• 대한원격탐사학회:학술대회논문집
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• 대한원격탐사학회 2006년도 Proceedings of ISRS 2006 PORSEC Volume II
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• pp.623-626
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• 2006

Group of genes controls the functioning of a cell by complex interactions. These interacting gene groups are called Gene Regulatory Networks (GRNs). Two previous data mining approaches, clustering and classification have been used to analyze gene expression data. While these mining tools are useful for determining membership of genes by homology, they don't identify the regulatory relationships among genes found in the same class of molecular actions. Furthermore, we need to understand the mechanism of how genes relate and how they regulate one another. In order to detect regulatory relationships among genes from time-series Microarray data, we propose a novel approach using frequent pattern mining and chain rule. In this approach, we propose a method for transforming gene expression data to make suitable for frequent pattern mining, and detect gene expression patterns applying FP-growth algorithm. And then, we construct gene regulatory network from frequent gene patterns using chain rule. Finally, we validated our proposed method by showing that our experimental results are consistent with published results.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2005년도 ICCAS
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• pp.1577-1580
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• 2005

With remarkable growth of using Internet, attempts to try intrusions on network are now increasing. Intrusion Detection System is a security system which detects and copes illegal intrusions. Especially with increasing dispersive attacks through network, concerns for this Distributed Intrusion Detection are also rising. The previous Intrusion Detection System has difficulty in coping cause it detects intrusions only on particular network and only same segment. About same attacks, system lacks capacity of combining information and related data. Also it lacks cooperations against intrusions. Systematic and general security controls can make it possible to detect intrusions and deal with intrusions and predict. This paper considers Distributed Intrusion Detection preventing attacks and suggests the way sending active packets between nodes safely and performing in corresponding active node certainly. This study suggested improved E-IDS system which prevents service attacks and also studied sending messages safely by encoding. Encoding decreases security attacks in active network. Also described effective ways of dealing intrusions when misuses happens thorough case study. Previous network nodes can't deal with hacking and misuses happened in the middle nodes at all, cause it just encodes ends. With above suggested ideas, problems caused by security services can be improved.

• 한국식품영양과학회지
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• 제28권6호
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• pp.1326-1331
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• 1999

In vitro anticancer effect of Chinese cabbage kimchi fractions was investigated by using human cancer cells, AGS human gastric adenocarcinoma cells and HT 29 human colon adenocarcinoma cells. The Chinese cabbage kimchi(fermented for 4 days at 15oC) was fractionated into 7 groups, methanol extract, hexane fraction(fr.), methanol soluble fr., dichloromethane fr., ethylacetate fr., butanol fr. and aqueous fr.. Chinese cabbage kimchi fractions inhibited the growth of AGS and HT 29 cancer cells as dose dependent. In particular, the dichloromethane fr. showed the highest inhibitory effect among other fractions. When the dichloromethane fr.(0.2mg/ml) was treated, the number of AGS and HT 29 survival cancer cells reduced to 12$\times$104/ml and 11$\times$104/ml compared to 166$\times$104/ml and 50$\times$104/ml of the controls, respectively. Chinese cabbage kimchi fractions also inhibited the DNA synthesis of the cancer cells. They inhibited the DNA synthesis of AGS human gastric adenocarcinoma cells more efficiently than that of HT 29 human colon adenocarcinoma cells. These results indicate that Chinese cabbage kimchi fractions show in vitro anticancer activity and the dichloromethane fr. among them reveals the highest effect.

• 한국정보통신학회논문지
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• 제17권11호
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• pp.2686-2692
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• 2013

본 논문에서는 무선센서네트워크 기술을 활용하여 각종 생장환경 정보들을 수집하고 모니터링 할 수 있는 무선센서네트워크 기반의 온실환경 모니터링 시스템을 설계하고 구현하였다. 또한, 원격지에서 온실 시설내 내부 환경 및 시설제어시스템을 통합 제어 관리하기 위한 시스템을 제안한다. 본 논문에서 제안한 시스템은 넓은 온실 내부의 환경 데이터 수집 및 온실 시설 제어 서비스를 제공함은 물론 무선센서네트워크 기반 온실환경 모니터링 시스템 및 온실시설 제어를 통하여 실시간 원격 온실 통합 서비스 제공이 가능하다. 통합관리시스템을 위한 GUI 구현은 HMI기반의 시스템 모니터링부로 설계하였으며, 센서정보들은 실시간으로 통합관리시스템의 모니터링 화면을 통해 센서 결과값을 출력할 수 있음을 결과로 얻을 수 있었다.

• 교육시설
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• 제14권1호
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• pp.14-22
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• 2007

This study is to examine the present situation relating to the works for landscape architecture in the universities of Korea with the aim of efficient landscape architecture in university campus and to provide the fundamental data of the logical and organized approach to the plans for campus landscape architecture. A survey of the staffs for landscape architecture in 20 national universities all over the country was carried out on the lot utilization ratio of each university, the development of landscape architecture department and its professionals in universities, the establishing status of the plans for landscape architecture of each university, and the satisfaction level of landscape architecture staffs. The results show that most universities pay a little attention to the whole campus landscape architecture according as they don't conduct the systematic works for landscape architecture and some which are done partially attach importance only to maintenance work such as simple controls of open space and trees. As a consequence, the active utilization of potential lot on campus and the organization of professionals and specialized teams for landscape architecture should be realized in order to make the works for campus landscape architecture effective. Besides, in policies, it is thought that the development of general plans and budgets for landscape architecture at the stage of establishing the medium-and long-tenn growth schemes of the universities is required.

