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Determination of Relative Reactivities of Free Hydroxyl Groups in β-Cyclodextrin, Amylose, and Cellulose by Reductive-Cleavage Method

  • 이창규;김은주;전중호
    • Bulletin of the Korean Chemical Society
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    • v.20 no.10
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    • pp.1153-1158
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    • 1999
  • β-Cyclodextrin, amylose, and cellulose were partially methylated and acetylated in order to examine the relative reactivities of 2-, 3-, and 6-OH groups to alkylation and acylation. The partially methylated samples of the polysaccharides were treated with excess of ethyl iodide and sodium hydroxide in dimethyl sulfoxide to convert all of the free hydroxyl groups to ethyl ether groups. The partially O-ethylated and O-methylated polysaccharides were reductively cleaved with triethylsilane in the presence of trimethylsilyl methanesulfonate and borontrifluoride etherate (5 : 1 by mole) and the resulting 4-OH group was acetylated and benzoylated to form mixtures of eight 4-O-acyl-1,5-anhydroalditols. The relative ratio of the alditol esters were analyzed by gas chromatography to determine the degree of substitution at each position. A similar sequence of reactions was carried out with partially acetylated polysaccharides. The results indicated that the order of relative reactivities for methylation are 2-OH > 6-OH > 3-OH and for acylation are 6-OH > 2-OH > 3-OH regardless of the anomeric configuration.

Donor-Site Morbidity Analysis of Thenar and Hypothenar Flap

  • Dong Chul Lee;Ho Hyung Lee;Sung Hoon Koh;Jin Soo Kim;Si Young Roh;Kyung Jin Lee
    • Archives of Plastic Surgery
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    • v.51 no.1
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    • pp.94-101
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    • 2024
  • Background For the small glabrous skin defect, Thenar and Hypothenar skin are useful donors and they have been used as a free flap. Because of similar skin characteristics, both flaps have same indications. We will conduct comparative study for the donor morbidity of the Free thenar flap and Hypothenar free flap. Methods From January 2011 to December 2021, demographic data, characteristics of each flap, and complications using retrospective chart review were obtained. Donor outcomes of the patient, who had been followed up for more than 6 months, were measured using photographic analysis and physical examination. General pain was assessed by Numeric Rating Scale (NRS) score, neuropathic pain was assessed by Douleur Neuropathique 4 Questions (DN4) score, scar appearance was assessed by modified Vancouver Scar Scale (mVSS), and patient satisfaction was assessed on a 3-point scale. Statistical analysis was performed on the outcomes. Results Out of the 39 survey respondents, 17 patients received Free thenar flaps, and 22 patients received Hypothenar free flaps. Thenar group had higher NRS, DN4, and mVSS (p < 0.05). The average scores for the Thenar and Hypothenar groups were 1.35 and 0.27 for NRS, 2.41 and 0.55 for DN4, and 3.12 and 1.59 for mVSS, respectively. Despite the Hypothenar group showing greater satisfaction on the 3-point scale (1.82) compared with the Thenar group (1.47), the difference was not significant (p = 0.085). Linear regression analysis indicated that flap width did not have a notable impact on the outcome measures, and multiple linear regression analysis revealed no significant interaction between flap width and each of the outcome measures. Conclusion Despite the limited number of participants, higher donor morbidity in general pain, neuropathic pain, and scar formation was noted in the Thenar free flap compared with the Hypothenar free flap. However, no difference in overall patient satisfaction was found between the two groups.

A Comparative Study on the Dietary Na, Ca Intake and Urinary Excretion of Na, Ca in Normotensive and Hypertensive Free-living Adults (정상인과 고혈압 환자에 있어서 나트륨과 칼슘의 섭취와 배설에 관한 비교 연구)

  • 임정현;윤진숙
    • Journal of the East Asian Society of Dietary Life
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    • v.3 no.2
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    • pp.41-50
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    • 1993
  • This study was intended to investigate the relationship of dietary Na and Ca intake and excretion in blood pressure regulation of free-living adults. Two separate surveys were conducted for 294 subjects in Taegu area, The results of this study are as follows ; When subjects were divided into normotensive and hypertensive, there were significant differences in age, BMI between two groups, When dietary intake were compared between two groups, no significant differences in energy, carbohydrates, fat and protein intakes were shown. While Na intake of hypertensive groups was not signidicantly different from that of normotensive groups, While Na intake of hypertensive groups was not significantly different from that of normotensive groups, ca intake of hypertensive group was significantly lower than that of normotensive group(P<0.005), Urinary Na excretion was significantly higher(P<0.05) in hyperten sive group. However, urinary Ca and K excretion in both groups were not significantly different. Urinary sodium was significantly correlated with urinary Ca and Na intake. Multiple regression analysis of variables showed that urinary sodiumwas affected by Na index, age and Ca Index. While urinary Ca, was significantly correlated with urinary Na and K excretion, it did not show significant correlation with Ca intake

