• Transactions of the Korean Society of Mechanical Engineers A
• /
• v.36 no.6
• /
• pp.653-663
• /
• 2012

The study considers the high maneuverability flight and path optimization is conducted to investigate the appropriate generation of the lift and thrust considering the angle of the stroke plane. The path optimization problem is defined according to the various purposes of the high maneuverability flight. The flying purposes are to maximize thrust force, lift force and both lift and thrust forces. The flapping motion of the airfoil is made by a combined sinusoidal plunging and pitching motion in each problem. The optimization process is carried out by using well-defined surrogate models. The surrogate model is determined by the results of two-dimensional computational fluid dynamics analysis. The Kriging method is used to make the surrogate model and a genetic algorithm is utilized to optimize the surrogate model. The optimization results show the flapping motions for the high maneuverable flight. The effects on the generation of lift and thrust forces are confirmed by analyzing the vortex.

• Economic and Environmental Geology
• /
• v.40 no.4
• /
• pp.375-387
• /
• 2007

The Iksan Mireuksaji stone pagoda, designated as national treasure No. 11 in Korea, has been in the process of disassembling for reconstruction as part of the cultural heritage conservation program. The pagoda is mainly consisting of granite, which is relatively resistant to weathering. However, it has lost its original rock color due to various contaminants deposited at the surface since it exposed to the atmospheric environment long time. In this research, we categorized the secondary inorganic contaminants into the genetic type, and also quantitatively examined occurrences and types of pollutants in the oxidation area of the pagoda surface in which the area is clearly distinguished by naked eyes. Geochemical behavior of soluble pollutants through reaction experiments are demonstrated, and effective methods of cleaning for the conservation and scientific applicability of the surface cleaner are also studied.

• Journal of Genetic Medicine
• /
• v.4 no.2
• /
• pp.179-185
• /
• 2007

Purpose : Catecholamines are the neuro-transmitters in the sympathetic nervous system (SNS) and are activated by stress stimulus. Tyrosine hydroxylase (TH) and Dopamine-${\beta}$-Hydroxylase (DBH) are very important enzymes in the catecholamine synthesis. Corticotropin releasing hormone (CRH) is released in the process of reacting to stresses. The aim of this study is to find out what effects immobilization stresses have on the expression of TH, BDH and CRH mRNA in a rat's brains. Methods : We compare expression levels in rat's brains of TH, DBH and CRH mRNA induced by immobilization stresses between the test group and controled group. The expression levels of TH, DBH and CRH mRNA are measured by RT-PCR and the Western Blotting Analysis (WBA). Results : In brains and adrenal glands of the immobilization stress group, the expression levels of TH and DBH mRNAs are significantly two to three times higher (P<0.01), and CRH mRNAs are approximately one and a half times higher (P<0.05) than those of controlled group. Conclusion : This study suggest that the expression levels of TH, DBH and CRH mRNAs are activated by stress stimulus in a rat's brains and adrenal glands.

• Journal of Pharmacopuncture
• /
• v.14 no.2
• /
• pp.81-91
• /
• 2011

Objectives & Methods: This suggestion was attempted to be elevated the recognition of common characteristics in disease. So, we performed to analyze the correlation of common cause of disease, characteristics of human body, and medical treatment. And the results are as follows. Results: 1. The cause of disease is consist of genetic factor, aging, habit, food of not good in health, weather, environment, deficit of the physical activity, stress and so on. 2. Generally, human has common and individual weakness. Individual weakness is appeared similar to the occurrence of volcano and lapse. 3. The correlation of disease and medical treatments is possible to explain using the quotation of the law of motion made by Isaac Newton, the great physicist. 4. When the process of the medical treatment was not progressed, the prognosis is determined by the correlation of the homeostasis(H') in human body and the homeostasis(H) of disease. 5. The prognosis of disease is determined by the relationship between the energy of disease(F) and medical treatment(F'). 6. The exact diagnosis is possible to predict the treatment sequence, and the facts that homeostasis in human body and disease, relationship between the energy of disease(F) and medical treatment(F'), action and reaction are important to determine the prognosis. 7. The careful observation of improving response and worsening action of disease becomes available for exact prognosis. Conclusion: The above described contents may be useful in clinical studies, and the concrete clinical reports about this will be made afterward.

• Clinics in Shoulder and Elbow
• /
• v.11 no.2
• /
• pp.71-76
• /
• 2008

The pathophysiology of rotator cuff tears and the progression of asymptomatic tears to symptomatic tears are yet unclear and much controversy. It is likely to involve a number of factors such as a genetic predisposition, extrinsic impingement from structures surrounding the cuff and intrinsic degeneration from changes within the tendon itself. Degenerative changes in the rotator cuff with aging seem to be related to the anatomic and mechanical environment of the rotator cuff. The histopathologic appearance of rotator cuff tendon rupture specimens demonstrates a consequence of degenerative changes at the site of tendon insertion into bone. It weakens the tensile strength of the tendon. Is the process of degeneration intrinsic or extrinsic in nature? I suggest that degeneration is intrinsic and not caused by extrinsic factors. Even though, rotator cuff tear may be secondary to multiple factors, I believe that primary cause of rotator cuff tears is preexisting degenerative change.

