• Structural Engineering and Mechanics
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• v.48 no.4
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• pp.547-567
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• 2013

Nonlinear behavior of functionally graded material (FGM) plates under thermal loads is investigated here using an efficient sinusoidal shear deformation theory. The displacement field is chosen based on assumptions that the in-plane and transverse displacements consist of bending and shear components, and the shear components of in-plane displacements give rise to the sinusoidal distribution of transverse shear stress through the thickness in such a way that shear stresses vanish on the plate surfaces. Therefore, there is no need to use shear correction factor. Unlike the conventional sinusoidal shear deformation theory, the proposed efficient sinusoidal shear deformation theory contains only four unknowns. The material is graded in the thickness direction and a simple power law based on the rule of mixture is used to estimate the effective material properties. The neutral surface position for such FGM plates is determined and the sinusoidal shear deformation theory based on exact neutral surface position is employed here. There is no stretching-bending coupling effect in the neutral surface-based formulation, and consequently, the governing equations and boundary conditions of functionally graded plates based on neutral surface have the simple forms as those of isotropic plates. The non-linear strain-displacement relations are also taken into consideration. The thermal loads are assumed as uniform, linear and non-linear temperature rises across the thickness direction. Closed-form solutions are presented to calculate the critical buckling temperature, which are useful for engineers in design. Numerical results are presented for the present efficient sinusoidal shear deformation theory, demonstrating its importance and accuracy in comparison to other theories.

• Structural Engineering and Mechanics
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• v.48 no.6
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• pp.879-914
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• 2013

In part I of the article, formulation and characteristics of the several well-known structural geometrical nonlinear solution techniques were studied. In the present paper, the efficiencies and capabilities of residual load minimization, normal plane, updated normal plane, cylindrical arc length, work control, residual displacement minimization, generalized displacement control and modified normal flow will be evaluated. To achieve this goal, a comprehensive comparison of these solution methods will be performed. Due to limit page of the article, only the findings of 17 numerical problems, including 2-D and 3-D trusses, 2-D and 3-D frames, and shells, will be presented. Performance of the solution strategies will be considered by doing more than 12500 nonlinear analyses, and conclusions will be drawn based on the outcomes. Most of the mentioned structures have complex nonlinear behavior, including load limit and snap-back points. In this investigation, criteria like number of diverged and complete analyses, the ability of passing load limit and snap-back points, the total number of steps and analysis iterations, the analysis running time and divergence points will be examined. Numerical properties of each problem, like, maximum allowed iteration, divergence tolerance, maximum and minimum size of the load factor, load increment changes and the target point will be selected in such a way that comparison result to be highly reliable. Following this, capabilities and deficiencies of each solution technique will be surveyed in comparison with the other ones, and superior solution schemes will be introduced.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.9
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• pp.4751-4756
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• 2012

Colon cancer continues to be one of the most common cancers, and the importance and necessity of new therapies needs to be stressed. The most important proto-oncogen factors for colon cancer appear to be epidermal growth factor receptor, EGFR, and c-Src with high expression and activity leading to tumor growth and ultimately to colon cancer progression. Application of c-Src and EGFR antisense agents simultaneously should theoretically therefore have major benefit. In the present study, anti-EGFR and c-Src specific antisense oligodeoxynucleotides were combined in a formulation using PAMAM dendrimers as a carrier. Nano drug entry into cells was confirmed by flow cytometry and fluorescence microscopy imaging and real time PCR showed gene expression of c-Src and EGFR, as well as downstream STAT5 and MAPK-1 with the tumor suppressor gene P53 to all be downregulated. EGFR and c-Src protein expression was also reduced when assessed by western blotting techniques. The effect of the antisense oligonucleotide on HT29 cell proliferation was determined by MTT assay, reduction beijng observed after 48 hours. In summary, nano-drug, anti-EGFR and c-Src specific antisense oligodeoxynucleotides were effectively transferred into HT-29 cells and inhibited gene expression in target cells. Based on the results of this study it appears that the use of antisense EGFR and c-Src simultaneously might have a significant effect on colon cancer growth by down regulation of EGFR and its downstream genes.

