• 대한인간공학회지
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• 제34권3호
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• pp.247-264
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• 2015

Objective: The purpose of this study is to determine the priority of information presentation and the effective menu type to be placed in the center of a gauge cluster display for commercial trucks and to present a set of ergonomic designs for the gauge cluster display. Background: An effective ergonomic design is specifically needed for the development of the gauge cluster display for the commercial trucks, because more diverse and heavier information is delivered to truck drivers, compared to the information to passenger car drivers. Method: First, all the information that must be shown on the commercial truck display was collected. Then, the severity, frequency of use, and display design parameters were evaluated for those information by commercial truck drivers. Next, an analysis on the information attributes and the heuristic evaluation utilizing the display design principles were carried out. According to the results, a design alternative of the main screen to be displayed was constructed by priority. A comparative analysis between the alternative and existing main screens was also conducted to see the efficacy of the designs. Lastly, we conducted an experiment for the selection of menu type. The experiment was conducted using the driving simulator with an eye-tracking device. The independent variables were four types of the menu reflecting the commercial truck characteristics such as grid type, icon type, list type, and flow type. We measured preference, total execution time, the total duration of fixation on the gauge cluster area, and the total number of fixation on the gauge cluster area as dependent variables. Results: Four types of driver convenience information and six types of driver assistance information were selected as the information to be placed primarily on the main screen of the gauge cluster. The Grid type was the most effective among the menu types. Conclusion: In this study, the information that appears on the main screen of the display, the division of the display and the design of the menu type for commercial truck drivers were suggested. Application: This study is expected to be utilized as guidelines on the ergonomic design of a gauge cluster display for commercial trucks.

• Asian Pacific Journal of Cancer Prevention
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• 제16권2호
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• pp.541-549
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• 2015

Triple negative breast cancer (TNBC) is an aggressive subtype of breast cancer (BC) with higher metastatic rate and both local and systemic recurrence compared to non-TNBC. The generation of reactive oxygen species (ROS) secondary to oxidative stress is associated with DNA damage, chromosomal degradation and alterations of both hypermethylation and hypomethylation of DNA. This study concerns differential methylation of promoter regions in specific groups of genes in TNBC and non-TNBC Saudi females in an effort to understand whether epigenetic events might be involved in breast carcinogenesis, and whether they might be used as markers for Saudi BCs. Methylation of glutathione S-transferase P1 (GSTP1), T-cadherin (CDH13), Paired box protein 5 (PAX5), death associated protein kinase (DAPK), twist-related protein (TWIST), DNA-binding protein inhibitor (ID4), High In Normal-1 (HIN-1), cyclin-dependent kinase inhibitor 2A (p16), cyclin D2 and retinoic acid receptor-${\beta}$ ($RAR{\beta}1$) genes was analyzed by methylation specific polymerase chain reaction (MSP) in 200 archival formalin-fixed paraffin embedded BC tissues divided into 3 groups; benign breast tissues (20), TNBC (80) and non-TNBC (100). The relationships between methylation status, and clinical and pathological characteristics of patients and tumors were assessed. Higher frequencies of GSTP1, ID4, TWIST, DAPK, PAX5 and HIN-1 hypermethylation were found in TNBC than in non-TNBC. Hypermethylation of GSTP1, CDH13, ID4, DAPK, HIN-1 and PAX5 increased with tumor grade increasing. Other statistically significant correlations were identified with studied genes. Data from this study suggest that increased hypermethylation of GSTP1, ID4, TWIST, DAPK, PAX5 and HIN-1 genes in TNBC than in non-TNBC can act as useful biomarker for BCs in the Saudi population. The higher frequency of specific hypermethylated genes paralleling tumor grade, size and lymph node involvement suggests contributions to breast cancer initiation and progression.

