• Food Science and Preservation
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• v.17 no.5
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• pp.727-732
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• 2010

Activity-guided fractionation of an ethyl acetate (EtOAc)-soluble portion of an ethanolic extract from the leaves of cultivated mountain ginseng, using pancreatic lipase inhibition assay, led to the isolation and identification of three flavonoids of a previously described structure, kaempferol-3-O-sophoroside (I), kaempferol-3-O-${\beta}$-Dglucopyranoside (astragalin, II) and kaempferol (III). All compounds (I.III) showed pancreatic lipase inhibitory activities, with $IC_{50}$ values ranging from $20.3{\pm}2.2$ to $9.1{\pm}1.5$ ${\mu}M$, kaempferol (III) showed the most potent inhibitory activity with an $IC_{50}$ of $9.1{\pm}1.5$ ${\mu}M$. The level of activity may depend on the number of C-3 glucosyl group(s) linked to the kaempferol backbone, and the isolated compounds may have promise as pancreatic lipase inhibitors.

• Tuberculosis and Respiratory Diseases
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• v.84 no.4
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• pp.291-298
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• 2021

Background: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a standard diagnostic method for mediastinal and hilar lymphadenopathy. Although rare, fatal infectious complications can occur following EBUS-TBNA. However, to date, there is a lack of effective preventive strategies to reduce these complications. We started a trial to investigate the effect of chlorhexidine mouthrinse on the prevention of microbial contamination during EBUS-TBNA. Methods: This study is a single-center, parallel-group, assessor-blinded randomized controlled trial (RCT). We will enroll 112 adult participants undergoing EBUS-TBNA using a convex probe, and randomly assign them to two groups at a 1:1 ratio. The intervention group will gargle for 1 minute with 100 mL of 0.12% chlorhexidine gluconate before EBUS-TBNA, while the control group will have no mouthrinse before the procedure. Immediately after completion of EBUS-TBNA on all targeted lesions with an aspiration needle, a needle wash sample will be taken by instilling 5 mL of sterile saline into the used needle. The primary outcome is colony forming unit (CFU) counts in aerobic cultures of the needle wash samples. Secondary outcomes are CFU counts in anaerobic cultures, fever within 24 hours after EBUS-TBNA, and infectious complications within 4 weeks after EBUS-TBNA. Conclusion: This trial was designed as the first RCT to investigate the effect of chlorhexidine mouthrinse on the prevention of microbial contamination during EBUS-TBNA. Results from this trial can provide clinical evidence for a simple, safe, and cost-effective strategy to prevent infectious complications following EBUS-TBNA (ClinicalTrials.gov ID: NCT04718922, registered on 22 January 2021).

• Tuberculosis and Respiratory Diseases
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• v.84 no.4
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• pp.326-332
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• 2021

Background: The association of invasive tracheobronchial aspergillosis (ITBA) with invasive pulmonary aspergillosis (IPA) is not well established. We aimed to compare clinical characteristics between patients who exhibited ITBA with IPA and those who exhibited isolated ITBA (iITBA). Additionally, the usefulness of serum or bronchial galactomannan (GM) tests in diagnosing ITBA was evaluated. Methods: This retrospective single-center case-control study was conducted over a period of 4 years. Fifteen patients were enrolled after confirming the presence of ITBA using bronchoscopy-guided biopsy (iITBA, 7 vs. ITBA+IPA, 8). Clinical characteristics of patients and results obtained from serum or bronchial GM tests were compared between the two groups. Mortality was assessed using data collected from a 6-month follow-up period. Results: The ITBA+IPA group showed a higher prevalence of hematologic malignancy (75% vs. 14%, p=0.029), a greater number of patients with multiple bronchial ulcers (75% vs. 14%, p=0.029), lower platelet counts (63,000/μL vs. 229,000/μL, p<0.001), and a mortality rate which was significantly higher (63% vs. 0%, p=0.026) than the iITBA group. In the ITBA+IPA group, 57% of patients tested positive according to the serum GM assay, whereas in the iITBA group, all patients tested negative (p=0.070). The bronchial GM level was high in both groups, but there was no significant difference between them. Conclusion: Patients with ITBA+IPA had a greater number of hematologic malignancies with lower platelet counts and a poorer prognosis than patients diagnosed with iITBA. Findings obtained from bronchoscopy and bronchial GM tests were more useful in diagnosing ITBA than the serum GM test results.