• Archives of Plastic Surgery
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• v.44 no.3
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• pp.194-201
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• 2017

Background Platelet-rich plasma (PRP) contains high concentrations of growth factors involved in wound healing. Hydrogel is a 3-dimensional, hydrophilic, high-molecular, reticular substance generally used as a dressing formulation to accelerate wound healing, and also used as a bio-applicable scaffold or vehicle. This study aimed to investigate the effects of PRP and hydrogel on wound healing, in combination and separately, in an animal wound model. Methods A total of 64 wounds, with 2 wounds on the back of each nude mouse, were classified into 4 groups: a control group, a hydrogel-only group, a PRP-only group, and a combined-treatment group. All mice were assessed for changes in wound size and photographed on scheduled dates. The number of blood vessels was measured in all specimens. Immunohistochemical staining was used for the analysis of vascular endothelial growth factor (VEGF) expression. Results Differences in the decrease and change in wound size in the combined-treatment group were more significant than those in the single-treatment groups on days 3, 5, 7, and 10. Analysis of the number of blood vessels through histological examination showed a pattern of increase over time that occurred in all groups, but the combined-treatment group exhibited the greatest increase on days 7 and 14. Immunohistochemical staining showed that VEGF expression in the combined-treatment group exhibited its highest value on day 7. Conclusions This experiment demonstrated improved wound healing using a PRP-hydrogel combined treatment compared to either treatment individually, resulting in a decrease in wound size and a shortening of the healing period.

• Journal of Gastric Cancer
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• v.1 no.4
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• pp.215-220
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• 2001

Purpose: The aim of the study was to obtain data on the anatomic and histologic distributions, the clinical features, and the treatment results for patients with primary gastric non-Hodgkin's lymphoma. Materials and Methods: One hundred thirty-two patients who were treated at 8 university hospitals and 2 general hospitals between January 1991 and December 2000 were enrolled to evaluate clinico-pathologic features. Results: The lower one-third of the stomach was the most frequent site ($42\%$), and the most frequent chief complaint was epigastric pain ($54\%$). Gastric resection was performed in 114 cases. Pathologic findings of preoperative endoscopic biopsy specimens from the 114 patients that underwent surgery were a gastric lymphoma in 94 cases ($82\%$), a carcinoma in 15 cases ($13\%$), an ulcer in 4 cases ($4\%$), and a gastrointestinal stromal tumor in 1 case ($1\%$). The stage distributions by Musshoff's criteria were 71 cases ($54\%$) of stage IE, 36 cases ($27\%$) of stage $II_{1}E$, 8 cases ($6\%$) of stage $II_{2}E$, 2 cases ($2\%$) of stage IIIE, and 15 cases ($11\%$) of stage IVE. Histologic gradings by the Working Formulation in were 31 cases ($23\%$) of low grade, 96 cases ($73\%$) of intermediate grade, and 5 cases ($4\%$) of high grade. Chemotherapy-related complications occurred in 25 cases ($22\%$) while operation-related complications occurred in 6 cases ($5\%$). Seventeen patients ($13\%$) only underwent surgery, 19 ($14\%$) had chemotherapy (CTx) and/or radiotherapy (RTx) only, and 96 patients ($73\%$) received surgery and CTx and/or RTx. No substantial differences in survival were found in relation to the different histologic grades and different treatments. The five-year survival was $85\%$ in stage I or II and $47\%$ in stage III or IV (P=0.0000). Conclusion: Pathologic stage appears to be the single most important prognostic indicator. Survival differences according to treatment modalities were not statistically significant. However, the low number of patients treated with various approaches over a long period precludes a firm conclusion.

• Journal of the Korea Fashion and Costume Design Association
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• v.14 no.3
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• pp.51-65
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• 2012

This research was conducted to provide basic data for the formulation of marketing strategies suitable to the increasingly globalizing clothing market for the elderly in the fashion industry, by comparing the clothing behavior and preferences of elderly women aged over 70 years in Korea with those of women in the U.S. The 106 questionnaire responses that were collected in the U.S. and the 235 responses that were collected in Korea were used for the analysis, The major objectives of this study were as follow; 1. It was found that the elderly women of Korea utilize mostly human information as information source when purchasing clothing, whereas women of U.S. utilize mostly media information. Comfort was found to be most important factor both countries, but the Korean women considered the aesthetic aspect of clothing more important than did American women. 2. The clothing preference of Korean elderly women aged over 70 years was concentrated in young and feminine images regardless of items, so it could be seen that they had strong desire for looking young. But American elderly women showed different preference depending on items, so it could be seen that they pursue diverse images depending on clothing items and personality without concentrating in one image. The comparison of the preference style by item of elderly women over 70 years of age between Korea and the U,S. showed significant difference. Accordingly, the designs of the clothes of the Korean and American women should be differentiated and developed according to the clothes item and country.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.8 no.1
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• pp.77-85
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• 1988

