• Proceedings of the PSK Conference
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• 2003.04a
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• pp.160.1-160.1
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• 2003

Persistent organic pollutants (POPs) have spread throughout the global environment to threaten human health and damage ecosystems. with evidence of POPs contamination in wildlife, human blood. and breast milk documented worldwide. Breast milk is an ideal medium for assessing exposures to POPs. POPs enter humans largely as contaminants of dietary animal products, where they sequester in adipose tissue, serum, and breast milk and equilibrate at similar levels on a fat weight basis. (omitted)

• Korean Journal of Agricultural and Forest Meteorology
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• v.18 no.3
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• pp.162-169
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• 2016

The agrometeorological reference index means 'the agrometeorological damage possibility' or the possibility of the normal year climate condition to damage the crop cultivation in a certain region. It is a reference used to compare the cultivation risk of a crop by region. The global climate warming is expected to increase the winter temperature. At the same time, the frequency of extreme weather events will also increase. Therefore, people pay attention to the potential of low temperature-induced damages (e.g., frost damage and injury) to fruit trees under the future climate condition. However, simple damage projection based on climate conditions does not help the climate change adaptation in the practical aspect because the climate change affects the phenology of fruit trees as well. This study predicted the phenology of the pear, peach, and apple trees by using the climate change scenarios of major regions. Furthermore, low temperature induced agrometeorological reference indices were calculated based on the effects of temperature on each plant growth stage to predict the damage possibility. It was predicted that the breaking rest would delay more in the future while the bud-burst date and flowering date will be earlier. In Daegu, Jeonju, and Mokpo, the breaking rest delayed more as time passed. The bud-burst date and flowering date of Seoul and Incheon regions were later than other regions. Seoul and Incheon showed a similar pattern, while Daegu and Jeonju revealed a similar pattern. Busan and Mokpo also showed a similar pattern. All regions were safe from the frost damage during the dormancy period. However, plants were vulnerable to frost damage between the breaking rest and the bud-burst period. Regions showed different frost damage patterns between the bud-burst period and the flowering period. During the bud-burst and flowering period, the risk level decreased in general, although the risk of some areas tended to increase.

• Journal of the Korean Institute of Landscape Architecture
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• v.41 no.4
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• pp.77-84
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• 2013

With the increase in occurrence frequency and severity of natural disasters due to climate changes arising from global warming, damage in the landscaping field is rising. This leads to legal disputes, and is increasing social and economic damage, too. Especially even though landscape trees which are highly affected by external environments, suffer lots of damage from natural disasters, there is no specific scope of disaster criteria and thus it brings plenty of problems of damage restoration and compensation. Therefore, this study aims to suggest that gives ways to improve related criteria for damage of landscape trees from natural disasters. For this objective, this study analyzed damage cases of landscape trees and precedents, and compared Korean and Japanese legal systems and criteria regarding natural disasters with each other. The analysis result showed that opinions of experts have a great deal of influence on judgment results, since there is no definite legal basis on damage from natural disasters in the landscaping field. This implies the need for a professional and objective appraisal process. According to the comparative analysis of Korean and Japanese legal systems and criteria regarding natural disasters, Korea lacked in laws and criteria on natural disasters of landscape plants in Korea, whereas there were concrete disaster assessment standards of landscape trees in Japan. For improving natural disaster-related systems and criteria in the landscaping field, therefore, this study presented 'Revision of related laws', 'Revision of appraisal and loss assessment criteria', 'Revision of standard specification of landscaping project', 'Compulsory insuring against disasters', 'Reasonable fulfillment of contract', and 'Compulsory cost estimation for disaster restoration', as improvement plans.

• Bulletin of the Society of Naval Architects of Korea
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• v.26 no.4
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• pp.81-93
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• 1989

The present study attempts to develop the theoretical model for the damage estimation of offshore tubular members which are subjected to the accidental impact loads due to collision, falling objects and so on. For the reasons of the simplicity of the problem being considered, however, this paper postulates that the accidental load can be approximated to be the quasi-static one, in which dynamic effects are negelcted. Based upon the theoretical and experimental results which are obtained from the present study as well as the existing literature, the load-displacement relations taking the interaction effect between the local denting and the global bending deformation into account are presented in the explicit form when the concentrated lateral load acts on the tubular member whose end condition is supposed to be rotation ally free and axially restrained, in which membrane forces develop. Thus, the practical estimation of damage deformation for the local denting and the global bending damage of tubular members against the accidental loads is possible and also the collision absorption capability of the member can be calculated by performing the integration of the area below the given load-displacement curves, provided that all the energy is dissipated to the deforming the member itself.

• International Journal of Stem Cells
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• v.15 no.3
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• pp.311-323
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• 2022

