• Transactions of the Society of Information Storage Systems
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• v.1 no.1
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• pp.23-28
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• 2005

This paper investigates the effects of disk thickness and Pemto slider on PES(position error signal) for high TPI(track per inch) drives above 150kTPI at early stage of their development. In order to reduce the disk flutter which becomes a dominant contributor to the TMR, the thicker disks with both 63 and 69mi1 have been used. Also, PES of a Pemto slider with thinner thickness than Pico slider has been estimated to decrease the conversion factor of disk motion in axial direction to head off-track motion. A frequency-domain PES estimation and prediction tool has been developed via measurement of disk flutter and HSA(head stack assembly) forced vibration. It has been validated by the measured PES in drive level. Based on the model and measurement of disk flutter, PES of a drive with the thicker disk and Pemto slider is predicted and their impact is investigated.

• Environmental and Resource Economics Review
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• v.15 no.2
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• pp.269-296
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• 2006

With the concern of the potential problems which can be observed in terms of the power supply of renewable energies, we need to analyze the impact of additional power generation capacities of renewable energy sources on peak load. Each renewable energy sources are dependent upon wind speed, solar radiation, head differences caused by lunar calendar. Considering that these exogenous renewable energy sources follow their own stochastic distributions, we analyze the probability distribution of the impact of each renewable energy power supply on peak load. As a conclusion, we note that traditional tools used for the analysis of power supply such as capacity factors are no longer appropriate for the analysis of renewable energy sources in that perspective.

• Proceedings of the Korean Geotechical Society Conference
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• 2005.03a
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• pp.33-40
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• 2005

Impact-echo test, a kind of simple and economical method to evaluate the integrity of drilled piles has some limitations to use because the stress wave can be generated only on the head of a pile and the wave propagation in the pile with surrounding soils are very complicated. Numerical analyses and model tests in the laboratory have shown that both the ratio of length to diameter of a pile and the stiffness ratio of pile to soil have influence on the resolution of testing results. Full scale testing piles which have artificial defects were used to verify the capability of impact-echo technique as a tool for the pile integrity evaluation. Behaviour of the reflected signal of stress wave was investigated according to the type of defects. Elastic modulus of the pile was calculated using the wave velocity in the pile and the unconfined strength of concrete specimen. Influences of the stiffness difference between the pile and the ground on the characteristics of a wave signal were also examined.

• Journal of Audiology & Otology
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• v.24 no.2
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• pp.61-70
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• 2020

Background and Objectives: To assess the academic performance, communication skills, and psychosocial development of prelingual deaf children with cochlear implants (CIs) attending mainstream schools, and to evaluate the impact of auditory speech perception on their classroom performance. Subjects and Methods: As participant, 67 children with CI attending mainstream schools were included. A survey was conducted using a structured questionnaire on academic performance in the native language, second language, mathematics, social studies, science, art, communication skills, self-esteem, and social relations. Additionally, auditory and speech performances on the last follow-up were reviewed retrospectively. Results: Most implanted children attending mainstream school appeared to have positive self-esteem and confidence, and had little difficulty in conversing in a quiet classroom. Also, half of the implanted children (38/67) scored above average in general academic achievement. However, academic achievement in the second language (English), social studies, and science were usually poorer than general academic achievement. Furthermore, half of the implanted children had difficulty in understanding the class content (30/67) or conversing with peers in a noisy classroom (32/67). These difficulties were significantly associated with poor speech perception. Conclusions: Improving the listening environment for implanted children attending mainstream schools is necessary.

• Korean Journal of Audiology
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• v.24 no.2
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• pp.61-70
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• 2020

Background and Objectives: To assess the academic performance, communication skills, and psychosocial development of prelingual deaf children with cochlear implants (CIs) attending mainstream schools, and to evaluate the impact of auditory speech perception on their classroom performance. Subjects and Methods: As participant, 67 children with CI attending mainstream schools were included. A survey was conducted using a structured questionnaire on academic performance in the native language, second language, mathematics, social studies, science, art, communication skills, self-esteem, and social relations. Additionally, auditory and speech performances on the last follow-up were reviewed retrospectively. Results: Most implanted children attending mainstream school appeared to have positive self-esteem and confidence, and had little difficulty in conversing in a quiet classroom. Also, half of the implanted children (38/67) scored above average in general academic achievement. However, academic achievement in the second language (English), social studies, and science were usually poorer than general academic achievement. Furthermore, half of the implanted children had difficulty in understanding the class content (30/67) or conversing with peers in a noisy classroom (32/67). These difficulties were significantly associated with poor speech perception. Conclusions: Improving the listening environment for implanted children attending mainstream schools is necessary.

