• 약학회지
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• 제36권4호
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• pp.303-314
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• 1992

Experiments were performed on mice to investigate the effect of methionine diets (MET) on the immunotoxicity of ethanol. ICR female mice were divided into 5 groups, Met (Basal (B)+0.19% methionine(M), B+1.71% M and B+5.13%W) and ethanol(4%) were administered ad libitum for 21 days. The mice were evaluated for changes in immune status as measured by antibody titer, Arthus reaction, delayed type hypersensitivity (DTH), rosette forming cell(RFC) and plaque forming cell (PFC) to sheep red blood cells (S-RBC). To investigate the change of the non-specific immune response, the number of leukocytes in peripheral blood and phagocyte activity were measured. The results were summarized as follows: (1) The weight ratios of spleen and thymus to body weight were significantly increased by the B+0.19% M, B+0.57% M and B+1.71% M groups in comparison with control group(B), but B+5.13% M group was significantly decreased. (2) Humoral immune responses were significantly increased by the B+0.19% M and B+0.57% M groups in comparison with control group, but B+5.13% M group was significantly decreased. (3) Cellular immune responses were significantly decreased by the B+1.71% M and B+5.13% M groups in comparison with control group. (4) Phagocyte activities were significantly increased by the B+0.19% M, B+0.57% M and B+1.71% M groups in comparison with control groups, but B+5.13% M group was significantly decreased. (5) The number of circulating leukocyte was significantly increased in the B+0.19% M and B+0.57% M groups in comparison with control group, but B+5.13% M group was significantly decreased.

• PNF and Movement
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• 제13권3호
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• pp.127-134
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• 2015

Purpose: The current study seeks to examine the effect of coordinative pattern exercises of the upper and lower extremities using harnesses and walking rails on the walking and balance abilities of chronic stroke patients, and to develop effective programs and training methods to improve the functions of such patients. Methods: Subjects included 16 patients with hemiplegia caused by stroke. The subjects were randomly divided into an experimental group (n=8), on which coordinative pattern exercises of the upper and lower extremities were conducted, and a comparison group (n=8) that received typical exercise therapy. The experimental group underwent 30 minutes of typical exercise therapy and 30 minutes of coordinative pattern exercises of the upper and lower extremities, while the comparison group underwent typical exercise therapy for 30 minutes twice a day, five days per week for a six-week period. To evaluate walking ability, 10-m walking tests (10MWT) and 6-m walking tests (6MWT) were conducted. To assess balance ability, timed up and go tests (TUG) were performed. Results: After the intervention, significant (p<0.05) differences were seen in the 10MWT, 6MWT, and TUG in both the experimental and comparison groups. As for the 10MWT, the experimental group showed more significant improvement than the comparison group (p<0.05). In terms of the 6MWT, no significant differences were found between the groups, while the experimental group showed more significant differences than the comparison group in the TUG (p<0.05). Conclusion: The results from the current research indicate that training programs that apply coordinative pattern exercises of the upper and lower extremities with harnesses are extremely effective for improving the walking and balance abilities of chronic stroke patients.

• 대한본초학회지
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• 제24권1호
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• pp.59-71
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• 2009

본 연구는 상표소와 상심자가 난소적출로 유발된 흰쥐의 골다공증 치료효과에 미치는 영향에 관한 것으로서 주요 내용은 다음과 같다. 본 연구에서는 상표소와 상심자 물 추출물을 난소를 절제한 흰쥐에 투여하여 대퇴골, 비골경골의 골밀도, 혈청 중 오스테오칼신 함량, 알칼리성 인산가수분해효소 활성도, 칼슘 함량, 인 함량, 소변 중 무기성분의 변화, deoxypyridinoline 함량 등과 뼈의 함량, 인 함량, ash 무게에 미치는 영향을 살펴보았다. 본 실험 결과 상표소와 상심자 물 추출물은 폐경기 이후 골다공증에 대한 치료에 효과적이라고 판단된다는 내용이다.

• 대한치과교정학회지
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• 제21권2호
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• pp.273-285
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• 1991