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A CYCLIC GROUP ACTION ON THE NILMANIFOLD

  • Shin, Joonkook;Kim, Jong-Il
    • Journal of the Chungcheong Mathematical Society
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    • v.13 no.2
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    • pp.71-79
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    • 2001
  • We study only free actions of finite abelian groups G on the 3-dimensional nilmanifold, up to topological conjugacy. we shall deal with only one out of 15 distinct almost Bieberbach groups up to Seifert local invariant.

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AN EXAMPLE OF LARGE GROUPS

  • Cevik, Ahmet Sinan
    • Bulletin of the Korean Mathematical Society
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    • v.57 no.1
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    • pp.195-206
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    • 2020
  • The fundamental idea of this article is to present an effective way to obtain the large groups in terms of the split extension obtained by a finite cyclic group and a free abelian group rank 2. The proof of the main result on largeness property of this specific split extension groups will be given by using the connection of large groups with the groups having deficiency one presentations.

사다리형태로 변화하는 지형 위를 통과하는 파군에 의한 장파의 생성 (Long Waves Generated by Wave Groups over Trapezoidally Varying Topography)

  • Cho, Yong-Sik;Lee, Jin-Woo;Jung, Tae-Hwa
    • Journal of Korean Society of Coastal and Ocean Engineers
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    • v.20 no.2
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    • pp.212-218
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    • 2008
  • A possible source of resonant problems in a harbor is long waves generated by incident wave groups. The analytical solutions of the governing equations of second-order long waves derived using a multiple-scale perturbation method consist of the locked and free long waves. The locked long waves propagate at some group velocity, whereas the free long waves propagate at the shallow-water speed. To study the resonance of free long waves, a trapezoidally varying topography is employed. With certain combinations of incident angle, water depth, and ambient current velocity, free long waves can be trapped and resonated.

Scavenging Strategy of Panax ginseng Against Formed Free Radicals Under Stress of Mercuric Chloride in Rattus norvegicus

  • Mahour, Kanhiya;Saxena, Prabhu N.
    • Journal of Ginseng Research
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    • v.32 no.2
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    • pp.150-154
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    • 2008
  • Twenty five albino rats were divided into five groups for conducting this experiment. The first group was for positive control (Vitamin C, ascorbic acid), the second group was of Panax ginseng (10 mg/kg body weight) treated group after bio-activity assay, the third group was of mercuric chloride treated group (0.033 mg/kg body weight) based on calculating $LD_{50}$ 9.26 mg/kg body weight by probit analysis, the fourth group was of mercuric chloride (0.033 mg/kg body weight) followed by Panax ginseng (10 mg/kg body weight) and the fifth group was Panax ginseng (10 mg/kg body weight) followed by mercuric chloride (0.033 mg/kg body weight) treated group. The interval between intake of Panax ginseng and mercuric chloride was of 2 hours in groups, fourth and fifth respectively. Comparative free radical scavenging property of Panax ginseng was studied under three in vitro models (role model for calculating scavenging activity) viz. DPPH method (hydroxyl free radicals), Nitric oxide method (nitrile free radicals) and Lipid peroxidation (mercury free radicals).

Effect of the Ethanol Extract of Lycium chinense on the Oxygen Free Radical and Alcohol Metabolizing Enzyme Activities in Rats (흰쥐에 있어서 구기자 알콜 추출물이 Oxygen Free Radical 및 Alcohol 대사효소 활성에 미치는 영향)