• 한국병원경영학회지
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• 제25권2호
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• pp.1-13
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• 2020

Purpose: The purpose of this study is to identify the effect of the disease duration on depression change in cancer survivors between the middle and old age groups. Methodology: To that end, we analyzed 275 patients using the Korea welfare panel survey from 2011 to 2016 jointly developed by the Korea Institute for Health and Social Affairs and Seoul National University. The duration of the elapsed and the experienced was measured as a independent variable. CES-D was used as a dependent variable. Frequency, paired t-test, ANOVA, and logistic regression analysis were conducted using Stata 14.0 for statistical analysis. Findings: Studies have shown that as the duration of the elapsed and the experienced increases, people under 65 are 1.17 times and 1.84 times each more likely to be included in depression-increase group than in depression-reduction group. The group that has been maintaining economic activities continuously since 2011 was significantly less likely to belong to the depression-increase group than the group that did not have economic activities in 2016. For those aged 65 and older, there was no significant difference in the duration of the elapsed and the experienced. The higher the likelihood of low-income households being included in the family of depression was 2.58 times higher than for ordinary households. Practical Implications: It is suggested that close policy management of the employment and working environment of cancer survivors is necessary, as both cancer survivors of productive age as well as older cancer survivors are analyzed to be beneficial to depression management. In addition, a systematic management program related to the mental health of cancer survivors is believed to be necessary for normal social recovery in the future.

• 한국조리학회지
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• 제23권2호
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• pp.23-34
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• 2017

본 연구는 국내 호텔산업에 종사하는 Y세대인 서비스담당 직원을 대상으로 상사 지원, 재미, 직무만족 및 고객지향성의 인과적 관계를 규명하고자 설계되었다. 본 연구의 목적을 달성하기 위하여 1981년에서 2000년 사이에 출생하여 Y세대라 불리는 직원만을 조사 대상으로 한정하였다. 확보된 실증자료 분석을 위해 빈도분석, 확인적 요인분석, 신뢰도 분석, 상관관계분석, 회귀분석 및 PROCESS Macro 분석이 실시되었으며, 이를 위한 분석 프로그램은 SPSS 18.0과 AMOS 18.0이 적용되었다. 분석 결과, 재미는 직무만족과 고객지향성 모두에게 긍정적인 영향을 미치는 변수로 확인되었다. 그러나 상사 지원은 직무만족에는 긍정적인 영향을 미치는 것으로 확인되었으나, 고객지향성에는 직접적인 영향을 미치지 않는 것으로 나타났다. 또한 직무만족은 고객지향성에 직접적인 영향을 미치는 것으로 나타났다. 마지막으로 직무만족은 상사 지원과 고객지향성의 관계 그리고 재미와 고객지향성의 관계에서 모두 매개 작용이 유의한 것으로 확인되었다. 본 연구를 통해 직장 내 재미와 직무에 대한 만족감이 높을수록 직원의 고객지향성 행동이 향상됨을 알 수 있었다. 또한 상사의 지원은 직무만족을 통해 직원의 고객지향성 개선에 긍정적인 영향을 미칠 수 있는 요인임을 알 수 있다.

• 한국사회복지학
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• 제54권
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• pp.295-319
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• 2003

본 연구는 저소득 모자가구주의 대부분이 일을 하고 있음에도 불구하고 경제적으로 여전히 어려운 노동빈민(working poor)으로서의 위치에서 벗어나지 못하고 있다는 문제의식 속에서 비롯되었으며, 저소득모자가구의 생활실태를 최근 사회과학 내에서 논의되고 있는 사회적 배제 개념을 이용하여 분석하고 이의 극복방안으로서 사회적 통합과 연대모색을 제안하였다. 구체적으로 본 연구는 남성가장을 중심으로 한 일반가구, 일반 모자가구, 사회적 빈곤선 이하에 놓인 저소득모자가구를 대상으로 각 가구유형별 특성과 생활실태를 비교분석하고 이를 통해 전반적인 모자가구의 사회적 배제과정을 살펴보았다. 본 연구는 2000년 지역사회복지협의회의 "사회복지욕구조사" 원자료를 이차분석(secondary analysis) 하였으며 총 3,182가구가 최종적으로 분석에 포함되었다. 연구결과에 의하면 전반적으로 모자가구는 일반모자가구, 저소득모자가구에 상관없이 고용형태, 주거형태, 소득, 소비생활 측면에서 일반(남성가장)가구에 비해 어려움을 겪고 있었다. 일반가구에 비해 모자가구는 가족으로부터 자원을 제공받기보다는 오히려 장애, 만성질환 등의 가족원을 보호해야 하는 상당한 부담을 안고 있었으며, 사회적 안전망에서도 모자가구는 전반적으로 제외되어 있는 것으로 나타났다. 이것은 모자가구가 일반가구에 비하여 전반적으로 사회적으로 취약해지거나 고립될 가능성이 매우 높은 현실을 반영하며, 현재 공식적으로 빈곤층, 혹은 저소득층으로 분류되지는 않았지만 일반모자가구도 포괄적인 사회적 안전 망이 확립되지 않는다면 향후 저소득층으로 배제될 가능성이 매우 높다는 사실을 확인시켰다. 마지막으로 연구결과에 기초하여, 전체 모자가족의 사회적 배제를 극복할 수 있는 사회적 통합방안이 모색되었다.

