Su;Kim, Jung-Min
    • Journal of radiological science and technology
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    • v.36 no.2
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    • pp.165-173
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    • 2013
  • This study was the estimation of the dose distribution for proton, prompt gamma rays and proton induced neutron particles, in case of exposing the proton beam to polymer gel dosimeter and water phantom. The polymer gel dosimeter was compositeness material of Gelatin, Methacrylic acid, Hydroquinone, Tetrakis and Distilled water. The density of gel dosimeter was $1.04g/cm^3$ which was similar to water. The 72, 116 and 140 MeV proton beams were used in the simulation. Proton beam interacted with the nuclei of the phantom and the nuclei in excited states emitted prompt gamma rays and proton induced neutron particles during the process of de-excitation. The proton particles, prompt gamma rays, proton induced neutron particles were detected by polymer gel dosimeter and water phantom, respectively. The gap of the axis for gel was 2 mm. The Bragg-peak for proton particles in gel dosimeter was similar to water phantom. The dose distribution for proton and prompt gamma rays in gel dosimeter and water phantom was approximately identical in case of 72, 116 and 140 MeV for proton beam. However, in case of proton induced neutron particles for 72, 116 and 140 MeV proton beam, particles were not detected in gel dosimeter, while the Water phantom absorbed neutron particles. Considering the resulting data, gel dosimeter which was developed in the normoxic state attentively detected the dose distribution for proton beam exposure except proton induced neutron particles.

The Degree of Requirements for Retirement Preparation and the Effect of Retirement Preparation on Quality of Life: The Moderated Mediating Effect of the Degree of Participation in Retirement Education (은퇴준비필요도와 은퇴준비가 삶의 질에 미치는 영향 : 은퇴교육참여도의 조절된 매개효과)

  • Park, Hae-Ri;Min, Hyun-Jung
    • Journal of radiological science and technology
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    • v.40 no.4
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    • pp.647-655
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    • 2017
  • This study was conducted to review the mediating effects of retirement preparation in how the degree of requirements for retirement education and the degree of preparation for retirement education affects quality of life, and how the degree of participation in retirement education which is a moderating variable is moderated. The study findings show that first, in terms of the difference in quality of life across different general characteristics, those who live in a city rather than a Gun, those who had received education of graduate school or higher rather than those with an education of undergraduate university programs or lower, those who were public officers or employees of corporations rather than those who were self-employed had a higher quality of life. The group satisfied with their economic status and health status were found to be more satisfied with their quality of life. Second, a correlation analysis showed that there was a positive correlation between retirement preparation, quality of life, and degree of requirements for retirement preparation. Moreover, there was also a positive correlation between quality of life, retirement education and the degree of requirements for retirement education. There was a positive correlation between retirement education and the degree of requirements for retirement preparation. Third, participation in retirement education moderated the indirect effect that the degree of preparation for retirement education affected quality of life through the degree of retirement preparation. In other words, the degree of requirements for retirement education affects retirement preparation and affects quality of life through the indirect effects of retirement education. As such, the moderated mediating effects of retirement education on retirement preparation was found to be greater. This indicates that quality of life may also vary in accordance with the requirements for retirement education.

Analysis of the Elderly Travel Characteristics and Travel Behavior with Daily Activity Schedules (the Case of Seoul, Korea) (활동 스케줄 분석을 통한 고령자의 통행특성과 통행행태에 관한 연구)

  • Seo, Sang-Eon;Jeong, Jin-Hyeok;Kim, Sun-Gwan
    • Journal of Korean Society of Transportation
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    • v.24 no.5 s.91
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    • pp.89-108
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    • 2006
  • Korea has been entering the ageing society as the population of age over 65 shared over 7% since the year 2000. The ageing society needs to have transportation facility considering elderly people's travel behavior. This study aims to understand the elderly people's travel behavior using recent data in Korea. The activity schedule approach begins with travel outcomes are part of an activitv scheduling decision. For tho?e approach. used discrete choice models (especially. Nested Logit Model) to address the basic modeling problem capturing decision interaction among the many choice dimensions of the immense activity schedule choice set The day activity schedule is viewed as a sot of tours and at-home activity episodes tied togather with overarching day activity pattern using the Seoul Metropolitan Area Transportation Survey data, which was conducted in June, 2002. Decisions about a specific tour in the schedule are conditioned by the choice of day activity pattern. The day activity scheduling model estimated in this study consists of tours interrelated in a day activity pattern. The day activity pattern model represents the basic decision of activity participation and priorities and places each activity in a configuration of tours and at-home episodes. Each pattern alternative is defined by the primary activity of the day, whether the primary activity occurs at home or away, and the type of tour for the primary activity. In travel mode choice of the elderly and non-workers, especially, travel cost was found to be important in understanding interpersonal variations in mode choice behavior though, travel time was found to be less important factor in choosing travel mode. In addition, although, generally, the elderly was likely to choose transit mode, private mode was preferred for the elderly over 75 years old owing to weakened physical health for such things as going up and down of stairs. Therefore. as entering the ageing society, transit mode should be invested heavily in transportation facility Planning tor improving elderly transportation service. Although the model has not yet been validated in before-and-after prediction studies. this study gives strong evidence of its behavioral soundness, current practicality. and potential for improving reliability of transportation Projects superior to those of the best existing systems in Korea.

