• 한국컴퓨터정보학회논문지
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• 제5권4호
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• pp.140-153
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• 2000

정보화는 산업활동에 필요한 정보의 유통을 촉진함으로써 경제전체의 활동을 배가함과 동시에 경제활동의 유연성을 증대할 수 있다. 또한 물류 인력 등 고비용 구조의 개선과 높은 성장 잠재력을 유지하기 위한 기반조성에 기여할 수 있으며, 고부가치를 창출할 수 있을 것으로 기대한다. 그럼으로 이 연구에서는 정보화의 효율적인 추진을 위해 중소기업을 대상으로 그 실태를 조사하고 문제점을 분석하여 보다 취약한 중소기업의 정보화를 위한 최적화한 정보시스템구축과 활용방안을 제시하여 기업의 경쟁력을 높이는데 있다. 정보화의 추진전략과 정보시스템화 전략을 통하여 중소기업이 주어진 환경에서 최대한의 효과를 가져올 수 있도록 단계적 전략을 세어 추진효과를 극대화하는 데 있다.

• 전산구조공학
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• 제10권2호
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• pp.243-254
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• 1997

기초 지반상에 존재하는 3차원 골조구조물에 진동을 유발시키는 기계하중, 풍하중, 지진과 같은 동적 하중이 작용한다면, 지반-골조구조물 상호작용계의 동적거동을 해석하여야한다. 따라서, 본 연구에서는 실제 구조물에 근접한 기하학적 형상으로 이상화 시키기 위해, 슬래브와 기초판은 유연성을 갖는 4-절점 판요소, 보.기둥은 2-절점 보요소, 탄성지반은 8-절점 입체요소를 사용하여 유한요소법으로 3차원 상호작용계를 해석하였다. 본 연구의 목적은 지반-골조구조물 상호작용계의 동적 거동을 해석하기 위해, 동적 운동 방정식을 정리한 후 유한요소 프로그램으로 상호작용계의 동적 거동을 해석하는 것이다.

• Structural Monitoring and Maintenance
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• 제7권4호
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• pp.295-317
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• 2020

Investigation of the stability of arch dam abutments is one of the most important aspects in the analysis of this type of dams. To this end, the Bakhtiari dam, a doubly curved arch dam having six wedges at each of its abutments, is selected. The seismic safety of dam abutments is studied through time history analysis using the design-based earthquake (DBE) and maximum credible earthquake (MCE) hazard levels. Londe limit equilibrium method is used to calculate the stability of wedges in abutments. The thrust forces are obtained using ABAQUS, and stability of wedges is calculated using the code written within MATLAB. Effects of foundation flexibility, grout curtain performance, vertical component of earthquake, nonlinear behavior of materials, and geometrical nonlinearity on the safety factor of the abutments are scrutinized. The results show that the grout curtain performance is the main affecting factor on the stability of the abutments, while nonlinear behavior of the materials is the least affecting factor amongst others. Also, it is resulted that increasing number of the contraction joints can improve the seismic stability of dam. A cap is observed on the number of joints, above which the safety factor does not change incredibly.

• Journal of Genetic Medicine
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• 제20권2호
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• pp.39-45
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• 2023

As advanced sequencing technologies continue to uncover an increasing number of variants in genes associated with human genetic diseases, there is a growing demand for systematic approaches to assess the impact of these variants on human development, health, and disease. While in silico analyses have provided valuable insights, it is essential to complement these findings with model organism studies to determine the functional consequences of genetic variants in vivo. Drosophila melanogaster is an excellent genetic model for such functional studies due to its efficient genetic technologies, high gene conservation with humans, accessibility to mutant fly resources, short life cycles, and cost-effectiveness. The traditional GAL4-UAS system, allowing precise control of gene expression through binary regulation, is frequently employed to assess the effects of monoallelic variants. Recombinase medicated cassette exchange or CRISPR-Cas9-mediated GAL4 insertion within coding introns or substitution of gene body with Kozak-Gal4 result in the loss-of-function of the target gene. This GAL4 insertion strategy also enables the expression of reference complementary DNA (cDNA) or cDNA carrying genetic variants under the control of endogenous regulatory cis elements. Furthermore, the CRISPR-Cas9-directed tissue-specific knockout and cDNA rescue system provides the flexibility to investigate candidate variants in a tissue-specific and/or developmental-timing dependent manner. In this review, we will delve into the diverse genetic techniques available in Drosophila and their applications in diagnosing and studying numerous undiagnosed diseases over the past decade.

