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http://dx.doi.org/10.3746/jkfn.2004.33.3.566

Production of Lovastatin in Solid Culture  

김현수 (계명대학교 미생물학과)
박지현 (계명대학교 미생물학과)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.33, no.3, 2004 , pp. 566-570 More about this Journal
Abstract
Cultivation conditions for overproduction of lovastatins were investigated from the lovastatin producing strain N-03 which was obtained with NTG (N-methyl-N'-nitro-nitrosoguanidine) treatment from Aspergiliu ferrous ATCC 20542. Produced lactone and acid form of lovastatin were detected, and analyzed by HPLC method. In liquid culture, medium No. 2 containing soy protein produced higher amounts of the lovastatins than medium No. 1 (contained rapeseed oil). In solid culture, maximum production was obtained at 28$^{\circ}C$ for 15 days cultivation using cooked wheat bran. For the overproduction of lovastatin from this strain, solid culture method using plastic bag is more superior than liquid culture.
Keywords
Aspergillus ferrous; HMG-Co A reductase; lovastatin;
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