• Title/Summary/Keyword: guidance

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Subgrouping of N1a Stage Papillary Thyroid Carcinoma with Positive Node Ratio (갑상선유두상암의 중앙림프절 전이율에 따른 N1a병기의 세분화)

  • Lee, Min-Wan;Cho, Jin-Seong;Cho, Dong-Hoon;Ryu, Young-Jae;Park, Min-Ho;Yoon, Jung-Han
    • Korean Journal of Head & Neck Oncology
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    • v.32 no.1
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    • pp.13-19
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    • 2016
  • Background : The 2015 American thyroid association (ATA) guidelines greatly expanded section on risk stratification of thyroid cancer. Definition of "Low risk of recurrence" has expanded, by inclusion of small volume lymph node involvement, such as less than 5 lymph node metastases each smaller than 2mm in central compartment. Purpose : We evaluated the number of positive nodes, Positive node ratio (PNR), recurrence, and radioablation therapy. Also, evaluated the safety of omitting strategy of radioablation after total thyroidectomy with PTC, especially on low-PNR N1a patients compared with high-PNR N1a patients. Methods : Consecutive 147 N1a and 216 N0 patients who underwent total thyroidectomy with central neck dissection between 2003 and 2004 were enrolled. We divided 147 N1a patients into two groups, such as 96 high-PNR versus 51 low-PNR group according to 50% of PNR, and compared these two groups with N0 group. Results: 7.2% (26/363) recurrences were occurred, and 21/147 (14.3 %) recurrences were on N1a patients, and 5/216 (2.3 %) were on N0 patients. Of these 21 recurrences in N1a stage patients, 20 (95.2 %) recurrences were occurred in high-PNR N1a group and only 1 (4.8 %) recurrence was in low-PNR N1a group. The recurrence of low-PNR N1a group was significantly lower than high-PNR N1a group (Log-rank p value = 0.003), but significantly not different from N0 group (Log-rank p value = 0.889). Although this study was a retrospective non-randomized trial with small number of patients, the 10-year recurrence of omitting RAI in low-PNR N1a patients with less than 50% of PNR were shown to be comparable with 216 N0 low risk patients. Conclusion : Positive node ratio could be a useful predictor of recurrence and useful guidance postoperative management -rather than absolute number of positive node.

A Study on the Development of Project Based Teaching$\cdot$Learning Materials for the Mathematically gifted (주제 탐구형 수학 영재 교수$\cdot$학습 자료 개발에 관한 연구)

  • Choi, Jong-Hyeon;Song, Sang-Hun
    • School Mathematics
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    • v.7 no.2
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    • pp.169-192
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    • 2005
  • The purpose of this study is to provide the conformity for developing project-based teaching$\cdot$learning materials for the mathematically gifted students. And this study presents development procedural model in order to improve the effectiveness, analyze its practical usage and examine the verification of the developed materials. It made the following results regarding the development of project-based teaching$\cdot$learning materials for gifted children in mathematics. First, it is necessary to provide appropriate teaching$\cdot$learning model to develop the materials, and the materials should be restructured to be available to other level students. Second, it is suggested to develop a prototype in order to develop teaching$\cdot$learning materials for gifted children in mathematics, further the prototype needs to be restructured until it satisfies theoretical frame. Third, an introduction should be made before the activity to perform the projects effectively. Fourth, a teacher's guidance should introduce children's examples corresponding to the objectives of learning, the examples of topics examined by students, and teacher's manual and attention for teaching. This study has a point of presenting the detailed guidelines with regards to development of teaching$\cdot$learning materials for gifted students in mathematics. This study has a point of presenting the detailed guidees with regards to development of teaching$\cdot$learning materials for gifted students in mathematics.

