• Title/Summary/Keyword: growth factors

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A Systematic Review Study on the Start-Up Sustainability Factors by Franchises Growth Cycle in Korea : Focusing on the ERIS Model

  • Kim, Insook;YANG, Jihee
    • The Korean Journal of Franchise Management
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    • v.12 no.2
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    • pp.23-33
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    • 2021
  • Purpose: The purpose of this study is to provide basic data such as development of sustainable support policies and performance management evaluation to support sustainable management of domestic franchises by deriving the sustainable growth cycle of domestic franchises. Research design, data, and methodology: This study is based on systematic review study. We combined search terms such as "Start-up", "Sustainability" and "Success" with four databases, RISS, KISS, e-article and DBpia and searched a total of 1,219 articles published by April 21, 2021. In the process, 35 studies were selected and analyzed after an expert review, excluding documents whose overlapping documents, gray zones (e.g., reports, conference presentations, etc.), degree papers, foreign language literature, and dependent variables were not related to the Sustainability factors. Using ERIS model, which is applied to research on the results of startup, and the franchise's growth cycle, which reflects the growth stage of franchises, we analyzed the factors behind the sustainability of franchise. Result: The results of the study are as follows. First, research on the sustainability of franchise has continued since 2009 in Korea, and has been conducted in various fields such as social welfare in addition to venture, start-up and management. Second, sustainability factors of franchise were analyzed from the ERIS performance model indicating the performance of venture, and the 68 subfactors were derived. Third, it is confirmed that there are important factors that affect the sustainable growth of franchise startups in each franchise's growth cycle. Conclusions: It is significant that through this study, we provided better understanding of the factors that sustain sustainability of franchises, policy suggestions, and presented the direction of future study. Theoretical suggestion is that the main reason for the continuous growth of franchise in each domestic franchise is based on the ERIS performance model. The practical implication is that the headquarters and Franchisor can use it to establish and evaluate performance indicators based on the business growth cycle. The results of this study are expected to be used as basic data for development and performance management evaluation of franchise start-up support policies to support the sustainable management of domestic franchises.

Factors Influencing Post-Traumatic Growth in Patients with Gastrointestinal Cancer (위장관 암환자의 외상 후 성장 영향요인)

  • Yang, Seul Gi;Boo, Sunjoo
    • Journal of Korean Clinical Nursing Research
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    • v.29 no.1
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    • pp.85-94
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    • 2023
  • Purpose: The purpose of this study was to investigate the influencing factors of post-traumatic growth in patients with gastrointestinal cancer. Methods: A cross-sectional study was conducted, enrolling 120 patients with gastrointestinal cancer. Their general characteristics, disease-related characteristics, perceived illness intrusiveness, levels of optimism, social support, and post-traumatic growth were assessed through self-administered questionnaires. The collected data were analyzed using descriptive statistics, independent t-test, oneway ANOVA, Pearson's correlation, and multiple regression analysis. Results: The mean score of post-traumatic growth was 52.74 points(total score of 92 points). Among the subscales of post-traumatic growth, levels of the preciousness of life were the highest, and relating with others was the lowest. The post-traumatic growth was found to be significantly correlated with optimism (r=.48, p<.001), social support (r=.47, p<.001), and depression (r=-.37 p<.001). Factors associated with post-traumatic growth were optimism (β=.36, p<.001), social support (β=.31, p<.001), and depression (β=-.27, p<.001). Conclusion: Given that prevalence of gastrointestinal cancer is increasing in Korea, identifying general, psychological, and social factors affecting post-traumatic growth among this population will be helpful in clinical practice. Integrated strategies to increase optimism and social support and lower depression should be considered to improve the post-traumatic growth of patients with gastrointestinal cancer.