Background and Objectives: Human mesenchymal stem cells (MSCs) are emerging as a treatment for atopic dermatitis (AD), a chronic inflammatory skin disorder that affects a large number of people across the world. Treatment of AD using human umbilical cord blood-derived MSCs (hUCB-MSCs) has recently been studied. However, the mechanism underlying their effect needs to be studied continuously. Thus, the objective of this study was to investigate the immunomodulatory effect of epidermal growth factor (EGF) secreted by hUCB-MSCs on AD. Methods and Results: To explore the mechanism involved in the therapeutic effect of MSCs for AD, a secretome array was performed using culture medium of hUCB-MSCs. Among the list of genes common for epithelium development and skin diseases, we focused on the function of EGF. To elucidate the effect of EGF secreted by hUCB-MSCs, EGF was downregulated in hUCB-MSCs using EGF-targeting small interfering RNA. These cells were then co-cultured with keratinocytes, Th2 cells, and mast cells. Depletion of EGF disrupted immunomodulatory effects of hUCB-MSCs on these AD-related inflammatory cells. In a Dermatophagoides farinae-induced AD mouse model, subcutaneous injection of hUCB-MSCs ameliorated gross scoring, histopathologic damage, and mast cell infiltration. It also significantly reduced levels of inflammatory cytokines including interleukin (IL)-4, tumor necrosis factor (TNF)-α, thymus and activation-regulated chemokine (TARC), and IL-22, as well as IgE levels. These therapeutic effects were significantly attenuated at all evaluation points in mice injected with EGF-depleted hUCB-MSCs. Conclusions: EGF secreted by hUCB-MSCs can improve AD by regulating inflammatory responses of keratinocytes, Th2 cells, and mast cells.

• Journal of Navigation and Port Research
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• v.37 no.4
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• pp.409-418
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• 2013

On the assumption of the rise of sea level, the inundation vulnerabilities on coastal areas of Korea are evaluated in different ways. The propose of this study is to find out the influences of sea level rise caused by global warming at Young-do coastal area, and to suggest the prevention schemes against the flooding damage caused by the sea level rise. The potential rates of sea level rise are assumed and with these rates the inundation vulnerabilities are simulated using CAD program. With the virtual maps, as the results of the previous CAD simulation, this study attempts to suggest the flood prevention schemes for each sector of damage-expected coastal area.

• Journal of the Society of Naval Architects of Korea
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• v.58 no.2
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• pp.97-104
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• 2021

Together with the emerging of the Eco-ship, the application of large-diameter and high-efficiency propeller required more careful attention than before in the design of the shafting system. After the adoption of Environmentally Acceptable Lubricants (EAL) to the stern tube lubrication oil, a number of aft stern tube bearing accidents have been reported, and a variety of institutions have actively conducted research on the cause relationship. This study attempted to find the cause of the accident by measuring the alignment of the shafting system of a medium-sized product/chemical tanker with aft stern tube bearing damage and analyzing the reaction force of each bearing. In addition, a reasonable solution to the correction of the shaft alignment was suggested and the feasibility was reviewed. Through various measured data and analysis, the actual installation of shafting system was slightly different from the design drawing condition, but it was found that each bearing load distribution was within the allowable range. Therefore, it was confirmed that the cause of this accident was due to the dissatisfaction the misalignment slope of aft stern tube bearing rather than the effect of the bearing overload. As a solution to this cause, countermeasures such as double slope were suggested in the aft stern tube bearing, and the characteristics of EAL also seem to have an indirect effect.

• Journal of Korean Society of Disaster and Security
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• v.13 no.4
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• pp.93-104
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• 2020

Climate change has emerged as a social issue, and efforts have been made to overcome it in various ways. However, climate change due to global warming is likely to accelerate further than we expected, and the associated damage is also likely to increase. This tendency is expected to continue in the future, leading to difficulties for the existing water resource management system based on historical data. The precipitation in 2020 caused property damage and loss of life due to the extreme rainfall exceeding the design rainfall with the very unusual prolonged rainy days. With this 2020 flood, we should no longer be passive in managing flood risk due to uncertainties in climate change.

• Journal of the Korea Institute of Building Construction
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• v.15 no.5
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• pp.515-525
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• 2015

Currently, according to the climate change, serious damage by typhoon has been occurred in the world. In this respect, the research on the prediction model to minimize the damage from various natural disaster has been conducted in several developed countries. In the case of U.S, various models to predict building damage costs have been used widely in many organizations such as insurance companies and governments. In South Korea, although studies regarding damage prediction model according to typhoon have been conducted, the scope has been only limited to consider the property of typhoon. However, it is necessary to consider various factors such as typhoon information, geography, construction environment, and socio-economy factors to predict the damages. Therefore, to address this issue, first, correlation analysis is conducted between various variables based on the data of typhoon from 2003 to 2012. Second, the damage prediction model by using regression analysis is developed based on suggested influence factors. The findings of this study can be utilized to develop the model for predicting the damage costs of buildings by typhoon like HAZUS-MH of US.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.34 no.5
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• pp.509-517
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• 2008

DNA damage accumulates in cells as a result of exposure to exogenous agents such as benzopyrene, cigarette smoke, ultraviolet light, X-ray, and endogenous chemicals including reactive oxygen species produced from normal metabolic byproducts. DNA damage can also occur during aberrant DNA processing reactions such as DNA replication, recombination, and repair. The major of DNA damage affects the primary structure of the double helix; that is, the bases are chemically modified. These modification can disrupt the molecules'regular helical structure by introducing non-native chemical bonds or bulky adducts that do not fit in the standard double helix. DNA repair genes and proteins scan the global genome to detect and remove DNA damage and damage to single nucleotides. Direct reversal of DNA damage, base excision repair, double strand break. DNA repair are known relevant DNA repair mechanisms. Four different mechanisms are distinguished within excision repair: direct reversal, base excision repair, nucleotide excision repair, and mismatch repair. Genetic variation in DNA repair genes can modulate DNA repair capacity and alter cancer risk. The instability of a cell to properly regulate its proliferation in the presence of DNA damage increase risk of gene mutation and carcinogenesis. This article aimed to review mechanism of excision repair and to understand the relationship between genetic variation of excision repair genes and head and neck cancer.