• 한국문헌정보학회지
• /
• 제45권2호
• /
• pp.61-74
• /
• 2011

The author analyses the challenging activities of Japanese libraries in this decade by launching two keywords; "product-sharing" and "outcome generation." "Product-sharing" means that libraries share knowledge, skills, and records which are produced as the result of the services or in the process of activities. And "outcome generation" means that libraries generate any efficiency or effectiveness through their services to users. Using these concepts, reported are the current situation and aspects of Japanese libraries which try to make various contributions to the society; research and learning of the people, and education and training for professional librarians, and so on. In the analysis, the author shows some examples of "product-sharing" at first, including the records of reference transaction and the multi-functioned online public access catalogue. Especially, focused is on the various possibility and adoptability of the Collaborative Reference Database System of the National Diet Library of Japan. This system is one of digital reference service in Japan, and the database of reference transaction records is expected to be useful for research and academic studyies as knowledge-base of professional librarians. And the system is also expected to be a platform for LIS education and professional development in the e-learning environment. Secondly, as the examples of "outcome generation", explained are the problem-solving-type activities, and provision of the collection about books on struggling against disease and illness. A few examples of outcome in the problem-solving-type activities are these; increase of sales in the services for shop managers, business persons, and entrepreneurs, contribution to affluent daily life by providing the local information services to residents and neighbourhoods, and etc. And for both the patients with serious cases and their family or those who nurse them, books about other persons' notes or memorandum are the greatest support, and sometime healing. The author discuss the 'raison d'etre' of these activities focusing on public libraries in Japan.

• Corrosion Science and Technology
• /
• 제7권3호
• /
• pp.162-167
• /
• 2008

Degradable implants have been in use for bone surgery for decades. However, degradable metal implants are one of the new research areas of biomaterials science. Magnesium has good biocompatibility due to its low toxicity, and it is a corroding, i.e. dissolvable, metal. Furthermore, magnesium is needed in human body, and naturally found in bone tissue. There have been some published reports also asserting the potential bone cell activation or bone healing effect of high magnesium ion concentrations. The classic method for achieving intertransverse process fusion involves autogenous iliac crest bone graft. Several investigations have been performed to enhance this type of autograft fusion. However, there is no research which has been undertaken to investigate the efficiency of pure magnesium particles in posterolateral spinal fusion. In this study, corrosion behavior of magnesium metal at the bone interface, the possibility of new bone cell formation and the degree of effectiveness in producing intertransverse process lumbar fusion in a sheep model have been investigated. Cortical bone screws were machined from magnesium alloy AZ31 extruded rod and implanted to hip-bones of sheep via surgery. Three months after surgery, the bone segments carrying these screws were removed from the sacrificed animals. Samples were sectioned to reveal Mg/bone interfaces and investigated using optical microscope, SEM-EDS and radiography. Optical and SEM images showed that there was a significant amount of corrosion on the magnesium screw. The elemental mapping results indicate, due to the presence of calcium and phosphorus elements, that there exists new bone formation at the interface. Furthermore, sixteen sheep were subjected to intertransverse process spinal fusions with pedicle screw fixation at various locations along their spines. Each animal was treated with 5cc autograft bone at one fusion level and 1cc magnesium+5cc autograft bone at the other. Six months after surgery, bone formation was evaluated by gross inspection and palpation, and radiological, histological, scanning electron microscopic and x-ray diffraction analyses. It may be stated that the potential for using useful corrosion of magnesium alloys in medical applications is expected to be significant.

• 의료ㆍ복지 건축 : 한국의료복지건축학회 논문집
• /
• 제20권2호
• /
• pp.37-45
• /
• 2014

Purpose: Numerous researches about healthcare buildings have been performed however, they were mainly focused on convenience or healing condition for medical treatments. The hospitals consume energy and generate $CO_2$ as twice as the residential or commercial buildings do(Lim, et al., 2010a:154). The public regional hospitals are especially in serious conditions. They are more than 20 years old in average. Energy efficiency and environmental friendliness in the public regional hospitals are far behind ones in private sectors. Even though the ministry of health & welfare is supporting renovation of the builidngs and enhancement of the facilities every year, it is not integrated including sustainibility. In this study, we investigates current conditions of the regional public hospital in envrionment-friendly standpoint, especially focused on Chungcheong Province area Hospitals. Methods: we investigates current conditions of the regional public hospital in envrionment-friendly standpoint, especially focused on Chungcheong Province area Hospitals. The study was executed by qualitative and quantitative evaluations with site inspection, drawing analysis and interviews. Results: Through this study, we found that the Chungnam regional public hospitals can be environmentally improved by management plans and programs. Implications: Based on this analysis, Korean Green Building Certification for healthcare facilities will be developed in near future.