• Korean Journal of Radiology
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• v.24 no.9
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• pp.860-870
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• 2023

Objective: The intra-parotid facial nerve (FN) can be visualized using three-dimensional double-echo steady-state water-excitation sequence magnetic resonance imaging (3D-DESS-WE-MRI). However, the clinical impact of FN imaging using 3D-DESS-WE-MRI before parotidectomy has not yet been explored. We compared the clinical outcomes of parotidectomy in patients with and without preoperative 3D-DESS-WE-MRI. Materials and Methods: This prospective, non-randomized, single-institution study included 296 adult patients who underwent parotidectomy for parotid tumors, excluding superficial and mobile tumors. Preoperative evaluation with 3D-DESS-WE-MRI was performed in 122 patients, and not performed in 174 patients. FN visibility and tumor location relative to FN on 3D-DESS-WE-MRI were evaluated in 120 patients. Rates of FN palsy (FNP) and operation times were compared between patients with and without 3D-DESS-WE-MRI; propensity score matching (PSM) and inverse probability of treatment weighting (IPTW) were used to adjust for surgical and tumor factors. Results: The main trunk, temporofacial branch, and cervicofacial branch of the intra-parotid FN were identified using 3D-DESS-WE-MRI in approximately 97.5% (117/120), 44.2% (53/120), and 25.0% (30/120) of cases, respectively. The tumor location relative to FN, as assessed on magnetic resonance imaging, concurred with surgical findings in 90.8% (109/120) of cases. Rates of temporary and permanent FNP did not vary between patients with and without 3D-DESS-WE-MRI according to PSM (odds ratio, 2.29 [95% confidence interval {CI} 0.64-8.25] and 2.02 [95% CI: 0.32-12.90], respectively) and IPTW (odds ratio, 1.76 [95% CI: 0.19-16.75] and 1.94 [95% CI: 0.20-18.49], respectively). Conversely, operation time for surgical identification of FN was significantly shorter with 3D-DESS-WE-MRI (median, 25 vs. 35 min for PSM and 25 vs. 30 min for IPTW, P < 0.001). Conclusion: Preoperative FN imaging with 3D-DESS-WE-MRI facilitated anatomical identification of FN and its relationship to the tumor during parotidectomy. This modality reduced operation time for FN identification, but did not significantly affect postoperative FNP rates.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.10
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• pp.5579-5587
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• 2013

Research indicates that a small population of cancer cells is highly tumorigenic, endowed with the capacity for self-renewal, and has the ability to differentiate into cells that constitute the bulk of tumors. These cells are considered the "drivers" of the tumorigenic process in some tumor types, and have been named cancer stem cells (CSC). Epithelial-mesenchymal transition (EMT) appears to be involved in the process leading to the acquisition of stemness by epithelial tumor cells. Through this process, cells acquire an invasive phenotype that may contribute to tumor recurrence and metastasis. CSC have been identified in human head and neck squamous cell carcinomas (HNSCC) using markers such as CD133 and CD44 expression, and aldehyde dehydrogenase (ALDH) activity. Head and neck cancer stem cells reside primarily in perivascular niches in the invasive fronts where endothelial-cell initiated events contribute to their survival and function. Clinically, CSC enrichment has been shown to be enhanced in recurrent disease, treatment failure and metastasis. CSC represent a novel target of study given their slow growth and innate mechanisms conferring treatment resistance. Further understanding of their unique phenotype may reveal potential molecular targets to improve therapeutic and survival outcomes in patients with HNSCC. Here, we discuss the state-of-the-knowledge on the pathobiology of cancer stem cells, with a focus on the impact of these cells on head and neck tumor progression, metastasis and recurrence due to treatment failure.