• 한국정보과학회논문지:데이타베이스
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• 제30권6호
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• pp.573-584
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• 2003

최근 유전체학과 단백질체학 분야에서 생성되는 방대한 분량의 데이타로부터 생물학적 의미를 추출해내기 위한 생물정보학적인 도구들에 대한 필요성이 크게 대두되고 있다. 본 논문에서는 세포 신호전달 경로에 관한 정보를 효율적으로 표현, 저장함은 물론 저장된 데이타로부터 생물학적 의미를 추출할 수 있도록 하기 위한 다양한 요구 조건들을 생물학자의 관점에서 분석하고, 이들 요구조건을 체계적으로 반영하여 설계한 ROSPath 데이타베이스 시스템을 제안한다. ROSPath 데이타 모델에서는 향후의 확장성을 고려하여 불완전한 지식의 표현이 가능하도록 하며 인터넷상에서 기존의 다른 생화학 데이타베이스를 공유할 수 있는 연결성을 제공한다. 또한, 객체지향 모델을 이용하여 계층적인 구성을 제공함으로써 효율적인 검색을 지원한다. ROSPath 데이타 모델은 두 가지 주요 데이타 요소인 ‘바이오 개체’와 ‘상호작용’으로 정의된다. 바이오 개체는 세포 신호전달 경로에 관여하는 단백질과 단백질 상태 등과 같은 개개의 생화학적인 개체를 의미하고, 상호작용은 단백질 상태 전이나 화학 반응, 단백질-단백질 상호작용 등과 같은 바이오 개체들 간의 다양한 관계 및 신호전달과정을 설명한다. 제안된 ROSPath 데이타 모델을 이용하여 구성되는 복잡한 정보 네트워크는 다양한 생화학 프로세스들을 기술하고 분석하는 데에 활용할 수 있다.

• Geomechanics and Engineering
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• 제22권3호
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• pp.197-206
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• 2020

Reutilization of solid waste such as Tire Derived Aggregate (TDA) and mixing it with soft soil for backfill material not only reduces the required volume of backfill soil (i.e., sand-mining procedures; reinforcement), but also preserves the environment from pollution by recycling. TDA is a widely-used material that has a good track record for improving sustainable construction. This paper attempted to investigate the performance of Kaolin-TDA mixtures as a backfill material underneath a strip footing and close to a retaining wall. For this purpose, different types of TDA i.e., powdery, shredded, small-size granular (1-4 mm) and large-size granular (5-8 mm), were mixed with Kaolin at 0, 20, 40, and 60% by weight. Static surcharge load with the rate of 10 kPa per min was applied on the strip footing until the failure of footing happened. The behaviour of samples K80-G (1-4 mm) 20 and K80-G (5-8 mm) 20 were identical to that of pure Kaolin, except that the maximum footing stress had grown by roughly three times (300-310 kPa). Therefore, it can be concluded that the total flexibility of the backfill and shear strength of the strip footing have been increased by adding the TDA. The results indicate that, a significant increase in the failure vertical stress of the footing is observed at the optimum mixture content. In addition, the TDA increases the elasticity behaviour of the backfill.

• 한국초등과학교육학회지:초등과학교육
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• 제21권1호
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• pp.71-80
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• 2002

The purpose of this study was to develop children's creativity by applying creative problem solving model to elementary school science. Creative problem solving(CPS), the theoretical frame of model is proposed by Treffinger et al.(1994). CPS model is based on a substantial foundation of theory and research about creativity and problem solving. It is a well organized, deliberate set of methods you can call upon whenever you need new ideas or solutions and a process anyone can use to deal with many of life's everyday problems, opportunities, and challenges. CPS consists of three components. Within these three components, there are six specific stages during which creative and critical thinking abilities are used in harmony. Each stage involves both divergent and convergent thinking. The study was conducted for six week during the 1998 two semester in A elementary school which is located in Incheon. Eighty three 2nd grade students are selected for this study. The students were divided into two groups--experimental group and control group. The experimental group were taught in applying the CPS model, and the control group were taught by the traditional manner. Data for this study were collected by questionnaire which were developed by this researcher, and were analyzed by SPSSWIN 8.0. The results of this study were as follows: There was a significant difference on creativity between the instruction by applying CPS model and the traditional instruction. There was also gender differences on creativity between two groups. On fluency and flexibility as components of creativity, there was a signigicant difference between two groups. In conclusion, the instruction by applying CPS model was more effective in developing children's creativity than the traditional instruction.

