• Preventive Nutrition and Food Science
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• v.19 no.4
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• pp.299-306
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• 2014

Hesperetin has been shown to possess a potential anti-angiogenic effect, including vascular formation by endothelial cells. However, the mechanisms underlying the potential anti-angiogenic activity of hesperetin are not fully understood. In the present study, we evaluated whether hesperetin has anti-angiogenic effects in human umbilical vascular endothelial cells (HUVECs). HUVECs were treated with 50 ng/mL vascular endothelial growth factor (VEGF) to induce proliferation as well as vascular formation, followed by treatment with several doses of hesperetin (25, 50, and $100{\mu}M$) for 24 h. Cell proliferation and vascular formation were analyzed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and tube formation assay, respectively. In addition, cell signaling related to cell proliferation and vascular formation was analyzed by western blot. Furthermore, a mouse aorta ring assay was performed to confirm the effect of hesperetin on vascular formation. Hesperetin treatment did not cause differences in HUVECs proliferation. However, hesperetin significantly inhibited VEGF-induced cell migration and tube formation of HUVECs (P<0.05). Moreover, hesperetin suppressed the expression of ERK, p38 MAPK, and PI3K/AKT in the VEGF-induced HUVECs. In an ex vivo model, hesperetin also suppressed microvessel sprouting of mouse aortic rings. Taken together, the findings suggest that hesperetin inhibited vascular formation by endothelial cells via the inhibition of the PI3K/AKT, ERK and p38 MAPK signaling.

• International Journal of Computer Science & Network Security
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• v.22 no.9
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• pp.396-402
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• 2022

The study deals with the problem of the formation of pre-service teachers' reflective skills in information environment. The role of reflection as a mechanism of formation of a modern teacher's self-consciousness was cleared up. The technology of formation of pre-service teachers' reflective skills was characterized and tested. The main stages of the technology were: a motivational and cognitive stage, a problematic and practical stage, and a reflective and operational stage. The substantiated pedagogical conditions of formation of pre-service teachers' reflective skills were adhered. The criterial and evaluative characteristics of the formation of pre-service teachers' reflective skills were worked out: components (reflection of personal conformity, reflection of the psychological and pedagogical barriers, reflection of professional growth); criteria (criterion of consistency, criterion of difficulty, criterion of potential); indicators (cognitive-evaluative, value-motivational, activity-creative). The levels of formation of pre-service teachers' reflective skills (insufficient level, acceptable level, and optimum level) were determined. The analysis of students' surveys showed the effectiveness and expediency of using the technology of formation of pre-service teachers' reflective skills in the process of professional training.

• Journal of Korea Technical Association of The Pulp and Paper Industry
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• v.31 no.4
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• pp.30-40
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• 1999

The possibility of the characterization of sheet formation by image analysis with transmitted light was evaluated. Specific perimenter, average perimeter and variation could not be used to predict the sheet formation because there were no corrleation. Although image analysis method still have a lot of problems , it was found that the contrast intensity obtained by image analysis with transmitted light can be used to predict the sheet formation. In the case of highly filled sheet, the intensity of transmitted light was too low to characterize the sheet formation . However, it was possible to characterize the formation of unfilled heavy weight paper($\leq$200g/㎡).

• Journal of Ocean Engineering and Technology
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• v.26 no.3
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• pp.6-12
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• 2012

In this paper, addressed is the control problem of generating a formation for a group of unmanned surface and underwater vehicles. The formation control scheme proposed in this work is based on a fusion of theleader-follower and virtual reference approaches. This scheme gives a formation constraint representation that is independent of the number of vehicles in the formation and the resulting control algorithm is scalable. One of the most important features in controller design is the ability of the controller to globally and exponentially stabilize the formation errors defined by the formation constraints. The proposed controller is based on feedback linearization, and the formation errors are shown to be globally and exponentially stable in the sense of Lyapunov.

• Tribology and Lubricants
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• v.14 no.4
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• pp.108-113
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• 1998

In order to investigate the characteristics of top ring groove deposit formation in diesel engine, engine test and simulation test were performed. From component analysis of used oils sampled from actual running engines, soot content in engine oil was selected as a main parameter for evaluating oil degradation. Deposit formation is highly related to soot content in lubricating oils. And high soot content oil accelerates deposit formation even in low temperature region below 26$0^{\circ}C$. In low temperature region below 26$0^{\circ}C$, deposit formation rate is mainly affected by top ring groove temperature. However, in high temperature region above 26$0^{\circ}C$, deposit formation rate is affected by soot content as well as top ring groove temperature. Therefore, soot content as well as top ring groove temperature should be kept a certain level in order to prevent troubles due to carbon deposit formation.

