• Korean Journal of Community Nutrition
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• v.24 no.6
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• pp.525-534
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• 2019

Objectives: Reduced glucose utilization in the main parts of the brain involved in memory is a major cause of Alzheimer's disease, in which ketone bodies are used as the only and effective alternative energy source of glucose. This study examined the effects of a low-carbohydrate and high-fat (LCHF) diet supplemented with a ketogenic nutrition drink on cognitive function and physical activity in the elderly at high risk for dementia. Methods: The participants of this study were 28 healthy elderly aged 60-91 years showing a high risk factor of dementia or whose Korean Mini-Mental State Examination (K-MMSE) score was less than 24 points. Over 3 weeks, the case group was given an LCHF diet with nutrition drinks consisting of a ketone/non-ketone ratio of 1.73:1, whereas the control group consumed well-balanced nutrition drinks while maintaining a normal diet. After 3 weeks, K-MMSE, body composition, urine ketone bodies, and physical ability were all evaluated. Results: Urine ketone bodies of all case group subjects were positive, and K-MMSE score was significantly elevated in the case group only (p=0.021). Weight and BMI were elevated in the control group only (p<0.05). Grip strength was elevated in all subjects (p<0.01), and measurements of gait speed and one leg balance were improved only in the case group (p<0.05). Conclusions: We suggest that adherence to the LCHF diet supplemented with a ketogenic drink could possibly influence cognitive and physical function in the elderly with a high risk factor for dementia. Further, we confirmed the applicability of this dietary intervention in the elderly based on its lack of any side effects or changes in nutritional status.

• Journal of the Korea Convergence Society
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• v.9 no.3
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• pp.111-119
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• 2018

This study was conducted to evaluate the converge effects of the Be Happy and Strong (BeHaS) exercise program on female elders living alone, using a nonequivalent control-group pretest-posttest design. The BeHaS exercise program was conducted twice each week for 4 weeks (total 8 sessions). The outcome measures included pain, shoulder flexibility, grip strength, depression, and suicidal ideation. Independent t-test, Chi-squre test, paired t-tests and ANCOVA were used for the statistical data analysis. A statistically significant improvement emerged in pain (t=4.044, p=.000) and right and left shoulder flexibility (t=2.192, p=.038 and t=2.568, p=.016) 4 weeks later. In a group comparison, a statistically significant difference arose in changed scores of suicidal ideation (F=7.32, p=.010) between groups. The BeHaS exercise program may effectively improve the physical and psychological health of female elders living alone.

• Journal of Korean Orthopaedic Sports Medicine
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• v.3 no.2
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• pp.134-140
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• 2004

Purpose: The reconstructive surgery of the anterior oblique ligament has been recommended for patients with unstable carpometacarpal joints. We reviewed retrospectively the functional results of two patients who had been treated by6 using a harvested portion of the tendon of flexor carpi radialis as a substitute for the anterior oblique ligament. Materials and Methods: In two patients with a instability of the trapeziometacarpal joint because of a rupture of the anterior oblique ligament, reconstruction was carried out using a slip of the tendon of flexor carpi radialis and the patients had been followed up for two years. Results: The results after a follow-up of two years that both of them had significant relief from pain and symptoms. The mean grip strength recovered to 90$\%$ of the controlateral side. patients felt that they had subjective improvement and would have undergone the operation again. Conclusion: Increased awareness of this lesion can lead to an early and clear diagnosis, so that the patient may be advised adequately.

• Journal of muscle and joint health
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• v.14 no.2
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• pp.127-136
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• 2007

