• 대한한의학방제학회지
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• 제25권4호
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• pp.449-456
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• 2017

Objective : Coptis rhizoma is traditional herb in Korean medicine, and Pelargonium sidoides extract has been used for relief of acute bronchitis in Western medicine. The present study examined the antibacterial effect of fusion formulation of Coptis rhizoma extract and Pelargonium sidoides extract against bronchial diseases bacteria. Methods : Test sample, fusion formulation of Korean and Western medicine, was prepared by mixing Coptis rhizoma extract and Pelargonium sidoides extract at a ratio of 1:2 (w/w). Antimicrobial properties of test sample were determined by agar diffusion assay and minimum inhibitory concentration (MIC) against bronchus diseases bacteria. Results : In agar diffusion assay, the highest amount of test sample (4 mg/disk) exhibited antibacterial activity against all microorganisms tested. Test sample showed the high activity for S. aureus (19.5 mm), C. diptheriae (16.5 mm), A. fumigatus (19.3 mm), F. nucleatum (22.7 mm) and Mycobactrium sp. (17.3 mm), whereas it showed a low activity for K. pneumonia (9.7 mm). The MIC value was determined as $250{\mu}g/m{\ell}$ against C. diptheriae. Test sample showed better growth inhibitory effects against S. aureus and A. fumigatus with the MIC valus of $125{\mu}g/m{\ell}$. Conclusion : These results suggest the possibility of application to chronic respiratory diseases of fusion formulation of Korean and Western medicine, which was prepared with Coptis rhizoma extract and Pelargonium sidoides extract.

• 대한원격탐사학회:학술대회논문집
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• 대한원격탐사학회 2003년도 Proceedings of ACRS 2003 ISRS
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• pp.248-250
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• 2003

An automatic approach and strategy for extracting building information from aerial images using combined image analysis and interpretation techniques is described in this paper. A dense DSM is obtained by stereo image matching. Multi-band classification, DSM, texture segmentation and Normalised Difference Vegetation Index (NDVI) are used to reveal building interest areas. Then, based on the derived approximate building areas, a shape modelling algorithm based on the level set formulation of curve and surface motion has been used to precisely delineate the building boundaries. Data fusion, based on the Dempster-Shafer technique, is used to interpret simultaneously knowledge from several data sources of the same region, to find the intersection of propositions on extracted information derived from several datasets, together with their associated probabilities. A number of test areas, which include buildings with different sizes, shape and roof colour have been investigated. The tests are encouraging and demonstrate that the system is effective for building extraction, and the determination of more accurate elevations of the terrain surface.

• 폴리머
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• 제39권1호
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• pp.33-39
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• 2015

올메사탄은 BCS 2단계에 해당하는 약물로 물에 잘 녹지 않는 난용성 약물이다. 이런 약물이 낮은 생체이용률과 제형을 설계하는 과정에서 어려움을 주는 원인이 된다. 본 연구에서는 올메사탄을 분무건조법 및 회전용매증 발법을 이용해 고체분산체를 제조하여 제법에 따른 난용성약물의 용출률을 확인하였다. 수용성 고분자로 PVP를 사용하여 약물과 고분자의 비율별로 고체분산체를 제조하였다. SEM을 이용하여 고체분산체의 형태학적인 특성을 분석하였고, 고체분산체의 결정학적 성질은 XRD와 DSC를 통하여 확인하였다. 또한 FTIR을 통해 화학적인 변화를 확인하고, 생체 외 용출거동 실험을 통하여 변화된 용출률을 확인하였다. 제조된 고체분산체는 pH 1.2에서 용출을 확인하였으며, 올메텍과 용출률을 비교하였으며, 분무건조를 통해 약물의 용출률을 향상시킬 수 있다는 것을 확인할 수 있다.

• 폴리머
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• 제34권3호
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• pp.269-273
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• 2010

본 연구는 염산 알푸조신의 서방화를 위한 과립제의 최적 구성을 찾기 위해 수행되었으며, 이에 따라 고분자의 점도에 따른 염산 알푸조신 과립정제를 제조하였다. 사용된 고분자는 경구를 통한 약물전달 시스템 설계에 가장 널리 사용되는 하이드록시프로필메틸셀룰로오스(HPMC)이며, HPMC의 팽윤성은 가장 중요한 특성으로 약물의 방출에 큰 영향을 미친다. 염산 알푸조신 과립정제의 구조변화를 확인하기 위하여 적외선분광법(FTIR)을 분석하였으며, 결정학적 특성을 알아보기 위해 X선 회절분석법(XRD)을 이용하여 분석하였다. 과립정제를 제조하여 인공장액에서의 방출거동을 알아보았으며, 본 연구를 통해 첨가제로 사용된 HPMC의 점도에 따라 모델약물인 염산 알푸조신의 방출거동을 조절할 수 있었다.