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A Study on the Legal Policy Problems and Countermeasures about Conflicts of Interest (연구 관련 이해상충에 대한 법정책적 문제와 대응방안에 관한 연구)

  • KIM, EUNAE
    • The Korean Society of Law and Medicine
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    • v.19 no.1
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    • pp.165-206
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    • 2018
  • Researchers, Institutional Bioethics Committee(IBC)/Institutional Review Board (IRB) members, Research Institutions that have multiple interests in relation to research should ensure that conflicts of interest(COI) do not arise in making professional judgments. In other words, according to the role that must be performed or the obligation to fulfill it, the primary interest, which must be considered or should be prioritized, should not be affected by the secondary interest. Therefore, standards and methods should be prepared so as to prevent and solve the problems of COI that have arisen, and the basic matters on standards and methods should be clearly defined in terms of the law and policy so that all parties such as Researchers can understand and follow them. In order to establish a more realistic legal policy, it is necessary to grasp the current situation. Therefore, I have reviewed results of the questionnaire survey and interview conducted for the administrative staff of IBC/IRB to confirm their opinions on legal policy problems related to COI and countermeasures for resolving them. Also, I have reviewed the main contents of issued by the US Department of Health and Human Services in order to assist in the preparation of domestic legal policy about conflicts of interest. Finally, I have analyzed the present state of domestic legal policy in relation to the Researcher's COI, the IBC/IRB member's COI, and Institutional COI and suggested way to improve it.

In vivo verification of regional hyperthermia in the liver

  • Noh, Jae Myoung;Kim, Hye Young;Park, Hee Chul;Lee, So Hyang;Kim, Young-Sun;Hong, Saet-Byul;Park, Ji Hyun;Jung, Sang Hoon;Han, Youngyih
    • Radiation Oncology Journal
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    • v.32 no.4
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    • pp.256-261
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    • 2014
  • Purpose: We performed invasive thermometry to verify the elevation of local temperature in the liver during hyperthermia. Materials and Methods: Three 40-kg pigs were used for the experiments. Under general anesthesia with ultrasonography guidance, two glass fiber-optic sensors were placed in the liver, and one was placed in the peritoneal cavity in front of the liver. Another sensor was placed on the skin surface to assess superficial cooling. Six sessions of hyperthermia were delivered using the Celsius TCS electro-hyperthermia system. The energy delivered was increased from 240 kJ to 507 kJ during the 60-minute sessions. The inter-session cooling periods were at least 30 minutes. The temperature was recorded every 5 minutes by the four sensors during hyperthermia, and the increased temperatures recorded during the consecutive sessions were analyzed. Results: As the animals were anesthetized, the baseline temperature at the start of each session decreased by $1.3^{\circ}C$ to $2.8^{\circ}C$ (median, $2.1^{\circ}C$). The mean increases in temperature measured by the intrahepatic sensors were $2.42^{\circ}C$ (95% confidence interval [CI], 1.70-3.13) and $2.67^{\circ}C$ (95% CI, 2.05-3.28) during the fifth and sixth sessions, respectively. The corresponding values for the intraperitoneal sensor were $2.10^{\circ}C$ (95% CI, 0.71-3.49) and $2.87^{\circ}C$ (1.13-4.43), respectively. Conversely, the skin temperature was not increased but rather decreased according to application of the cooling system. Conclusion: We observed mean $2.67^{\circ}C$ and $2.87^{\circ}C$ increases in temperature at the liver and peritoneal cavity, respectively, during hyperthermia. In vivo real-time thermometry is useful for directly measuring internal temperature during hyperthermia.

Portal Placement for Thoracoscopic Right Middle Lung Lobectomy with One-Lung Ventilation in Beagle Dogs (비글견에서 편측성 분리폐 환기를 이용한 흉강경 우중폐엽 절제술을 위한 포트 위치)

  • Park, Ji Young;Lee, Hae-Beom;Jeong, Seong Mok
    • Journal of Veterinary Clinics
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    • v.32 no.1
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    • pp.9-15
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    • 2015
  • Purpose of this study is to determine the reasonable portal approach for thoracoscopic right middle lung lobectomy in small sized dogs under 10 kg. Ten healthy beagle dogs weighing $8.67{\pm}0.49kg$ were included. Under general anesthesia, one-lung ventilation (1LV) was achieved using endobronchial blocker with guidance of fiber-optic bronchoscope. Two portal approaches were used; 8-6-10 intercostal space (ICS) and 8-6-5 ICS approach. Thoracoscopic right middle lung lobectomy was performed using endoscopic linear self-cutting stapler and specimen retrieval bag. Each approach was evaluated by scoring 0; bad, 1; endurable, 2; good, 3; excellent in following five category, 1) visualization, 2) triangulation; instrumental sword fighting in the thoracic cavity, 3) approach to hilar pedicle; application of stapler, 4) any obstacles in applicating Lap Bag, and 5) the operator's convenience. Favorable working space was secured by 1LV and thoracoscopic right middle lung lobectomy was successfully completed in all dogs. There was no need to change the portal location and iatrogenic complication. Most of scores were good to excellent in both approaches. Consequently, both approaches are feasible methods for thoracoscopic right middle lung lobectomy with one lung ventilation using endoscopic linear self-cutting stapler in dogs weighing less than 10 kg.

