• Journal of dental hygiene science
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• v.19 no.1
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• pp.9-22
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• 2019

Background: The purpose of this systematic review was to investigate the effects of topical fluoride gel application on dental caries prevention in the permanent teeth of children and adolescents. Methods: We searched the EMBASE, PubMed, and Cochrane Library databases for randomized controlled trials (RCTs) assessing the effects of self-applied or professionally applied topical fluoride gels in patients <18 years of age; the search was completed on April 1, 2018. All included trials involved an experimental group (fluoride gel application) and a control group (placebo or no treatment). The outcome measures were the D(M)FS and D(M)FT indices, which were compared between the two groups. Review Manager software was used for quantitative synthesis of the final selected articles, and a forest plot was generated via a meta-analysis conducted using a random effects model. Results: The results showed that the D(M)FS and D(M)FT indices were lower in the fluoride application group than in the control group, thus indicating that fluoride gel application was effective in dental caries prevention. We also performed a subgroup analysis to determine whether the effects of fluoride application differed if patients received oral prophylaxis (self or professional) before fluoride gel application. Therefore, the two groups showed slightly larger differences when studies without oral prophylaxis before fluoride gel application were considered; however, the difference was not statistically significant. Conclusion: These findings should be utilized to raise awareness about the caries-prevention effects of topical fluoride application among patients and guardians. Further RCTs should evaluate the effects of fluoride application with or without preceding oral prophylaxis, and appropriate fluoride application guidelines should be developed to maximize the effects of fluoride application in clinical practice.

• Journal of the korean academy of Pediatric Dentistry
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• v.26 no.2
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• pp.377-398
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• 1999

Calcium fluoride, created by topical fluoride application, is the reservoir for fluoride ion regulated by pH in the oral environment. Therefore, the amount and the maintenance of calcium fluoride have an important role in preventing dental caries. The aim of this study is to evaluate the effect of Nd:YAG laser irradiation on the generation of calcium fluoride and the acid resistance of tooth enamel. The bovine anterior permanent teeth were prepared (n=276), and divided into following groups : no treatment (control) fluoride application alone, laser irradiation alone, laser irradiation after fluoride application, and fluoride application after laser irradiation. And each group was subdivided based on the application time of 1.23% acidulated phosphate fluoride (APF) (5 min and 30 min) and the irradiation energy of Nd:YAG laser ($20J/cm^2\;and\;40J/cm^2$). In case of fluoride application, each group was divided according to KOH treatment. Twenty three treatment conditions were made for this experiment and twelve specimens were assigned to each treatment condition. In each treatment condition, ten specimens were used for chemical analysis and two specimens were observed under SEM. In groups without treating KOH, fluoride content and the depth of enamel dissolved were measured using enamel biopsy technique. In groups with treating KOH, the amount of calcium fluoride was measured by the treatment with 1 M KOH for 24 hours and enamel biopsy was performed after KOH treatment. The results were analyzed by the fluoride content and the depth of enamel dissolved by enamel biopsy, amount and thickness of calcium fluoride, and the surface structures of enamel. The results are as follows: 1. In groups without treating KOH, the fluoride content of removed enamel showed a positive relationship with the energy density of laser when the laser irradiated before fluoride application 2. In groups without treating KOH, the depth of enamel dissolved decreased more with the combined laser and fluoride treatment than with laser or fluoride treatment, except for the case of $20J/cm^2$ laser irradiation after 5 minute fluoride application (p<0.05). 3. The amount of calcium fluoride did not increased by laser treatment with no statistical significance(p>0.05). 4. The particle size of calcium fluoride increased in case of fluoride treatment after laser irradiation, compared with fluoride application alone. In case of laser treatment after fluoride application, the particle size of calcium fluoride increased and some of the particles fused as well. 5. There were no significant differences in the fluoride content of dissolved enamel between groups without treating KOH and control group, except for the case of laser irradiation after treatment of APF for 30 minutes (p>0.05). 6. In groups with treating KOH, depth of removed enamel in the groups of combined treatment with laser and fluoride was shallower than that in fluoride application groups (p<0.05). 7. In groups without treating KOH, the relationship between fluoride content and the depth of enamel dissolved showed more negative (Spearman correlation coefficient: -0.6281) than in groups with treating KOH (Spearman correlation coefficient: -0.3792). The greater amount of calcium fluoride could be found in case where there was a significant differences of the depth of enamel dissolved between groups with and without treating KOH. From these results, it can be concluded that laser seems to be a little effects on the amount of calcium fluoride formation, but has some effect on the lowering the solubility of calcium fluoride. As the combined treatment of laser and fluoride application showed more effective acid-resistant property, more extended recall period for fluoride application can be achieved with this combined treatment in the clinic.

