• Journal of Korean Academy of Fundamentals of Nursing
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• v.4 no.2
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• pp.175-192
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• 1997

The purpose of this study was to identify the care needs of family-caregivers to the patients with stroke. Subjects were 115 family-caregivers caring for the patients while they were in-patients or out-patients with stroke in two general hospitals and one oriental medicine hospital located in Seoul and Kwang-Ju. The instrument used for this study was made by the researcher on the basis of results of literature review and interviews with family-caregivers, composed of 35 items. Internal validity by calculation of cronbach's alpha with data of respondents was 0.91, which was regarded as high. The Data were analyzed by SAS program, with percentage, mean, t-test, and ANOVA. Factor structures of care needs of family-caregivers were elicited by factor analysis(PCA, Varimax rotation). Datum collection had been from July 1 to August 14, 1997. The results of this study were as follows : 1. The mean score of the sum of the care needs of family-caregivers was 3.96 and the highest-mean item was 'need for immediate care(M=4.77)', and the lowest-mean item was 'need for chaplian's visit (M=2.82)'. 2. Care needs of the family-caregivers were : Need to be informed of the disease, treatment and care ; need of education and assistance related to physical functional level ; need of social support and consultation ; need of management of nursing problem related to immobility ; need of appreciation ; need of the way to communicate with patients ; need of immediate care and help. The highest mean factor was the 'need for immediate care and help(M=4.74)', and the lowest mean factor was the 'need of appreciation(M=3.58)'. 3. The variables influencing the degree of care needs perceived by family-caregivers to the patients with stroke were as follows : There were significant differences between need to be informed of the disease, treatment and care and general characteristic factors, which were family caregiver's sex (p=.0178), caring period(p=.0223) and patient's suffering period(p=.0244). There were significant differences between need of education and assistance related to physical functional level and general characteristic factors, which were patient's paralysis(p=.0177), patient's ADL dependency(p=.0032). There were significant differences between need of social support and consultation and general characteristic factors, which were family caregiver's sex(p=.0055), occupation(p=.0159), religion(p=.0093) and patient's sex(p=.0134). There was significant difference in the degree of need of management of nursing problem related to immobility, according to the patient's ADL dependency(p=.0493). There were significant differences between need of appreciation and general characteristic factors, which were family caregiver's age(p=.0107), sex(p=.0133), and patient's age(p=.0338). There were significant differences between need of the way to communicate with patient and general characteristic factors, which were patient's paralysis(p=.0002) and aphasia(p=.0001). There were significant differences between need of immediate care and help and general characteristic factors, which were family caregiver's caring period(p=.0162) and patient's suffering period(p=.0116). 4. The mean score of patient's ADL dependency was 3. 38 and the highest-mean item was 'ascending and descending stairs(M=4.12)', and the lowest-mean item was 'drinking(M=2.60)'. There was no significant difference in the degrees of care needs related to the patient's ADL dependency. 5. The highest information source of family-caregivers was from the doctors about the disease, treatment and care(26.1%). The second highest one was from mass media(20.8%), and the third one was from the nurses. The above findings may be used as the basic data to seek more efficient way of elevating nursing practice and quality for family-caregivers to the patients with stroke.

• Journal of Plant Biology
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• v.39 no.2
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• pp.85-92
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• 1996

Small GTP-binding proteins are divided into three major group: Ras, Rho and Ypt/Rab. They have the conserved regions designed G1 to G5 that are critical in GDP/GTP exchange, GTP-induced conformational change and GTP hydrolysis. We isolated and characterized genomic DNA or cDNAfragments encoding G1 to G3 domains of small GTP-binding protein Rab and Rho from several plant species using two different PCR-based cloning strategies. Seven rab DNA fragments were isolated from 4 different plants, mung-bean, tobacco, rice and pepper using two degenerate primers corresponding to the GTP-binding domain G1 and G3 in small GTP-binding proteins. The amino acid sequences among these rab DNA fragments and other known small GTP-binding proteins shows that they belong to the Ypt/Rab family. Six rho DNA fragments were isolated from 5 different plants, mung-bean, rice, Arabidopsis, Allium and Gonyaulax using the nested PCR method that involves four degenerate primers corresponding to the GTP-binding domain G1, G3 and G4. The rho DNA fragments cloned show more than 90% homology to each other. Sequence comparison between plant and other known Rho family genes suggests that they are closely related (67 to 82% amino acid identity). Sequence analysis and southern blot analysis of rab and rho in mung-bean suggest than thses genes are encoded by multigene family in mung-bean.

• Korean Journal of Child Studies
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• v.28 no.2
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• pp.251-265
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• 2007

Participants in this study were 1.245 4th and 5th graders and their parents from 8 elementary schools in Seoul, Daejeon, and Pusan. Using the Korean Youth Self-Report (K-YSR), children's behavior problems were measured and assigned to either clinical or normal groups. Between group differences were that the educational level of mothers of internalizing girls was lower than that of normal girls. Girls with internalizing problems had more siblings than normal girls. Parents of both boys and girls with either internalizing or externalizing problems were more rejecting and/or permissive than parents of children without behavior problems. Fathers of children with behavior problems perceived more marital conflicts, while mothers whose children have behavior problems had more negative family-of-origin experiences compared to parents of normal children.

