• BMB Reports
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• 제46권5호
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• pp.237-243
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• 2013

Heart failure is one of the leading causes of sudden death in developed countries. While current therapies are mostly aimed at mitigating associated symptoms, novel therapies targeting the subcellular mechanisms underlying heart failure are emerging. Failing hearts are characterized by reduced contractile properties caused by impaired $Ca^{2+}$ cycling between the sarcoplasm and sarcoplasmic reticulum (SR). Sarcoplasmic/endoplasmic reticulum $Ca^{2+}$ ATPase 2a (SERCA2a) mediates $Ca^{2+}$ reuptake into the SR in cardiomyocytes. Of note, the expression level and/or activity of SERCA2a, translating to the quantity of SR $Ca^{2+}$ uptake, are significantly reduced in failing hearts. Normalization of the SERCA2a expression level by gene delivery has been shown to restore hampered cardiac functions and ameliorate associated symptoms in pre-clinical as well as clinical studies. SERCA2a activity can be regulated at multiple levels of a signaling cascade comprised of phospholamban, protein phosphatase 1, inhibitor-1, and $PKC{\alpha}$. SERCA2 activity is also regulated by post-translational modifications including SUMOylation and acetylation. In this review, we will highlight the molecular mechanisms underlying the regulation of SERCA2a activity and the potential therapeutic modalities for the treatment of heart failure.

• 한국재료학회:학술대회논문집
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• 한국재료학회 2011년도 춘계학술발표대회
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• pp.48.1-48.1
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• 2011

In this presentation, We monitored weather data, such as global irradiance, ambient temperature, temperature of PV module, relative humidity and windspeed for 2 years, for determining accelerated test condition. then, we determined the temperature limit of accelerated test through weather data and FEM analysis. Detailed procedures will be summarized in this work. After analysing outdoor stress such as thermal stress, we decided main failure modes and mechanisms of PV module, especially solder joint of ribbon wire. we carried out the measurement of material properties such as thermal expansion coefficient for planning of accelerated test. we designed accelerated test based on FEM analysis results. we carried out thermal cycling test with 1 cell mini module for 3 months. We monitored the change of electrical performance every 1 week such as Voc, Isc, Pmax, etc. and then, we analized the ribbon wire/electrode intefaces. Detailed results will be summarized in this work.

• KIEAE Journal
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• 제2권2호
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• pp.23-31
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• 2002

The purpose of this study is to suggest an environmentally friendly energy system of ecological architecture, with the reference to foreign cases, judge feasibility of it. The ecological architecture is very similar to the natural ecosystem. There is growing international scientific consensus that human activities are having a discernible effect on the global climate. Therefore, with a precise understanding of the concept of ecological approach and concrete perception of the necessity it, an establishment of planning which recognizes the ecological architecture as a organism a same time, ensures diversity, stability and cycling stemmed from the ecosystem to various activities through a ecological structure shall bring the introduction of substantial ecological architecture into domestic realm. As a result, in this Age of industrial science, We are proposing useful materials and suggestion regarding the ecological architecture planning of korean cities, by preestimating the characteristics of a city heading toward the Age of the new ecological environment.

• Mass Spectrometry Letters
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• 제12권4호
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• pp.163-171
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• 2021

Emiliania huxleyi is a marine phytoplankton that plays a critical role in global carbon and sulfur cycling. The genome of E. huxleyi has been sequenced, and an in-depth proteomic profile of this organism has been reported. This study analyzed the phosphoproteome of E. huxleyi and identified its changes under calcium-limited conditions. A TiO₂ microcolumn was used for phosphopeptide enrichment, followed by liquid chromatography-tandem mass spectrometry analysis. Overall, we identified 7,010 phosphorylated sites on 3,355 phosphopeptides associated with 2,929 phosphoproteins in E. huxleyi. Quantitative analysis revealed changes in the phosphoproteome in E. huxleyi when ambient conditions changed to calcium-limited conditions, notably the phosphorylation of some transporters was altered. This study provides an overview of protein phosphorylation in E. huxleyi and paves the way for further investigations of its biological functions.

