• Journal of The Korean Society of Integrative Medicine
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• v.11 no.4
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• pp.281-289
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• 2023

Purpose : In this study, we aimed to determine how frequencies different of repetitive transcranial magnetic stimulation applied to the less affected contalesional corticomotor area affect upper extremity motor function in patients with acute stroke within 3 months of onset. By doing so, we aimed to propose a new method of rTMS intervention based on the degree of damage and recovery status of the patient, rather than the generalized rTMS intervention that has been used uniformly. Methods : The rTMS intervention was applied on the contralesional side of the cerebral hemisphere damage. 15 subjects in the HF-rTMS group, 12 subjects in the LF-rTMS group, and 14 subjects in the SF-rTMS group were randomized to receive the rTMS intervention in each group for a total of 10 sessions on five consecutive weekdays for two weeks, and underwent FMA-U to determine changes in upper extremity function following the intervention in each group. FMA-U was performed within 24 hours before and after the rTMS intervention. Results : When the FMA-U was performed to determine the pre- and post-intervention changes in upper extremity motor function within the groups, no statistically significant differences were found in the SF-rTMS group before and after the intervention, but significant statistical differences were found in the HF-rTMS group (p=.006) and the LF-rTMS group (p=.020), with greater significance in the HF-rTMS group than the LF-rTMS group. Conclusion : This study confirmed that compensatory action by activating the less affected contralesional corticomotor area based on the bimodal balance-recovery model can support upper extremity recovery patients with acute stroke within 3 months of onset, depending on the degree of damage level and recovery status. Therefore, the results of the contralesional HF-rTMS application in this study may provide a basis for proposing a new rTMS intervention for upper extremity recovery in stroke patients.

• The Korean Journal of Applied Statistics
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• v.36 no.6
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• pp.591-618
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• 2023

This paper evaluates the performance of various distribution assumptions in regression settings for estimating insurance loss. The gamma distribution is commonly used to handle the asymmetry property of loss distribution. However, recent studies highlight the significance of heavy-tailedness in loss distribution. Through an analysis of real home fire insurance data, we compare the effectiveness of different distribution assumptions in regression methods. Our findings show that the choice of parametric distributional assumption is crucial in determining premiums for various insurance products, including "excess of loss insurance" and "limit insurance". Additionally, we discuss practical considerations for applying our results in home fire insurance.

• Journal of Soil and Groundwater Environment
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• v.28 no.6
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• pp.58-70
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• 2023

The improper management of radioactive waste or accidents caused by natural disasters can result in the release of radioactive materials into the surrounding environment, potentially leading to soil and groundwater contamination by radionuclides. In this study, adsorption-desorption behaviors of the radionuclides (cobalt and strontium) in natural soil, montmorillonite, Mn-PILC, Fe-PILC, and fishbone were investigated. Several models were used to predict adsorption isotherms of radionuclides on various absorbents. Adsorption isotherms of cobalt and strontium in several adsorbents were examined at pH 5.5. The amount of sorbed cobalt and strontium were represented fishbone > natural soil > Mn-PILC > Fe-PILC > montmorillonite and natural soil > Mn-PILC > fishbone > Fe-PILC > montmorillonite, respectively. Adsorption datas were fitted with several models such as Freundlich, Langmuir, Sips, Redlich-Peterson, Khan, and Generalized model. The results of curve fitting showed R²> 0.98 in all of adsorption models, except Sr²⁺ adsorption onto montmorillonite. For modified clays (Mn-PILC, Fe-PILC), it is suggested that, unlike natural soils and fish bones, there are not only single adsorption mechanisms but also adsorption mechanisms based on chemical adsorption and surface charge. In the case of fish bones, due to the relatively higher adsorption capacity than modified clays and its characteristic of significant desorption, it is expected more suitable for the removal of radionuclides in aquatic environments than for the immobilization of radionuclides in soil.

• Journal of Korea Society of Industrial Information Systems
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• v.29 no.3
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• pp.121-135
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• 2024

Entrepreneurship is essential in education or courses related to startup. Despite the importance of entrepreneurship, studies on the preceding factors that influence entrepreneurship are insufficient. This study analyzed the relationship between the founder's curiosity and entrepreneurship. In the relationship between curiosity and entrepreneurship, a research model and hypothesis using stress tolerance as a mediation variable was presented and empirically analyzed. As a result of collecting and analyzing data from prospective entrepreneurs and entrepreneurs, it was found that playful inquiry, social curiosity, and pursuit of stimulus had a statistically significant effect on innovation and competition pursuit through stress tolerance. This study is significant in that it analyzed curiosity in multiple dimensions. However, there is a limitation in that the survey is limited to Daegu and Gyeongbuk and the results cannot be generalized.