Crowded group is composed of 60 subjects who visited Yonsei University for orthodontic treatment and has no history of orthodontic treatment. Noncrowded group is composed of 26 subjects who has no crowding, considered to have a normal occlusion and no history of orthodontic treatment. Currently available and approved analytic method was used. Interrelationship between tooth size and arch size, and it's correlation on tooth crowding was studied and the following results were obtained. 1. In comparison of sum of mesiodistal width, of crown size of teeth was greater in noncrowded group than that of crowded group on both arch. (p < 0.01). 2. In comparison of arch lengths, the values measured from arch length 2 showed greater in noncrowded group (p < 0.01). Also in crowded group, arch length 1 showed greater value than arch length 2 on both arch (p < 0.01). 3. In comparison of arch widths, upper interlateral (p < 0.01) and upper intercanine width (p < 0.05) showed greater value in noncrowded group on upper arch and intermolar width showed greater value in noncrowded group on both upper and lower arches (p < 0.05). 4. In comparison of arch perimeters, arch perimeter 2 was greater value in noncrowded group on both upper and lower arches (p < 0.01). 5. Dentoalveolar disproportion was greater in noncrowded group on both upper and lower arches (p < 0.01). 6. In lower incisors MD/FL ratio, the central and lateral incisors were greater in crowded group, but statistial significance was only in lateral incisors (p < 0.01) 7. The irregularity index of lower incisors showed greater value in crowded group (p < 0.01).

• 사상체질의학회지
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• 제24권1호
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• pp.54-65
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• 2012

1. Objective : The purpose of this study is to investigate the effects of TAM (Taraxacum mongolicum) on Th2 cytokine production in MC/9 mast cells. 2. Methods : The effects of TAM was analyzed by ELISA and Real-time PCR in MC/9 mast cells. Levels of IL-5, IL-13 were measured using enzyme-linked immunosorbent assays(ELISA). mRNA levels of IL-4, IL-5, IL-6, IL-13 were analyzed with Real-time PCR. 3. Results : 1) TAM inhibited the IL-4 production significantly in comparison to PI-control group at concentration of $50{\mu}g/ml$, $100{\mu}g/ml$, $200{\mu}g/ml$. 2) TAM inhibited the IL-13 production significantly in comparison to PI-control group at concentration of $50{\mu}g/ml$, $100{\mu}g/ml$, $200{\mu}g/ml$. 3) TAM inhibited the IL-4 mRNA expression significantly in comparison to PI-control group at concentration of $100{\mu}g/ml$. 4) TAM inhibited the IL-5 mRNA expression significantly in comparison to PI-control group at concentration of $50{\mu}g/ml$, $100{\mu}g/ml$. 5) TAM inhibited the IL-6 mRNA expression significantly in comparison to PI-control group at concentration of $100{\mu}g/ml$. 6) TAM inhibited the IL-13 mRNA expression significantly in comparison to PI-control group at concentration of $100{\mu}g/ml$. 4. Conclusions : These results indicate that TAM (Taraxacum mongolicum) has the effect of decreasing the Th2 cytokine production in the MC/9 mast cell.

• 대한물리의학회지
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• 제14권1호
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• pp.35-41
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• 2019

PURPOSE: This study examined the effects of a vestibular stimulation training program on the walking ability of chronic stroke patients over a six month period. METHODS: Forty stroke patients were enrolled in this study. The patients were divided randomly into a control group (n=20) and experimental group (n=20). A general exercise program was applied to Group I and vestibular stimulation training was applied to Group II(30 min, three times a week for six weeks). The changes in straight walking ability, curved walking ability, and functional walking ability were measured using a 10 m walking test figure-of-eight-walking test, and dynamic gait index, respectively. The measures before and after the program were compared using a paired t-test for a comparison of each group and an independent t-test for a comparison between groups. RESULTS: The changes in each group were examined according to the measurement period. The Experimental group showed significant functional improvement in all three tests after the vestibular stimulation training program, but the control group did not show significant improvement in any of the tests after the general exercise program. A comparison of the changes between groups revealed the experimental group to show significantly higher improvement than the control group in all tests. CONCLUSION: The vestibular stimulation training program helps improve the gait function of stroke patients. Based on the results of this study, it is expected that various vestibular stimulation training programs will be developed and applied in a range of places.

• 디지털융복합연구
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• 제16권10호
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• pp.485-496
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• 2018

본 연구는 대학 신입생이 느끼는 심리적 진로장벽 해소를 위한 집단프로그램을 구성하여 적용하고, 심리적 진로장벽, 진로결정 자기효능감과 자기결정성에 미치는 효과를 검증하고자 하였다. 이를 위해 처치집단에 8명, 비교집단에 9명을 할당하여 처치집단에는 7회기에 해당하는 심리적 진로장벽 해소 집단프로그램을 실시하고 비교집단에는 아무런 처치를 하지 않았다. 프로그램의 효과를 알아보기 위해 처치집단과 비교집단 각각 사전검사와 사후검사로 심리적 진로장벽, 진로결정 자기효능감, 자기결정성검사를 실시한 후 사전 사후 차이 검증을 실시하였다. 그 결과, 첫째, 심리적 진로장벽점수는 비교집단에 비해 처치집단의 점수가 유의하게 낮아진 것으로 나타났다. 둘째, 진로결정 자기효능감점수는 비교집단에 비해 처치집단의 점수가 유의하게 향상된 것으로 나타났다. 셋째, 자기결정성점수는 비교집단에 비해 처치집단의 점수가 유의하게 향상된 것으로 나타났다. 즉, 본 집단프로그램은 대학 신입생의 심리적 진로장벽 인식을 낮추고 진로결정 자기효능감과 자기결정성을 향상시키는 데 효과가 있었다. 본 연구결과의 활용과 향후 연구에 대해 논의하였다.

