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Inactivation of the Muscarinic Receptor Subtype by Dibenamine (디벤아민에 의한 무스카린 수용체 아형의 불활성화)

  • 이신웅;장태수
    • YAKHAK HOEJI
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    • v.39 no.6
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    • pp.645-653
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    • 1995
  • Dibenamine inhibited [$^{3}$H]quinuclidinyl benzilate ([$^{3}$H]QNB) binding in both concentration and incubation time-dependent manners. The $IC_{50}$/ value of dibenamine for the inhibition of the specific binding of 100 pM [$^{3}$'H]QNB following incubation of cerebral microsomes with dibenamine at 37.deg. C for 15 min was 20.mu.M. Dibenamine irreversibly decreased the binding site concentration for [$^{3}$H]QNB binding without affecting the affinity of [$^{3}$H]QNB for the muscarinic receptor. Analysis of the pirenzepine inhibition curve of [$^{3}$H]QNB binding to cerebral microsomes indicated the presence of two receptor subtypes with high(M$_{1}$ receptor, Ki=5nM) and low (M$_{2}$ receptor, Ki=160nM) affinity for pirenzepine. However, dibenamine(20.mu.M) treatment under the condition employed in these experiments caused steepening of the pirenzepine competition curve. The Ki value for pirenzepine in dibenamine treated-microsomes was approximately 120nM. suggesting a selective decrease in the number of M$_{1}$ receptor. Although dibenamine also inhibited [$^{3}$H]QNB binding to ventricular microsomes with $IC_{50}$/ value of 120.mu.M, the sensitivity for dibenamine in the ventricle was much lower than that in the cerebrum. These results indicate that dibenamine at low concentrations welectively inactivates the muscarinic M$_{1}$ receptor.

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Some Properties on Receding Horizon $H_{\infty}$ Control for Nonlinear Discrete-time Systems

  • Ahn, Choon-Ki;Han, Soo-Hee;Kwon, Wook-Hyun
    • 제어로봇시스템학회:학술대회논문집
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    • 2004.08a
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    • pp.460-465
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    • 2004
  • In this paper, we present some properties on receding horizon $H_{\infty}$ control for nonlinear discrete-time systems. First, we propose the nonlinear inequality condition on the terminal cost for nonlinear discrete-time systems. Under this condition, noninceasing monotonicity of the saddle point value of the finite horizon dynamic game is shown to be guaranteed. We show that the derived condition on the terminal cost ensures the closed-loop internal stability. The proposed receding horizon $H_{\infty}$ control guarantees the infinite horizon $H_{\infty}$ norm bound of the closed-loop systems. Also, using this cost monotonicity condition, we can guarantee the asymptotic infinite horizon optimality of the receding horizon value function. With the additional condition, the global result and the input-to-state stable property of the receding horizon value function are also given. Finally, we derive the stability margin for the saddle point value based receding horizon controller. The proposed result has a larger stability region than the existing inverse optimality based results.

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The Study on the Characteristics of Ryodoraku Score in the Children Who Visited Department of Pediatrics, Hospital of Oriental Medicine for Growth Treatment (한방소아과에 성장치료를 주소로 내원한 환아들의 양도락 특성에 관한 연구)

  • Lee, Dong-Hyung;Lee, Jin-Yong
    • The Journal of Pediatrics of Korean Medicine
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    • v.21 no.3
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    • pp.145-156
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    • 2007
  • Objectives The object of this study is to investigate the characteristics of Ryodoraku score in the Children who visited Department of Pediatrics, Hospital of Oriental Medicinewith Growth treatment as a chief complaint. Methods Subjects were 58 children who visited Department of Pediatrics, Hospital of Oriental Medicine the first time with Growth treatment as a chief complaint. We measured the height and Ryodoraku score, and we also checked bone age from some of them. This study was designed to investigate the characteristics of Ryodoraku score in children with Growth treatment as a chief complaint. Results and Conclusions The results were follows 1. The average value of Ryodoraku score in 58 children was $41.8800{\pm}13.82641$. 2. The value of H1(肺), H5(三焦), H6(大腸), H2(心包), H3(心), F4(膀胱) and F5(膽) had significant statistical differences compared to its total average. 3. The value of F3(腎) had no relationship with Mid-Parental Height(MPH) percentile. 4. The value of F1(脾), F3(腎) and total average was classified by the height percentile values when children visitedand the difference between the predicted height percentile, and it resulted as there were no relationship between those two