Interpretation of Diameter Growth Pattern and Correlation of Climatic Factors with Diameter Growth for Quercus Species Based on Tree-Ring Measurement (연륜해석에 의한 참나무류의 직경생장과 기상요인과의 상관관계)

  • Shin Chang-Seob
    • Korean Journal of Agricultural and Forest Meteorology
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    • v.8 no.3
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    • pp.145-151
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    • 2006
  • The purpose of this study was to analyze the relationship between the annual variation in diameter growth of Quercus spp. and climatic factors such as monthly temperature, precipitation and solar radiation in central and northern Korea. Annual diameter growth was measured by using stem cores of 262 Quercus trees, and the correlation between the diameter growth and the climatic factors was analyzed. Mean diameter growth of Quercus spp. in Jungwangsan was larger than that in Woraksan, and mean diameter growth by the species was large in order of Q. serrata>Q. variablis>Q. mongolica>Q. dentata. The diameter growth pattern of Quercus spp. in Woraksan was different from that in Jungwangsan. Positive correlations between diameter growth of Quercus trees and temperature or the solar radiation during July were found in Jungwangsan. Significant correlations between diameter growth and solar radiation during March and precipitation during June were found in Woraksan. It is suggested that climatic factors similarly affect the diameter growth of Quercus spp. in a mountainous terrain, but influences of the climatic factors depend on other environmental conditions such as altitude, topography and soil depth.

ENDOCRINE CHANGES AND CIRCULATING INSULIN-LIKE GROWTH FACTORS IN NEWBORN CALVES FED COLOSTRUM, MILK OR MILK REPLACER

  • Lee, C.-Y.;Head, H.H.;Feinstein, C.R.;Hayen, J.;Simmen, F.A.
    • Asian-Australasian Journal of Animal Sciences
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    • v.8 no.1
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    • pp.51-58
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    • 1995
  • To examine whether colostral growth factors are transferred to the general circulation, concentrations of plasma cortisol, insulin, prolactin, growth hormone, insulin-like growth factors(IGFs) -I and -II, IGF-binding proteins(IGFBPs) and total protein were measured in newborn calves fed colostrums, milk of milk replacer before and after feeding at 12 h intervals during the first two days after birth. Plasma protein concentrations increased with time after than in milk- or milk replacer-fed calves. The mean protein concentration was greater in colostrum-fed than in milk- or milk replacer-fed calves. Plasma cortisol levels transiently declined after each feeding regardless of the type of diet, while insulin levels tended to increase. Mean concentrations of these hormones did not differ between dietary groups, nor did they change with time after birth. Plasma concentrations of prolactin and growth hormone did not differ between dietary groups and also did not change with time after birth or after feeding. Concentrations of IGF-I and IGF-II transiently increased at the second feeding period, but these, as well as plasma IGFBP profiles, were not different between groups or before and after feeding. Results did not indicate significant transfer of colostral growth factors across the newborn ruminant small intestine.

Effect of Single Growth Factor and Growth Factor Combinations on Differentiation of Neural Stem Cells

  • Choi, Kyung-Chul;Yoo, Do-Sung;Cho, Kyung-Sock;Huh, Pil-Woo;Kim, Dal-Soo;Park, Chun-Kun
    • Journal of Korean Neurosurgical Society
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    • v.44 no.6
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    • pp.375-381
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    • 2008
  • Objective : The effects on neural proliferation and differentiation of neural stem cells (NSC) of basic fibroblast growth factor-2 (bFGF). insulin growth factor-I (IGF-I). brain-derived neurotrophic factor (BDNF). and nerve growth factor (NGF) were assessed. Also, following combinations of various factors were investigated : bFGF+IGF-I, bFGF+BDNF, bFGF+NGF, IGF-I+BDNF, IGF-I+NGF, and BDNF+NGF. Methods : Isolated NSC of Fisher 344 rats were cultured with individual growth factors, combinations of factors, and no growth factor (control) for 14 days. A proportion of neurons was analyzed using $\beta$-tubulin III and NeuN as neural markers. Results : Neural differentiations in the presence of individual growth factors for $\beta$-tubulin III-positive cells were : BDNF, 35.3%; IGF-I, 30.9%; bFGF, 18.1%; and NGF, 15.1%, and for NeuN-positive cells was : BDNF, 34.3%; bFGF, 32.2%; IGF-I, 26.6%; and NGF, 24.9%. However, neural differentiations in the absence of growth factor was only 2.6% for $\beta$-tubulin III and 3.1% for NeuN. For $\beta$-tubulin III-positive cells, neural differentiations were evident for the growth factor combinations as follows : bFGF+IGF-I, 73.1 %; bFGF+NGF, 65.4%; bFGF+BDNF, 58.7%; BDNF+IGF-I, 52.2%; NGF+IGF-I, 40.6%; and BDNF+NGF, 40.0%. For NeuN-positive cells : bFGF+IGF-I, 81.9%; bFGF+NGF, 63.5%; bFGF+BDNF, 62.8%; NGF+IGF-I, 62.3%; BDNF+NGF, 56.3%; and BDNF+IGF-I, 46.0%. Significant differences in neural differentiation were evident for single growth factor and combination of growth factors respectively (p<0.05). Conclusion : Combinations of growth factors have an additive effect on neural differentiation. The most prominent neural differentiation results from growth factor combinations involving bFGF and IGF-I. These findings suggest that the combination of a mitogenic action of bFGF and post-mitotic differentiation action of IGF-I synergistically affects neural proliferation and NSC differentiation.

