• Journal of the Korean Wood Science and Technology
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• 제23권1호
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• pp.49-53
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• 1995

The terpenoids are one of the secondary metabolities in Pinus species and functioned the protection them from insects or/and fungus etc. Since Pinus koraiensis has not any damage by Pine needle gall midge but Pinus densiflora has great injury by them in South Korea. It may great helf to find these reasons to analize their monoterpenenoids and to compare the seasonal variation of their amounts. Terpenoids were analized by GC, GC/MS. Some biogenetic analysis of terpenoids also was elucidated. The seasonal variation of terpenoid was distinguished at March and August and/or September. Most of major component of monoterpenes were increased or decreased in these periods in Pinus koraiensis. Especially 3-carene was showed significant variation between the period of physiological activity and the period of domain. The effect of infection by Pine needle gall midge was significant in Pinus densiflora for amount of monoterpene during the period of infection. The components of p-menthane series between Pinus densiflora and Pinus koraiensis was recognized a significant difference during the experiment. Biogenetic cooccurrance of pmenthane series also was recognized between 3-carene and terpinolene in Pinus koraiensis.

• The Korean Journal of Pain
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• 제9권1호
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• pp.239-243
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• 1996

MS-Contin is an oral controlled-release preparation of morphine sulfate that has been used widely in the management of advanced cancer pain. It prolongs plasma concentration of morphine with no observable accumulation properties following repeated dosing, thereby promoting uninterrupted sleep and hopefully improving patient's quality of life. The common side effects of MS Contin are nausea, vomiting, drowsiness and constipation. But these symptoms are usually mild and respiratory depression is a rare problem. We experienced respiratory depression during oral administration of MS contin for the pain management of advanced gall bladder cancer of 76 years old male patient with metastasis at liver, intestine and cervical lymph node. After we increased the dosage of MS Contin from 160mg to 220mg per day, due to abdominal pain, we observed morphine reaction of MS Contin overdose such as pinpoint pupil, deeply slow respiration below 8/minute, and drowsiness. After intravenous bolus injection of 0.4 mg naloxone followed by continuous administration of 0.2 mg/hr for 4 hours, the patient regained consciousness. The administered route of morphine was changed to intravenous PCA (patient controlled analgesia). There was no aspiration sign as confirmed by chest x-ray. The patient was comfortable and delayed no signs of respiratory depression until now.

• 대한약리학회지
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• 제16권1호
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• pp.35-39
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• 1980

In this study, the effects of phenoxybenzamine and related drugs on the action of CCK-PZ and caerulein were examined in isolated gall bladder of guinea pig and higher esophagus strip of fowl. The strips were placed in a bath containing Locke-Ringer solution maintained at $38^{\circ}C$. Oxygen was continuously bubbled through the solution. The contractile response was measured isometrically by a force displacement transducer connected to polygraph. In isolated gall bladder preparation caerulein produced contractile response of CCK-PZ type, but the relative potency on a weight basis was 30 times stronger than CCK-PZ. The response of caerulein or CCK-PZ was not blocked by cholinergic blocking agent and both alpha and beta adrenergic blockades, however, the response of caerulein or CCK-PZ was exceptionally blocked by phenoxybenzamine. In isolated esophagus strip CCK-PZ with high concentration produced marked contraction which was not modified by atropine and other blocking agents, whereas the response was blocked by phenoxybenzamine. These results lead to the conclusion that phenoxybenzamine inherently inhibits the contractile response of CCK-PZ and caerulein on esophagus and other smooth muscle.

• 혜화의학회지
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• 제14권1호
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• pp.149-154
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• 2005

I have come to next conclusions in consequence of documentary study about medical books of many generations regarding Medical treatment with Acupuncture Point of Flank pain. The urinary bladder channel of foot-taiyang is most used. Next there are the ren channel, the gall baldder channel of foot-shaoyang, the liver channel of foot-jueyin, the triple-warmer channel of hand-shaoyang, the kidney channel of foot-shaoyin, the stomach channel of foot-yangming, the spleen channel of foot-taiyin, the pericardium channel of hand-jueyin, the lung channel of hand-taiyin, the small intestine channel of hand-taiyang, the large intestine channel of hand-yangming, the heart channel of hand-shaoyin in the order of frequency in used channel among the twelve channels. The liver channel of foot-jueyin is most used. The gall baldder channel of foot-shaoyang, the urinary bladder channel of foot-taiyang, the triple-warmer channel of hand-shaoyang, the spleen channel of foot-taiyin, the stomach channel of foot-yangming, the ren channel, the small intestine channel of hand-taiyang, the kidney channel of foot-shaoyin, the pericardium channel of hand-jueyin, the large intestine channel of hand-yangming, the lung channel of hand-taiyin, the heart channel of hand-shaoyin in the order of frequency in used point among the twelve channels.