• Korean Journal of Health Education and Promotion
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• v.13 no.1
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• pp.28-44
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• 1996

The purpose of this study is to examine the associated risk factors for adolescent cigarette smoking. In February 1995, a total of 1793 students from 17 general high schools in Seoul were assessed with a self-completing questionnaire pertaining current smoking status and school.family.peer environmental factors. The results are as follows; 1. The overall proportion of current smoker among students in the study was 17.3%; 27.7% in males and 6.6% in females. 2. There was significant association between smoking status and all school environmental factors (ranks at school, satisfaction at school, study hours after school, extracurricular activity) examined. 3. Siblings smoking in males and family structure in females were significantly associated with the smoking status of students. 4. Functional aspect of family environmental factors, such as APGAR score, parental supervision, attachment to father or to mother were related to smoking status of students. 5. Association with friends who smoke was significantly associated with smoking status of students. 6. In males, association with friends who smoke, ranks at school, siblings smoking were significant positive predictors and APGAR score, parental supervision, attchment to mother were significant negative predictors. In females, association with friends whosmoke, ranks at school, satisfaction at school were significant positive predictors and parental supervision, attchment to father were significant negative predictors. These findings suggest that strategies that influence smoking behavior need to be directed not only to the individual student but also to their peer group, family and school environment.

• Journal of the Korean Home Economics Association
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• v.30 no.3
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• pp.141-158
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• 1992

The purpose of this study was to identify general characteristics of social lifespaces in Korean family houses and to investigate the changes in the physical aspects and room functions of social lifespaces from Yi-dynasty to the present. The documentary research method was used for this study. Total of 972 out of 1,109 floor plans were analyzed for this study. The major findings were that changes of social lifespaces from Yi-dynasty to the present have been affected by natural and socio-cultural environments. The changes in the physical aspects of social lifespaces have shown from one or two social lifespaces to various single-purpose social lifespaces such as living room, family room, drawing room, and study room. In the past, the cnetral social lifespaces, Anbang(women's quarter) was larger than the living room/Daechung(wooden floor) but the living room in the present has become a central social lifespaces and larger. The room function of Anbang has changed from multi-purpose space to private space. Living room/Daechung had used as a pathway rather than a social lifespaces in the past but the living room has played many fuctional roles of family social activities in the present. The kitchen has also begun to use as a social lifespace. This is a new symptom that kitchen and dining spaces will be included as a new social lifespaces.

• BMB Reports
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• v.52 no.3
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• pp.181-189
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• 2019

Cancer remains a life-threatening disease and accounts for the major mortality rates worldwide. The practice of using biomarkers for early detection, staging, and customized therapy may increase cancer patients' survival. Deubiquitinating enzymes (DUBs) are a family of proteases that remove ubiquitin tags from proteins of interest undergoing proteasomal degradation. DUBs play several functional roles other than deubiquitination. One of the important roles of DUBs is regulation of tumor progression. Several reports have suggested that the DUB family members were highly-elevated in various cancer cells and tissues in different stages of cancer. These findings suggest that the DUBs could be used as drug targets in cancer therapeutics. In this review, we recapitulate the role of the DUB family members, including ubiquitin-specific protease, otubain protease, and important candidates from other family members. Our aim was to better understand the connection between DUB expression profiles and cancers to allow researchers to design inhibitors or gene therapies to improve diagnosis and prognosis of cancers.

• Journal of muscle and joint health
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• v.5 no.2
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• pp.191-205
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• 1998

This study was conducted to identify the relations between the factors influencing syndrome and physical disability of fibromyalgia patients. The subjects of this study were 125 outpatients selected at H. Rheumatism clinic from February to July in 1997, The Collected data were analyzed by Frequency, Pearson correlation using SPSS Windows and Path analysis using LISREL 7.16. The results were as follows. 1. General characteristics of subjects About 2/3 of subjects were over 40years of age and most of them were graduated from high school. The Christian were over a half (54.0%) of subjects. 2. Correlation between Family support, knowledge, Self-efficacy, Syndrome and physical disability. As knowledge was positively related to self-efficacy(r=.306), the family support was positively related to self-efficacy(r=.217), and family support was negatively to syndrome. Self-efficacy showed negative relation with syndrome and Physical disability. Syndrome as physical disability represent positive relation. Therefore all hypotheses were supported. 3. Causal relations between research variables. Family support influenced on syndrome, as syndrome on physical activity, as well as knowledge on self-efficacy & physical disability. The model also showed a good fit to the data[$X^2$=1.21 df=1(p=.546), GFI=.996, AGFI=.971, RMSR=.023]. 4. Correlation between symptoms of Fibromyalyia. Having analyzed the relations between tender point, pain, stiffness, functional disturbance, sleep disturbance, depression, fatigue, anxiety, the results were as follows ; All relations show statistically positive correlation, which means close relationship between symptoms, except between pain and depression, pain and anxiety. As a result, symptoms of Fibromyalgia had close relation. Therefore, these were common, rather than individual symptoms. This syndrome influenced on physical disability, and self-efficacy on the both, as knowledge on self-efficacy. In conclusion, to improve syndrome relief and physical disability of fibromyalgia, nursing interventions such as education, self-efficacy increasing stratagy, and family counseling are needed.