• The Journal of Korean Physical Therapy
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• 제13권2호
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• pp.313-324
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• 2001

The 15 male students of T-college which is located in Taegu, who don't have any cardiovascular diseases and skin diseases and agreed to the experiment for finding out the effects of hot and cold therapy. They were divided 5 experimental groups, that is hot therapy in blood Pressures, hot therapy group showed significantly difference of systolic blood Pressure. And the hot therapy group and hot and cold therapy showed the distinctive differences in Scheffes' s analysis after the fact. 3. There was no significant difference in pulsation between before and after experiment and there were no differences in each group. 4. The hot therapy group showed significant difference in WBC and didn't show any difference in RBC(p<.05). 5. Timing does not effect to each group in the changes of HGB and HCT. 6. In the comparison between before and after the experiments in the changes of MCV, cold therapy group showed significant measurement. And in the comparison between before and after one hour the experiment in the changes of MCV, cold therapy group showed significant measurement. The experimental group 1 and 3 showed the distinctive differences in Scheffe' s analysis after the fact(p<.05). 7. In the comparison between before and after one hour experiments in MCV changes, the cold therapy group had significant differences(p<.05). 8. There were no significant differences between before and after the experiments in MCHC changes. 9. In the comparison between before and after one hour experiments in PLT changes, cold therapy group had significant changes(p<.05) and there were no differences among three group.

• 대한본초학회지
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• 제25권4호
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• pp.61-67
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• 2010

Objectives : For the purpose of verifying the anti-depressant effect of Paeoniae Radix Rubra(PR), the expression of corticotropin-releasing factor(CRF), c-Fos and tyrosine hydroxylase(TH) was evaluated after performing the Forced Swimming Test(FST). Methods : Spraque-Dawley rats were ingested PR extract(100mg/kg, 400mg/kg, p.o.) for 3 times prior to FST. And the expression of corticotropin-releasing factor(CRF), c-Fos in the paraventricular nucleus(PVN) and tyrosine hydroxylase(TH) in the locus coelureus(LC) and ventral tegmental area(VTA) was measured immunohistochemically after FST. Results : The duration of immobility was significantly decreased in PR 100mg/kg Group and PR 400mg/kg Group, in comparison with the control group (p<0.001). The expression of CRF in the PVN was significantly decreased in PR 400mg/kg Group in comparison of the control group (p<0.05). The expression of c-Fos in the PVN was rather significantly increased in PR 100mg/kg Group in comparison with the control group, while almost no change was demonstrated in PR 400mg/kg Group. The expression of TH was significantly decreased in VTA in comparison with the control group (p<0.05), but the number of expression cells in LC was slightly decreased in case of PR 100mg/kg group while it was increased in case of PR 400mg/kg Group. Conclusion : Judging from the result of the aforementioned tests, Paeoniae Radix Rubra has decreased immobility. In addition, it has also decreased the expression of CRF and the expression of TH in VTA, while the expression of c-Fos and of TH in LC has no significance. Therefore, it is believed that Paeoniae Radix Rubra has an anti-depressant effect by decreased immobility through the reduced expression of CRF and TH in VTA.

• 대한물리치료과학회지
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• 제28권2호
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• pp.19-29
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• 2021

Background: The purpose of this study was to investigate the effects of pulsed-ultrasound intervention and continued-ultrasound on the MVIC (maximal voluntary isometric contraction) and active ROM (range of motion) recovery of before EIMD (exercise-induced muscle damage). Design: Randomized controlled trial. Methods: Thirty subjects who are student in their 20s at a university participated in this study, these subjects were assigned into three groups, a control group (n=10), experiment group I (n=10) and experiment group II (n=10). The subjects in experimental group were intervened by pulsed-ultrasound and continued-ultrasound, while ones on control group weren't by any intervention after induced EIMD. Results: First, In comparison of the MVIC, in the among group comparison, the MVIC of continued-ultrasound group was significantly larger than those of other groups (p<.005). Second, In the among group comparison, the active extension angle of continued-ultrasound group was significantly smaller than those of other groups (p<.005). Third, In the among group comparison, the active flexion angle of continued-ultrasound group was significantly lager than those of other groups (p<.05). Conclusion: The above results revealed that the continued-ultrasound intervention before an exercise had a significantly improve of muscle function after EIMD. Therefore we can consider the continued ultrasound as a considerable intervention method to prevent or reduce an exercise injury.