• International Journal of Quality Innovation
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• v.3 no.2
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• pp.174-182
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• 2002

System identification and controller formulation are essential in dynamic process control. In system identification, data for system identification are obtained, and then they are analyzed so that the system model of the process is built, identified, and diagnosed. In controller formulation, the control equation is derived based on the result of the system identification. There has been much theoretical research on system identification and controller formulation. These theories are very useful when they are appropriately applied. To our regret, however, these theories are not always effectively applied in practice because the engineers and the operators who manage the process often do not have the necessary understanding of required time series analysis methods. On the other hand, because of widespread use of statistical packages, system identification such as estimating ARMA models can be done with little understanding of time series analysis methods. Therefore, it might be said that the most theoretically difficult part in practice is the controller formulation. In this paper, lists of control equations are proposed as a useful tool for practitioners to use. The tool supports bridging the gap between theory and practice in dynamic process control. Also, for some models, the generalized control equations are obtained.

• Journal of Veterinary Clinics
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• v.24 no.3
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• pp.312-314
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• 2007

Cheyletiellosis is a very common infestation in pet rabbits that causes dermatosis with pruritus and scale. In this study, thirty two rabbits with cheyletiellosis were treated with a single dermal application of a formulation containing imidacloprid 10% (w/v) and moxidectin 1% (w/v) at a dose 0.4 ml. The therapeutic effects of the formulation were 100% at 4, 8 and 12 weeks without adverse reactions. This suggests that a formulation containing imidacloprid and moxidectin is an effective treatment for cheyletiellosis in rabbits.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.30 no.3 s.246
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• pp.262-269
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• 2006

Segregation algorithms of the incompressible Wavier-Stokes equations using P1P1/P2P1 finite element formulation are newly proposed. P1P1 formulation allocates velocity and pressure at the same nodes, while P2P1 formulation allocates pressure only at the vertex nodes and velocity at both the vertex and the midpoint nodes. For a comparison of both the elapsed time and the accuracy between the two methods, they have been applied to the well-known benchmark problems. The three cases chosen are the two-dimensional steady and unsteady flows around a fixed cylinder, decaying vortex, and impinging slot jet. It is shown that the proposed P2P1 semi-segregation algorithm performs better than the conventional P1P1 segregation algorithm in terms of both accuracy and computation time.

• Korean Journal of Food Science and Technology
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• v.18 no.3
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• pp.221-225
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• 1986

The possibility of by-products utilization in a sausage formulation was studied using Linear Programming. Among constraints groups (1: moisture and meat content, 1 + heart, 1 + organ, 1 + head, 1 + heart + backfat, 1 + heart + organ, 1 + heart + head, 1 + heart + head + backfat), the group in which moisture and meat content, and the use of heart and organ were considered appeared to give the least-cost formulation. The groups where the use of backfat was considered resulted in higher-cost formulations. However, if the formulation contains bindery and extenders such as vegetable proteins or milk proteins which are not limited in use antler the Korean regulation, the result would be different from that obtained here.

• The Journal of Korean Obstetrics and Gynecology
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• v.27 no.3
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• pp.104-115
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• 2014

Objectives: As treating acne is difficult and demands of cosmetic are increasing, the development of new Korea traditional herbal formulation and functional cosmetics of acne is required. The aim of this study is the discovery and composition for the development of new Korea traditional herbal formulation and functional cosmetics of acne. Methods: Searched patent informations related to herbal cosmetics published in 1996~2014, we extracted the patent information and analysis component about effecting of anti-inflammatory and anti-acne. Results: Out of 759 patent informations we searched, 72 those about effecting anti-inflammatory and anti-acne were selected. Also, 159 components of 72 patent informations were reclassified by frequency and characteristic. Conclusions: We expect the effect and safety of new traditional herbal formulation which is composed of high frequency herb in patent informations related to herbal cosmetics.

• Archives of Pharmacal Research
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• v.25 no.4
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• pp.534-540
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• 2002

To develop novel transdermal formulation for aceclofenac, microemulsion was prepared for increasing its skin permeability. Based on solubiity and phase studies, oil and surfactant was selected and composition was determined. Microemulsion was spontaneously prepared by mixing ingredients and the physicochemical properties such was investigated. The mean diameters of microemulsion were approximately 90 nm and the system was physically stable at room temperature at least for 3 months. In addition, the in vitro and in vivo performance of microemulsion formulation was evaluated. Aceclofenac was released from microemulsion in acidic aqueous medium, and dissolved amounts of aceclofenac was approximately 30% after 240 min. Skin permeation of aceclofenac from microemulsion formulation was higher than that of cream. Following transdermal application of aceclofenac preparation to delayed onset muscle soreness, serum creatine phosphokinase and lactate dehydrogenase activity was significantly reduced by aceclofenac. Aceclofenac in microemulsion was more potent than cream in the alleviation of muscle pain. Therefore, the microemulsion formulation of aceclofenac appear to be a reasonable transdermal delivery system of the drug with enhanced skin permeability and efficacy for the treatment of muscle damage.