• 대한교통학회지
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• 제23권8호
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• pp.203-213
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• 2005

자동차교통에 의한 환경오염의 대책으로서 대중교통서비스의 향상과 함께 자전거이용 촉진이 주목되고 있다. 본 연구에서는 지구교통을 대상으로 자전거이용을 촉진시키기 위한 자전거 주행환경의 개선방안을 제시하고, 그 효과를 평가할 수 있는 평가수법에 대해 연구하였다. 먼저, 자전거 주행환경 개선을 위한 개선안으로서 기존의 자동차를 중심으로 이뤄진 지구교통체계와 자전거가 중심인 네덜란드의 하우텐시를 참고로 한 2가지 개선안을 제시하고, 연구 대상지역에 각 개선안을 적용한 지구교통정비를 가정하여 개선안의 효과를 종합적으로 평가하였다. 평가방법은 현재와 두 개선안을 환경, 안전, 편리측면에서 비교평가를 수행하고, 또한 AHP수법을 이용하여 각 평가측면의 가중치를 산정하여 종합적인 평가를 수행하였다. 이때 평가지표로서는 환경측면에서 이산화탄소 배출량, 안전측면에서 교차점에서의 교통수단 간 교착가능횟수, 편리성측면에서 누적빈도곡선을 이용한 접근성 지표이다. 분석결과, 자동차를 중시한 현재의 지구교통환경과 비교하여 도로공간의 재배분에 의한 자전거도로 설치와 자동차와 분리된 자전거 도로망을 구성한 개선안이 가장 효과적인 것으로 나타났다.

• 한국환경보건학회지
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• 제24권3호
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• pp.77-86
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• 1998

The concentrations of atmospheric dimethylsulfide (DMS) and the relevant environmental parameters were measured as part of the 3rd year project (August 1997-July 1998) to investigate the long range transport of atmospheric pollutants (LRTAP) between China and Korea. The main purpose of this study was to derive the contribution of natural sulfur emissions (represented by oceanic DMS fluxes) in estimating the total budgets of sulfur transported across the Yellow Sea. To this end, DMS concentrations were determined from the two western coastal monitoring sites (Cheju and Kang Hwa islands) during three field intensive experiments covering fall, winter, and spring seasons. From these series of experiments, we found that DMS concentrations of Cheju and Kang Iffwa were averaged at 74 $\pm$ 49.5 (range: 19~282 pptv (N=81)) and 63.7 $\pm$ 35.1 (range:25.8~131 pptv (N=19)), respectively. By combining these 3rd year data with those measured previously from the 2nd year, we were able to derive some general pictures of seasonal distribution patterns of DMS. Although DMS data were difficult to derive relationships with other parameters determined simultaneously, they were rarely exhibiting good correlations with temperature or wind speed. The oceanic flux of DMS for the western coastal regions of Korea, when estimated based on our data from two islands, was found on the range of 8.8~12.2 GgS/yr. By considering the relationship between DMS and non-seasalt sulfate, we could also provide rough estimate of relative significance of natural emissions of sulfur. If oceanic DMS emitted from those regions is entirely converted to sulfate, it could represent 10 to 25% of total sulfur budgets in the western Sea of Korea.

• Ocean and Polar Research
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• 제33권2호
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• pp.135-147
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• 2011

Zooplankton is an important constituent in assessing ecosystem responses to global warming. The northern East China Sea is an important ecosystem for carbon cycling with a net sink of carbon dioxide. Despite their importance as a major component in carbon cycling, relatively little is known about zooplankton biomass structure and its regulating factors in the northern East China Sea. This study examined zooplankton biomass distribution pattern in the region from multiple cruises encompassing various seasons between 2004 and 2009. Results showed that zooplankton biomass exhibits less cross-shelf gradient in general with declining biomass to the eastern shelf towards the Tsushima Current Water. Size-fractionated biomass showed that the 1.0~2.0 mm size group, mostly copepods, dominated zooplankton biomass, comprising 38 to 48% of total biomass. Smaller zooplankton (0.2~1.0 mm) biomass, consisting mainly of Paracalanus spp, a particle eating herbivorous copepod, was positively related to chlorophyll-a concentration, but no relationship was established for larger zooplankton (1.0~5.0 mm). Spatially-averaged mean total zooplankton biomass was also highly related to chlorophyll-a concentration. These result suggest that the long-term trend of zooplankton biomass increase in this region is partly accounted for by the increases of phytoplankton biomass and productivity underway in the region. However, the underlying mechanisms of how sea surface warming in the study area leads to increased phytoplankton biomass and productivity remains unclear.

