• Journal of the Korea Society of Computer and Information
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• v.5 no.4
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• pp.140-153
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• 2000

Process of information is not only to double economic activities but also to increase the flexibility of them. By promoting information which is necessary for industrial society, we can expect that information is able to contribute to base the foundation in maintaining potencialities of growth such as material circulation. man power. Information is also expected to create high values in this industrialized society. This study examines and analizes the actual condition and the problems of Small and Medium Industry in order to accelerate effective promotion of information system. Because we believe that in order to gam highly competitive power of enterprises, optimization of information system of Small and Medium Industry is required.

• Computational Structural Engineering
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• v.10 no.2
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• pp.243-254
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• 1997

When dynamic loads such as mechanical load, wind load, and seismic load, which causing a vibration, acts on the body of the 3-D framework resting on soil foundation, it is required to consider the dynamic behavior of soil-space framework interation system. Thus, this study presents the 3-dimensional soil-interaction system analyzed by finite element method using 4-node plate elements with flexibility, 2-node beam elements, and 8-node brick elements for the purpose of idealizing an actual structure into a geometric shape. The objective of this study is the formulation of the equation for a dynamic motion and the development of the finite element program which can analyze the dynamic behavior of soil-space framework interaction system.

• Structural Monitoring and Maintenance
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• v.7 no.4
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• pp.295-317
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• 2020

Investigation of the stability of arch dam abutments is one of the most important aspects in the analysis of this type of dams. To this end, the Bakhtiari dam, a doubly curved arch dam having six wedges at each of its abutments, is selected. The seismic safety of dam abutments is studied through time history analysis using the design-based earthquake (DBE) and maximum credible earthquake (MCE) hazard levels. Londe limit equilibrium method is used to calculate the stability of wedges in abutments. The thrust forces are obtained using ABAQUS, and stability of wedges is calculated using the code written within MATLAB. Effects of foundation flexibility, grout curtain performance, vertical component of earthquake, nonlinear behavior of materials, and geometrical nonlinearity on the safety factor of the abutments are scrutinized. The results show that the grout curtain performance is the main affecting factor on the stability of the abutments, while nonlinear behavior of the materials is the least affecting factor amongst others. Also, it is resulted that increasing number of the contraction joints can improve the seismic stability of dam. A cap is observed on the number of joints, above which the safety factor does not change incredibly.

• Journal of Genetic Medicine
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• v.20 no.2
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• pp.39-45
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• 2023

As advanced sequencing technologies continue to uncover an increasing number of variants in genes associated with human genetic diseases, there is a growing demand for systematic approaches to assess the impact of these variants on human development, health, and disease. While in silico analyses have provided valuable insights, it is essential to complement these findings with model organism studies to determine the functional consequences of genetic variants in vivo. Drosophila melanogaster is an excellent genetic model for such functional studies due to its efficient genetic technologies, high gene conservation with humans, accessibility to mutant fly resources, short life cycles, and cost-effectiveness. The traditional GAL4-UAS system, allowing precise control of gene expression through binary regulation, is frequently employed to assess the effects of monoallelic variants. Recombinase medicated cassette exchange or CRISPR-Cas9-mediated GAL4 insertion within coding introns or substitution of gene body with Kozak-Gal4 result in the loss-of-function of the target gene. This GAL4 insertion strategy also enables the expression of reference complementary DNA (cDNA) or cDNA carrying genetic variants under the control of endogenous regulatory cis elements. Furthermore, the CRISPR-Cas9-directed tissue-specific knockout and cDNA rescue system provides the flexibility to investigate candidate variants in a tissue-specific and/or developmental-timing dependent manner. In this review, we will delve into the diverse genetic techniques available in Drosophila and their applications in diagnosing and studying numerous undiagnosed diseases over the past decade.

• Journal of KIISE:Databases
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• v.30 no.6
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• pp.573-584
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• 2003

Recent massive data generation by genomics and proteomics requires bioinformatic tools to extract the biological meaning from the massive results. Here we introduce ROSPath, a database system to deal with information on reactive oxygen species (ROS)-mediated cell signaling pathways. It provides a structured repository for handling pathway related data and tools for querying, displaying, and analyzing pathways. ROSPath data model provides the extensibility for representing incomplete knowledge and the accessibility for linking the existing biochemical databases via the Internet. For flexibility and efficient retrieval, hierarchically structured data model is defined by using the object-oriented model. There are two major data types in ROSPath data model: ‘bio entity’ and ‘interaction’. Bio entity represents a single biochemical entity: a protein or protein state involved in ROS cell-signaling pathways. Interaction, characterized by a list of inputs and outputs, describes various types of relationship among bio entities. Typical interactions are protein state transitions, chemical reactions, and protein-protein interactions. A complex network can be constructed from ROSPath data model and thus provides a foundation for describing and analyzing various biochemical processes.

• Geomechanics and Engineering
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• v.22 no.3
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• pp.197-206
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• 2020

Reutilization of solid waste such as Tire Derived Aggregate (TDA) and mixing it with soft soil for backfill material not only reduces the required volume of backfill soil (i.e., sand-mining procedures; reinforcement), but also preserves the environment from pollution by recycling. TDA is a widely-used material that has a good track record for improving sustainable construction. This paper attempted to investigate the performance of Kaolin-TDA mixtures as a backfill material underneath a strip footing and close to a retaining wall. For this purpose, different types of TDA i.e., powdery, shredded, small-size granular (1-4 mm) and large-size granular (5-8 mm), were mixed with Kaolin at 0, 20, 40, and 60% by weight. Static surcharge load with the rate of 10 kPa per min was applied on the strip footing until the failure of footing happened. The behaviour of samples K80-G (1-4 mm) 20 and K80-G (5-8 mm) 20 were identical to that of pure Kaolin, except that the maximum footing stress had grown by roughly three times (300-310 kPa). Therefore, it can be concluded that the total flexibility of the backfill and shear strength of the strip footing have been increased by adding the TDA. The results indicate that, a significant increase in the failure vertical stress of the footing is observed at the optimum mixture content. In addition, the TDA increases the elasticity behaviour of the backfill.

