• 생물정신의학
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• 제21권4호
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• pp.168-174
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• 2014

Objectives Sensory gating dysfunctions in patients with schizophrenia and bipolar disorder have been investigated through two similar methods ; P50 suppression and prepulse inhibition paradigms. However, recent studies have demonstrated that the two measures are not correlated but rather constitute as distinct neural processes. Recent studies adopting spectral frequency analysis suggest that P50 suppression reflects the interaction between gamma and other frequency bands. The aim of the present study is to investigate which frequency component shows more significant interaction with gamma band. Methods A total of 108 mood disorder patients and 36 normal subjects were included in the study. The P50 responses to conditioning and test stimuli with an intra-pair interval of 500 msec were measured in the study population. According to P50 ratio (amplitude to the test stimulus/amplitude to the conditioning stimulus), the subjects with P50 ratio less than 0.2 were defined as suppressed group (SG) ; non-suppressed group (NSG) consisted of P50 ratio more than 0.8. Thirty-five and 25 subjects were included in SG and NSG, respectively. Point-to-point correlation coefficients (PPCCs) of both groups were calculated between two time-windows : the first window (S1) was defined as the time-window of one hundred millisecond after the conditioning auditory stimulus and the second window (S2) was defined as the time-window of 100 msec after the test auditory stimulus. Spectral frequency analysis was performed to investigate which frequency band results in the difference of PPCC between SG and NSG. Results Significant reduction of PPCC between S1 and S2 was observed in the SG (Pearson's r = 0.24), compared to PPCC of the NSG (r = 0.58, p < 0.05). In spectral frequency analysis, gamma band showed "phase-reset" and similar responses after the two auditory stimuli in suppressed and non-suppressed group. However in the case of alpha band, comparison showed significantly low PPCC in SG (r = -0.14) compared to NSG (r = 0.36, p < 0.05). This may be reflecting "phase-out" of alpha band against gamma band at approximately 50 msecs after the test stimulus in the SG. Conclusions Our study suggests that normal P50 suppression is caused by phase-out of alpha band against gamma band after the second auditory stimulus. Thus it is demonstrated that normal sensory gating process is constituted with attenuated alpha power, superimposed on consistent gamma response. Implications of preserved gamma and decreased alpha band in sensory gating function are discussed.

• Biomolecules & Therapeutics
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• 제7권3호
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• pp.242-248
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• 1999

Diazepam, a benzodiazepine (BDZ) agonist, produces sedation and flumazenil, a BDZ antagonist, blocks these actions. The aim of this study was to examine the effects of BDZs on cortical electroencephalogram (EEG) in rats. The recording electrodes were implanted over the frontal and parietal cortices bilaterally, and the reference and ground electrodes over cerebellum under ketamine anesthesia. To assess the effects of diazepam and flumazenil, rats were injected with diazepam (1 mgHg, i.p.) and/or flumazenil ( 1 mg/kg, i.p.), and the EEG was recorded before and after drugs. Normal awake had theta peak in the spectrum and low amplitude waves, while normal sleep showed large amplitude of slow waves. The powers of delta, theta and alpha bands were increased during sleep compared with during awake. Diazepam reduced the mobility of the rat and induced sleep with intermittent fast spindles and large amplitude of slow activity, and it produced broad peak over betaL band and increased the power of gamma band, which were different from EEG patterns in normal sleep. Saline injection awakened rats and abolished fast spindles for a short period about 2-5 min from EEG pattern during diazepam-induced sleep. Flumazenil blocked both diazepam-induced sleep and decreased the slow activities of delta, theta, alpha and betaL, but not of gamma activity for about 10 min or more. This study may indicate that decrease in power of betaL and betaH bands can be used as the measure of central action of benzodiazepines, and that the EEG parameters of benzodiazepines have to be measured without control over the behavioral state by experimenter.