• Molecules and Cells
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• 제40권9호
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• pp.655-666
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• 2017

We constructed a large $na{\ddot{i}}ve$ human Fab library ($3{\times}10^{10}$ colonies) from the lymphocytes of 809 human donors, assessed available diversities of the heavy-chain variable (VH) and ${\kappa}$ light-chain variable (VK) domain repertoires, and validated the library by selecting Fabs against 10 therapeutically relevant antigens by phage display. We obtained a database of unique 7,373 VH and 41,804 VK sequences by 454 pyrosequencing, and analyzed the repertoires. The distribution of VH and VK subfamilies and germline genes in our antibody repertoires slightly differed from those in earlier published natural antibody libraries. The frequency of somatic hypermutations (SHMs) in heavy-chain complementarity determining region (HCDR)1 and HCDR2 are higher compared with the natural IgM repertoire. Analysis of position-specific SHMs in CDRs indicates that asparagine, threonine, arginine, aspartate and phenylalanine are the most frequent non-germline residues on the antibody-antigen interface and are converted mostly from the germline residues, which are highly represented in germline SHM hotspots. The amino acid composition and length-dependent changes in amino acid frequencies of HCDR3 are similar to those in previous reports, except that frequencies of aspartate and phenylalanine are a little higher in our repertoire. Taken together, the results show that this antibody library shares common features of natural antibody repertoires and also has unique features. The antibody library will be useful in the generation of human antibodies against diverse antigens, and the information about the diversity of natural antibody repertoires will be valuable in the future design of synthetic human antibody libraries with high functional diversity.

• 대한의생명과학회지
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• 제15권3호
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• pp.199-205
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• 2009

This study was designed to investigate direct effects of [D-$Pen^2$, D-$Pen^5$]-enkephalin, a $\delta$-opioid receptor agonist on the neuronal activity of medial vestibular nuclear (MVN) neurons by whole-cell configuration patch clamp experiments. The spike frequency of MVN neuron was increased to $9.50{\pm}0.55$ (P<0.05) and $10.56{\pm}0.66$ (P<0.05) by 5 and $10{\mu}M$ [D-$Pen^2$, D-$Pen^5$]-enkephalin from the control level of $8.05{\pm}0.55$ spikes/sec, respectively (n=18). The resting membrane potential of the neurons was increased to $-37.86{\pm}0.92$ and $-36.97{\pm}0.97$ (P<0.05) from $-38.74{\pm}1.13\;mV$ by 5 and $10{\mu}M$ [D-$Pen^2$, D-$Pen^5$]-enkephalin, respectively. The amplitude of afterhyperpolarization was decreased to $23.78{\pm}0.65$ and $21.67{\pm}0.89$ (P<0.05) from $23.73{\pm}0.53\;mV$ by 5 and $10{\mu}M$ [D-$Pen^2$, D-$Pen^5$]-enkephalin, respectively. The spike width was changed to $2.22{\pm}0.08$ and $2.24{\pm}0.07$ from $2.20{\pm}0.08\;mV$ by 5 and $10{\mu}M$ [D-$Pen^2$, D-$Pen^5$]-enkephalin, respectively. After pretreatment of naltrindole, a highly selective 8-opioid receptor antagonist, [D-$Pen^2$, D-$Pen^5$]-enkephalin did not change firing rate, resting membrane potential, afterhyperpolarization amplitude, and spike width of MVN neurons. The above experimental results suggest that [D-$Pen^2$, D-$Pen^5$]-enkephalin increases the neuronal activity of MVN neurons via inhibition of calcium-dependent potassium currents underlying the afterhyperpolarization.