• Genomics & Informatics
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• v.21 no.4
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• pp.50.1-50.9
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• 2023

Vaccine development is one of the key efforts to control the spread of coronavirus disease 2019 (COVID-19). However, it has become apparent that the immunity acquired through vaccination is not permanent, known as the waning effect. Therefore, monitoring the proportion of the population with immunity is essential to improve the forecasting of future waves of the pandemic. Despite this, the impact of the waning effect on forecasting accuracies has not been extensively studied. We proposed a method for the estimation of the effective immunity (EI) rate which represents the waning effect by integrating the second and booster doses of COVID-19 vaccines. The EI rate, with different periods to the onset of the waning effect, was incorporated into three statistical models and two machine learning models. Stringency Index, omicron variant BA.5 rate (BA.5 rate), booster shot rate (BSR), and the EI rate were used as covariates and the best covariate combination was selected using prediction error. Among the prediction results, Generalized Additive Model showed the best improvement (decreasing 86% test error) with the EI rate. Furthermore, we confirmed that South Korea's decision to recommend booster shots after 90 days is reasonable since the waning effect onsets 90 days after the last dose of vaccine which improves the prediction of confirmed cases and deaths. Substituting BSR with EI rate in statistical models not only results in better predictions but also makes it possible to forecast a potential wave and help the local community react proactively to a rapid increase in confirmed cases.

• Annals of Occupational and Environmental Medicine
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• v.35
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• pp.14.1-14.10
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• 2023

Background: Shift work is known to cause changes in the circadian rhythm of the human body and adversely affect not only physical health but also mental health. Some studies have demonstrated the correlation between shift work and thyroid stimulating hormone (TSH), a hormone that changes according to the diurnal rhythm, but few studies have reported the different TSH levels according to the shift work type. This study aimed to investigate changes in TSH according to the shift work type. Methods: This study included 1,318 female workers who had a medical checkup at a university hospital in Changwon from 2015 to 2019. Shift work types were classified as non-shift work, regular 2 shifts, and irregular three shifts, and a TSH ≥ 4.2 mIU/L was defined as abnormal. A general linear model (GLM) was used to compare the TSH levels and the risk of subclinical hypothyroidism in each year, and a binary logistic analysis was performed using a generalized estimation equation (GEE) to compare the risk of subclinical hypothyroidism over the 5-year period. Results: Of the 1,318 participants included in this study, 363, 711, and 244 were non-shift, two-shift, and irregular three-shift workers, respectively. In the GEE analysis, after adjusting for age, body mass index, smoking, and alcohol consumption, the odds ratios (ORs) were 1.81 (95% confidence interval [CI]: 1.15-2.86; p = 0.011) in 2 shifts and 2.02 (95% CI: 1.23-3.32; p = 0.006) in irregular three shifts, compared to non-shift. Conclusions: Our results showed that shift work had a higher risk of subclinical hypothyroidism than non-shift work and that there was a significant difference in the risk of subclinical hypothyroidism according to the shift work type. These findings suggest that the shift work type can be considered in future thyroid function tests and evaluations.

• Journal of Microbiology and Biotechnology
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• v.33 no.11
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• pp.1484-1494
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• 2023

NUC1 (Nutraceutical compound 1) is an ethanol extract composed of a formulation based on medicinal herbs traditionally used for the treatment of arthritis in Korea and China. This study investigated the therapeutic effects of NUC1 on osteoarthritis (OA). The protective effect of NUC1 on OA was tested in a rabbit model of collagenase-induced arthritis (CIA) for 4 weeks. Results were compared among four groups (n = 9 per group): the normal group (untreated), the CIA group (vehicle control), the NUC1 group (CIA rabbits treated with 200 mg/kg NUC1), and the JOINS group (positive control, CIA rabbits treated with 200 mg/kg JOINS tablet). NUC1 significantly inhibited NO production (p < 0.05 at 125 ㎍/ml, p < 0.01 at 250 ㎍/ml, and p < 0.001 at 500 ㎍/ml) and iNOS expression in macrophages, in a concentration-dependent manner. NUC1 also inhibited the release and protein expression of MMP-1, 3, and 13, in TNF-α-induced chondrosarcoma cells in a concentration-dependent manner. In vivo, the MMP-1 and MMP-3 levels in synovial fluids were significantly (p < 0.05) lower in NUC1 group (77.50 ± 20.56 and 22.50 ± 7.39 pg/ml, respectively) than in the CIA group (148.33 ± 68.58 and 77.50 ± 20.46 pg/ml, respectively). Also, in histopathological, NUC1 ameliorated articular cartilage damage in OA by increasing the abundance of chondrocytes and proteoglycan in the articular cartilage. Thus, NUC1 showed promise as a potential therapeutic agent, and it can be generalized to a broader study population in different OA animal models.

