• 약학회지
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• 제27권4호
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• pp.309-314
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• 1983

Six hydantoin derivatives, 3-(2-chloroethyl) hydantoin (6a), 3-(2-chloroethyl)-5-isopropylhydantoin (6b), 3-(2-chloroethyl)-5-isobutylhydantoin (6c), 3-(2-chloroetbyl)5-(2-butyl) hydantoin (6d), 3-(2-chloroethyl)-5-benzylhydantoin (6e), 3-(2-chloroethyl)-5-(indolyl-3-methyl) hydantoin (6f), were prepared by the treatment of the corresponding salt of amino acids with 2-chloroethyl isocyanate in cold water, followed by refluxing in concentrated HCl solution. Anticancer activity of the synthesized hydantoin derivatives were examined on murine leukemia L1210 cells growing in Fischer medium. Among them, 3-(2-chloroethy)-5-isobutyl-hydantoin (6c) showed substantially low $ED_{50}$ value of $9.6{\mu}g/ml$.

• 한국인터넷방송통신학회논문지
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• 제11권4호
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• pp.217-222
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• 2011

최근 SNS가 급격하게 성장하고 있고 많은 사용자들이 이 SNS를 하나의 다른 커뮤니케이션 매체로 사용하고 있다. SNS를 이용하는 개인 사용자들은 자신의 소식과 감정의 변화를 표현하는 수단으로 SNS를 이용하고 있다. 이에 본 연구에서는 감정을 나타내는 감정 요소를 이용하여 메시지를 분류하는 프로그램을 구현하였다. 감정 성분 추출은 OMLS(Ocean-Monmouth Legal Services)에 있는 감정 어휘를 이용하여 로젯(Roget)의 시소러스와 워드넷(WordNet)을 이용하여 이루어졌다.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2002년도 추계학술대회 논문집 전기물성,응용부문
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• pp.164-166
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• 2002

Over the past two decades, the electrochemical supercapaictors are receiving growing attention due to their possible applications as power backup in electronic equipment and electrical vehicles. Both of amorphous cobalt oxide and manganese dioxide were prepared by sol-gel process reported in our previous work. Nano-structured supramolecular oligomer of 1,5-diamino anthraquinone(DAAQ) coated metal oxides were successfully prepared by electrochemical oxidation from an acidic non-aqueous medium. We established process parameters of the technique for the formation of nano-structured materials. Furthermore, improved the capacitive properties of the nano structured metal oxide electrodes using controlled solution chemistry. $CoO_2$ and $MnO_2$-based composite electrode showed relatively good electrochemical behaviors in acidic electrolyte system with respect to specific capacity and scan rate dependency

• 한국잠사곤충학회지
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• 제44권2호
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• pp.56-58
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• 2002

뽕잎 두께가 비교적 두껍고 수량성이 높은 후엽녹의 생장점에 Colchicine용액 적하처리를 하여 창성한 4배성인 4원뽕 28호의 주요 특성은 다음과 같다. 1. 체세포의 염색체수는 2n=56인 4배체이다. 2. 봄철 발아개엽기는 중생뽕이고 잎모양은 삼각형에 가까운 타원형으로 폭광형이고 잎두께는 매우 두께우며 잎면적당 염록소 함량이 많다. 3.가지길이는 비교적 짧고 가지수도 다소 적으며 가지굵기는 굵은 편이고 기부불발아장비율이 높고 내동성은 약하다.

• 약학회지
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• 제39권5호
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• pp.516-520
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• 1995

The anti-dansyl antibodies were specifically labeled with stable isotope by growing hybridoma cells in serum-free medium. Assignments of the observed carbonyl carbon resonances have been determined by using $^{13}C-{15}N$ double labeling method in order to assign the Leu resonances. However, when the identical dipeptide appears more than twice in the polypeptide sequences, we applied the proteolytic fragments in the fragment-specific method. Carboxypep-tidase B-treated antibody has also been used to assign the Lys-447 in C terminal amino acid. These unambiguously assigned carbonyl carbon resonances in antibodies are thought to be useful in elucidating not only the structure of antibodies but also the structure-function relationship in the antibody by $^{13}C$ neuclear magnetic resonance spectroscopy.

