Polymer(Korea) (폴리머)

The Polymer Society of Korea (한국고분자학회)
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Characterization and Improvement of Dissolution Rate of Solid Dispersion of Celecoxib in PVP K30/Eudragit EPO

PVP K30/Eudragit EPO에 의한 셀레콕시브 고체분산체의 용출률 향상 및 특성

  • Jeon, Dae Yeon (Dept. of BIN Fusion Technology, Department of PolymerNano Science Technology and Polymer BIN Fusion Research Center, Chonbuk National University) ;
  • Jang, Ji Eun (Dept. of BIN Fusion Technology, Department of PolymerNano Science Technology and Polymer BIN Fusion Research Center, Chonbuk National University) ;
  • Lee, Jeong Hwan (Dept. of BIN Fusion Technology, Department of PolymerNano Science Technology and Polymer BIN Fusion Research Center, Chonbuk National University) ;
  • Yang, Jae Won (Dept. of BIN Fusion Technology, Department of PolymerNano Science Technology and Polymer BIN Fusion Research Center, Chonbuk National University) ;
  • Park, Sang Mi (Dept. of BIN Fusion Technology, Department of PolymerNano Science Technology and Polymer BIN Fusion Research Center, Chonbuk National University) ;
  • Lim, Dongkwon (Dept. of BIN Fusion Technology, Department of PolymerNano Science Technology and Polymer BIN Fusion Research Center, Chonbuk National University) ;
  • Khang, Gilson (Dept. of BIN Fusion Technology, Department of PolymerNano Science Technology and Polymer BIN Fusion Research Center, Chonbuk National University)
  • 전대연 (전북대학교 BIN융합공학과, 고분자나노공학과) ;
  • 장지은 (전북대학교 BIN융합공학과, 고분자나노공학과) ;
  • 이정환 (전북대학교 BIN융합공학과, 고분자나노공학과) ;
  • 양재원 (전북대학교 BIN융합공학과, 고분자나노공학과) ;
  • 박상미 (전북대학교 BIN융합공학과, 고분자나노공학과) ;
  • 임동권 (전북대학교 BIN융합공학과, 고분자나노공학과) ;
  • 강길선 (전북대학교 BIN융합공학과, 고분자나노공학과)
  • Received : 2013.11.25
  • Accepted : 2014.02.10
  • Published : 2014.07.25
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Abstract

We prepared nanoparticles containing insoluble celecoxib by the method of solid dispersions using a spray dryer to improve solubility of celecoxib. We used PVP K30 and Eudragit EPO as water-soluble carriers for the solid dispersion, and poloxamer 407 as a surfactant. Characterization of celecoxib solid dispersion was performed by scanning electron microscope (SEM), differential scanning calorimetry (DSC), X-ray diffraction (XRD) and Fourier-transform infrared spectroscopy (FTIR). The results of SEM, DSC and XRD demonstrated that celecoxib is amorphous in solid dispersion. The dissolution rate measured in intestinal juice showed that the method of solid dispersion improved celecoxib solubility as compared with a conventional drug (Celebres$^{(R)}$). In conclusion, solid dispersion formulation prepared by a spray dryer would improve the solubility of celecoxib in oral administration.

셀레콕시브는 높은 결정성을 갖는 난용성 약물로서 이러한 난용성 약물의 용해도를 증진시키기 위해 고체분산법을 바탕으로 한 분무건조기를 이용하여 고체분산체를 제조하였다. PVP K30과 Eudragit EPO를 수용성 담체로 사용하였고 폴록사머 407은 계면활성제로 사용하였다. 제조된 셀레콕시브 고체분산체의 특성을 SEM, DSC, XRD 그리고 FTIR을 이용하여 확인하였다. SEM과 DSC 그리고 XRD를 통하여 셀레콕시브 고체분산체가 무정형임을 알 수 있었다. 제조된 고체분산체는 pH 1.2에서 용출을 실시하였으며 시판제인 Celebres$^{(R)}$ 용출률을 비교하였으며 분무건조를 통해 제조한 고체분산체가 Celebres$^{(R)}$보다 용출률이 크다는 것을 확인하였다.

Keywords

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