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http://dx.doi.org/10.7317/pk.2014.38.4.434

Characterization and Improvement of Dissolution Rate of Solid Dispersion of Celecoxib in PVP K30/Eudragit EPO  

Jeon, Dae Yeon (Dept. of BIN Fusion Technology, Department of PolymerNano Science Technology and Polymer BIN Fusion Research Center, Chonbuk National University)
Jang, Ji Eun (Dept. of BIN Fusion Technology, Department of PolymerNano Science Technology and Polymer BIN Fusion Research Center, Chonbuk National University)
Lee, Jeong Hwan (Dept. of BIN Fusion Technology, Department of PolymerNano Science Technology and Polymer BIN Fusion Research Center, Chonbuk National University)
Yang, Jae Won (Dept. of BIN Fusion Technology, Department of PolymerNano Science Technology and Polymer BIN Fusion Research Center, Chonbuk National University)
Park, Sang Mi (Dept. of BIN Fusion Technology, Department of PolymerNano Science Technology and Polymer BIN Fusion Research Center, Chonbuk National University)
Lim, Dongkwon (Dept. of BIN Fusion Technology, Department of PolymerNano Science Technology and Polymer BIN Fusion Research Center, Chonbuk National University)
Khang, Gilson (Dept. of BIN Fusion Technology, Department of PolymerNano Science Technology and Polymer BIN Fusion Research Center, Chonbuk National University)
Publication Information
Polymer(Korea) / v.38, no.4, 2014 , pp. 434-440 More about this Journal
Abstract
We prepared nanoparticles containing insoluble celecoxib by the method of solid dispersions using a spray dryer to improve solubility of celecoxib. We used PVP K30 and Eudragit EPO as water-soluble carriers for the solid dispersion, and poloxamer 407 as a surfactant. Characterization of celecoxib solid dispersion was performed by scanning electron microscope (SEM), differential scanning calorimetry (DSC), X-ray diffraction (XRD) and Fourier-transform infrared spectroscopy (FTIR). The results of SEM, DSC and XRD demonstrated that celecoxib is amorphous in solid dispersion. The dissolution rate measured in intestinal juice showed that the method of solid dispersion improved celecoxib solubility as compared with a conventional drug (Celebres$^{(R)}$). In conclusion, solid dispersion formulation prepared by a spray dryer would improve the solubility of celecoxib in oral administration.
Keywords
celecoxib; Eudragit EPO; PVP K30; spray drying; solid dispersion;
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