• Archives of Pharmacal Research
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• v.18 no.4
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• pp.219-223
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• 1995

Rectal absorption of opeprazole, a proton pump inhibitor, from suppositories was studied in rabbits. The suppositories were prepared by the conventional melting method with two types of bases, water-soluble polyethylene glycol (PEG) 4000 and oil-soluble Witepsol H15 bases, and administered intractally (ir) to rabbits at a dose of 10 mg omeprazole/kg. The plasma omeprazole concentration-time profiles of the two suppositories were compared with those following intravenous 9iv) administration of the same dose. There were no significant differences between the two suppositories in bioabailabilities and peak plasma concentrations $(C_{max})$. Bioavaiabilities and $C_{max}$ of PEG- and Witpsol suppositories were 30.3 and 33.9%, and 7.0 and $5.6\mug/ml$, resepectively. However, PEG suppository showed significantly (p<0.05) shorter time to reach peak plasma concentration $(T_{max})$ mean absorption time (MAT) and mean residence time in the plasma (MRT) than Witepsol suppository. The $T_{max}$ MRT nad MAT were 25.0, 83.0 and 38.5 min for PEG syppository, but were 90.0, 122.5 and 78.0 min for Wiepsol supposiotory, respectively. These differences between thw two suppositories could be explanined by the difference in the in vitro dissolution rates between the suppositories. The dissolution of omeprazole form PEG suppository was reportedly much faster than that from Witepsol suppository. It suggests that plasma profiles of omeprazole, especially $C_{max}$ MAT and MRT, could be controlled by modifying the in vitro dissolution rate of the drug from the suppositories. Above results suggest that rectal suppository is worth developing as an alternative dosage form of omeprazole to the conventional oral preparations which need sophisticated treatments, such as enterix coating, to prevent acid degradation of the drug in the stomach fluid.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.29 no.2 s.43
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• pp.181-191
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• 2003

This study described about method that form liquid crystal gel (LCG) by main ingredient with hydrogenated lechin (HL) in OW emulsion system. Result of stability test is as following with most suitable LCG's composition. Composition of LCG is as following. To form liquid crystal, an emulsifier used $4.0\;wt\%$ of cetostearyl alcohol (CA) by $4.0\;wt\%$ of HL as a booster, Moisturizers contained $2\;wt\%$ of glycerin and $3.0\;wt\%$ of 1.3-butylene glycol (1,3-BG). Suitable emollients used $3.0\;wt\%$ of cyclomethicone, $3.0\;wt\%$ of isononyl isononanoate (ININ), $3.0\;wt\%$ of cerpric/carprylic triglycerides (CCTG), $3.0\;wt\%$ of macademia nut oil (MNO) in liquid crystal gel formation. On optimum conditions of LCG formation, the pHs were formed all well under acidity or alkalinity conditions. Considering safety of skin, PH was the most suitable $\pm61.0$ ranges. The stable hardness of LCG formation appeared best in $32\;dyne/cm^2.$ Particle of LCG is forming size of $1{\~}20\;{\mu}m$ um range, and confirmed that the most excellent LCG is formed in $1{\~}6\;{\mu}m$ range. According to result that observe shape of LCG with optical or polarization microscope, LCG could was formed, and confirmed that is forming multi-layer lamellar type structure around the LCG. Moisturizing effect measured clinical test about 20 volunteers. As a result, moisturizing effect of LCG compares to placebo cream was increased $30.6\%$. This could predicted that polyol group is appeared the actual state because is adsorbed much to round liquid crystal droplets to multi-lamellar layer's hydrophilic group. It could predicted that polyol group is vast quantity present phase that appear mixed because is adsorbed to round liquid crystal to multi-lamellar layer's hydrophilic group. This LCG formation theory may contribute greatly in cosmetics and pharmacy industry development.