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Quality Characteristics of Fried Fish Paste Added with Ethanol Extract of Onion (양파 에탄올 추출물을 첨가한 튀김어묵의 품질 특성)

  • 박양균;김현주;김명희
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.33 no.6
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    • pp.1049-1055
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    • 2004
  • The effects of ethanol extract of onion (EEO) on the qualify of fried fish paste were investigated. EEO was added at 0, 1, 3 and 5% level. Quality attributes including moisture content, pH, acid value, TBA value, volatile basic nitrogen, color value, viable cell count and sensory evaluation were analyzed. Moisture content was not changed by addition of EEO. Increasing the amount of EEO, pH, acid value and TBA value of fried fish paste tended to decreased but volatile basic nitrogen increased. L-value was decreased and a-value and b-value were increased by addition of EEO. Viable cell count was decreased by addition of EEO. In sensory evaluation, the higher amount of EEO obtained higher favorite score in flavor and taste, and 3% EEO had the best score in overall acceptance. These results suggest that EEO can be applied to fried fish paste for the purpose of high quality and functionality.

Effect of pH Level on the Characteristics of a Landfill Clay Liner Material (pH에 따른 점토차수재의 특성)

  • Jung, Soo-Jung;Lee, Yong-Su;Kim, Tae-Hyung
    • Journal of the Korean Geotechnical Society
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    • v.23 no.8
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    • pp.97-106
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    • 2007
  • In this study, experiments are conducted to find out the effect of waste leachate on landfill clay liner system. Tensile test, hydrometer analysis and crack pattern test were conducted on sand-bentonite mixtures with different pH values of water. The tensile strength of specimen compacted with pH 9 of water is smaller than that of specimen compacted with for pH 3 and 6 of water. That is, the higher the pH value, the smaller the tensile strength, because a higher pH solution decreases flocculation phenomenon. The percent finer also increased with high pH value in particle size distribution of fine grained soil (<0.075 mm), because the velocity of particles settling decreases. This trend becomes the clearer as the content of bentonite, becomes the larger, because the higher pH value decreases flocculation structure of fine soils. The results of the crack pattern tests also showed the effect of pH values of water.

Leaching of Iron and Aluminum from Red Mud and Preparation of Coagulants (적니로부터 철과 알루미늄의 침출 및 응집제의 제조)

  • Lee, Jae-Rok;Hwang, In-Gook;Bae, Jae-Heum
    • Clean Technology
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    • v.15 no.1
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    • pp.38-41
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    • 2009
  • Red mud is generated as a waste byproduct during the production of aluminum hydroxide/alumina from bauxite ore in the Bayer process. In this study coagulants for wastewater treatment were prepared by leaching iron and aluminum from red mud with hydrochloric acid. The removal efficiency of heavy metal ions by the red mud coagulant increased with increasing the adjusted pH value of the synthetic wastewater. When the red mud coagulant was prepared, the leaching efficiency of Fe decreased with increasing the weight of red mud, while the pH value of the red mud coagulant increased. The solution of the red mud coagulant mixed with water was reacted again with red mud to produce the leached solution, which had higher concentrations of Fe and Al and a higher pH value than the red mud coagulant. Also, its pH value was comparable to that of other coagulants: $FeCl_3$ and $Fe_2(SO_4)_3$.