• Restorative Dentistry and Endodontics
• /
• 제23권1호
• /
• pp.20-42
• /
• 1998

The present study was designed to understand the basic principles of the laser system and to assess the optimal coditions of the Nd:YAG laser irradiation system in order to expand the use of the laser system in the dental field. The laser system used in this study was a pulsed-wave output type and the power level is 9 watts. The incisors of developing rats were irradiated with the laser system explained above for 0.5, 1, and 2 seconds giving energy density 71, 167, and 215 J/$cm^2$ respectively. The rats were sacrificed just after irradiation or 10 minutes and 10 days after irradiation. The specimens were examined with the stereoscope, light microscope and transmission electron microscope. The results are as follows: 1. The tissue removal efficiency (depth of the cavity formed) is increased with the energy density after Nd:YAG laser irradiation. 2. The carbonized area is increased with the energy density. Cracks and melted appearance are seen in all kinds of the energy densities. 3. The lacunae in the damaged alveolar bone by the laser irradiation were empty, while those in the newly formed bone were occupied with the osteocytes. The damaged alveolar bone was repaired by the osteoblasts and macrophages on the periphery of the bone matrix. 4. The damaged enamel was replaced by the loose connective tissues showing many kinds of cells. The ameloblasts were differntiated on the replaced loose connective tissue. 5. The damaged dentin was repaired by the irregular dentin formed by the odontoblasts differentiated from the mesenchymal cells migrated from the pulp core.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
• /
• 제45권5호
• /
• pp.276-284
• /
• 2019

Objectives: This study sought to compare efficiency results between the use of a customized implant (CI) and a reconstruction plate (RP) in mandibular defect reconstruction in an animal model. Materials and Methods: Fifteen rabbits underwent surgery to create a defect in the right side of the mandible and were randomly divided into two groups. For reconstruction of the mandibular defect, the RP group (n=5) received five-hole mini-plates without bone grafting and the CI group (n=10) received fabricated CIs based on the cone-beam computed tomography (CBCT) data taken preoperatively. The CI group was further divided into two subgroups depending on the time of CBCT performance preoperatively, as follows: a six-week CI (6WCI) group (n=5) and a one-week CI (1WCI) group (n=5). Daily food intake amount (DFIA) was measured to assess the recovery rate. Radiographic images were acquired to evaluate screw quantity. CBCT and histological examination were performed in the CI subgroup after sacrifice. Results: The 1WCI group showed the highest value in peak average recovery rate and the fastest average recovery rate. In terms of reaching a 50% recovery rate, the 1WCI group required the least number of days as compared with the other groups ($2.6{\pm}1.3days$), while the RP group required the least number of days to reach an 80% recovery rate ($7.8{\pm}2.2days$). The 1WCI group showed the highest percentage of intact screws (94.3%). New bone formation was observed in the CI group during histological examination. Conclusion: Rabbits with mandibular defects treated with CI showed higher and faster recovery rates and more favorable screw status as compared with those treated with a five-hole mini-plate without bone graft.