• Journal of Microbiology and Biotechnology
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• v.11 no.4
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• pp.607-613
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• 2001

The biodegradation rates of diesel oil by a selected diesel-degrading bacterium, Pseudomonas stutzeri strain Y2G1, and microbial consortia composed of combinations of 5 selected diesel-degrading bacterial were determined in liquid and soil systems. The diesel degradation rate by strain Y2G1 linearly increased $(R^2=0.98)$ as the diesel concentration increased up to 12%, and a degradation rate as high as 5.64 g/l/day was obtained. The diesel degradation by strain Y2G1 was significantly affected by several environmental factors, and the optimal conditions for pH, temperature, and moisture content were at pH8, $25^{\circ}C$, and 10%, respectively. In the batch soil microcosm tests, inoculation, especially in the form of a consortium, and the addition of nutrients both significantly enhanced the diesel degradation by a factor of 1.5 and 4, respectively. Aeration of the soil columns effectively accelerated the diesel degradation, and the initial degradation rate was obviously stimulated with the addition of inorganic nutrients. Based on these results, it was concluded that the major rate-limiting factors in the tested diesel-contaminated soil were the presence of inorganic nutrients, oxygen, and diesel-degrading microorganisms. To resolve these limiting parameters, bioremediation strategies were specifically designed for the tested soil, and the successful mitigation of the limiting parameters resulted in an enhancement of the bioremediation efficiency by a factor of 11.

• Asian-Australasian Journal of Animal Sciences
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• v.18 no.2
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• pp.282-295
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• 2005

The processing of dietary lipids can be distinguished in several sequential steps, including their emulsification, hydrolysis and micellization, before they are absorbed by the enterocytes. Emulsification of lipids starts in the stomach and is mediated by physical forces and favoured by the partial lipolysis of the dietary lipids due to the activity of gastric lipase. The process of lipid digestion continues in the duodenum where pancreatic triacylglycerol lipase (PTL) releases 50 to 70% of dietary fatty acids. Bile salts at low concentrations stimulate PTL activity, but higher concentrations inhibit PTL activity. Pancreatic triacylglycerol lipase activity is regulated by colipase, that interacts with bile salts and PTL and can release bile salt mediated PTL inhibition. Without colipase, PTL is unable to hydrolyse fatty acids from dietary triacylglycerols, resulting in fat malabsorption with severe consequences on bioavailability of dietary lipids and fat-soluble vitamins. Furthermore, carboxyl ester lipase, a pancreatic enzyme that is bile salt-stimulated and displays wide substrate reactivities, is involved in lipid digestion. The products of lipolysis are removed from the water-oil interface by incorporation into mixed micelles that are formed spontaneously by the interaction of bile salts. Monoacylglycerols and phospholipids enhance the ability of bile salts to form mixed micelles. Formation of mixed micelles is necessary to move the non-polar lipids across the unstirred water layer adjacent to the mucosal cells, thereby facilitating absorption.

• Journal of the Korean Society of Food Science and Nutrition
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• v.33 no.3
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• pp.566-570
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• 2004

Cultivation conditions for overproduction of lovastatins were investigated from the lovastatin producing strain N-03 which was obtained with NTG (N-methyl-N'-nitro-nitrosoguanidine) treatment from Aspergiliu ferrous ATCC 20542. Produced lactone and acid form of lovastatin were detected, and analyzed by HPLC method. In liquid culture, medium No. 2 containing soy protein produced higher amounts of the lovastatins than medium No. 1 (contained rapeseed oil). In solid culture, maximum production was obtained at 28$^{\circ}C$ for 15 days cultivation using cooked wheat bran. For the overproduction of lovastatin from this strain, solid culture method using plastic bag is more superior than liquid culture.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2002.05a
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• pp.778-781
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• 2002

Durability of rubber dust cover in the ball joint for automotive suspension parts were analyzed by FEM and compared with experimental data. Upper open area of ball joint is sealed by dust cover for preventing outflow of the lubricating oil and intrusion of send, dust, water, etc. This rubber cover undergoes repeated loadings such as tension and compression while the car is running. Analysis about rubber material needs to consider every kinds of nonlinearities arise in finite element analysis, which are geometric nonlinearity due to large displacement and small strain, materially nonlinearity and nonlinear boundary condition such as contact. So in the study, the deformation behavior of dust cover was analysed by using the commercial finite element program MARC. This program could solve these kinds of nonlinear analysis accurately. Finite element model of dust cover is considered as 3-dimensional half model based on 2-dimensional axisymmetric model. Material property of rubber was modeled by Ogden model and input data for calculation takes form uniaxial tension test of rubber specimen, The final object of the study is obtaining the design specification of dust covers and the result of analysis should be a useful data to design of rubber

• Proceedings of the Korean Society of Applied Pharmacology
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• 1996.04a
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• pp.284-284
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• 1996

