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http://dx.doi.org/10.7317/pk.2015.39.1.6

Improved Dissolution Behavior of Aceclofenac Loadings with Kollidon VA 64 Using Spray Drying and Rotary Evaporation Process  

Yang, Jaewon (Dept. of BIN Fusion Technology, Polymer Fusion Research Center & Dept. of PolymerNano Science Technology, Chonbuk National University)
Park, Jin Young (Dept. of BIN Fusion Technology, Polymer Fusion Research Center & Dept. of PolymerNano Science Technology, Chonbuk National University)
Lee, Cheon Jung (Dept. of BIN Fusion Technology, Polymer Fusion Research Center & Dept. of PolymerNano Science Technology, Chonbuk National University)
Kim, Hye Min (Dept. of BIN Fusion Technology, Polymer Fusion Research Center & Dept. of PolymerNano Science Technology, Chonbuk National University)
Lee, Hyun Gu (Dept. of BIN Fusion Technology, Polymer Fusion Research Center & Dept. of PolymerNano Science Technology, Chonbuk National University)
Jang, Na Gum (Dept. of BIN Fusion Technology, Polymer Fusion Research Center & Dept. of PolymerNano Science Technology, Chonbuk National University)
Ko, Hyun Ah (Dept. of BIN Fusion Technology, Polymer Fusion Research Center & Dept. of PolymerNano Science Technology, Chonbuk National University)
Cho, Seon Ah (Dept. of BIN Fusion Technology, Polymer Fusion Research Center & Dept. of PolymerNano Science Technology, Chonbuk National University)
Yang, Dae Hyeok (Institute of Cell & Tissue Engineering, College of Medicine, The Catholic University of Korea)
Khang, Gilson (Dept. of BIN Fusion Technology, Polymer Fusion Research Center & Dept. of PolymerNano Science Technology, Chonbuk National University)
Publication Information
Polymer(Korea) / v.39, no.1, 2015 , pp. 6-12 More about this Journal
Abstract
In order to improve the poor water solubility of aceclofenac, it was loaded into solid Kollidon VA 64 dispersion prepared by spray drying and rotary evaporation methods using different drug and polymer ratios. Morphology and physicochemical behavior of the aceclofenac loaded solid dispersions was analyzed by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffractometry (XRD), and differential scanning calorimetry (DSC). Encapsulation efficiency and dissolution behavior in a simulated intestinal juice of aceclofenac in the solid dispersions was measured using HPLC and the latter was compared with that of the active pharmaceutical ingredient (API) and Airtal$^{(R)}$. It was demonstrated that two methods could significantly improve the dissolution behavior of aceclofenac.
Keywords
aceclofenac; dissolution rate; rotary evaporation; solid dispersion; spray drying;
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