• The Journal of Korean Academy of Prosthodontics
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• v.59 no.4
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• pp.478-486
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• 2021

This report demonstrates a method of generating a chair-side and computer-aided template for implant surgery based on the Top-Down and restoration-driven concept. Compared to the traditional CAD-CAM process which requires multiple steps to be taken between dental clinic and laboratory, this alternative procedure, VARO guide system (VARO Guide, CAD, Pre-Guide, VARO-mill, NeoBiotech, Seoul, South Korea) enables accurate and patient-friendly implant surgery as well as immediate provisional restoration in a single visit. First, bite-registration at centric jaw relation and CBCT were taken using the Pre-Guide. The CBCT data was then reorganized directly through the chair-side CAD, and we could determine the most appropriate 3-dimensional position of implant. The STL file was extracted and put into the chair-side CAM (VARO-mill) to fabricate a VARO. This surgical guide allowed the implants to be accurately positioned into the planned sites within an hour.

• Journal of the Korean GEO-environmental Society
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• v.22 no.11
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• pp.31-37
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• 2021

To prevent accidents due to the cavities and loosened layers formed due to water leakage from the deteriorated buried pipes, evaluation of the changes in water contents around the buried pipes is required. As a method to evaluate the water contents of the soils, time domain reflectometry (TDR) system can be adopted. However, slender electrodes used in standard TDR probe may be damaged when buried in the ground. Thus, in this study, buried type TDR module was developed for the evaluation of the water contents with maintaining required shape of the electrodes in the ground. The TDR module is composed of three electrodes connected to the core conductor and outer conductor and a casing to prevent deformation and maintain alignment of the electrodes in the ground. For the verification of TDR waveforms measured using the TDR module, comparative analysis was conducted with the TDR waveforms measured using the standard TDR probe, and the relationship between the volumetric water content of the soils and the travel time of the guided electromagnetic wave was constructed. In addition, a model test was conducted to test the applicability of the buried type TDR module, and the experimental result shows that the TDR module clearly evaluates the changes in volumetric water contents due to the leakage from the modeled buried pipe. Therefore, the buried type TDR module may be effectively used for the health monitoring of the buried pipe and the evaluation of the water contents around the pipes buried in the urban pavements.

• Korean Journal of Clinical Laboratory Science
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• v.53 no.4
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• pp.309-316
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• 2021

Sepsis is a physiological response to a source of infection that triggers mechanisms that compromise organ function, leading to death if not treated early. Biomarkers with high sensitivity, specificity, speed, and accuracy that could differentiate sepsis from non-infectious systemic inflammatory response syndrome (SIRS) could bring about a revolution in sepsis treatment. Given the limitations and time required for microbial verification of pathogens, the accurate diagnosis of infection before employing antibiotic therapy is important and clinically necessary. Procalcitonin (PCT), lactate, C-reactive protein (CRP), cytokines, and proadrenomedullin (ProADM) are the common biomarkers used for diagnosis. The procalcitonin (PCT)-guided antibiotic treatment in patients with acute respiratory infections effectively reduces antibiotic exposure and side effects while improving survival rates. The evidence regarding sepsis screening in hospitalized patients is limited. Clinicians, researchers, and healthcare decision-makers should consider these findings and limitations when implementing screening tools, future research, or policy on sepsis recognition in hospitalized patients. The use of biomarkers in pediatric sepsis is promising, although such use should always be correlated with clinical evaluation. Biomarkers may also improve the prediction of mortality, especially in the early phase of sepsis, when the levels of certain pro-inflammatory cytokines and proteins are elevated.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.11
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• pp.224-229
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• 2018