• 제어로봇시스템학회논문지
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• 제16권2호
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• pp.177-187
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• 2010

A MTG (Multimode Tracking and Guidance) system is employed to compensate for the limitations of individual seekers such as RF (Radio frequency) or IIR (Imaging Infra-red) and to improve the overall tracking and guidance performance in jamming, clutter, and adverse weather environments. In the MTG system, tracking filter, data association, and data fusion methods are important elements to maximize the effectiveness of precision homing missile guidance. This paper proposes the formulation of a Kalman filter for the estimation of line-of-sight rate from seeker measurements in missiles guided by proportional navigation. Also, we suggest the HPDA (Highest Probability Data Association) and data fusion methods of the MTG system for target tracking in the adverse environments. Mont-Carlo simulation is employed to evaluate the overall tracking performance and guidance accuracy.

• International Journal of Fuzzy Logic and Intelligent Systems
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• 제6권4호
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• pp.314-320
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• 2006

Navigation in environments that are densely cluttered with obstacles is still a challenge for Autonomous Ground Vehicles (AGVs), especially when the configuration of obstacles is not known a priori. Reactive local navigation schemes that tightly couple the robot actions to the sensor information have proved to be effective in these environments, and because of the environmental uncertainties, STSF(Space and Time Sensor Fusion)-based fuzzy behavior systems have been proposed. Realization of autonomous behavior in mobile robots, using STSF control based on spatial data fusion, requires formulation of rules which are collectively responsible for necessary levels of intelligence. This collection of rules can be conveniently decomposed and efficiently implemented as a hierarchy of fuzzy-behaviors. This paper describes how this can be done using a behavior-based architecture. The approach is motivated by ethological models which suggest hierarchical organizations of behavior. Experimental results show that the proposed method can smoothly and effectively guide a robot through cluttered environments such as dense forests.

• Journal of Pharmaceutical Investigation
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• 제41권3호
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• pp.179-184
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• 2011

This study aimed to confirm the effect of molecular weight (MW) in solid dispersion of carvedilol with poly-vinylpyrrolidone (PVP) of various MW. Solid dispersion of carvedilol with PVP was prepared by spray-drying method. Scanning electron microscopy (SEM) was used to analyze the surface of solid dispersion samples. Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) were used to analyze the crystalline of solid dispersion. Fourier transform infrared spectroscopy (FT-IR) was used to analyze the change of chemical structure characteristic of solid dispersion. DSC and XRD show that drug crystalline was changed. FT-IR revealed that chemical structure of solid dispersion comparing the chemical structure of drug was changed. The dissolution studies of solid dispersion presented at simulated gastric juice (pH 1.2). The dissolution rate of solid dispersion was dramatically enhanced than pure drug and the MW of PVP has an effect on the release property of carvedilol in solid dispersion. In conclusion, the present study has confirmed the effect of MW of PVP on release property of solid dispersion formulation of carvedilol with PVP.

• 폴리머
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• 제38권4호
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• pp.434-440
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• 2014

셀레콕시브는 높은 결정성을 갖는 난용성 약물로서 이러한 난용성 약물의 용해도를 증진시키기 위해 고체분산법을 바탕으로 한 분무건조기를 이용하여 고체분산체를 제조하였다. PVP K30과 Eudragit EPO를 수용성 담체로 사용하였고 폴록사머 407은 계면활성제로 사용하였다. 제조된 셀레콕시브 고체분산체의 특성을 SEM, DSC, XRD 그리고 FTIR을 이용하여 확인하였다. SEM과 DSC 그리고 XRD를 통하여 셀레콕시브 고체분산체가 무정형임을 알 수 있었다. 제조된 고체분산체는 pH 1.2에서 용출을 실시하였으며 시판제인 Celebres$^{(R)}$ 용출률을 비교하였으며 분무건조를 통해 제조한 고체분산체가 Celebres$^{(R)}$보다 용출률이 크다는 것을 확인하였다.

• 전자공학회논문지SC
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• 제49권3호
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• pp.1-11
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• 2012

데이터 연관은 지능시스템의 자율적인 작동에 매우 중요한 문제이다. 본 논문에서는 데이터 연관 문제를 Bayesian 방식으로 구성하고 이를 성공적으로 지능시스템에 응용한 예를 설명한다. 먼저 데이터 연관 문제가 어떻게 Bayesian 방식으로 구성하여 혼잡한 환경에서의 다 물체 추적 문제에 적용되는지 알아본다. 그리고 데이터 연관이 지능시스템에 어떻게 응용될 수 있는지 정체 관리를 이용한 항공 교통 관제, 카메라 네트워크 위치 및 관점 자동 보정, 멀티 센서 퓨젼의 세 가지 예를 이용해 살펴본다.

• Nuclear Engineering and Technology
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• 제52권5호
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• pp.1002-1007
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• 2020

The purpose of the current study was to evaluate a spectrum formulation set employed to modify the neutron spectrum of D-D fusion neutrons in a IS plasma focus device using GEANT4, MCNPX2.6, and FLUKA codes. The set consists of a moderator, reflector, collimator and filters of fast neutron and gamma radiation, which placed on the path of 2.45 MeV neutron energy. The treated neutrons eliminate cancerous tissue with minimal damage to other healthy tissue in a method called neutron therapy. The system optimized for a total neutron yield of 10⁹ (n/s). The numerical results indicate that the GEANT4 code for the cubic geometry in the Beam Shaping Assembly 3 (BSA3) is the best choice for the energy of epithermal neutrons.