• Korean Journal of Applied Biomechanics
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• v.17 no.1
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• pp.91-97
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• 2007

The purpose of this study was to investigate the changes of various balls velocity under the different surface conditions after impact. For this study, four different balls were used which are golf ball, tang-tang ball, table tennis ball, and iron ball. And two different types of ground conditions were used which are artificial grass green and glass green. Movements of putter head and ball were recorded with 2 HD video cameras(60 Hz, 1/500s shutter speed). Small size control object($18.5cm{\times}18.5cm{\times}78.5cm$) was used in this study. To transfer the same amount of kinetic energy to the ball, pendulum putting machine was used. Analyzing the process of impact and the ball movement, a putter was digitized the whole movement but the ball was digizited within the 50cm movement. Velocities were calculated by the first central difference method(Hamill & Knutzen, 1995). Putter head velocities were about 112.2cm/s-116.2cm/s at impact. Maximum ball velocities were appeared 0.08s-0.10s after impact no matter what the ground conditions are. Table tennis ball recorded higher ball velocities than the other ball velocities and iron ball recorded the lowest ball velocity in this group. But Table tennis ball was influenced with the frictional force and immediately was decreased at the artificial grass green condition. If an object is received the kinetic energy under the static condition(v=0cm/s), the object recorded the maximum velocity shortly after the impact and then decreased the velocity because of the frictional force. The ball distance from the start position to the peak velocity position is about 6cm-10cm under the 112.2cm/s-116.2cm/s putting velocity with putter. 0.25 seconds later after impact balls were placed 40cm distance from the original position except iron ball. In this study, ball moving distances were too short therefore it was not possible to investigate the reactions after the translational force is disappeared. Rotational force would play a major role at the end of the ball movement. Future study must accept two things. One is long distance movement of ball and the other is balanced ground. Three-piece ball is a good item to investigate the golf ball movement on the different surface conditions.

• Molecular & Cellular Toxicology
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• v.5 no.2
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• pp.133-140
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• 2009

Caveolin may be a molecular target for modulation of aging process in cochlear hair cells and have association with oxotoxicity. First we investigated the basal expression of caveolin-1, caveolin-2, caveolin-3, nitric oxide synthase, and superoxide dismutase in UB/OC-1 cochlear hair cell line. By using a RNA interference technique, we investigated whether down-regulation of caveolin influenced telomerase activity and reactive oxygen species (ROS) production in cochlear hair cells. In addition, cisplatin and gentamycin, known ototoxic drugs, were administered to the cochlear cells to determine their impact on caveolin expression. Further attempts at elucidating cellular aging mechanism with caveolin and ototoxic drugs were carried out. The main discoveries were the presence of caveolin-1 in UB/OC-1 cells and that down-regulation of caveolin-1 reduced protein kinase A activity. Telomerase was activated by caveolin down-regulation and caveolin down-regulation inhibited oxidative stress at the mitochondrial level. When cisplatin and gentamycin were administered to the cochlear hair cells during a caveolin expression state, a decrease in telomerase activity and increase ROS activity was observed. Caveolin-1 may modulate the senescent mechanisms in cochlear cells. An increase in caveolin-1 levels can lead to ROS production in the mitochondria which may cause ototoxicity.

• Journal of Auto-vehicle Safety Association
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• v.12 no.4
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• pp.31-38
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• 2020

This study is to develop the prediction model for the HIC15 in frontal vehicle crash tests. The 28 frontal impact test results of the MY2019 and MY2020 USNCAP are utilized. The metrics for evaluating the crash pulse severity such as moving average acceleration, Restraint Quotient (RQ) and ride-down efficiency are reviewed to find out whether the metrics can predict the HIC15. It is observed that the R² values based on the linear regression of all pairs between the existing metrics and the occupant injuries such as the HIC15, 3 ms chest g's and chest deflection are very low. In this study, using the vehicle crash pulses, the linear regression model for estimating the HIC15 is developed. The vehicle crash pulse is splitted seven 10 ms intervals in 70 ms after impact for extracting the average accelerations in each intervals. The prediction model can predict effectively not only the HIC15 but also the maximum head g's, chest deflection and 3 ms chest g's of 13 vehicles out of 28 vehicles.