Performance Improvement of Current-mode Device for Digital Audio Processor (디지털 오디오 프로세서용 전류모드 소자의 성능 개선에 관한 연구)

  • Kim, Seong-Kweon;Cho, Ju-Phil;Cha, Jae-Sang
    • The Journal of the Institute of Internet, Broadcasting and Communication
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    • v.8 no.5
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    • pp.35-41
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    • 2008
  • This paper presents the design method of current-mode signal processing for high speed and low power digital audio signal processing. The digital audio processor requires a digital signal processing such as fast Fourier transform (FFT), which has a problem of large power consumption according to the settled point number and high speed operation. Therefore, a current-mode signal processing with a switched Current (SI) circuit was employed to the digital audio signal processing because a limited battery life should be considered for a low power operation. However, current memory that construct a SI circuit has a problem called clock-feedthrough. In this paper, we examine the connection of dummy MOS that is the common solution of clock-feedthrough and are willing to calculate the relation of width between dummy MOS for a proposal of the design methodology for improvement of current memory. As a result of simulation, in case of that the width of memory MOS is 20um, ratio of input current and bias current is 0.3, the relation of width between switch MOS and dummy MOS is $W_{M4}=1.95W_{M3}+1.2$ for the width of switch MOS is 2~5um, it is $W_{M4}=0.92W_{M3}+6.3$ for the width of switch MOS is 5~10um. Then the defined relation of MOS transistors can be a useful design guidance for a high speed low power digital audio processor.

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A Study on Current Status of English Education for Toddlers and Influential Variables upon Mothers' Demand (영아영어교육 실태 및 영아어머니의 영아영어교육 요구에의 영향 변인 분석)

  • Chun, Hui Young;Seo, Hyun Ah;Jwa, Seung Hwa;Bae, Mi Sook
    • Korean Journal of Childcare and Education
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    • v.7 no.3
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    • pp.43-65
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    • 2011
  • The purpose of this study was to investigate the current status of English education for toddlers at home and institutes, and influential variables upon mothers' demand on English education for their toddlers. Four hundred forty-one mothers who have toddlers under 36 months-old were surveyed using a questionnaire. Data were analyzed using frequency and logistic regression. Results of this study were as follows: It was found that 30.9% of mothers were providing English education to their toddlers. They started English education when their toddlers were between 24 months and 36 months because of parents' decision or English education in child care centers. English education was mostly given to their toddlers once or twice a week, less than 30 minutes a time with Korean teachers who majored in English. English lessons were focused on simple dialogue using multi media, worksheets, and workbooks. In other sense, 66.0% of mothers showed a positive perspective toward English education for toddlers. The higher salary, years of education, and degree of agreement on English education based on physiological, linguistic, and social perspectives were, the stronger the demand on English education was. Results of this study suggested that appropriate guidance for English education for toddlers needs to be provided.

Appearance Management Activities of Female High School Students Through Star-Entertainer Imitation - School Uniform Modification, Hairstyle, and Makeup - (여고생들의 연예인 모방유형에 따른 외모관리행동의 차이 - 교복변형, 헤어스타일, 화장을 중심으로 -)