• BMB Reports
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• 제47권10호
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• pp.540-545
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• 2014

Balanced cell growth is crucial in animal development as well as tissue homeostasis. Concerted cross-regulation of multiple signaling pathways is essential for those purposes, and the dysregulation of signaling may lead to a variety of human diseases such as cancer. The time-honored Wnt/${\beta}$-catenin and recently identified Hippo signaling pathways are evolutionarily conserved in both Drosophila and mammals, and are generally considered as having positive and negative roles in cell proliferation, respectively. While most mainstream regulators of the Wnt/${\beta}$-catenin signaling pathway have been fairly well identified, the regulators of the Hippo pathway need to be more defined. The Hippo pathway controls organ size primarily by regulating cell contact inhibition. Recently, several cross-regulations occurring between the Wnt/${\beta}$-catenin and Hippo signaling pathways were determined through biochemical and genetic approaches. In the present mini-review, we mainly discuss the signal transduction mechanism of the Hippo signaling pathway, along with cross-talk between the regulators of the Wnt/${\beta}$-catenin and Hippo signaling pathways.

• Interdisciplinary Bio Central
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• 제4권2호
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• pp.3.1-3.7
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• 2012

Epidermal growth factor receptor (EGFR) is a member of the ErbB family (ErbB1-4) of receptor tyrosine kinases (RTKs). EGFR controls numerous physiological functions, including cell proliferation, migration, differentiation and survival. Importantly, aberrant signaling by EGFR has been linked to human cancers in which EGFR and its various ligands are frequently overexpressed or mutated. EGFR coordinates activation of multiple downstream factors and is subject of various regulatory processes as it mediates biology of the cell it resides in. Therefore, many studies have been devoted to understanding EGFR biology and targeting the protein for the goal of controlling tumor in clinical settings. Endocytic regulation of EGFR offers a promising area for targeting EGFR activity. Upon ligand binding, the activated receptor undergoes endocytosis and becomes degraded in lysosome, thereby terminating the signal. En route to lysosome, the receptor becomes engaged in activating various signaling pathways including PI-3K, MAPK and Src, and endocytosis may offer both spatial and temporal regulation of downstream target activation. Therefore, endocytosis is an important regulator of EGFR signaling, and increasing emphasis is being placed on endocytosis in terms of cancer treatment and understanding of the disease. In this review, EGFR signaling pathway and its intricate regulation by endocytosis will be discussed.

• 한국식품영양학회지
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• 제10권3호
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• pp.320-324
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• 1997

유기산 처리법을 이용하여 15$^{\circ}C$ 저장 동안 생굴의 V. vulnificus strain 29307의 세균수 변화에 대한 영향을 조사하였다. 각각 3분 동안 0.5% 초산, 0.5% 유산, 또는 0.5% 구연산을 침지한 생굴은 저장 4일 후부터 V. vulnificus가 검출되지 않았다. 2% 초산 함유한 3% 알지닉산 처리구는 저장 2일 후부터 V. vulnificus가 검출되지 않았으며, 수돗물로 처리한 대조구는 저장 4일 동안 V. vulnificus가 분리되었다. 본 연구의 결과를 토대로 알지닉산과 초산의 조합은 각 유기산 처리구보다 V. vulnificus에 대한 항균력을 증진하였다.

• 대한설비공학회:학술대회논문집
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• 대한설비공학회 2009년도 하계학술발표대회 논문집
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• pp.1343-1347
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• 2009

In order to comply with the global energy crisis and environment problem, it is necessary to research and develop the energy utilization technology with the reduction of the primary energy usage. Although the increasing rate of energy consumption started to attenuate, the entire consumption of energy as well as $CO_2$ emission rate tends to increase steadily along with an economic growth in Korea. The energy demand in Korea increases by annual 3.7% during the period from 2000 to 2006. And it is expected that we should take a charge of the greenhouse gas reduction obligation by the Climatic Change Convention(Kyoto Protocol) during the 2nd pledge period($2013{\sim}2017$). According to the IEA report in 2005, the emission amount of carbon dioxide is the 10th place in the world, and the increasing rate is 4.7% annually. Considering the economic scale of Korea, the degradation of energy usage is inevitable when the greenhouse gas reduction obligation come into effect. Therefore, effective energy usage is a very important issue to minimize baneful influence on industrial and economic activities.

• Natural Product Sciences
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• 제26권2호
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• pp.158-164
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• 2020

Helicobacter pylori is a well-known pathogen that is responsible for gastric disorders. Overcoming of the antibiotic-resistance is a main barrier to treat H. pylori infection. In our search for anti-H. pylori compounds from natural resources, bioactivity-guided isolation on the ethyl acetate fraction of Fraxinus mandshurica bark that had shown anti-H. pylori activity gave twelve compounds (1 - 12) of six coumarins, three phenylethanoids, two secoiridoids, and a lignan using silica gel column chromatography, Sephadex-LH 20, and recrystallization. The chemical structures were identified by spectroscopic data analysis, including 1D, 2D NMR, and mass spectrometry. Among them, compounds 2, 10, and 11 showed moderate growth inhibitory activity against three strains of H. pylori, compared with positive controls of quercetin and metronidazole. Compounds 5, 6, 8, and 12 exhibited the inhibitory activity against strains 26695 or 43504. This is the first report on the anti-H. pylori activity of this plant and the isolated compounds.