• Korean Journal of Acupuncture
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• 제25권4호
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• pp.17-29
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• 2008

Objectives : This study was carried out to investigate the correlation of meridian system in oriental medicine and muscular system in western medicine. Methods : Muscles were assigned to meridians by their main functions and the acupoints on them. New mutual relationships between meridians in lower limb were studied based on the muscular function. Results : In gluteal & femoral region, iliopsoas & quadratus femoris are assigned to spleen & stomach meridians, gluteus maximus & hamstrings to urinary bladder & kidney meridians, adductor muscle groups to liver meridian, gluteus medius & minimus & iliotibial tract to gall bladder meridian. In crural region, anterior crural muscles are assigned to stomach meridian, lateral crural muscles to gall bladder meridian, suferficial posterior crural muscles to urinary bladder (& kidney) meridian, deep posterior crural muscles to liver, spleen, kidney meridians. In lower limb, urinary bladder meridian and stomach meridian lead the muscular functions and correspond to each other, while spleen meridian assists stomach meridian, and kidney meridian assists urinary bladder meridian. Conclusions : Muscles may be assigned to meridians by their functions and the acupoints on them. From the view of muscular function, Yang meridians lead Yin meridians in lower limb.

• 한국응용곤충학회지
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• 제43권2호
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• pp.103-109
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• 2004

경남 김해와 창원의 단감원에서 감관총채별레(Ponticulothrips diospyrosi Haga et Okajima)의 발생생태와 피해양상을 조사하였다. 황색끈끈이 트랩 조사(2002년)와 피해권엽 내부 정밀조사(2002,2003년)에 의하면 월동세대 성충은 4월 하순부터 5월 하순 사이에 월동처에서 단감원으로 이동하여 단감의 새 잎에 산란하며, 제 1세대 성충의 발생 최성기는 6월 상중순이었다. 피해권엽 정밀조사에 의한 제1세대 난, 약충, 번데기의 발생 최성기는 각각 5월 상중순, 5월 하순6월 상순, 6월 상순이었다. 대부분의 제1세대 성충은 우화후 월동처로 이동하지만 일부 성충이 산란한 개체가 발육하여 제2세대 성충이 되는데, 7월 하순 이후에 발생하는 성충이 제2세대 성충인 것으로 생각된다. 피해엽율은 시기가 경과할수록 증가하였으며 창원포장에서 6월 상순에 9.7%로 가장 높았다. 피해과율은 6월 중순 낙화 이후부터 관찰되었으며 김해 B포장에서 9월 상순의 피해과율이 30.2%로 가장 높았다. 과수원의 가장자리에 가까이 위치한 나무일수록 피해엽 발생시기가 빨랐으며, 특히 소나무 군락을 중심으로 l0m이내에 피해가 심하였다. 성충의 발생시기와 관련하여 방제시기 문제를 고찰하였다.

• Applied Biological Chemistry
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• 제36권6호
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• pp.463-468
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• 1993

솔잎혹파리(Thecodiplosis japonensis Uchida et Inouye) 방제용으로 소나무의 수간에 주입된 침투성 살충제 phosphamidon(2-chloro-2-diethylcarbamoyl-1-methylvinyl dimethyl phosphate)의 이행 및 분포를 구명하기 위하여 $[vinyl,\;carbonyl-^{14}C]phosphamidon$을 약 10년생의 적송과 해송에 각각 수간주사하였다. 이 약제의 최고이행속도는 적송(Pinus densiflora Sieb. et Zucc.)과 해송(Pinus thunbergii Parl.)에서 각각 약 10 cm/hr(7월)와 2 cm/hr(12월)이었다. 처리된 방사능은 하계의 적송에서는 75일까지 일정한 수준을 유지하였으나 동계의 해송에서는 150일까지 유지하였다. 본 약제가 살충가능한 농도로 top에 도달하는데 걸리는 기간은 적송(7월)에서는 3일 이내인 반면 해송(12월)에서는 15일 이내이었으며, 그 이행정도는 약제처리시기 및 수종에 의하여 영향을 받았다. 솔잎에 잔류하는 phosphamidon과 그 대사산물은 methanol로 잘 추출되었으며, 솔잎시료의 methanol 추출액을 autoradiography한 결과 phosphamidon은 소나무내에서 신속히 분해되어 7일 내에 약 80% 정도가 분해되었다.