• Journal of Institute of Control, Robotics and Systems
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• v.19 no.4
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• pp.349-356
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• 2013

This paper presents formation control based on potential functions for unicycle robots. The unicycle robots move to formation position which is made from a reference point and neighboring robots. In the framework, a local minimum case occurred by combination of potential repulsed from neighboring robots and potential attracted from a formation line is presented, in which the robot escapes from a local minimum using a virtual escape point after recognizing trapped situation. As well, in the paper, potential functions are designed to keep the same distance between neighboring robots on a formation line, i.e. the relative distance between neighboring robots on a formation line is controlled by a potential function parameter. The simulation results show that the proposed approach can effectively construct straight line, V, and polygon formation for multiple robots.

• Journal of the Korean earth science society
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• v.27 no.7
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• pp.745-756
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• 2006

Early Ordovician graptolites from the Mungok Formation of Yeongwol area, Korea comprise seven species belonging to six genera: Callograptus curvithecalis, Callograptus sinicus, Aspidograptus lotolatzensis, Dendrograptus suni, Dictyonema uniforme, Adelograptus cf. tenellus, and Psigraptus jacksoni. Two graptolite zones with three subzones are recognized in the eight sections of the Mungok Formation. The Adelograptus Zone is correlated with (1) La 1b of the Lancefield Formation of Victoria, Australia, (2) the Adelograptus-Clonograptus Zone of the Yehli Formation of Jilin, China, and (3) the Adelograptus Zone of the Road River Formation of Yukon, Canada. It suggests that the upper part of the Mungok Formation corresponds to early Late Tremadocian of Early Ordovician.

• International Journal of Fuzzy Logic and Intelligent Systems
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• v.5 no.3
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• pp.222-229
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• 2005

This paper presents a self-organizing scheme for multi-agent swarm systems based on coupled nonlinear oscillators (CNOs). In this scheme, unicycle robots self-organize to flock and arrange group formation through attractive and repulsive forces among themselves. The main result is the maintenance of flexible and scalable formation. It is also shown how localized distributed controls are utilized throughout group behaviors such as formation and migration. In the paper, the proposed formation ensures safe separation and good cohesion performance among the robots. Several examples show that the proposed method for group formation performs the group behaviors such as reference path following, obstacle avoidance and flocking, and the formation characteristics such as flexibility and scalability, effectively.

• Journal of Institute of Control, Robotics and Systems
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• v.18 no.2
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• pp.87-93
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• 2012

In this paper, a formation guidance method for UAVs (Unmanned Aerial Vehicles) to simulate the formation flight of birds proposed. The proposed method solves all issues of approaching for formation, formation keeping, and scarce chance to be collided with each UAV during formation process. Also, we design the feedforward controller to compensate the change of speed and heading for maneuvering of the leader UAV and the feedback controller to consider the response lag of the system. The stability and performance of the proposed controller is verified via numerical simulations of the full 6-Dof model of UAV.

• The Bulletin of The Korean Astronomical Society
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• v.44 no.1
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• pp.75.3-75.3
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• 2019

Understanding how ram pressure stripping (RPS) affects the star formation activity of cluster galaxies is one of the important issues in astrophysics. To examine whether we can identify any discernible trend in the star formation activity of galaxies undergoing ram pressure stripping, we study the star formation properties of galaxies in the Virgo cluster for which high-resolution HI images are available. We first classify galaxies in the Extended Virgo Cluster Catalog into different stages of RPS based on their HI morphology, HI deficiency, and location in phase space. We then examine various star formation activity indicators of these galaxies, which include starburstiness, g - r color, and WISE [3.4]-[12] color. No noticeable enhancement in star formation was identified for galaxies undergoing early or active stripping. Our results suggest that star formation activity at best seems to be enhanced locally in such galaxies, making it challenging to detect with integrated photometry. With the combination of HI deficiencies and locations in phase space, we were instead able to capture the overall quenching of star formation activity with increasing degree of ram pressure stripping, which agree with previous studies.