  • Choi, Na-Young
    • Journal of Korean Home Economics Education Association
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    • v.24 no.3
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    • pp.175-189
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    • 2012
  • This paper examines the effect of star-entertainer imitation on female high school students in terms of their appearance management activities such as school uniform modification behaviors, hair style care behaviors, and make-up behaviors. For this research, data of 379 female high school students living in Jeollabuk-do was analyzed through reliability analysis, factorial analysis, cluster analysis, one-way analysis of variance, and cross-tabulation analysis. In the research, based on the type of star-entertainer imitation, the female high school students were divided into three categories: active followers, psychological followers, and passive followers. The research showed that active followers, who exhibited imitation behavior most frequently and had the highest imitation desire, were most frequently involved in school uniform modification. Inclined to imitate the school uniform styles of star-entertainers in soap operas, they modified their school uniforms. The active followers were also enthusiastic about hair care, were well aware of trendy hair styles, and demonstrated a fondness for star-entertainer hair styles. In addition, they were actively involved in make-up activities. They put on basic make-up everyday and exhibited a desire to learn about make-up styles. However, passive followers, who showed the least frequent imitation behavior and the lowest imitation desire, were not as keenly involved in school uniform modification behaviors, hair style care behaviors, or make-up behaviors. The study concludes that by providing teenagers with systematic education on desirable mass media and educating them on proper behavior, an effective educational tool for guidance on clothing habits can be derived.

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The Difference of Growth Environment and High School Students' Career Decision Making (고등학생의 성장환경에 따른 진로의사결정의 유형과 자기효능감의 차이)

  • Kim, Jin-Hee;Paik, Sun-Ah
    • Journal of Korean Home Economics Education Association
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    • v.25 no.1
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    • pp.1-14
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    • 2013
  • The purpose of the study was investigated on that whether there was any statistical difference or not in terms of the career decision making according to the growth environment of High school students. The researcher surveyed 600 questionnaires for high school students and was using 539 questionnaires in the final analysis. They were analyzed by cluster analyses according to the growth environment scale and it classified into two cluster groups. The cluster group A and B had a significant difference on scores of the growth environment scale. The group A had more interested in activities such as political, social, intellectual, and cultural ones and participated at social and leisure activities. Moreover, the group was emphasis on moral and religious values. The group B got the higher score than group A about the score of the rational type of the career decision making: the group A got the higher score than the group B to the score of the dependent type. On the matter of the job information collection sub-scale, the group A got the higher score than the group B: the group A scored higher points than group B about the goal establishment and the self-estimate sub-scales. Therefore, in order to do the career-guidance of youths, each family had to provide positive growth environment which required various stimuli and affluent in experience settings for them to mature.

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A Study on the Masticatory Muscle Activity According to the Occlusal Guidance Patterns (교합 유도 형태에 따른 저작근 활성도에 관한 연구)

  • Kim, Ok-Hee;Kay, Kee-Sung
    • The Journal of Korean Academy of Prosthodontics
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    • v.27 no.2
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    • pp.189-200
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    • 1989
  • The purpose of this study was to investigate the muscle activity of the group function occlusion and the changed canine guided occlusion using EM2. In this study, 13 subjects with group function occlusion and without temporomandibular disorders were selected, each subject was changed to the canine guided occlusion by forming the lingual ramps in the upper canines with light curing composite resin. The muscle activities of the anterior temporal and masseter muscle were recorded in the group function occlusion and immediately, one week, and two weeks after changing to the canine guided occlusion under the condition of maximum voluntary clenching in centric occlusion, lateral excursion, and during gum chewing. The results were as follows: 1. In case of maximum voluntary clenching in centric occlusion, the muscle activities of the anterior temporal and masseter muscle of working and balancing side didn't show any difference immediately after changing to the canine guided occlusion, one week after changing to the canine guided occlusion, one week after changing to it the muscle activities of the anterior temporal masseter muscle of working and balancing side were increased significantly, and two weeks after changing to it the muscle activities of the masseter muscle were increased significantly in comparison with the group function occlusion. 2. In case of maximum voluntary clenching in lateral excursion, the muscle activities of the anterior temporal and masseter muscle of working and balancing side were reduced significantly immediately after changing to the canine guided occlusion, one week after changing to it the muscle activities of the anterior temporal muscle of balancing side and of the anterior temporal and masseter muscle of working side were reduced significantly, and 2 weeks after changing to it the muscle activities of the anterior temporal and masseter muscle of working side were reduced significantly in comparison with the .group function occlusion. 3. During gum chewing, the muscle activities of the anterior temporal and masseter muscle of working and balancing side didn't show any difference immediately after changing to the canine guided occlusion, one week after changing to it the muscle activities of the masseter muscle of working and balancing side were increased significantly, and two weeks after changing to it only the muscle activities of masseter muscle of working side were increased significantly.

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