• 한국응용곤충학회지
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• 제19권1호
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• pp.5-9
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• 1980

본 시험은 살충제 제제원액(Sumithion ULV 80, Sevin oil ULV 50, Salithion EC25, Dimethoate EC 50, Zolone EC 25, Folimat EC 50)과 고농도 희석액(Salithion, Dimethoate 10, 20, 40배)의 ULV 엽면살포에 의한 술잎혹파리방제 효과를 비교 검토코자 실시하였다. 1. 제제원액 살포시험에서는 약제의 종류와 철포시기(5월 19일, 26일, 6월 2일, 9일)에 따라 방제효과에 현저한 차이가 있었으면 그 방제효과는 Salithion, Sumithion, Dimethoate, Sevin oil, Zolone 및 Folimat의 순이였으며 대부분 5월 26일 처리에서 비교적 방제 효과가 좋았다. 그리나 문제는 Zolone을 제외한 다른 공시약제들은 보다 처리시기에 상관없이 약해가 발생하였다. 2. 고농도 희석액 살포시험에서는 희석배수, 처리시기(6월 2일, 9일)에 상관없이 Dimethoate에 비하여 Salithion 처리에서 방제효과가 높았으며 약해도 발생하지 않었다. 3. 본 시험의 결과를 종합하여 볼 때 Salithion 유제를 10배로 희석하여 5월 중하순에서 6월 상순경에 걸쳐 ULV 1회 엽면살포로서 성력적인 솔잎혹파리적 약제방제가 가능할 것으로 사료된다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권13호
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• pp.5557-5563
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• 2015

Background: Cholelithiasis is associated in 54%-98% of patients with carcinoma of the gallbladder, and a high incidence among females suggests a role of female hormones in the etiology of the disease. Cytochrome $P450C17{\alpha}$ (CYP-17) is a key enzyme involved in estrogen metabolism and polymorphisms in CYP-17 are associated with altered serum levels of estrogens. Thus, we investigated whether the CYP-17 MspA1 gene polymorphism might impact on risk of gall bladder cancers or gallstones, as well as to determine if this gene polymorphism might be linked with estrogen serum levels and lipid profile among the North Indian gall bladder cancer or gallstone patients. Materials and Methods: CYP-17 gene polymorphisms (MspA1) were genotyped with PCR-RFLP in cancer patients (n=96), stone patients (n=102), cancer + stone patients (n=52) and age/sex matched control subjects (n= 256). Lipid profile was estimated using a commercial kit and serum estrogen was measured using ELISA. Results: The majority of the patients in all groups were females. The lipid profile and estrogen level were significantly higher among the study as compared to control groups. The frequency of mutant allele A2 of CYP17 MspA1 gene polymorphism was higher among cancer (OR=5.13, 95% CI+3.10-8.51, p=0.0001), stone (OR=5.69, 95%CI=3.46-9.37, p=0.0001) and cancer + stone (OR=3.54, 95%CI=1.90-6.60, p=0.0001) when compared with the control group. However there was no significant association between genotypes of CYP17 MspA1 gene polymorphism and circulating serum level of estrogen and lipid profile. Conclusions: A higher frequency of mutant genotype A1A2 as well as mutant allele A2 of CYP-17 gene polymorphism is significantly associated with risk of gallbladder cancer and stones. Elevated levels of estrogen and an altered lipid profile can be used as predictors ofgall bladder stones and cancer in post menopausal females in India.

• Asian Pacific Journal of Cancer Prevention
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• 제17권4호
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• pp.2137-2140
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• 2016

Background: Gall bladder cancer (GBC) usually presents as unresectable or metastatic disease. We conducted a feasibility study to evaluate the effect of neoadjuvant therapy (NAT) on radiologic downstaging and resectability in unresectable GBC cases. Materials and Methods: Patients with locally advanced disease were treated with chemoradiotherapy [CTRT] ( external radiotherapy (45Gy) along with weekly concurrent cisplatin $35mg/m^2$ and 5-FU 500 mg) and those with positive paraaortic nodes were treated with neoadjuvant chemotherapy [NACT (cisplatin $25mg/m^2$ and gemcitabine $1gm/m^2$ day 1 and 8, 3 weekly for 3 cycles). Radiological assessment was according to RECIST criteria by evaluating downstaging of liver involvement and lymphadenopathy into complete response (CR), partial response (PR), stable disease (SD) and progressive disease (PD). Results: A total of 40 patients were evaluated from January 2012 to December 2014 (CTRT=25, NACT=15). Pretreatment CT scans revealed involvement of hilum (19), liver infiltration (38), duodenum involvement (n=22), colon involvement (n=11), N1 involvement (n=11), N2 disease (n=8), paraaortic LN (n=15), and no lymphadenopathy (n=6). After neoadjuvant therapy, liver involvement showed CR in 11(30%), PR in 4 (10.5%), SD in 15 (39.4%) and lymph node involvement showed CR in 17 (50%), PR in 6 (17.6%), SD in 4 (11.7 %). Six patients (CTRT=2, NACT=4) with 66.6 % and 83% downstaging of liver and lymphnodes respectively underwent extended cholecystectomy. There was 16.6 % and 83.3% rates of histopathological CR of liver and lymph nodes. All resections were R0. Conclusions: Neoadjuvant therapy in unresectable gall bladder cancer results in a 15% resectability rate. This approach has a strong potential in achieving R0 and node negative disease. Radiologic downstaging (CR+PR) of liver involvement is 40.5% and lymphadenopathy is 67.5%. Nodal regression could serve as a predictor of response to neoadjuvant therapy.