• 한국측량학회지
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• 제36권5호
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• pp.413-422
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• 2018

Many applications using satellite data from high-resolution multispectral sensors require an image fusion step, known as pansharpening, before processing and analyzing the multispectral images when spatial fidelity is crucial. Image fusion methods are to improve images with higher spatial and spectral resolutions by reducing spectral distortion, which occurs on image fusion processing. The image fusion methods can be classified into MRA (Multi-Resolution Analysis) and CSA (Component Substitution Analysis) approaches. To suggest the efficient image fusion method for Pleiades and KOMPSAT (Korea Multi-Purpose Satellite) 3 satellites, this study will evaluate image fusion methods for multispectral and panchromatic images. HPF (High-Pass Filtering), SFIM (Smoothing Filter-based Intensity Modulation), GS (Gram Schmidt), and GSA (Adoptive GS) were selected for MRA and CSA based image fusion methods and applied on multispectral and panchromatic images. Their performances were evaluated using visual and quality index analysis. HPF and SFIM fusion results presented low performance of spatial details. GS and GSA fusion results had enhanced spatial information closer to panchromatic images, but GS produced more spectral distortions on urban structures. This study presented that GSA was effective to improve spatial resolution of multispectral images from Pleiades 1A and KOMPSAT 3.

• BMB Reports
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• 제38권4호
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• pp.373-380
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• 2005

For measles viruses, fusion on the cell membrane is an important initial step in the entry into the infected cells. The recent research indicated that hemagglutinin firstly leads the conformational changes in the fusion protein then co-mediates the membrane fusion. In the work, we use the co-immunoprecipitation and pull-down techniques to identify the interactions among fusion protein, hemagglutinin and signaling lymphocyte activation molecule (SLAM), which reveal that the three proteins can form a functional complex to mediate the SLAM-dependent fusion. Moreover, under the confocal microscope, fusion protein and hemagglutinin protein can show the cocapping mediated by the SLAM. So fusion protein not only is involved in the fusion but also might directly interact with the SLAM to be a new fusion-trimer model, which might account for the infection mechanism of measles virus.

• 제어로봇시스템학회논문지
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• 제13권12호
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• pp.1230-1242
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• 2007

This paper describes an IIR/FIR fusion filter for a nonlinear system, and analyzes the stability of the fusion filter. The fusion filter is applied to INS/GPS integrated system, and the performance is verified by simulation and experiment. In the fusion filter, an IIR-type filter (SPKF) and FIR-type filter (MRHKF filter) are processed independently, then the two filters are merged using the mixing probability calculated using the residuals and residual covariance information of the two filters. The merits of the SPKF and the MRHKF filter are embossed and the demerits of the filters are diminished via the filter fusion. Consequently, the proposed fusion filter has robustness against to model uncertainty, temporary disturbing noise, large initial estimation error, etc. The stability of the fusion filter is verified by showing the closeness of the states of the two sub filters in the mixing/redistribution process and the upper bound of the error covariance matrices. This fusion filter is applied into INS/GPS integrated system, and important factors for filter processing are presented. The performance of the INS/GPS integrated system designed using the fusion filter is verified by simulation under various error environments and is confirmed by experiment.

• Journal of Pharmaceutical Investigation
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• 제41권6호
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• pp.363-369
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• 2011

In this study, we demonstrated the release behavior of carvedilol with the content of polyvinylpyrrolidone K-30 (PVP K-30) and the effect of citric acid and fumaric acid as acidifiers on the release behavior of drug. In addition, it tries to inquire into the release behavior difference of the carvedilol according to the manufacturing method. The release behavior of the tablets was compared with Dilatrand$^{(R)}$ in the simulated gastric fluid (pH1.2). Differential scanning calorimeter (DSC), X-ray diffraction (XRD) and Fourier-transform infrared spectroscopy (FT-IR) were characterized for the physicochemical properties of the tablets. In case of mixing the carvedilol and PVP K-30, in case the ratio of the carvedilol and PVP K-30 was 1:5, the release behavior was the highest among. As well as the dissolution rate of tablets manufactured by lyophilization and rotary evaporator was higher than physical mixture. The dissolution rate of containing acidifiers was more improved. But, rather the excessive amount of the acidifier addition reduced the dissolution rate.

• 복식
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• 제57권3호
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• pp.124-135
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• 2007

Being called 'the period of diversity', the 21st century is taking on a new aspect which is different from the past where a certain phenomenon of a specific area was prescribed as one representative icon of a period. In particular, the globalization culture acted as the catalyst to accept such diversity and it appeared as a new culture code, 'fusion' throughout society and culture. Especially, unlike two-hour movies, the recent drama $\lceil$Gung$\rfloor$ showed various fusion style costume over a period of three months and created a sensation of fusion style costume. Therefore, this study is aimed at investigating fusion style costume by selecting the TV drama $\lceil$Gung$\rfloor$ which was on the air in 2006. Though various studies on fusion style costume, which is becoming a new culture code, have been conducted, this study is meaningful in that it's time to conduct a new study through a popular TV drama. Based on preceding studies on fusion style, the elements of fusion style were analyzed by capturing the most frequently exposed heroine's costume, and new design development introducing fusion elements was attempted for empirical studies. The study results are as follows. First, it was found that the fusion trend is a culture code which already spread to the public and is shown in the fashion in various ways. Second, the drama $\lceil$Gung$\rfloor$, is commented as a new dram which introduced the fusion style costume into Korea through a modern version of constitutional monarchy and is commented as a medium which created an interest in the fusion costume among the public as well. Third, new trend elements of the fusion style could be derived through empirical studies by design development.