• Journal of the Korea institute for structural maintenance and inspection
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• v.13 no.3 s.55
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• pp.101-109
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• 2009

An algorithm is proposed for estimating dynamic displacements of a bridge by using FBG sensors and by superposing some measurable low modes. Modal displacements are obtained from the beam theory and the generalized coordinates are deduced from the strains measured by FBG sensors. By considering flexural and torsional modes occurred in bridges only as flexural modes of a simply supported beam by separating a bridge into multiple girders or parts, the proposed algorithm can be applied to various types of bridges. Guidelines are provided theoretically for determining the number of modes and the number of strain gages to be used. The proposed algorithm has been examined through simulation studies on various types of bridges, laboratory experiments on a model bridge, and field tests on a simple span PC Box girder bridge. Through the simulation study, the effects of the error in the vibration modes and measurement noise on estimating the dynamic displacements are analyzed.

• Smart Structures and Systems
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• v.34 no.3
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• pp.157-169
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• 2024

Accidents involving inland waterway vessels have raised concerns regarding monitoring their navigation tracks. The economical and convenient deployment of video surveillance equipment and computer vision techniques offer an effective solution for tracking vessel trajectories in narrow inland waterways. However, field applications of video surveillance systems face challenges of small object detection and the limited field of view of cameras. This paper investigates the feasibility of using multiple monocular cameras to monitor long-distance inland vessel trajectories. The one-stage CNN model, YOLOv5, is enhanced for small object detection by incorporating generalized intersection over union loss and a multi-scale fusion attention mechanism. The Bytetrack algorithm is employed to track each detected vessel, ensuring clear distinction in multiple-vessel scenarios. An inverse projection formula is derived and applied to the tracking results from monocular camera videos to estimate vessel world coordinates under potential water level changes in long-term monitoring. Experimental results demonstrate the effectiveness of the improved detection and tracking methods, with consistent trajectory matching for the same vessel across multiple cameras. Utilizing the Savitzky-Golay filter mitigates jitter in the entire final trajectory after timing-alignment merging, leading to a better fit of the dispersed trajectory points.

• Restorative Dentistry and Endodontics
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• v.49 no.3
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• pp.30.1-30.12
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• 2024

Objectives: The aim of the current study was to evaluate the effect of polishing systems and surface sealant on the color stability and whiteness index of single-shade resin composites after staining and bleaching. Materials and Methods: Three single-shade (Omnichroma, Charisma Diamond One, Zenchroma) and one multi-shade (Filtek Z250) materials were tested. From each resin composite, 40 specimens were prepared. The specimens were divided into 4 subgroups (n = 10) according to the surface treatments: 1-step polishing, 1-step + Biscover LV, 2-step polishing, and 2-step polishing + Biscover LV. Color differences (ΔE₀₀) were calculated after being immersed in the coffee solution for 12 days. After the staining, the specimens were immersed in a whitening mouthrinse (Crest-3D White) for 12 hours. Whiteness index differences (ΔWI_D = WI_D after staining - WI_D after bleaching) values were recorded. The generalized linear model was used for analysis (p< 0.05). Results: The lowest and highest ΔE₀₀ values were found for Zenchroma and Charisma Diamond One respectively. Sealed groups indicated higher ΔE₀₀ values than nonsealed groups with significant differences (p = 0.008). The lowest and highest ΔWI_D values were found for Zenchroma and Charisma Diamond One respectively. Sealed groups indicated lower ΔWI_D values than nonsealed groups with significant differences (p = 0.022). Conclusions: The use of surface sealant increased the discoloration and showed less whiteness change in resin materials. When the 1-step was compared with the 2-step polishing, the effects on the color stability and whiteness index values of the resin materials were similar.