• Toxicological Research
• /
• v.34 no.4
• /
• pp.291-296
• /
• 2018

Chemical carcinogenesis is a multistep process. Genotoxic carcinogens, which are DNA-reactive, induce DNA adduct formation and genetic alterations in target cells, thereby generating mutated cells (initiation). Subsequently, preneoplastic lesions appear through clonal proliferation of the mutated cells and transform into tumors (promotion and progression). Many factors may influence these processes in a dose-dependent manner. Therefore, quantitative analysis plays an important role in studies on the carcinogenic threshold of genotoxic carcinogens. Herein, we present data on the relationship between key carcinogenic events and their deriving point of departure (PoD). Their PoDs were also compared to those of the carcinogenesis pathway. In an experiment, the liver of rats exposed to 2-amino-3,8-dimethylimidazo-(4,5-f)quinoxaline (MeIQx) was examined to determine the formation of MeIQx-DNA adducts, generation of mutations at LacI transgene, and induction of preneoplastic glutathione S-transferase placental form (GST-P)-positive foci and tumors (benign and malignant). The PoDs of the above key events in the carcinogenicity of MeIQx were increased as the carcinogenesis advanced; however, these PoDs were lower than those of tumor induction. Thus, the order of key events during tumor induction in the liver was as follows: formation of DNA adducts ${\ll}$ Mutations ${\ll}$ GST-positive foci (preneoplasia) ${\ll}$ Tumor (adenoma and carcinoma). We also obtained similar data on the genotoxic and carcinogenic PoDs of other hepatocarcinogens, such as 2-amino-3,8-dimethylimidazo(4,5-f)quinoline. These results contribute to elucidating the existence of a genotoxic and carcinogenic threshold.

• Journal of Sericultural and Entomological Science
• /
• v.4
• /
• pp.85-95
• /
• 1965

This report is to observe the amino acid composition at silk fibroins among varieties by using paper chromatography method and to study how they may concern with the genetical problem and the biochemical synthesis of the fibroin in silkgland. The results reached are as follows: 1. The amino acid composition of silk fibroin among varieties were observed as similar with each other on the paper chromatogram pictures. 2. In spite of the results of the amino acid composition analysis was similar with other workers results, there was some difference among varieties in numerical analysis. 3. The amino acid composition was considered to concern somewhat with the genetic problem of silkworm. 4. Some nutritive amino acids are considered to related with the worm growth more than the silk fibroin. 5. The paper chromatography of this report showed an unknown amino acid which was not found before in specific species silk fibroin and it is imagined as Hydroxyproline in view of other worker's graphy result. 6. The biochemical synthesis mechanism of silk fibroin in the silk gland, neither Stepwise process nor Template, could stand with the results of this paper satisfactory one side.

• Journal of Korean Society of Transportation
• /
• v.23 no.4 s.82
• /
• pp.57-69
• /
• 2005

The goal of this paper is to develop freeway Origin-Destination (OD) demand estimation model using real-time traffic data collected from Freeway Traffic Management System (FTMS). In existing research, the micro-simulation models had been used to get a link distribution proportion by time process. Because of hi-level problem between the traffic flow model and the optimal OD solution algorithm, it is difficult for the existing models to be loaded at FTMS. The formulation of methodology proposed in this paper includes traffic flow technique to be able to remove the bi-level problem and optimal solution algorithm using a genetic algorithm. The proposed methodology is evaluated by using the real-time data of SOHAEAN freeway, South Korea.

• Journal of Wetlands Research
• /
• v.13 no.3
• /
• pp.697-705
• /
• 2011

The aim of this study was to examine ozonation disinfection efficiency for Escherichia coli DH5alpha removal, containing the multi-resistance plasmid pB10 as well as chlorination disinfection efficiency. In addition, plasmid pB10 removal rates were estimated by ozonation and chlorination. The removal efficiency of pB10 via ozonation was about 2 to 4 times higher than chlorination. High removal efficiency of pB10 is likely due to OH radical produced during ozonation. These results suggest that integration of advanced oxidation process such as ozonation (or photocatalytic oxidation) with conventional disinfection such as chlorination may be needed for effective control of antibiotic resistant bacteria and genetic materials.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.11 no.9
• /
• pp.3390-3397
• /
• 2010

The purpose of this study was to evaluate the validity and utility of the Korean-Ages and Stages Questionnaires(K-ASQ) as a screening tool for detecting developmental delay of preschool child in community. Informed consents from parents of 229 children were received for the process of the study. The subjects were 229 parents and the children of three to five years old who did not have reported genetic diseases or developmental delays. The result of this study, validity were calculated for the K-ASQ sensitivity 0.41%, specificity 0.76%, hyper-referral 0.14%, hypo-referral 0.21%. Predictive value of delayed development were K-ASQ 0.70% and that of normal development were K-ASQ 0.77%. K-ASQ can be feasibly used in the setting of health clinic and be the highly predictive criteria for delayed development and normal development.