• Journal of Microbiology and Biotechnology
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• 제26권5호
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• pp.867-875
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• 2016

Archaea substantially contribute to global geochemical cycling and energy cycling and are impacted by land-use change. However, the response of archaeal communities to a change from upland field to paddy field has been poorly characterized. Here, soil samples were collected at two depths (0-20 cm and 20-40 cm) from one upland field and six paddy fields that were established on former upland fields at different times (1, 5, 10, 20, 30, and 40 years before the study). Barcoded pyrosequencing was employed to assess the archaeal communities from the samples at taxonomic resolutions from phylum to genus levels. The total archaeal operational taxonomic unit (OTU) richness showed a significant positive correlation with the land-use change duration. Two phyla, Euryarchaeota and Crenarchaeota, were recorded throughout the study. Both the relative abundance and OTU richness of Euryarchaeota increased at both depths but increased more steadily at the subsurface rather than at the surface. However, these data of Crenarchaeota were the opposite. Additionally, the archaeal composition exhibited a significant relationship with C/N ratios, total phosphorus, soil pH, Olsen phosphorus, and the land-use change duration at several taxonomic resolutions. Our results emphasize that after a change from upland fields to paddy fields, the archaeal diversity and composition changed, and the duration is an important factor in addition to the soil chemical properties.

• 유기물자원화
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• 제20권4호
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• pp.127-133
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• 2012

소위 '쎔쥐쥐'(SSaM-GG =Smart, Shared, and Mutual- Green Growth)라는 진화된 개념을 지속가능/영속 발전 나아가 안녕성 평가 등에 응용되길 바라며 개발/제안 한다. SSaM-GG는 5개의 알파벳으로 이루어져 있는데 이것들이 뜻하는 것은 '녹, 경, 사, 과, 자'로서, 각각 '환경+보전성, 경제성장성, 사회발전성, 과학기술성, 자율자발성'의 5가지를 뜻한다. 이 5가지 조건은 원래 지속가능한 발전의 3가지 조건(녹, 경, 사)에서 시작되었으나 서로간의 상반/교착현상으로써 완벽한 발전의 지표로서의 부족함이 보임에 과학기술성과 자율자발성을 추가하여 5개축(녹색별; Green Star)으로서 지난 12년간의 관찰/분석/경험 등으로 점차적으로 진화하여 개발되었다.

• Mass Spectrometry Letters
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• 제12권4호
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• pp.192-199
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• 2021

Alpine glaciers harbor a large quantity of bio-labile dissolved organic matter (DOM), which plays a pivotal role in global carbon cycling as glacial-fed streams are headwaters of numerous large rivers. To understand the complexity, origin, and fate of DOM in glaciers and downstream-linked streams and lakes, we elucidated the molecular composition of DOM in two different Tibetan Plateau glaciers, eight glacial-fed streams and five lakes, using an ultrahigh-resolution 15 Tesla Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometer. The compositional changes of the DOM samples revealed that glacier DOM mostly exhibited sulfur-containing organic compounds (CHOS species). We also found that aliphatic formulae contributed more than 50% of the total abundance of assigned molecules in glacier samples, and those compounds were significantly related to CHOS species. The CHO proportions of glacial-fed streams and lakes samples increased with increasing distance from glacial terminals. The relative contribution of terrestrial-derived organics (i.e., lignins and tannins) declined while microbial-originated organics (aliphatics) increased with increasing elevation. This suggested the gradual input of allochthonous materials from non-glacial environment and the degradation of microbe-derived compounds along lower elevations. Alpine glaciers are retreating as a result of climate change and they nourished numerous streams, rivers, and downstream-linked lakes. Therefore, the interpretations of the detailed molecular changes in glacier ice, glacial-fed streams, and alpine lakes on the Tibetan Plateau could provide broad insights for understanding the biogeochemical cycling of glacial DOM and assessing how the nature of DOM impacts fluvial ecosystems.