A Study on the Export Growth Factors of the SM Ventures (중소벤처기업의 수출성장 요인분석 연구)

  • Park, Woo-Sik;Kim, Dae-Ho
    • 한국벤처창업학회:학술대회논문집
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    • 2006.11a
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    • pp.197-217
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    • 2006
  • Korea economy's latent growth rate has already been decreased about 4%. During 1983-1989, the latent growth rate was 8%, before the foreign exchange crisis, 1990-1997 was 6.7%, and during $2000{\sim}2004$, it had been decreased 4.4%. The latent growth rate means economy growth rate which one nation can achieve capital, labor, and factors as applying these. Our economy growth rate was 8% in 1980s, but it had been decreased about 6.7% during $1990{\sim}1997$, after 2000, it remarkably decreased 4.8% which shows weakness of our economy's strength. This study attempts to investigate about export growth factor of venture company in our nation's growth that depends on export. This thesis studied the companies continuance and growth in external environment's regular correlation and casual relationship which surround company's factors and internal. Also, the external environment, which surrounds company, can be thought that company can't control itself, so that the company's continuance and growth can be decided because of its internal primary factors. This thesis establishes and analyzes the study model that how factors can affect to company's growth.

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Korea's Limit to Growth from Circular Causation Perspective: Focusing on Crisis Factors, Population, Economy, Resources, Environment, and Food (인과지도로 본 한국의 성장의 한계: 인구, 경제, 자원, 환경, 식량 위기요인을 중심으로)

  • Moon, Tae-Hoon;Kim, Byung-Suk
    • Korean System Dynamics Review
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    • v.10 no.3
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    • pp.47-79
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    • 2009
  • The paper examines dynamic relationship among 'Limit to Growth' factors in Korea using causal loop diagram. It also aims to explore policy implications for Korea in overcoming current difficulties and future crisis we may face. For this purpose, five factors -economy, population, resource, environment, food- used in the were adopted as an analytical framework. Findings show that Korea is fragile to external shock such as world economic crisis, food price surge, and resource price -including energy price- hike. High dependency of energy, food and resource on foreign market was found to be a major source of limit to growth in Korea. Furthermore, environmental problems like global warming could be a major external shock that could hit Korea harder than the rest of the world. Policy implications and measures for these problems were discussed too.

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MOLECULAR BIOLOGY IN DENTAL IMPLANT (치과 임플란트에서의 분자생물학적 연구)