• 약학회지
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• 제38권5호
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• pp.602-607
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• 1994

Based upon the previous experiments showing that kidney and lung tissues of rat had relatively abundant bradykinin binding sites, we tried to characterize and determine the densities of the bradykinin binding sites in the rabbit kidney tissue and proximal tubular cells under different growing conditions. Among the kidney tissue renal medulla segments showed the highest bradykinin binding sites. To determine which growth factors are to add in the serum free culture medium to express selectively the bradykinin binding sites in the rabbit kidney proximal tubular cells, we tried so called hormone-deletion approach and in here insulin, hydrocortisone, transferrin, triiodothyronine and prostaglandin $E_1$ are examined. By performing receptor binding assay and determination of protein concentrations, we may conclude that the most required hormones in the expression for bradykinin binding sites are insulin and transferrin, and fetal bovine serum is shown to be less effective in this regard.

• International Journal of Internet, Broadcasting and Communication
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• 제13권4호
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• pp.90-96
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• 2021

The logistics market is continuously growing due to the development of technology and the growth of the online market. In addition, the social atmosphere that emphasizes non-face-to-face due to the pandemic situation is accelerating the growth of logistics. Delivery of goods ordered online requires delivery process through courier worker. In order for the courier worker to ship the product, the work of loading the product on the truck must be preceded. The accident caused by such delivery and loading work is increasing and it is emerging as a social problem. This study proposes a robot-based automated loading system to efficiently handle the increasing volume of courier service and to construct a more efficient and safe working environment by replacing the physical labor that was overloaded to courier workers. The proposed system replaces the loading of the courier worker and proposes the optimal loading function through the automation system.

• 한국수소및신에너지학회논문집
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• 제31권6호
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• pp.578-586
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• 2020

There is growing interest worldwide in a hydrogen economy that uses hydrogen as an energy medium instead of hydrocarbon-based fossil fuels as a way to combat climate change. Since hydrogen has a very low energy density per unit volume at room temperature, hydrogen must be compressed and stored in order to use as an energy carrier. There are mechanical and non-mechanical methods for compressing hydrogen. The mechanical method has disadvantages such as high energy consumption, durability problems of moving parts, hydrogen contamination by lubricants, and noise. Among the non-mechanical compression methods, electrochemical compression consumes less energy and can compress hydrogen with high purity. In this paper, research trends are reviewed, focusing on research papers on electrochemical hydrogen compression technology, and future research directions are suggested.

• International Journal of Internet, Broadcasting and Communication
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• 제14권1호
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• pp.188-193
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• 2022

The energy efficiency of memory systems is an important task in designing future computer systems as memory capacity continues to increase to accommodate the growing big data. In this article, we present an energy-efficient last-level cache management policy for future mobile systems. The proposed policy makes use of low-power PCM (phase-change memory) as the main memory medium, and reduces the amount of data written to PCM, thereby saving memory energy consumptions. To do so, the policy keeps track of the modified cache lines within each cache block, and replaces the last-level cache block that incurs the smallest PCM writing upon cache replacement requests. Also, the policy considers the access bit of cache blocks along with the cache line modifications in order not to degrade the cache hit ratio. Simulation experiments using SPEC benchmarks show that the proposed policy reduces the power consumption of PCM memory by 22.7% on average without degrading performances.

• Journal of Applied Biological Chemistry
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• 제65권4호
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• pp.447-451
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• 2022

Phytoestrogenic S-equol production in human gut exclusively depends on the biotransformation of daidzein to dihydrodaidzein (DHD). With a growing demand for the DHD enriched biomaterials, the commercial soybean hypocotyl extract (SHE) was chosen as a substrate for the microbial DHD production by human gut bacterium MRG-1, anaerobic DHD producer. To optimize the production of DHD, anaerobic fermentation conditions, including sterilization time, growth stage of inoculum, and growth media, were investigated. Maximum DHD production (1.2 g/L) was achieved after 48 h incubation when 1% (w/v) of SHE in the 20-min-sterilized Gifu Anaeboic Medium media was inoculated with OD₆₀₀ 0.3-0.4 of MRG-1. This is the first report that crude soy biomaterial, instead of pure compounds, such as daidzin and daidzein, is utilized for the production of the DHD enriched biomaterial.