Korea is experiencing a rapid increase in electricity consumption due to rapid economic development, and many power transmission towers are installed to provide smooth power supply. The high-voltage transmission line is mainly made of aluminum stranded wire, and the wire is loosely guided so that some deflection is maintained. The degree of deflection has a great influence on the quality of the construction and the life of the cable. As the time passes, the shrinkage and expansion occur repeatedly due to the weight of the cable and the surrounding environment. Therefore, periodic monitoring is essential for the management of the power transmission line. In this study, the power transmission lines were monitored using 3D laser scanning technology. The data of the power transmission line of the study area was acquired and the point cloud type 3D geospatial information of the transmission line was extracted through data processing. The length of the transmission line and deflection amount were calculated using the 3D geospatial information of the transmission line, and the distance from the surrounding obstacles could be calculated effectively. The result of study shows the utilization of 3D laser scanning technology for transmission line management. Future research will contribute to the efficiency of transmission line management if a transmission line monitoring system using 3D laser scanning technology is developed.

• Journal of the Korean Chemical Society
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• v.63 no.4
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• pp.280-288
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• 2019

The purpose of this study is to draw implication for scientific inquiry study by investigating level of understanding and actual state regarding the elementary school teachers' scientific inquiry. The survey was conducted toward 42 elementary school teachers who work at the D city by using questionnaire of Views About Scientific Inquiry. Actual state of understanding of scientific inquiry was investigated by categorized the responses to the level of understanding of the eight aspects of scientific inquiry in three levels (informed, mixed, naive) based on analysis criteria. And analyze whether the characteristic of the subjects affect to level of understanding about aspect of scientific inquiry. As a result of the analysis, the two aspects among the eights aspects of scientific inquiry; 'Inquiry procedures are guided by the question asked' and 'Research conclusions must be consistent with the data collected' were appeared to have high rates of informed level of understanding. In the remaining six perspectives, most of elementary school teachers had naive and mixed level of understanding, so informed level of understanding took a relatively low proportion. It implies that elementary school teachers who teach inquiry in the field have limit to understand about scientific inquiry. These results indicated that experiences that have taught students and science related training courses that open sofar have a little influence to increase comprehension about scientific inquiry. Therefore, it is required to reinforce the teachers' understanding about scientific inquiry and to formulate different form of plan unlike existing way of teaching for teaching scientific inquiry.

• Journal of the Korean earth science society
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• v.39 no.6
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• pp.617-629
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• 2018

The purpose of this study was to explore the elementary school teachers' perceptions about making a model of volcanic activity. Thirty elementary teachers participated in the study after they in which they conducted the experiment of "Making a Model of Volcanic activity". A questionnaire was used to investigate how the teachers understood the strengths and weaknesses of the experiment in terms of the goals of school science inquiry. The results showed that 50-60% of the teachers were able to conduct the experiment as guided in the textbook regardless of their career or area of concentration. The teachers perceived that the experiment of current textbook was safe and useful for students to develop their creativity. However, they pointed out three major weaknesses of the textbook experiment: First, the textbook experiment does not clearly present the main purpose of the activity. Second, it does not appropriately reflect the natural volcanic activity. Third, it is a merely simple craft activity. In addition, the teachers agreed that the main goals of school science inquiry are the application of scientific knowledge, development of inquiry skills and cultivation of student's curiosity. However, the teachers perceived that the experiment of current textbook did not meet these three goals. They suggest that the experiment reflect the nature of real volcanic activities.

• 재활복지
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• v.17 no.4
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• pp.197-219
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• 2013

The aim of this study was to examine self-efficacy and work ethic on the moderating effect of retraining program for personal assistants to influence job environments and job satisfaction. The data were obtained from 330 personal assistants working at the Personal Assistance Association of Gyeonggi-do. The data were analyzed using the Structural Equation Modeling with relative effect analysis. The result of this study showed that self-efficacy and work ethics should have an impact job environments and job environments should have a positive impact job satisfaction. The retraining program for personal assistants showed a moderating effect on the relationship between work ethics and job environments. However, the findings did not support the moderator effect on the retraining program for personal assistants in the relationship between self-efficacy and job environments. Using these findings, social work administration agency, in particular, can be guided in terms of human resource management under social work administration.