  • Jee, Yu-Jin;Ryu, Dong-Mok;Lee, Deok-Won
    • Journal of the Korean Association of Oral and Maxillofacial Surgeons
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    • v.34 no.6
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    • pp.616-621
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    • 2008
  • Osseointegration is a result of bone formation and bone regeneration processes, which takes place at the interface between bone and implant, and it indicates a rigid fixation that can be stably maintained while functional loading is applied inside the oral cavity as well as after implant placement. Although many researches were carried out about osseointegration mechanism, but cellular and molecular events have not been clarified. With recent development of molecular biology, some researches have examined biological determinants, such as cytokine, growth factors, bone matrix proteins, during osseointegration between bone and implant surface, other researches attempted to study the ways to increase bone formation by adhering protein to implant surface or by inserting growth factors during implant placement. Cellular research on the reaction of osteoblast especially to surface morphology (e.g. increased roughness) has been carried out and found that the surface roughness of titanium implant affects the growth of osteoblast, cytokine formation and mineralization. While molecular biological research in dental implant is burgeoning. Yet, its results are insignificant. We have been studying the roles of growth factors during osseointegration, comparing different manifestations of growth factors by studying the effect of osseointegration that varied by implant surface. Of many growth factors, $TGF-{\beta}$, IGF-I, BMP2, and BMP4, which plays a significant role in bone formation, were selected, and examined if these growth factors are manifested during osseointegration. The purpose of this article is to present result of our researches and encourage molecular researches in dental implant.

Relationships of Concentrations of Endocrine Factors at Antemortem and Postmortem Periods to Carcass Weight and Backfat Thickness in Pigs

  • Yun, J.S.;Seo, D.S.;Rhee, M.S.;Oh, S.;Kim, B.C.;Ko, Y.
    • Asian-Australasian Journal of Animal Sciences
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    • v.16 no.3
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    • pp.335-341
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    • 2003
  • Carcass weight and backfat thickness are two of important elements in determining the carcass trait in pigs and are studied on animal genetics, nutrition, and endocrinology. Growth factors stimulate or inhibit the proliferation and differentiation of various cells. In particular, insulin-like growth factors (IGFs), transforming growth factor (TGF)-$\beta$, and epidermal growth factor (EGF) are involved in the growth and maintenance of muscle. Also, dehydroepiandrosterone-sulfate (DHEA-S) and cortisol are known to be related to the obesity and subcutaneous fat depth in pigs. Therefore, this study was performed to relate growth factors (IGFs, TGF-${\beta}1$, and EGF) and hormones (cortisol and DHEA-S) concentrations at antemortem and postmortem periods to carcass traits including carcass weight and backfat thickness. Blood and m. Longissimus were collected in pigs at antemortem (30 days before slaughter) and postmortem periods. After slaughtered, carcass weight and backfat thickness were measured. Growth factors and hormones in serum and m. Longissimus were measured by radioimmunoassay or enzyme-linked imuunosorbent assay. Before antemortem period, serum IGF-I and -II concentrations were positively correlated with the carcass weight and backfat thickness in gilts, and the concentrations of TGF- ${\beta}1$ and cortisol in barrows show the correlation with only carcass weight. Also, the positive correlations of muscular IGFs and TGF-${\beta}1$ at postmortem 45 min with the carcass weight and backfat thickness were detected. Consequently, these results suggest that the serum and muscular endocrine factors are involved in the carcass weight and backfat thickness in pigs.

An analysis of the wrinkling initiation in sheet metal forming using bifurcation theory (분기좌굴이론을 이용한 박판성형공정에서의 주름발생해석)

  • 김종봉;양동렬;윤정환
    • Proceedings of the Korean Society for Technology of Plasticity Conference
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    • 1998.03a
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    • pp.28-31
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    • 1998
  • Wrinkling is one of the major defects in sheet metal products and may be also attributable to the wear of the tool. The initiation and growth of the wrinkles are influenced by many factors such as stress state, mechanical properites of the sheet material, geometry of the body, and contact condition. It is difficult to analyze the wrinkling initiation and growth considering the factors because the effects of the factors are very complex and the wrinkling behavior may show wide variation for small deviation of the factors. In this study, the bifurcation theory is introduced for the finite element analysis of wrinkling initiation and growth, All the above mentioned factors are conveniently considered by finite element method. The finite element formulation is based on the incremental deformation theory and elastic-plastic material modeling. The finite element analysis is carried out using the continuum-based resultant shell elements considering the planar anisotropy of the sheet metal. The proposed method is verified by employing to column buckling problem. And then, the initiation and growth of wrinkling in deep drawing of cylindrical cup are analyzed.

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