Purpose: There has been a need to integrating the self-help program for arthritis with the TaiChi for arthritis patient. The purpose of this study was to develop and to examine the effect of the Self-help and Tai Chi for arthritis (SHTCA) program for arthritis. Method: This study was designed non equivalent control group pre-post test, quasi-experimental design. A total 40 participants were recruited in W-city, 29 participants(14-experimental group and 15-control group) completed post test. The experimental group participated in the SHTCA once a week for 8 weeks. SHTCA program was consisted of understanding of the arthritis, contracting of the promise, exercise for muscle strength and joint flexibility and 8 movements of Tai Chi exercise. Coloring plus program to cellular phone was used to encourage the exercise and participation by the KT-SHUT twice a week. Measures used to examine the effect of the SHTCA were EQ-5D standardized five dimensions(mobility, self-care, usual activities, pain & discomfort, and anxiety & depression), and health perception, joint flexibility, grasping power, and balance. Collected data was analyzed by SPSS WIN 14.0. Results: The experimental group had significantly increased the EQ-mobility(p=.033), health perception(p=.000), right shoulder flexibility(p=.007), and left shoulder flexibility(p=.002) compared to the control group. In addition, pain was decreased(p=.052) and right grip was increased(p=.052) after 8 weeks program in the experimental group. Conclusion: This SHTCA using coloring plus program was found partially effective and satisfactory. We recommended further research on the effect of this SHTCA effects.

• Journal of the Korean Applied Science and Technology
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• v.38 no.4
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• pp.1081-1092
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• 2021

The purpose of the study was to examine the effects of the 16-week combined exercise on the blood dopamine concentrations, functional fitness and QOL in patients with parkinson's disease. To this end, 24 persons parkinson's disease in over 60 years old who participated in this study were classified in to the exercise group(n=12) and control group(n=12), and then the exercise group was twice a week for 16-weeks, 70 min per session combined exercise was applied. The test dada were analyzed by two-way repeated measures ANOVA, paired t-test, and independent t-test. The alpha level of .05 of significance. As a result, first, parkinson's disease who regularly participated in the combined exercise significantly increased blood dopamine concentrations(p<.001). Second, parkinson's disease who regularly participated in the combined exercise significantly improved grip strength(p<.001), arm curl(p<.001), stand up and sit down a chair(p<.001), 3m walk and come back(p<.01). Third, parkinson's disease who regularly participated in the combined exercise significantly improved QOL(p<.001). Thus, the combined exercise had the positive effects and may be helpful to increased the blood dopamine concentration and improved functional fitness and QOL.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.5
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• pp.267-274
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• 2019

The purpose of this study is to investigate the effect of a practiced aquatic exercise program on the body function of obese women in the community, with knowledge of obesity preceded by obesity management education. The subjects were 20 obese women aged 51 to 79 who participated in the program for 8 weeks among the participants of health program in S healthcare center in D city. The aquatic exercise program, which includes obesity management training, consists of a total of 110 minutes, including twice a week, 20 minutes of obesity management training, and 60 minutes of aquatic exercise program. Obesity management education focuses on physical activity practice and dietary training. The results of this study showed that the aquatic exercise program including the 8 - week obesity management training decreased abdominal circumference, body weight and body mass index (p <.001, p <.001, p <.001),increased grip strength(P <.05), which is an effective program for reducing obesity and improving muscle power. In the follow-up study, it is necessary to increase the number of subjects and to develop the experimental design study with the control group and the participatory obesity management underwater exercise program that the participant directly participates and leads. It also suggests that additional strategies for continuous lifestyle improvement are needed.

• Journal of the Korea Convergence Society
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• v.13 no.4
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• pp.553-560
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• 2022

This study was conducted to identify the factors affecting the quality of life of women over 10 years after menopause using data from 2014 to 2019 of the National Health and Nutrition Examination Survey. The subjects were 6,330. The data were analyzed by frequency analysis, t-test and multiple regression analysis using SPSS 25. As a result of the study, the factors affecting the health-related quality of life of women 10 years after menopause were age(F=30.625, p<.001), educational level(F=20.106, p<.001), perceived health status(F=187.925, p<.001, activity limitation(t=201.051, p<.001), arthritis(t=91.131, p<.001), osteoporosis(t=4.709, p=.030), hand grip strength(t=22.151, p<.001), perceived stress(F=32.775, p<.001), and depression(t=20.117, p<.001). The factors accounted for 35.1%(F=110.393, p<.001). In order to improve the quality of life of postmenopausal women, it is necessary to continuously evaluate and improve the factors affecting the quality of life from the early menopause.