• Toxicological Research
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• 제26권4호
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• pp.261-266
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• 2010

In the workplace, the arsenic is used in the semiconductor production and the manufacturing of pigments, glass, pesticides and fungicides. Therefore, workers may be exposed to airborne arsenic during its use in manufacturing. The purpose of this study was to evaluate the potential toxicity of particulate matters (PMs) doped with arsenic (PMs-Arsenic) using a rodent model and to compare the genotoxicity in various concentrations and to examine the role of PMs-Arsenic in the induction of signaling pathway in the lung. Mice were exposed to PMs $124.4{\pm}24.5\;{\mu}g/m^3$ (low concentration), $220.2{\pm}34.5\;{\mu}g/m^3$ (middle concentration), $426.4{\pm}40.3\;{\mu}g/m^3$ (high concentration) doped with arsenic $1.4\;{\mu}g/m^3$ (Low concentration), $2.5\;{\mu}g/m^3$ (middle concentration), $5.7\;{\mu}g/m^3$ (high concentration) for 4 wks (6 h/d, 5 d/wk), respectively in the whole-body inhalation exposure chambers. To determine the level of genotoxicity, Chromosomal aberration (CA) assay in splenic lymphocytes and Supravital micronucleus (SMN) assay were performed. Then, signal pathway in the lung was analyzed. In the genotoxicity experiments, the increases of aberrant cells were concentration-dependent. Also, PMs-arsenic caused peripheral blood micronucleus frequency at high concentration. The inhalation of PMs-Arsenic increased an expression of phosphorylated Akt (p-Akt: protein kinase B) and phpsphorylated mammalian target of rapamycin (p-mTOR) at high concentration group. Taken together, inhaled PMs-Arsenic caused genotoxicity and altered Akt signaling pathway in the lung. Therefore, the inhalation of PMs-Arsenic needs for a careful risk assessment in the workplace.

• 산업진흥연구
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• 제2권1호
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• pp.93-99
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• 2017

본 연구는 중소기업 근로자의 연금보험이 인적자원 관리에 미치는 영향을 분석하였다. 연구 결과, 조사대상은 연금보험에 가입한 충남지역 60개 중소기업체 근로자를 대상으로 총 128명이며, 분석 자료는 SPSS Statistics 20을 사용하여 빈도분석, 요인분석, 신뢰도분석, 상관관계분석, 회귀분석 및 사후분석을 포함한 분산분석을 실시하였다. 분석결과, 첫째, 연금보험이 인적자원관리에 유의한 영향을 미쳤으며, 독립변수(명확성, 적합성, 만족성)와 종속변수(직무효율성)간 상관관계가 높게 나타났다. 둘째, 연금보험과 직무성과 간의 상관관계는 명확성과 직무성과(.339), 적합성과 직무성과(.541), 만족성과 직무성과(.531), 직무성과와 직무효율성(.563), 직무성과와 이직의도(.549) 간에는 p<.01 수준에서 유의하게 나타났다. 셋째, 연금보험에 가입한 근로자의 근속년수에 따른 이직의도 간의 차이분석은 통계적으로 유의한 차이가 없는 것으로 나타났다. 본 연구는 중소기업 핵심인력의 장기 재직 촉진 및 인력양성으로 성공적인 정책목적 달성을 위한 연금보험이 인적자원 관리에 미치는 영향을 분석함으로써 본 연구의 의의가 있다.

• 한국응용곤충학회지
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• 제52권1호
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• pp.5-12
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• 2013

비트의 주요 해충인 흰띠명나방을 9개의 다른 온도조건(15.0, 17.5, 20.0, 22.5, 25.0, 27.5, 30.0, 32.5 및 $35.0^{\circ}C$), 상대습도 $65{\pm}5%$, 광조건 16L:8D에서 발육특성을 조사한 결과, 알에서 성충 우화 전까지의 발육기간은 $17.5^{\circ}C$에서 51.0일로 가장 길었고, $35^{\circ}C$에서 14.6일로 가장 짧게 조사되었다. 온도와 발육율의 관계를 직선회귀에 의해 분석한 결과, 결정계수($R^2$) 값이 0.87 이상으로 나타났으며, 온도에 따른 발육은 직선회귀에 부합되었다. 알부터 성충 우화 전까지의 발육영점온도와 유효적산온도는 $10.4^{\circ}C$와 384.7일도를 나타내었다. 각 태별 발육모형은 $R^2$값이 0.97~0.99로 비선형회귀식에 잘 부합되었다. 각 태별 발육누적분포와 발육기간에 대한 평균 발육기간으로 나눈 값을 Weibull 함수에 적용한 결과 $r^2$값이 0.63~0.87이었다.