Distribution and Species Prediction of Epilithic Diatom in the Geum River Basin, South Korea (금강권역 주요 하천의 돌 부착돌말류 분포 및 출현예측)

  • Cho, In-Hwan;Kim, Ha-Kyung;Choi, Man-Young;Kwon, Yong-Su;Hwang, Soon-Jin;Kim, Sang-Hoon;Kim, Baik-Ho
    • Korean Journal of Ecology and Environment
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    • v.48 no.3
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    • pp.153-167
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    • 2015
  • In order to understand the relationship between the distribution of epilithic diatoms and the habitual environments, land-use, water qualities, and epilithic diatoms were studied at 141 sampling sites in the midwestern stream of Korean peninsula (Geum river, Mangyeong river, Dongjin river, and Sapgyo river). The total 183 diatom taxa was appeared in the study, while the dominant species were found to be Nitzschia palea (10.9%) and Achnanthes convergens (8.4%). Based on the abundance of epilithic diatoms, a cluster analysis results indicate that the sampling sites divided the sampling sites into 4 groups (G) at the 25% level. In term of geographic and aquatic environments, G-I and -II accounted for the upper and mid streams of the Geum river, and had large forest areas and good in water quality. G-III accounted for farmland and urban, and high concentration nutrient levels (TN and TP) and electric conductivity. G-IV accounted for mostly farmland, and high levels in turbidity, BOD, nutrient and electric conductivity. CCA results showed that the saproxenous taxa Meridion circulare was the indicator species of G-I, which strongly influenced by altitude and forests. In G-II, the indifferent taxa Navicula cryptocephala was influenced by Chl-a, AFDM, and DO. In G-III and -IV, the indifferent taxa Fragilaria elliptica and saprophilous taxa Aulacoseira ambigua were influenced by electric conductivity, turbidity, and nutrient counts. Meanwhile, random forest results showed that the predicting factor of indicator species appearance in G-I, -II, and -III was found to be electric conductivity whereas in G-IV it was found to be turbidity. Collectively, the distribution of diatoms in the midwestern of Korean peninsula was found to depend more on the land-use and its subsequent water qualities than the inherent characteristics of the aquatic environment.

Chinese Consumer Preference of Chicken Burgers Cooked by Sous-vide with Korean-styled Seasoning and Available on the Chinese Fast Food Market (진공저온조리를 이용한 한식 스타일 치킨버거와 중국 시판 치킨버거의 중국 소비자 기호도)

  • Bae, Sungeun;Jang, Jin A;Oh, Jieun;Lee, Kyungwon;Cho, Mi Sook
    • Korean Journal of Food Science and Technology
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    • v.45 no.1
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    • pp.126-132
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    • 2013
  • The purpose of this study is to examine the difference of Chinese consumer preference between chicken burgers cooked by Sous-vide adding Korean-styled seasoning and chicken burgers from local fast food restaurants. For Chinese women in their 20s who reside in Beijing, China, the most important attribute for eating-out was taste (M=6.5), health (M=6.0) and pleasure (M=5.6) in order and 68.60% of them replied that they were interested in Korean cuisine. More than 90% answered they like Korean food for its good taste, shape and color. As for burger preference, BB was significantly higher in terms of the overall and appearance preference. However, there was no significant difference between AB and SB. As for flavor and texture, it showed no significant differences among BB, AB, and SB products. For SB, total balance, soft texture of patty and balance of flavor characteristics were the reasons for their preference of the burger.