• 천문학회보
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• 제40권2호
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• pp.38.1-38.1
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• 2015

Supernova remnants (SNRs) are one of the most energetic astrophysical events and are thought to be the dominant source of Galactic cosmic rays (CRs). A recent report on observations of gamma rays from the vicinity of SNRs have shown strong evidence that Galactic CR protons are accelerated by the shock waves of the SNRs. The actual gamma-ray emission from pion decay should depend on the diffusion of CRs in the interstellar medium. In order to quantitatively analyze the diffusion of high-energy CRs from acceleration sites, we have performed test particle numerical simulations of CR protons using a three-dimensional magnetohydrodynamics (MHD) simulation of an interstellar medium swept-up by a blast wave. We analyse the CRs diffusion at a length scale of order a few pc, and show the Richtmeyer-Meshkov instability can provide enough turbulence downstream of the shock to make the diffusion coefficient close to the Bohm level for energy larger than 30 TeV for a realistic interstellar medium.

• 천문학회지
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• 제47권1호
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• pp.15-39
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• 2014

Polarization is a basic property of light and is fundamentally linked to the internal geometry of a source of radiation. Polarimetry complements photometric, spectroscopic, and imaging analyses of sources of radiation and has made possible multiple astrophysical discoveries. In this article I review (i) the physical basics of polarization: electromagnetic waves, photons, and parameterizations; (ii) astrophysical sources of polarization: scattering, synchrotron radiation, active media, and the Zeeman, Goldreich-Kylafis, and Hanle effects, as well as interactions between polarization and matter (like birefringence, Faraday rotation, or the Chandrasekhar-Fermi effect); (iii) observational methodology: on-sky geometry, influence of atmosphere and instrumental polarization, polarization statistics, and observational techniques for radio, optical, and $X/{\gamma}$ wavelengths; and (iv) science cases for astronomical polarimetry: solar and stellar physics, planetary system bodies, interstellar matter, astrobiology, astronomical masers, pulsars, galactic magnetic fields, gamma-ray bursts, active galactic nuclei, and cosmic microwave background radiation.

• 대한통합의학회지
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• 제7권3호
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• pp.171-180
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• 2019

Purpose : The purpose of this study was to investigate the difference in motor cortical excitability during mental practice and action observation in subjects with forward head posture. Methods : This study was performed in two groups, a forward head posture group (n=17) and a normal posture group (n=17). Electroencephalography (EEG) was conducted to investigate cerebral cortex activity, and six electrodes were attached to Fp1, Fp2, C1, C2, C3, and C4 to measure the relative alpha power, relative beta power, relative gamma power, and mu rhythms. The subjects were requested to perform the four different conditions, which were eye opening, eye closing, mental practice, and action observation for 300 seconds. Results : The results showed that the relative alpha waves showed a significant difference between the normal and forward head posture groups in the C1, C2, C3, and C4 regions with the eyes open (p<.05). The relative beta waves also showed a significant difference between the two groups in the Fp1 and Fp2 regions during action observation (p<.05). The relative gamma waves were significantly different between the normal and forward head posture groups in the Fp1 and Fp2 regions during action observation (p<.05) in C1, C2, and C3 with eyes closed (p<.05) and in C1, C2, C3, and C4 with eyes open (p<.05). Conclusion : The results of this study showed that EEG change in the forward head posture group was different from that in the normal control group in action observation rather than in mental practice. Therefore, we are expected to provide a neurophysiological basis for applying action observation to motor skill learning during exercise for correcting forward head posture.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1997년도 하계학술대회 논문집 E
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• pp.1678-1680
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• 1997

The pulsed power with the high voltage and current can be used to the fields of high speed pulses of energy in different forms such as electric current and voltage, electron beam, ion beam, x-rays, gamma rays, heat, magnetics fields, sound and shock waves. This paper is directed mainly at electrical engineers working on production and practical application of high speed pulsed power with high voltage and current.

• 한국해안·해양공학회논문집
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• 제20권4호
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• pp.342-354
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• 2008

다양한 파랑 관측 및 후측 자료를 이용하여 한국 연안의 심해파 통계 특성을 연구하였다. 설계파에 준하는 큰 파랑에 대해서는, 유의파고와 유의파주기 사이의 관계에 대하여 1977년 Shore Protection Manual 공식과 2003년 Goda 공식의 평균값을 사용하는 것이 바람직하다. 일정한 유의파고에 대하여 평균값으로 무차원화 시킨 유의파주기의 표준편차는 해역과 유의파고의 범위에 따라 0.04부터 0.21까지 변하며 전형적인 값은 0.1이다. 한반도 주변 106개 연안 격자점에서의 심해 주파향의 평균과 표준편차를 제시하였다. 비교적 큰 파랑에 대한 방향분산계수 $s_{max}$의 확률밀도함수는 대수정규분포로 표시된다. 우리나라 연안에서 가장 적합한 주파수 스펙트럼은 TMA 스펙트럼이다. 스펙트럼 첨두증대계수 $\gamma$의 확률밀도함수 또한 대수정규분포로 표시되며, 북해에서의 값과 비슷한 2.94의 평균값을 보인다.