  • 윤종국;전태원;오만진;이규희;정재홍
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.29 no.2
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    • pp.268-273
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    • 2000
  • To investigate an effect of the ethanol extract of Lycium chinense(EELC) on the activities of enzymes scavenging oxygen free radicals or detoxicating alcohol. The ground Lycium chinense was extracted with 30% edible ethanol and then diluted with 6% ethanol to contain 2% EELC(w/v). Three different groups of male Sprague-Dawley rats had taken a drink EELC, ethanol(ETH) or water(control), respectively for 2 months. At the end of experimental period, the animals were sacrificed and obtained the following findings. The EELC-treated animals showed the highest activity of hepatic glucose-6-phosphatase among three groups. The activities of xanthine oxidase and cytochrome p-450 from EELC treatment group were lower than those from ETH-treated group. However, the activity of superoxide dismutase was higher in the EELC-treated group than the ETH-treated(p<0.005). Furthermore, hepatic alcohol or aldehyde dehydrogenase activity, and glutathione content and glutathione peroxidase were significantly higher in EELC-treated animals than in ETH-treated those. The activity of glutathione S-transferase in liver was appeared the orderly higher value in EELC, ETH and control-treated group. As the result, EELC may affect the reduction of oxygen free radical production and help the detoxication of ethanol.

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Effect of Lycii Fructus Powder on Lipid Metabolism in 1% Cholesterol Fed Rats (구기자 분말 첨가 식이가 1% 고콜레스테롤 급여 흰쥐의 지질 대사에 미치는 영향)

  • Han, Sung-Hee;Park, Sung-Hyee
    • Journal of the Korean Society of Food Culture
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    • v.23 no.4
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    • pp.521-528
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    • 2008
  • This study examined the effects of 2% Lycii fructus powder (LFP) supplementation on lipid metabolism in rats. Male Sprague-Dawley rats were administered 1% cholesterol and 0.25% sodium cholate to induce hypercholesterolemia. Then, 40 rats were divided into four diet groups: a normal diet group (NC), high cholesterol diet group (HC), normal diet plus 2% Lycii fructus powder (NC-LFP) group, and high cholesterol diet plus 2% Lycii fructus powder (HC-LFP) group. The HC group presented higher growth rates and liver weights than NC and NC-LFP however, growth rates and liver weights in the 2% LFP administered groups gradually decreased. HC also showed increased serum triglyceride, total cholesterol, free cholesterol, and LDL-cholesterol levels and decreased atherogenic index values, HDL-cholesterol, and phospholipid levels, whereas LFP group showed decreased serum triglyceride, total cholesterol, free cholesterol, and LDL-cholesterol levels as compared to HC. There were no differences in serum triglyceride, phospholipid, LDL-cholesterol, HDL-cholesterol, and free cholesterol concentrations between the normal diet groups (NC and NC-LFP). The high cholesterol diet groups (HC and HC-LFP) had significant increases in serum alanine aminotransferase (ALT), asparate aminotransferase (AST), alkaline phosphatase (ALP), and lactate dehydrogenase (LDHase) activities. And the 2% LFP administered groups had lower hepatic concentrations of total cholesterol and triglycerides than the HC groups. Overall, the results suggest that Lycii fructus powder has hypochloesterolemic effects by reducing serum and liver cholesterol contents.

Effects of High Fat Diet on the Level of Serum Lipids, Glucose and Free-fatty Acid for Soccer Player at the Before and After Game.

  • Han, Sung-Sup;Baek, Yeong-Ho;Yeom, Jong-Woo;Baek, Yeong-Ho
    • Journal of Life Science
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    • v.11 no.2
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    • pp.135-139
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    • 2001
  • The goal of this study was to find out the effective diet prescription for the exercises. To accomplish this purpose, we investigated the effect of free-fatty acid diet (FFAD) on two groups of the K technical high school soccer players; one group with 7 members for normal diet (NORD) and another group with 7 members for high-fat diet (HFD). HFD group was fed far three days before the game. Results were as follows: i) Blood glucose level was increased with statistical significance in HFD group (P<.01) compared to the NORD group. After plying game, the glucose level was increased in the both groups ii) The contents of free-fatty acid (FFA) was significantly increased in HFD group (P<.0001) compared to the NORD group. After playing game, the FFA level was also increased in both groups iii) The levels of T-C, HDL-C and LDL-C were slightly increased in both NORD and HFD groups after playing game, while the TG level was slightly decreased. However, the differences were not significant. These results imply that HFD may not affect the level of seam lipids. Overall, the level of glucose and FFA were increased, but other types of lpids were not changed. From these studies, we observed the increase in the level of glucose and FFA but not other sew lipid. These results indicate that HFD may induce the body energy-utilizing system during long-lasting exercise such as playing soccer game.

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