• Journal of Korean Elementary Science Education
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• v.21 no.1
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• pp.71-80
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• 2002

The purpose of this study was to develop children's creativity by applying creative problem solving model to elementary school science. Creative problem solving(CPS), the theoretical frame of model is proposed by Treffinger et al.(1994). CPS model is based on a substantial foundation of theory and research about creativity and problem solving. It is a well organized, deliberate set of methods you can call upon whenever you need new ideas or solutions and a process anyone can use to deal with many of life's everyday problems, opportunities, and challenges. CPS consists of three components. Within these three components, there are six specific stages during which creative and critical thinking abilities are used in harmony. Each stage involves both divergent and convergent thinking. The study was conducted for six week during the 1998 two semester in A elementary school which is located in Incheon. Eighty three 2nd grade students are selected for this study. The students were divided into two groups--experimental group and control group. The experimental group were taught in applying the CPS model, and the control group were taught by the traditional manner. Data for this study were collected by questionnaire which were developed by this researcher, and were analyzed by SPSSWIN 8.0. The results of this study were as follows: There was a significant difference on creativity between the instruction by applying CPS model and the traditional instruction. There was also gender differences on creativity between two groups. On fluency and flexibility as components of creativity, there was a signigicant difference between two groups. In conclusion, the instruction by applying CPS model was more effective in developing children's creativity than the traditional instruction.

• Korean Institute of Interior Design Journal
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• no.17
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• pp.65-72
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• 1998

This study intends to analyze the various spatial structures and characteristics of the museum based on the two of the Renzo Piano's recent projects Menil Collection '||'&'||' Museum and Beyeler Foundation Museum Which defined the direction of the "Third Generation" in museum architecture with reference to the quality of spatial experience and design applications. Comparison and analysis were done on the basic spatial organization floor layout accessibility exhibition area lighting plan and circulation between the two museum. Through the itemized common characteristics of the museum the architect's proposal on meaning and direction of the new museum architecture can be viewed. The contemporary museums distinguish themselves quite clearly from their predecessors and this applies both to their own form and to their spatial organization. As the public demands and requests toward the museum building facility expand everyday the architect must respond by providing multiple types of space where people can experience different atmosphere in each area. One concept he used to create multi experienced area was manipulation of the natural light using by the state-of-the-art techniques of the light filtering system and multi-layering roof system to protect the valuable collections against the direct sunlight. But mainly it was to prove his strong belief in "architecture of light" by creating space with minimized meaning by purposely distinguished area in order to provide maximum support to the physical value of the collection " The connection with nature" is another concept which Piano used to provide the public a tranquil experience through out the architecture which engages in a lively dialogue with art. In spatial organization Piano concerned on functionality which not only concentrated on the visitor's point of view but also on the museum staff's comfort. Unlkie the traditional museum he alternates various size of exhibition areas for spatial hierarchy. Specially the spatial flexibility that the temporary exhibition areas are able to be expanded to the permanent exhibition areas by adjoining t재 spaces differentiate Piano's new museum from the rest. museum from the rest.

• BMB Reports
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• v.39 no.4
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• pp.441-447
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• 2006

Abuse of drugs can elicit compulsive drug seeking behaviors upon repeated administration, and ultimately leads to the phenomenon of addiction. We developed a procedure for the standardization of microarray gene expression data of rat brain in drug addiction and stored them in a single integrated database system, focusing on more effective data processing and interpretation. Another characteristic of the present database is that it has a systematic flexibility for statistical analysis and linking with other databases. Basically, we adopt an intelligent SQL querying system, as the foundation of our DB, in order to set up an interactive module which can automatically read the raw gene expression data in the standardized format. We maximize the usability of this DB, helping users study significant gene expression and identify biological function of the genes through integrated up-to-date gene information such as GO annotation and metabolic pathway. For collecting the latest information of selected gene from the database, we also set up the local BLAST search engine and non-redundant sequence database updated by NCBI server on a daily basis. We find that the present database is a useful query interface and data-mining tool, specifically for finding out the genes related to drug addiction. We apply this system to the identification and characterization of methamphetamine-induced genes' behavior in rat brain.

• Korean Institute of Interior Design Journal
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• v.23 no.5
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• pp.183-191
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• 2014

Children stage is an important period the foundation of growth is accomplished. During the period, children are the most sensitive to environmental effects and experiences and interactions with surroundings can make lots of effects on their physical and cognitive development. Under the background of the above contents, a representative institution of the society, which is helpful to cultivate children's reading habit, will be children library. The purposes of this research are to analyze intensively reading room among the children library's spatial organization and compare/analyze cases of children library's reading room with the elements of interior environment. The methods of research are theory study and case study. Through the on-the-site visiting and shooting, interior environment design was investigated and then, it was arranged, analyzed and evaluated. Cases were analyzed by elements of interior environment design evaluation. As the result, comfort was the highest and variety was the lowest. Especially, Songpa children library showed various factors generally through the various designs. 7 evaluative elements of children library's reading room were mutually different, but there was a certain different in relation of them. Especially, variety and flexibility must be more strengthened. So, children can interests and joy in reading room various designs are requested by getting out of library's uniformed furniture and arrangement plan.