• Title/Summary/Keyword: growth controls

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CONSTRUCTING GENE REGULATORY NETWORK USING FREQUENT GENE EXPRESSION PATTERN MINING AND CHAIN RULES

  • Park, Hong-Kyu;Lee, Heon-Gyu;Cho, Kyung-Hwan;Ryu, Keun-Ho
    • Proceedings of the KSRS Conference
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    • v.2
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    • pp.623-626
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    • 2006
  • Group of genes controls the functioning of a cell by complex interactions. These interacting gene groups are called Gene Regulatory Networks (GRNs). Two previous data mining approaches, clustering and classification have been used to analyze gene expression data. While these mining tools are useful for determining membership of genes by homology, they don't identify the regulatory relationships among genes found in the same class of molecular actions. Furthermore, we need to understand the mechanism of how genes relate and how they regulate one another. In order to detect regulatory relationships among genes from time-series Microarray data, we propose a novel approach using frequent pattern mining and chain rule. In this approach, we propose a method for transforming gene expression data to make suitable for frequent pattern mining, and detect gene expression patterns applying FP-growth algorithm. And then, we construct gene regulatory network from frequent gene patterns using chain rule. Finally, we validated our proposed method by showing that our experimental results are consistent with published results.

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A Distributed Communication Model of Intrusion Detection System in Active Network

  • Park, Soo-Young;Park, Sang-Gug
    • 제어로봇시스템학회:학술대회논문집
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    • 2005.06a
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    • pp.1577-1580
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    • 2005
  • With remarkable growth of using Internet, attempts to try intrusions on network are now increasing. Intrusion Detection System is a security system which detects and copes illegal intrusions. Especially with increasing dispersive attacks through network, concerns for this Distributed Intrusion Detection are also rising. The previous Intrusion Detection System has difficulty in coping cause it detects intrusions only on particular network and only same segment. About same attacks, system lacks capacity of combining information and related data. Also it lacks cooperations against intrusions. Systematic and general security controls can make it possible to detect intrusions and deal with intrusions and predict. This paper considers Distributed Intrusion Detection preventing attacks and suggests the way sending active packets between nodes safely and performing in corresponding active node certainly. This study suggested improved E-IDS system which prevents service attacks and also studied sending messages safely by encoding. Encoding decreases security attacks in active network. Also described effective ways of dealing intrusions when misuses happens thorough case study. Previous network nodes can't deal with hacking and misuses happened in the middle nodes at all, cause it just encodes ends. With above suggested ideas, problems caused by security services can be improved.

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Invitro Anticancer Effect of Chinese Cabbage Kimchi Fractions (배추김치 분획물의 in vitro 항암효과)

  • 박건영;조은주;이숙희;강갑석
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.28 no.6
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    • pp.1326-1331
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    • 1999
  • In vitro anticancer effect of Chinese cabbage kimchi fractions was investigated by using human cancer cells, AGS human gastric adenocarcinoma cells and HT 29 human colon adenocarcinoma cells. The Chinese cabbage kimchi(fermented for 4 days at 15oC) was fractionated into 7 groups, methanol extract, hexane fraction(fr.), methanol soluble fr., dichloromethane fr., ethylacetate fr., butanol fr. and aqueous fr.. Chinese cabbage kimchi fractions inhibited the growth of AGS and HT 29 cancer cells as dose dependent. In particular, the dichloromethane fr. showed the highest inhibitory effect among other fractions. When the dichloromethane fr.(0.2mg/ml) was treated, the number of AGS and HT 29 survival cancer cells reduced to 12$\times$104/ml and 11$\times$104/ml compared to 166$\times$104/ml and 50$\times$104/ml of the controls, respectively. Chinese cabbage kimchi fractions also inhibited the DNA synthesis of the cancer cells. They inhibited the DNA synthesis of AGS human gastric adenocarcinoma cells more efficiently than that of HT 29 human colon adenocarcinoma cells. These results indicate that Chinese cabbage kimchi fractions show in vitro anticancer activity and the dichloromethane fr. among them reveals the highest effect.

