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http://dx.doi.org/10.20307/nps.2020.26.2.158

Anti-Helicobacter pylori Activity of Compounds Isolated from Fraxinus mandshurica Bark  

Akter, Kazi-Marjahan (College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University)
Kim, Hye-Jin (College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University)
Park, Woo Sung (College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University)
Khalil, Atif Ali Khan (College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University)
Ahn, Mi-Jeong (College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University)
Publication Information
Natural Product Sciences / v.26, no.2, 2020 , pp. 158-164 More about this Journal
Abstract
Helicobacter pylori is a well-known pathogen that is responsible for gastric disorders. Overcoming of the antibiotic-resistance is a main barrier to treat H. pylori infection. In our search for anti-H. pylori compounds from natural resources, bioactivity-guided isolation on the ethyl acetate fraction of Fraxinus mandshurica bark that had shown anti-H. pylori activity gave twelve compounds (1 - 12) of six coumarins, three phenylethanoids, two secoiridoids, and a lignan using silica gel column chromatography, Sephadex-LH 20, and recrystallization. The chemical structures were identified by spectroscopic data analysis, including 1D, 2D NMR, and mass spectrometry. Among them, compounds 2, 10, and 11 showed moderate growth inhibitory activity against three strains of H. pylori, compared with positive controls of quercetin and metronidazole. Compounds 5, 6, 8, and 12 exhibited the inhibitory activity against strains 26695 or 43504. This is the first report on the anti-H. pylori activity of this plant and the isolated compounds.
Keywords
Fraxinus mandshurica; Anti-Helicobacter pylori; Fraxetin; Calceolarioside A; Calceolarioside B;
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