• 한국노년학
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• v.41 no.3
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• pp.295-308
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• 2021

This study is a descriptive study conducted to find out the predictive factors according to the level of the frailty of the communitydwelling older adult in a rural area. Data were collected from 400 older adults aged 65 years or older living in rural areas of Gyeongsangnam-do from October 2019 to March 2020. Data were analyzed using logistic regression to examine the predictive factors according to the level of frailty. The results showed that 27.8% for robust older adults, 30.9% for pre-frailty older adults, and 41.3% for frailty older adults. As a result of analyzing the predictive factors according to the level of frailty, the predictors from the robust stage to the pre-frailty stage were grip strength, nutritional status, and depression. The predictive factors for entering the pre-frailty stage into the frailty stage were gender, nutritional status, physical performance ability, and depression. Also, it was found that the predictive factors for entering from the robust stage to the frailty stage were sex, occupation, nutritional status, physical performance ability, and depression. Through this study, it was possible to understand the level of the frailty of the older adults living in rural communities and the effects of multidimensional variables. These results can be used as basic data necessary to find a way to prevent and manage the progression of frailty among older adults in rural areas.

• Journal of Life Science
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• v.32 no.8
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• pp.611-621
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• 2022

Dimethyl sulfoxide (DMSO) is commonly used as control or vehicle solvent in preclinical research of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) due to its ability to dissolve lipophilic compounds and cross the blood brain barrier. However, the biochemical effects of DMSO on the outcomes of preclinical research are often overlooked. In the present study, we investigated whether the long-term oral administration of 5% DMSO affects the neurological, functional, and histological disease phenotype of the copper/zinc superoxide dismutase glycine 93 to alanine mutation (SOD1-G93A) mouse model of amyotrophic lateral sclerosis. SOD1-G93A transgenic mice showed shortened survival time and reduced motor function. We found that administration with DMSO led to increased mean survival time, reduced neurological scores, and improved motor performance tested using the rotarod and grip strength tests. On the other hand, DMSO treatment did not attenuate motor neuron loss in the spinal cord and denervation of neuromuscular junctions in the skeletal muscle. These results suggest that DMSO administration could improve the quality of life of the SOD1-G93A mouse model of ALS without affecting motor neuron denervation. In conclusion, the use of DMSO as control or vehicle solvent in preclinical research may affect the behavioral outcomes in the SOD1-G93A mouse model. The effect of the vehicle should be thoroughly considered when interpreting therapeutic efficacy of candidate drugs in preclinical research.

• Journal of muscle and joint health
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• v.16 no.2
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• pp.174-183
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• 2009

Purpose: The purposes of this study were to develop and examine the self-help and Tai Chi program for arthritis, and to identify the effect when combined with a supportive follow up phone-calls. Method: The design for this study was a 3*2 quasi-experimental design. Sixty-six participants were recruited in W-city, and assigned to Exp 1 group (n=21) or Exp 2 group (n=24) according to supportive follow-up phone call method, or to the control group (n=21). Fifty-two subjects (17 and 20 in Exp 1 and 2, and 15 in the control group) completed pretest and posttest. Both experimental groups participated in the self-help and Tai Chi program for arthritis once a week for 8 weeks. Exp 1 received automated follow up phone-calls made up in KT-SHUT program, and Exp 2 received follow up phone-calls made up by researchers. The control group received no education and no phone call. Measures used to examine the effect self-help and Tai Chi program for arthritis were joint flexibility, hand muscle strength, balance with closed eyes and self-efficacy. The final analysis of the post-test measures was conducted by ANCOVA with age and self efficacy as covariates. Results: Both experimental group had significantly increased right shoulder flexibility (p=.002), left shoulder flexibility (p=.000), right hand grip (p=.024), and self efficacy (p=.008) compared with the control group. But there were no significant differences between two experimental groups in any physical indicators and self efficacy. Conclusion: Automated follow up phone-call would be helpful in managing the self-help and Tai Chi program for arthritis as well as researcher's phone call. The automated follow up phone-call program which was a new method could be recommended for use to encourage home exercise practice and the program participation.