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Implementation of Greenhouse Environment Monitoring System based on Wireless Sensor Networks (무선센서네트워크 기반 온실환경 모니터링 시스템 구현)

  • Lee, Young-Dong
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.17 no.11
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    • pp.2686-2692
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    • 2013
  • In this paper, various growth environment data collecting and monitoring based on wireless sensor network for greenhouse environmental monitoring system is designed and implemented. In addition, greenhouse control system is proposed to integrated control and management in internal environment and greenhouse facilities. The system provides real-time remote greenhouse integrated management service which collects greenhouse environment information and controls greenhouse facilities based on wireless sensor network. Graphical user interface for an integrated management system is designed based on the HMI and the experimental results show that the sensor data were collected by integrated management in real-time.

A Study on the Meaning and Revitalization Strategy of Landscape Architecture in University Campus (대학 캠퍼스 조경의 의미와 활성화 방안에 관한 연구)

  • Kim, Jong-Pyo;Kim, Yong-Soo
    • Journal of the Korean Institute of Educational Facilities
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    • v.14 no.1
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    • pp.14-22
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    • 2007
  • This study is to examine the present situation relating to the works for landscape architecture in the universities of Korea with the aim of efficient landscape architecture in university campus and to provide the fundamental data of the logical and organized approach to the plans for campus landscape architecture. A survey of the staffs for landscape architecture in 20 national universities all over the country was carried out on the lot utilization ratio of each university, the development of landscape architecture department and its professionals in universities, the establishing status of the plans for landscape architecture of each university, and the satisfaction level of landscape architecture staffs. The results show that most universities pay a little attention to the whole campus landscape architecture according as they don't conduct the systematic works for landscape architecture and some which are done partially attach importance only to maintenance work such as simple controls of open space and trees. As a consequence, the active utilization of potential lot on campus and the organization of professionals and specialized teams for landscape architecture should be realized in order to make the works for campus landscape architecture effective. Besides, in policies, it is thought that the development of general plans and budgets for landscape architecture at the stage of establishing the medium-and long-tenn growth schemes of the universities is required.

Cross-talk between Wnt/β-catenin and Hippo signaling pathways: a brief review

  • Kim, Minseong;Jho, Eek-hoon
    • BMB Reports
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    • v.47 no.10
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    • pp.540-545
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    • 2014
  • Balanced cell growth is crucial in animal development as well as tissue homeostasis. Concerted cross-regulation of multiple signaling pathways is essential for those purposes, and the dysregulation of signaling may lead to a variety of human diseases such as cancer. The time-honored Wnt/${\beta}$-catenin and recently identified Hippo signaling pathways are evolutionarily conserved in both Drosophila and mammals, and are generally considered as having positive and negative roles in cell proliferation, respectively. While most mainstream regulators of the Wnt/${\beta}$-catenin signaling pathway have been fairly well identified, the regulators of the Hippo pathway need to be more defined. The Hippo pathway controls organ size primarily by regulating cell contact inhibition. Recently, several cross-regulations occurring between the Wnt/${\beta}$-catenin and Hippo signaling pathways were determined through biochemical and genetic approaches. In the present mini-review, we mainly discuss the signal transduction mechanism of the Hippo signaling pathway, along with cross-talk between the regulators of the Wnt/${\beta}$-catenin and Hippo signaling pathways.

Endocytic Regulation of EGFR Signaling

  • Chung, Byung-Min
    • Interdisciplinary Bio Central
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    • v.4 no.2
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    • pp.3.1-3.7
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    • 2012
  • Epidermal growth factor receptor (EGFR) is a member of the ErbB family (ErbB1-4) of receptor tyrosine kinases (RTKs). EGFR controls numerous physiological functions, including cell proliferation, migration, differentiation and survival. Importantly, aberrant signaling by EGFR has been linked to human cancers in which EGFR and its various ligands are frequently overexpressed or mutated. EGFR coordinates activation of multiple downstream factors and is subject of various regulatory processes as it mediates biology of the cell it resides in. Therefore, many studies have been devoted to understanding EGFR biology and targeting the protein for the goal of controlling tumor in clinical settings. Endocytic regulation of EGFR offers a promising area for targeting EGFR activity. Upon ligand binding, the activated receptor undergoes endocytosis and becomes degraded in lysosome, thereby terminating the signal. En route to lysosome, the receptor becomes engaged in activating various signaling pathways including PI-3K, MAPK and Src, and endocytosis may offer both spatial and temporal regulation of downstream target activation. Therefore, endocytosis is an important regulator of EGFR signaling, and increasing emphasis is being placed on endocytosis in terms of cancer treatment and understanding of the disease. In this review, EGFR signaling pathway and its intricate regulation by endocytosis will be discussed.