• 한국자연치유학회지
• /
• 제9권2호
• /
• pp.57-61
• /
• 2020

목적: 본 연구는 갱년기 증상이 있는 50대 여성 대상자들이 족욕을 하였을 때 갱년기 증상 및 수면장애에 미치는 효과를 연구하는 것이 목적이었다. 방법: 12주간 주 3회 족욕요법을 실시한 후에 갱년기 증상의 사전 및 사후 변화를 조사하였다. 결과: 안면홍조, 심장 불편감, 수면 문제, 우울감, 과민성, 불안감, 신체 및 정신적 피로, 성적인 문제, 배뇨문제, 질 건조감, 관절 및 근육 불편감이 있는 대상자는 사전보다 사후에 모두 유의성이 있게 개선되었다(p < .001). 족욕 후에 주관적 수면의 질, 수면 잠복기, 수면 기간, 수면 방해점수, 수면 약물 이용 및 수면 기능장애는 사전보다 사후가 유의하게 감소하였다(p < .001). 습관적 수면 효율성 유의하게 증가하였다. 결론: 대상자들이 족욕 후에 갱년기 증상과 수면의 질이 전반적으로 개선된 것으로 나타났다. 따라서 족욕요법은 갱년기 증상 및 수면 개선에 적합한 자연치유적 요법이라 평가한다.

• Journal of Korean Neurosurgical Society
• /
• 제63권6호
• /
• pp.698-706
• /
• 2020

Objective : To study the physiochemical characteristics of podophyllotoxin (PPT) conjugated stearic acid grafted chitosan oligosaccharide micelle (PPT-CSO-SA), and evaluate the ability of the potential antineoplastic effects against glioma cells. Methods : PPT-CSO-SA was prepared by a dialysis method. The quality of PPT-CSO-SA including micellar size, zeta potential, drug encapsulation efficiency and drug release profiles was evaluated. Glioma cells were cultured and treated with PPT and PPT-CSO-SA. The ability of glioma cells to uptake PPT-CSO-SA was observed. The proliferation of glioma cells was determined by 3-[4, 5-dimethyl-2-thiazolyl]-2, 5-diphenyl-2H-tetrazolium bromide (MTT) assay. The apoptosis and morphology of U251 cells were observed by 4',6-Diamidino-2-phenylindole dihydrochloride (DAPI) dye staining. Cell cycle analysis was performed by flow cytometry. The migration ability of U251 cells was determined by wound healing test. Results : PPT-CSO-SA had nano-level particle size and sustained release property. The encapsulation efficiency of drug reached a high level. The cellular uptake percentage of PPT in glioma cells was lower than that of PPT-CSO-SA (p<0.05). The inhibitory effect of PPT-CSO-SA on glioma cells proliferation was significantly stronger than that of PPT (p<0.05). The morphologic change of apoptosis cell such as shrinkage, karyorrhexis and karyopyknosis were observed. The percentage of U251 cells in G2/M phase increased significantly in the PPT-CSO-SA group compared with PPT group (p<0.05). Compared with the PPT group, the cell migration ability of the PPT-CSO-SA group was significantly inhibited after 12 and 24 hours (p<0.05). Conclusion : PPT-CSO-SA can effectively enhance the glioma cellular uptake of drugs, inhibit glioma cells proliferation and migration, induce G2/M phase arrest of them, and promote their apoptosis. It may be a promising anti-glioma nano-drug.

• Maxillofacial Plastic and Reconstructive Surgery
• /
• 제29권6호
• /
• pp.485-493
• /
• 2007

Introduction: Although several types of calcium-phosphate coumpound have been frequently applied to osseous defects at maxillofacial area for many years, there is a controversy about its efficiency on bone conductivity comprared to xenograft bone substitute. Alloplastic carbonapatite has been introduced to improve disadvantages of hydroxyapatite and to mimic natural bone containing carbon elements. However, a preclinical study about its efficiency of osteoconductivity has not been reported. This study was performed to evaluate the early osteoconductive potential of synthetic carbonapatite with multiple pores relative to anorganic bovine xenograft. Materials and methods: Total 5 beagle dogs were used for maxillary augmentation model. The control (anorganic bovine xenograft) and experimental groups (synthetic carbonapatite) were randomly distributed in the mouth split design. After bone graft, all animals were sacrificed 4 weeks after surgery. Histological specimens with Masson Trichrome staining were made and histomorphometrically analysed with image analyser. The statistical analysis was performed using paired t-test. Results: In both groups, all animals had no complications. The experimental group showed relatively much new bone formation around and along the bone substitutes, whereas it was clearly reduced in the control group. The ratios of new bone area to total area, to material area and to the residual area excluding materials were higher in the experimental group ($0.13{\pm}0.03,\;0.40{\pm}0.13,\;0.20{\pm}0.06$ respectively) than in the control group ($0.01{\pm}0.01,\;0.03{\pm}0.02,\;0.03{\pm}0.03$, respectively). And the differences between both groups were statistically significant (p<0.001, <0.01, <0.01, respectively), while the ratio of material area to total area in two groups was not significant. Conclusion: Carbonapatite showed a high osteoconductivity in the early stage of bone healing compared to bovine derived anorganic bone substitute. This study suggests that this bone materials can be applied as a reliable bone substitute in the clinical treatment.