A pH Measurement Study on Commercial Alcoholic Drinks (시판주류의 pH 측정 연구)

  • Shim, Jae-Sun;Song, Ae-Hee
    • Journal of dental hygiene science
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    • v.12 no.6
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    • pp.696-701
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    • 2012
  • The purpose of this study was to determine pH value of some alcoholic drinks sold in Korea and to provide the basic information which can cause dental erosion. Alcoholic drinks commercially sold were purchased from various big markets in Korea. The sorts of drinks tested in this study consisted of 5 brands of beers, 24 brands of makgeollis, 9 brands of wines and 12 brands of sojus. The test groups were selected randomly and the pH of each beverage was determined using a pH meter he each pH was measured. For statistical data, Mann-Whitney test was used to analyze difference for red wine and white wine and Kruskal-Wallis test was used to compare the pH of each test group. The result of this study was as followings: the mean pH of 5 brands of beers was 4.21, that of 24 brands of makgeollis 3.88, of 9 brands of wines 3.34 and of 12 brans of sojus 7.86. Each test group was significantly different (p<0.05). Except for soju groups, the test groups had a low pH value which can cause dental erosion. In terms of comparing between pH value of red wine and white wine, the result of this study represented that the mean pH of red wine was 3.45 and that of white wine was 3.21. This result showed the pH of two kinds of wine had a low pH which can lead to dental erosion and the difference of two wine were significantly different (p<0.05). As a result, some drinks sold in Korea have a high erosive potential on teeth since they have a comparatively low pH expect soju. Hence, when we consume some kinds of alcoholic drinks, we make sure to remember that the alcoholics which had a low pH, can have an effect on dental erosion that mean we should avoid to drink some alcoholic drinks with low pH for long time.

The Identification of the Magnetic Bearing Control System's Parameters using RCGA (실수코딩 유전알고리즘을 이용한 자기베어링 제어시스템 파라미터의 동정)

  • Jeong, H.H.;Kim, Y.B.;Yang, J.H.
    • Journal of Power System Engineering
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    • v.13 no.4
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    • pp.68-73
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    • 2009
  • The mathematical model has a different response character with the real system because this mathematical model has the modeling errors and the imprecise value of system's parameters. Therefore to find the value of system parameters as possible as near by real value in the model is necessary to design the controlled system. This study concern about the identification method to estimate the parameter for the magnetic bearing system with RCGA(Real Coded Genetic Algorithm). Firstly, we will get the mathematical model from the current amplifier circuit and the magnetic bearing system. Secondly we will get the step response data in this circuit and system. Finally, we will estimate the unknown parameter's value from the data.

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Discharge Waveform Properties on Electrical Sterilization by HV Impulse (고전압 펄스에 의한 전기 살균에서 방전 파형의 특성 분석)

  • Lee, H.K.;Suehiro, J.;Hara, M.;Lee, D.C.
    • Proceedings of the KIEE Conference
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    • 1998.11c
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    • pp.944-946
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    • 1998
  • We evaluated cell survivability by changing RLC value on HV impulse network. When the L value is changed from 0 to 10mH in this circuit. we found that cell survivability is shown large decline with 4mH of L value. I respect to this result, when waveshapes of oscillatory decay are presented along the variation of L value in RLC circuit, we analyzed whether discharge waveform properties have an effect on sterilization ratio, and measured threshold voltage as the minimum peak voltage of a single pulse which can sterilize cells. Finally, we found that the sterilization effect was related to number of threshold voltage waveforms being applied.

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A Study on the Variation of Nutrients and Water Quality in Suk Chon Lake (石村湖의 營養鹽類 및 수질의 動態에 관한 조사연구)

  • Choi, Han-Young;Kim, Tai-Jeon;Park, Sung-Bae
    • Journal of Environmental Health Sciences
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    • v.14 no.1
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    • pp.47-53
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    • 1988
  • This study was performed to investigate a seasonal and vertical variation of the nutrients, water temperature, pH, DO, BOD, COD in Sukchon lake from May 1985 to Jan. 1986. The results were as follows. 1. Vertical descent of water temperature was the remarkable situation on Jul. and difference between surface layer and bottom layer was 3.5$\circ$C. 2. The value of pH was average 8.0 in both lake. The value of pH in the winter was average 7.6, and Summer was average 8.3. 3. The contents of dissolved oxygen was the highest value (13.0mg/l in surface layer on Jan. and the lowest value (8.1mg/l in bottom layer on Ul. 4. The contents of PO$_4$-P, NH$_3$-N, NO$_3$-N and T-N were 0.03~O.17mg/l 0.12~0.34mg/l 0.36~0.91mg/l and 0.76~1.37mg/l respectively.

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