A stochchastic analysis procedure of generating floor response spectra for proportionally damped linear systems subject to earthquake loading is presented. Theories of random vibration and mode acceleration method are used in the formulation of governing equations. The structure-oscillator interaction is not considered. It is assumed that the input motions and oscillator responses are stationary Gaussian processes with mean zero. The nonstationary characteristics of earthquake motion are incorporated in the peak factor which is based on Vanmarcke's theory. Floor response spectra for both resonance and non-resonance cases are calculated under the assumption that the peak factors for structure and oscillator are equal to that for ground response spectrum. The validity of this method is demonstrated by comparing the results obtained by proposed method with those by time history analyses. The results obtained by this method are conservative and accurate with tolerable precision. This method saves much computing time compared with time history analysis method.

• Journal of Korea Technical Association of The Pulp and Paper Industry
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• v.48 no.1
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• pp.27-33
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• 2016

This study was carried out in order to investigate the effect of binder properties in pre-coating layer on the characteristics of top-coating layer and print mottle of coated paper. Four different latices were used as a binder in pre-coating layer, and coating color prepared with a same formulation was applied for top-coating. The properties and print mottle of coated paper were evaluated. It was found that glass transition temperature (Tg) was the important factor to control the properties of pre- and top-coating layer. PPS roughness of coated paper was decreased and paper gloss was increased with applying binder which has lower Tg. Properties of top-coating layer were affected by the binder used in pre-coating layer. Print mottle of coated paper was improved with using binder which has lower Tg in pre-coating layer. These results indicate that final printability and properties of top-coating layer can be improved with using suitable binder in pre-coating layer.

• Journal of Ocean Engineering and Technology
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• v.25 no.3
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• pp.73-84
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• 2011

This is the fifth in a series of companion papers dealing with the dynamic hardening properties of various marine structural steels at intermediate strain rates. Five steps of strain rate levels (0.001, 1, 10, 100, 200/s) and three steps of temperature levels (LT ($-40^{\circ}C$), RT, and HT ($200^{\circ}C$)) were taken into account for the dynamic tensile tests of three types of marine structural steels: API 2W50 and Classifications EH36 and DH36. The total number of specimens was 180 pieces. It was seen that the effects of dynamic hardening became clearer at LT than at RT. Dynamic strain aging accompanying serrated flow stress curves was also observed from high temperature tests for all kinds of steels. The dynamic hardening factors (DHFs) at the two temperature levels of LT and RT were derived at the three plastic strain levels of 0.05, 0.10, 0.15 from dynamic tensile tests. Meanwhile, no DHFs were found for the high temperature tests because a slight negative strain rate dependency due to dynamic strain aging had occurred. A new formulation to determine material constant D in a Cowper-Symonds constitutive equation is provided as a function of the plastic strain rate, as well as the plastic strain level. The proposed formula is verified by comparing with test flow stress curves, not only at intermediate strain rate ranges but also at high strain rate ranges.

• Journal of the Korean Wood Science and Technology
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• v.45 no.5
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• pp.572-579
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• 2017

Determination of the wood content in wood plastic composite (WPC) is crucial to form reliable WPC market. WPC with simple formulation consisting of only two components (wood flour and polypropylene) was examined using thermogravimetric analysis (TGA) and accelerator mass spectrometry (AMS) for determining wood content in the WPC. TGA method using derivative peak temperature (DTp) of polypropylene under low heating rate ($5^{\circ}C/min$) showed more reliable calibration curve and lower error factor compared to method of using the percentage of weight loss of wood flour. In addition, AMS using bio-based carbon content showed greater reliability for the determination of wood content in the WPC in comparison with the TGA method.