• 한국실내디자인학회논문집
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• 제17호
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• pp.65-72
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• 1998

This study intends to analyze the various spatial structures and characteristics of the museum based on the two of the Renzo Piano's recent projects Menil Collection '||'&'||' Museum and Beyeler Foundation Museum Which defined the direction of the "Third Generation" in museum architecture with reference to the quality of spatial experience and design applications. Comparison and analysis were done on the basic spatial organization floor layout accessibility exhibition area lighting plan and circulation between the two museum. Through the itemized common characteristics of the museum the architect's proposal on meaning and direction of the new museum architecture can be viewed. The contemporary museums distinguish themselves quite clearly from their predecessors and this applies both to their own form and to their spatial organization. As the public demands and requests toward the museum building facility expand everyday the architect must respond by providing multiple types of space where people can experience different atmosphere in each area. One concept he used to create multi experienced area was manipulation of the natural light using by the state-of-the-art techniques of the light filtering system and multi-layering roof system to protect the valuable collections against the direct sunlight. But mainly it was to prove his strong belief in "architecture of light" by creating space with minimized meaning by purposely distinguished area in order to provide maximum support to the physical value of the collection " The connection with nature" is another concept which Piano used to provide the public a tranquil experience through out the architecture which engages in a lively dialogue with art. In spatial organization Piano concerned on functionality which not only concentrated on the visitor's point of view but also on the museum staff's comfort. Unlkie the traditional museum he alternates various size of exhibition areas for spatial hierarchy. Specially the spatial flexibility that the temporary exhibition areas are able to be expanded to the permanent exhibition areas by adjoining t재 spaces differentiate Piano's new museum from the rest. museum from the rest.

• BMB Reports
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• 제39권4호
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• pp.441-447
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• 2006

Abuse of drugs can elicit compulsive drug seeking behaviors upon repeated administration, and ultimately leads to the phenomenon of addiction. We developed a procedure for the standardization of microarray gene expression data of rat brain in drug addiction and stored them in a single integrated database system, focusing on more effective data processing and interpretation. Another characteristic of the present database is that it has a systematic flexibility for statistical analysis and linking with other databases. Basically, we adopt an intelligent SQL querying system, as the foundation of our DB, in order to set up an interactive module which can automatically read the raw gene expression data in the standardized format. We maximize the usability of this DB, helping users study significant gene expression and identify biological function of the genes through integrated up-to-date gene information such as GO annotation and metabolic pathway. For collecting the latest information of selected gene from the database, we also set up the local BLAST search engine and non-redundant sequence database updated by NCBI server on a daily basis. We find that the present database is a useful query interface and data-mining tool, specifically for finding out the genes related to drug addiction. We apply this system to the identification and characterization of methamphetamine-induced genes' behavior in rat brain.

• 한국실내디자인학회논문집
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• 제23권5호
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• pp.183-191
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• 2014

Children stage is an important period the foundation of growth is accomplished. During the period, children are the most sensitive to environmental effects and experiences and interactions with surroundings can make lots of effects on their physical and cognitive development. Under the background of the above contents, a representative institution of the society, which is helpful to cultivate children's reading habit, will be children library. The purposes of this research are to analyze intensively reading room among the children library's spatial organization and compare/analyze cases of children library's reading room with the elements of interior environment. The methods of research are theory study and case study. Through the on-the-site visiting and shooting, interior environment design was investigated and then, it was arranged, analyzed and evaluated. Cases were analyzed by elements of interior environment design evaluation. As the result, comfort was the highest and variety was the lowest. Especially, Songpa children library showed various factors generally through the various designs. 7 evaluative elements of children library's reading room were mutually different, but there was a certain different in relation of them. Especially, variety and flexibility must be more strengthened. So, children can interests and joy in reading room various designs are requested by getting out of library's uniformed furniture and arrangement plan.