Titrated Extract of Centella asiatica (TECA) is a poorly water-soluble extract from the Centella asiatica. Despite excellent wound preparation causes pain due to a low aqueous solubility and high hypertonicity and therefore, the patient's compliance of this drug is low. The objective of this study is to design a formulation of TECA with an improved therapeutic applicability via an adequate solubilization. A mixture of propylene glycol and ethoxylated hydrogenated caster oil achieved an acceptable solubilization of TECA (i.e. 10%) via a formulation of micelle. A preparation of extemporaneous TECA micelle was achieved by a dilution of the original micellar formulation with either water or saline. An estimated distribution of particle size was between 15.9 and 32.6 ㎜. The osmotic pressure of the formulation was found to be much lower than that found In a commercially available injectable (i.e. Madecassole). The erthrocytic hemolysis of micellar solution was lower than that with the conventional dosage form, consistent with the osmotic pressure data. Pain score after an injection of the micellar solution was assessed by the hind-paw writhing test using ICR mice and compared with that found with the conventional injectable. The data indicated that the injection of the micellar solution was a significantly less painful. These results indicated that a micellar solubilization, followed by an extemporaneous dilution, is a novel formulation of TECA with an improved therapeutic applicability.

• Journal of Korean Biological Nursing Science
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• v.13 no.2
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• pp.142-148
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• 2011

Purpose: The purpose of this study was to investigate the effects of aromatherapy massage in the elderly with knee osteoarthritis. Methods: Participants were assigned randomly to an intervention (n=21) group and a control (n=21) group. In order to increase a lasting effect of aromatherapy massage, an essential oil used in the form of cream. Each participant had aromatherapy massage on lower legs for 20 minutes each time twice a week for four weeks. Numerical rating scale was used for self-report of pain intensity. Sleep disturbance was measured by Korean Sleep Scale consisting of 15 items. Stride length had been obtained by measuring the distance from the heel of one foot to the heel of the other foot. Results: There was a significant difference between the pain scores of the experimental group and that of control group after the aromatherapy massage (p=.001). Whereas, no significant differences between sleep scores of the two groups (p=.592) was found. The experimental group's stride length significantly increased than those of the control group (p=.009). Conclusion: Aromatherapy massage could be recommended as an effective intervention to decease pain and to increase stride length in the elderly with knee osteoarthritis.

• Journal of Advanced Research in Ocean Engineering
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• v.1 no.1
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• pp.55-62
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• 2015

Floating structure such as tension leg platform, semi-submersible and spar are widely used in field of oil exploration and renewable energy system. All of these structures have the base cylinder support structure which have effective rule in overall dynamic of response. So the accurate and reliable modeling is needed for optimum design and understanding the physical background of these systems. The aim of this article is an analytical discussion on stochastic modeling of floating cylinder based support structure but an applicable one. Due to this a mathematical mass-damper-spring system of a floating cylinder of HAWAII WTG offshore wind as an applicable and innovative system is adopted to model a coupled degrees using random vibration in analytical way. A fully develop spectrum is adopted to solve the stochastic spectrum analytically by a proper approximation. Some acceptable assumption is adopted. The simplified but analytical and innovative hydrodynamic analysis of this study not only will help researcher to concentrate more physically on hydrodynamic analysis of floating structures but also can be useful for any quick, simplified and closed form analysis of a complicated problem in offshore engineering.

• Proceedings of the KSME Conference
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• 2007.05a
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• pp.114-119
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• 2007

Sulfide stress cracking (SSC) of materials exposed to oilfield environment containing hydrogen sulfide $(H_{2}S)$ has been recognized as a materials failure problem. Laboratory data and field experience have demonstrated that extremely low concentration of $H_{2}S$ may be sufficient to lead to SSC failure of susceptible materials. In some cases, $(H_{2}S)$ can act synergistically with chlorides to produce corrosion and cracking failures. SSC is a form of hydrogen embrittlement that occurs in high strength steels and in localized hard zones in weldment of susceptible materials. In the heat-affected zones adjacent to welds, there are often very narrow hard zones combined with regions of high residual stress that may become embrittled to such an extent by dissolved atomic hydrogen. On the base of understanding on sulfide stress cracking and its mechanism, SSC resistance for the several materials, those are ASTM A106 Gr B using in the oil industries, are evaluated.