• 대한족부족관절학회지
• /
• 제13권2호
• /
• pp.162-168
• /
• 2009

Purpose: To evaluate the efficiency of the minimally invasive percutaneous plate osteosynthesis (MIPPO) with locking compression plate (LCP) for distal tibial metaphyseal intra-articular fracture compared with extra-articular fracture. Materials and Methods: From February 2006 to June 2008, 21 patients with distal tibia metaphyseal intra-articular fracture and 20 patients with extra-articular fracture were treated operatively by MIPPO technique with LCP and followed for at least one year. In the group with intra-articular fracture, mean age was 48.85 years old and a mean follow-up was 15 months. In the other group with extra-articular fracture, mean age was 52.35 years old and a mean follow-up was 14.5 months. The type of fracture was evaluated using the AO/OTA classification and open-fractures were according to the Gustilo-And gron classification. Radiologic evaluation with fracture healing and tibial alignment, clinical evaluation with Olerud and Molander ankle score and restriction of motion were done for treatment. Results: According to AO/OTA classification, There were 21 type A, 15 type B, 5 type C. Average union time of the intra-articular fracture (type B, C) was 18.7 weeks. Average union time of the extra-articular fracture (type A) was 17.1 weeks. All fractures were healed without malunion. There were no difference of mean restriction angle between intra-articular fracture (ankle dorsiflexion was 3.57 degree, plantar-flexion was 5.95 degree) and extra-articular fracture (ankle dorsiflexion was 3 degree, plantar-flexion was 3.75 degree). There were no difference of Olerud and Molander ankle score between them as a mean score of intra-articular and extra-articular was 89.25, 91.25 each other. As a complication, there were 3 case of skin necrosis, 8 case of discomfortable skin tenting by plate and 1 superficial infection, but could be healed by conservative care. Conclusion: MIPPO technique, combined articular reduction, with LCP of distal tibial metaphyseal fracture was a good method with high functional recovery.

• 대한정형외과스포츠의학회지
• /
• 제4권1호
• /
• pp.49-54
• /
• 2005

목적: 무지 중수 수지 관절 척측 측부 인대 손상은 완전 파열 시 파열된 인대의 연속성을 방해하는 Stener 병변 때문에 수술적 치료인 탐색술 및 봉합술을 시행하고 있다. 저자들은 무지 중수 수지 관절 척측 측부 인대 손상에서 관절경을 이용, 진단과 치료를 시행하고 관절경적 수기에 대한 효용성을 알아보고자 하였다. 대상 및 방법: 무지 중수 수지 관절 척측 측부 인대 완전 파열로 관절경적 진단 및 치료를 받고 1년 이상 추시 가능하였던 13예를 대상으로 하였다. 평균 연령은 35.6세었다. 관절경으로 척측 측부 인대 손상, Stener 병변 등을 진단하였으며 관절경을 이용하여 치료하고 그 결과를 관절 불안정성 여부, 무지 의 집게력 파악력, 관절 운동 범위 등으로 판정하였다. 결과: 13예중 5예에서 Stener 병변이 관찰되었다. 전예에서 추시상 무지 중수 수지 관절의 불안정성이 없었고 무지의 집게력 및 파악력 은 건측의 92%, 94%로 회복되었으며 중수 수지 관절 운동 범위는 평균 52 도로 건측과 비슷하였다. 결론: 무지 중수 수지 관절 척측 측부 인대 손상에서 관절경 수기는 Stener 병변의 확진 및 치료를 가능하게 하고 연부조직 손상을 최소화시켜 조기 기능 회복을 기대할 수 있게 하는 유용한 치료 방법으로 사료되었다.