• Journal of Pharmacopuncture
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• v.24 no.3
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• pp.142-151
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• 2021

Objectives: Although Korean Medicine (KM) subsidized by the National Health Insurance (NHI) has been used for a long time, there has been no active analysis using claims data. Therefore, the purpose of this study was to examine the NHI KM utilization trend using NHI statistics and to measure the level of market concentration by year. Methods: By restructuring the contents of NHI Statistics for Pharmaceuticals for 2010-2019, the claim cases, costs, and annual growth rates of KM were demonstrated by year, sex, age group, region, therapeutic group, and KM treatment. The proportion of highly used k treatments in cost was calculated as the concentration ratio (CR) k and its trend by year was investigated. Results: In 2019, the NHI cost on KM amounted to ₩38.2 billion KRW, increasing by 11.6% per year on average in 2010-2019. Notably, KM was used more frequently among women and patients aged ≥ 65 years, and the mixed formulation accounted for 95% of the total cost of KM. The CR of the simple formulation increased rapidly, whereas that of the mixed formulation remained constant. In 2019, three simple formulation treatments- peony, licorice, and ginseng- accounted for 93.8% of the total cost for KM (CR3 = 93.8%). Conclusion: NHI KM is rapidly increasing. Investigating the CR of KM confirmed that KM prescriptions have been concentrated in small numbers over the past 10 years.

• Structural Engineering and Mechanics
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• v.69 no.6
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• pp.615-626
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• 2019

The 3-noded metric Timoshenko beam element with an offset of the internal node from the element centre is used here to demonstrate the best-fit paradigm using function space formulation under locking and mesh distortion. The best-fit paradigm follows from the projection theorem describing finite element analysis which shows that the stresses computed by the displacement finite element procedure are the best approximation of the true stresses at an element level as well as global level. In this paper, closed form best-fit solutions are arrived for the 3-noded Timoshenko beam element through function space formulation by combining field consistency requirements and distortion effects for the element modelled in metric Cartesian coordinates. It is demonstrated through projection theorems how lock-free best-fit solutions are arrived even under mesh distortion by using a consistent definition for the shear strain field. It is shown how the field consistency enforced finite element solution differ from the best-fit solution by an extraneous response resulting from an additional spurious force vector. However, it can be observed that when the extraneous forces vanish fortuitously, the field consistent solution coincides with the best-fit strain solution.

• Smart Structures and Systems
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• v.29 no.2
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• pp.279-286
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• 2022

In this article, a novel propagation formulation of Rayleigh waves in a compressible isotropic half-space with impedance boundary condition is proposed by embedding the normal stress. In a two-dimensional case, it is assumed that a design boundary is free of normal traction and a shear traction depends on linearly a normal component of displacements multiplied by frequencies. Therefore, impedance boundary conditions affect the normal stress, where the impedance parameters correspond to dimensions of stresses over velocity. On the other hand, vanished impedance values are traction-free boundary conditions. The main purpose of this article is to present theoretically the existence and uniqueness of a Rayleigh wave formulation relying on secular equation's mathematical analyses. Its velocity varies along with the impedance parameters. Moreover, numerical experiments with different values for the velocity of Rayleigh waves are carried out. The present Rayleigh waves study is a fundamental step in analyzing the cause and effect of physical states such as building or structure damages resulting from natural dynamics. The results of the study generate a basic design formulation theory to test the effects of Rayleigh waves affecting structures when an earthquake occurs. The presence and uniqueness of the proposed formulation is verified by mutual comparisons of several numerical examples.

• The Journal of Korean Medicine
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• v.35 no.3
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• pp.49-59
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• 2014

Background: Eight positions for new formulations in Jingyuequanshu is a unique classifying system and each position can be presented as a network. Network analysis is an effective method of visualizing the relationship of textual information. Purpose: This study aimed to analyze the structure of the eight positions for new formulations in Jingyuequanshu, and to acquire information about composing materia medica. Methods: We constructed an initial database and binary matrix of eight positions for new formulation in Jingyuequanshu, including its herbs and formulations. With this data, we carried out frequency and network analysis. Results: We analyzed each of the eight positions for new formulation, entire positions, and five positions after removing 'causal/cold/hot' positions. We found that the formulas of the causal position are distributed throughout the new formulation, and those of the cold and hot positions are also distributed similarly but the two groups are exclusive to each other. The other 5 positions are distributed exclusively to one another. Conclusions: Eight positions for new formulation of Jingyuequanshu were classified into three axes by exploratory network analysis. One is an axis of causal position, another is an axis of cold/hot positions, and the last is an axis of the other five positions.