• 센서학회지
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• 제12권6호
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• pp.289-297
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• 2003

본 논문에서는 정신적 과제수행 동안 EEG 뇌파의 정확한 분류방법에 관하여 기술한다. 피험자는 실험 task에서 시각적 자극에 대한 반응, 문제의 해석, 손동작 제어와 키 선택을 수행한다. 선택시간을 감지하기 위하여 측정한 뇌파로부터 $\alpha$, $\beta$, $\theta$, $\gamma$를 분리하고 4가지의 특징들을 해석한파. 이 특징들을 분석하여 각 피험자별로 공통적인 특징플로 구성된 일반 규칙을 설정한다. 본 시스템의 신경망은 1개의 은닉층을 갖는 3층의 피드포워드 신경망 구조를 가지며 학습에는 역전파 학습 알고리즘을 이용하였다. 4명의 피험자를 대상으로 설정한 알고리즘들을 적용하여 평균 87% 분류 성공률을 보였다. 본 논문에서 제안한 방법은 인지적인 정신과제 판별을 위한 방법들과 결합하여 BCI 기술을 위한 기반 기술로 활용될 수 있다.

• Biomolecules & Therapeutics
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• 제25권2호
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• pp.105-111
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• 2017

It has been known that RA, one of major constituents of Perilla frutescens which has been used as a traditional folk remedy for sedation in oriental countries, shows the anxiolytic-like and sedative effects. This study was performed to know whether RA may enhance pentobarbital-induced sleep through ${\gamma}-aminobutyric$ acid $(GABA)_A-ergic$ systems in rodents. RA (0.5, 1.0 and 2.0 mg/kg, p.o.) reduced the locomotor activity in mice. RA decreased sleep latency and increased the total sleep time in pentobarbital (42 mg/kg, i.p.)-induced sleeping mice. RA also increased sleeping time and number of falling sleep mice after treatment with sub-hypnotic pentobarbital (28 mg/kg, i.p.). In electroencephalogram (EEG) recording, RA (2.0 mg/kg) not only decreased the counts of sleep/wake cycles and REM sleep, but also increased the total and NREM sleep in rats. The power density of NREM sleep showed the increase in ${\delta}-waves$ and the decrease in ${\alpha}-waves$. On the other hand, RA (0.1, 1.0 and $10{\mu}g/ml$) increased intracellular $Cl^-$ influx in the primary cultured hypothalamic cells of rats. RA (p.o.) increased the protein expression of glutamic acid decarboxylase ($GAD_{65/67}$) and $GABA_A$ receptors subunits except ${\beta}1$ subunit. In conclusion, RA augmented pentobarbital-induced sleeping behaviors through $GABA_A-ergic$ transmission. Thus, it is suggested that RA may be useful for the treatment of insomnia.

• 한국멀티미디어학회논문지
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• 제23권7호
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• pp.862-869
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• 2020

This study attempted to analyze human brain responses toward visual content through EEG signals and intended to measure brain wave reactions of different age groups to determine the sexuality level of the media. The experimental stimuli consist of three different video footage (rated ages 12, 15, and 18) to analyze how subjects react in situations where they actually watch sexual content. For measuring and analyzing brain wave reactions, EEG equipment records alpha, beta, and gamma wave responses of the subjects' left and right frontal lobes, temporal lobes, and occipital lobes. The subjects of this study were 28 total and they are divided into two groups. The experiment configures a sexual content classification scale with age or gender as a discriminating variable and brain region-specific response frequencies (left/right, frontal/temporal/occipital, alpha/beta/gamma waves) as independent variables. The experimental results showed the possibility of distinguishing gender and age differences. The apparent differences in brain wave response areas and bands among high school girls, high school boys, and college students are found. Using these brain wave response data, this study explored the potential of developing algorithm for measurement of age-specific responses to sexual content and apply it as a film rating.