Inhibition of Vibrio vulnificus in Oysters using Organic Acids (유기산을 이용한 생굴의 Vibrio vulnificus 억제)

  • 김창렬;이재일;신은하;이용규
    • The Korean Journal of Food And Nutrition
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    • v.10 no.3
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    • pp.320-324
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    • 1997
  • The number of Vivrio vulnificus strain 29307 was assessed for oysters treated with acetic, lactic, citric, and alginic acids during storage at 15$^{\circ}C$. When oysters were dipped with 0.5% acetic, 0.5% lactic, or 0.5% citric acids for 3 min, V. vulnificus was not detected after 4 days of storage. V. vulnificus in the treatment of 3% alginic acid (AL) containing 2% acetic acid (AA) was not detected after 2 days of storage, while it was isolated in the controls for 4 days of storage. Based on these results, the combination of AL and AA was more effective for preventing the growth of V. vulnificus in oysters than the treatments of the acid alone.

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Compact module and control system for district heating system (지역난방용 콤팩트 유닛 및 제어기 개발)

  • Lee, Young-Soo;Baik, Young-Jin;Jung, Dae-Hun;Kim, Jin;Um, Chul-Jun
    • Proceedings of the SAREK Conference
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    • 2009.06a
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    • pp.1343-1347
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    • 2009
  • In order to comply with the global energy crisis and environment problem, it is necessary to research and develop the energy utilization technology with the reduction of the primary energy usage. Although the increasing rate of energy consumption started to attenuate, the entire consumption of energy as well as $CO_2$ emission rate tends to increase steadily along with an economic growth in Korea. The energy demand in Korea increases by annual 3.7% during the period from 2000 to 2006. And it is expected that we should take a charge of the greenhouse gas reduction obligation by the Climatic Change Convention(Kyoto Protocol) during the 2nd pledge period($2013{\sim}2017$). According to the IEA report in 2005, the emission amount of carbon dioxide is the 10th place in the world, and the increasing rate is 4.7% annually. Considering the economic scale of Korea, the degradation of energy usage is inevitable when the greenhouse gas reduction obligation come into effect. Therefore, effective energy usage is a very important issue to minimize baneful influence on industrial and economic activities.

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Anti-Helicobacter pylori Activity of Compounds Isolated from Fraxinus mandshurica Bark

  • Akter, Kazi-Marjahan;Kim, Hye-Jin;Park, Woo Sung;Khalil, Atif Ali Khan;Ahn, Mi-Jeong
    • Natural Product Sciences
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    • v.26 no.2
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    • pp.158-164
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    • 2020
  • Helicobacter pylori is a well-known pathogen that is responsible for gastric disorders. Overcoming of the antibiotic-resistance is a main barrier to treat H. pylori infection. In our search for anti-H. pylori compounds from natural resources, bioactivity-guided isolation on the ethyl acetate fraction of Fraxinus mandshurica bark that had shown anti-H. pylori activity gave twelve compounds (1 - 12) of six coumarins, three phenylethanoids, two secoiridoids, and a lignan using silica gel column chromatography, Sephadex-LH 20, and recrystallization. The chemical structures were identified by spectroscopic data analysis, including 1D, 2D NMR, and mass spectrometry. Among them, compounds 2, 10, and 11 showed moderate growth inhibitory activity against three strains of H. pylori, compared with positive controls of quercetin and metronidazole. Compounds 5, 6, 8, and 12 exhibited the inhibitory activity against strains 26695 or 43504. This is the first report on the anti-H. pylori activity of this plant and the isolated compounds.