• Perspectives in Nursing Science
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• v.8 no.1
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• pp.62-72
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• 2011

Purpose: The purpose of this study was to investigate QOL and the factors related to family caregivers who care for Amyotrophic Lateral Sclerosis (ALS) patients. Methods: The subjects were 83 family caregivers caring for ALS patients who visited the neurology outpatient section of a tertiary hospital located in Seoul between January and July of 2008. Their demographic characteristics were assessed and data were collected using the amyotrophic lateral sclerosis functional rating scale (ALSFRS), the caregiver burden inventory (CBI), HADS, and SF-36. Results: The mean score of the physical health component (PHC) of the family caregiver's QOL was $62.6{\pm}24.4$, and the mean score of the mental health component (MHC) of their QOL was $57.7{\pm}22.4$. The mean score of caregiver burden was $76.5{\pm}30.7$. Anxious family caregivers amounted to 55.4% and depressed family caregivers accounted for 63.9% overall. In a multivariate analysis, the PHC of QOL was explained by caregiver burden (41.1%), depression (9.4%), caregiver gender (3.8%), and caregiver age (3.1%). Anxiety (39.8%), caregiver burden (10.9%), patient gender (5.4%) and depression (1.7%) were predictive factors of the MHC of QOL. Conclusion: Caregiver burden and depression affected both the PHC and the MHC. Caregiver burden affected the PHC more than it did the MHC of QOL, but anxiety affected the MHC more than it did the PHC of QOL.

• Journal of Korean Neurosurgical Society
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• v.45 no.6
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• pp.341-349
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• 2009

Objective : The purpose of this study was to identify independent predictors of mortality and functional recovery in patients with primary intracerebral hemorrhage (PICH) and to improve functional outcome in these patients. Methods : Data were collected retrospectively on 585 patients with supratentorial PICH admitted to the Stroke Unit at our hospital between 1st January 2004 and the 31st July 2008. Using multivariate logistic regression analysis, the associations between all selected variables and 30-day mortality and 90-day functional recoveries after PICH was evaluated. Results : Ninety-day functional recovery was achieved in 29.1% of the 585 patients and 30-day mortality in 15.9%. Age (OR=7.384, p=0.000), limb weakness (OR=6.927, p=0.000), and hematoma volume (OR=5.293, p=0.000) were found to be powerful predictors of 90-day functional recovery. Furthermore, initial consciousness (OR=3.013, p=0.014) hematoma location (lobar, OR=2.653, p=0.003), ventricular extension of blood (OR=2.077, p=0.013), leukocytosis (OR=2.048, p=0.008), alcohol intake (drinker, OR=1.927, p=0.023), and increased serum aminotransferase (OR=1.892, p=0.035) were found to be independent predictors of 90-day functional recovery after PICH. On the other hand, a pupillary abnormality (OR=4.532, p=0.000) and initial unconsciousness (OR=3.362, p=0.000) were found to be independent predictors of 30-day mortality after PICH. Conclusion : The predictors of mortality and functional recovery after PICH identified during this analysis may assist during clinical decision-making, when advising patients or family members about the prognosis of PICH and when planning intervention trials.

• Korean Journal of Family Social Work
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• no.23
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• pp.263-302
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• 2008

The study had four purposes as follows; First, the researcher tried to find the characteristics of conflict. Second, the researcher attempted to find the factors influencing the conflict between mother and the eldest son, Third, the study attempted to find the therapist's intervention techniques, which were caused the change of the conflict between mother and the eldest son. Lastly, the study was to find the changed contents of family relationships. The total family counseling was 13 sessions, which included individual and family counseling. The study used constant comparative analysis by using open coding method to find the factors. Also, the researcher used Miles and Huberman's matrix and graphical network display to show the relationships among factors influencing the conflicts between mother and the eldest son. The study found the boundary problem of family, family's undifferentiated ego, dysfunctional communication patterns, and mother's experience from family of origin as factors influencing the conflict between mother and the eldest son. On the other hand, the study found that the therapist used the formation of therapeutic alliance relationship, guide of communication skills, the reflection of repeated pattern, reframing and a metaphor as intervention methods. The result of study revealed that changed level of family relationship, activating functional communication, changed boundary among family members, differentiated ego of family members, and changed cognition as the changed contents of family relationship.