• 폴리머
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• 제39권1호
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• pp.6-12
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• 2015

난용성 약물인 아세클로페낙의 용해도를 개선하기 위해 약물과 고분자의 다른 비율을 사용하여 분무건조와 용매증발의 방법으로 Kollidon VA 64의 고체분산체를 제조하였다. 아세클로페낙을 포접하는 고체분산체의 형태학적, 물리화학적 분석을 하기 위해, 전자주사현미경(SEM), 푸리에변환 적외선분광법(FTIR), 시차주사 열량측정법(DSC) 등이 사용되었다. 포접률과 인공장액에서의 용출 거동은 HPLC를 사용하여 측정하였고, 비교를 위해 원약물과 시판제 Airtal$^{(R)}$이 사용되었다. 이것은 두 가지 방법에 따라 개선된 용출 거동을 나타내었다.

• 폴리머
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• 제39권1호
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• pp.33-39
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• 2015

올메사탄은 BCS 2단계에 해당하는 약물로 물에 잘 녹지 않는 난용성 약물이다. 이런 약물이 낮은 생체이용률과 제형을 설계하는 과정에서 어려움을 주는 원인이 된다. 본 연구에서는 올메사탄을 분무건조법 및 회전용매증 발법을 이용해 고체분산체를 제조하여 제법에 따른 난용성약물의 용출률을 확인하였다. 수용성 고분자로 PVP를 사용하여 약물과 고분자의 비율별로 고체분산체를 제조하였다. SEM을 이용하여 고체분산체의 형태학적인 특성을 분석하였고, 고체분산체의 결정학적 성질은 XRD와 DSC를 통하여 확인하였다. 또한 FTIR을 통해 화학적인 변화를 확인하고, 생체 외 용출거동 실험을 통하여 변화된 용출률을 확인하였다. 제조된 고체분산체는 pH 1.2에서 용출을 확인하였으며, 올메텍과 용출률을 비교하였으며, 분무건조를 통해 약물의 용출률을 향상시킬 수 있다는 것을 확인할 수 있다.

• 폴리머
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• 제38권5호
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• pp.656-663
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• 2014

생분해성 고분자인 폴리옥살레이트(POX)를 이용하여 아토르바스타틴 칼슘을 함유한 미립구를 $O_1/O_2/W$ 에멀젼용매증발법으로 제조하였다. 약물의 함량, POX의 분자량과 농도 그리고 유화제인 PVA의 농도를 달리하여 아토르바스타틴 칼슘이 함유된 미립구의 형태학적 특성, 방출거동, 분해거동 등을 평가하였다. 아토르바스타틴 칼슘이 함유된 미립구에 대한 물리화학적 성질 및 형태를 X선 회절분석법과 시차주사열량계, 적외선 분광분석기, 그리고 주사 전자 현미경을 이용하여 분석하였다. 또한 미립구의 방출거동과 포접률을 분석하기 위하여 고성능 액체 크로마토그래피를 이용하였으며 분해성을 분석하기 위하여 10일 동안 in vitro 실험을 통해 관찰하였다. 본 연구를 통하여 제조 조건에 따라 아토르바스타틴 칼슘을 함유한 POX 미립구의 약물방출과 형태 제어를 확인할 수 있었으며, 이를 통해 아토르바스타틴 뿐만 아니라 유사 약물의 약물 방출과 형태 제어에 도움이 될 것으로 기대된다.

• 폴리머
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• 제35권4호
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• pp.289-295
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• 2011

망막조직공학을 위한 생체 재료는 기계적 안정성, 생체적합성, 낮은 분해속도 등을 포함하여 in vivo에서 잠재적인 유용성을 위한 몇 가지 중요한 특징이 입증되어야 한다. 실크 필름 생체재료는 이러한 기능적인 요구에 맞게 디자인되었다. 0, 10, 20, 40, 및 80 wt%의 실크가 함유된 천연합성물질과 하이브리드화된 silk/PLGA 필름을 용매 증발법으로 제조하였다. 1, 2, 및 3일 후에 부착된 세포 수를 확인하기 위해 MTT 분석을 하였고 SEM을 통해 필름에 부착된 세포 모폴로지를 확인하였다. 또한, mRNA 발현정도를 알아보기 위해 retinal pigment epithelitun(RPE) 세포의 프라이머인 RPE65를 사용하여 RT-PCR을 실시하였고 RPE 세포의 특정 단백질인 cytokeratin의 발현을 확인하고 세포의 증식을 비교하기 위해 면역화학염색을 실시하였다. 본 실험을 통해 실크/PLGA 필름에서 20~40 wt% 실크를 함유한 경우에 RPE 세포의 부착과 증식에 가장 좋은 영향을 미치는 것을 확인하였다.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2007년도 제32회 학술대회 초록집
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• pp.197-197
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• 2007