• The Journal of the Korean dental association
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• v.48 no.6
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• pp.454-458
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• 2010

Dental caries is one of the most common chronic diseases in the world, which are caused by complex actions of oral such factors as the bacteria, food, tooth, saliva and other factors. Although this is one of the typical oral diseases, we can acquire a high prophylactic effect by use of proper prophylactic measures and management. At the beginning of the 1940s, fluorine was first introduced to prevent dental caries which now is widely used. The fluorine application effects are varied from different concentrations and categories of fluorine, and different application method and frequency, etc. There is great debate on the best application method at the present. Dental clinics use iontophoresis as the application method and use it clinically. It uses APF (1.23%, Acidulated phosphate fluoride, APF) and uses 2% NaF so as to encourage more absorption of fluorine. Recently, fluoride varnish, which uses admixture mucus of colophony resin into 5% NaF, and a variety of forms that can be applied in the oral cavity are still being continuously researched. When using fluoride topical application on the enamel surface, it was highly recommended that fluoride varnish be used directly after fluoride iontophoresis rather than fluoride iontophoresis only or fluoride varnish by itself. The new method is more effective and does not need repeated application.

• Restorative Dentistry and Endodontics
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• v.41 no.2
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• pp.121-129
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• 2016

Objectives: The purpose of this study was to assess the effect of single and combined applications of fluoride on the amount of fluoride release, and the remineralization and physical properties of enamel. Materials and Methods: Each of four fluoride varnish and gel products (Fluor Protector, FP, Ivoclar Vivadent; Tooth Mousse Plus, TM, GC; 60 Second Gel, A, Germiphene; CavityShield, CS, 3M ESPE) and two fluoride solutions (2% sodium fluoride, N; 8% tin(ii) fluoride, S) were applied on bovine teeth using single and combined methods (10 per group), and then the amount of fluoride release was measured for 4 wk. The electron probe microanalysis and the Vickers microhardness measurements were conducted to assess the effect of fluoride application on the surface properties of bovine teeth. Results: The amount of fluoride release was higher in combined applications than in single application (p < 0.05). Microhardness values were higher after combined applications of N with FP, TM, and CS than single application of them, and these values were also higher after combined applications of S than single application of A (p < 0.05). Ca and P values were higher in combined applications of N with TM and CS than single application of them (p < 0.05). They were also increased after combined applications of the S with A than after single application (p < 0.05). Conclusions: Combined applications of fluoride could be used as a basis to design more effective methods of fluoride application to provide enhanced remineralization.

• Journal of the korean academy of Pediatric Dentistry
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• v.23 no.2
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• pp.306-326
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• 1996

The purpose of this study was to compare the enamel fluoride uptake and anticariogenic effect following topical application with different physical form of fluoride and application time. The results can be summarized as follows: 1. While the 4-minute applicaton increased the enamel fluoride uptake significantly than 1-minute application regardless of physical form of applied topical fluoride agents, no siginificant difference could be found between foam and gel type when applied for the identical period of time. 2. The application time or the physical form of topical agents had no singificant influence on the reduction of caries lesion. 3. Based upon the above-mentioned results of this study, it cannot be concluded that the amount of enamel fluoride uptake has an absolute impact on the change of lesion depth. Therefore, the clinical application of 1-minute topical fluoride application which appears to have a similar anticariogenic efficacy to 4-minute fluoride application may be encouraged.

• Bulletin of the Korean Chemical Society
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• v.33 no.7
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• pp.2145-2148
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• 2012

A new thiourea based receptor (1) was synthesized and applied to fluoride ion recognition in acetonitrile solution. Receptor 1 displayed dual changes in absorption and fluorescence emission intensities selectively for fluoride ions. The interaction of 1 with fluoride undergoes a deprotonation process that is confirmed by $^1H$ NMR titration.

• Journal of Korean society of Dental Hygiene
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• v.16 no.4
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• pp.525-530
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• 2016

Objectives: The purpose of the study is to investigate remineralization effect according to application cycle of fluoride varnish in preschool children. Methods: The study subjects were fifty six children (92 teeth) having one or more early dental caries lesion. Fluoride varnish was applied to the primary area of maxillary and anterior mandibular teeth with the interval of one month, three months, and six months. Results: Dft index was 3.54 in male and 3.44 in female. The fluorescence loss(${\Delta}F$) value due to early caries lesions showed a significant difference in experiment groups I and II after the application of fluoride varnish, but there was no significant difference in experiment group III. After fluoride varnish application, there was a significant change in experimental group I and III. The maximum fluorescence loss(${\Delta}Fmax$) from early caries lesions showed a significant difference after application of the fluoride varnish in all three experiment groups of I, II, and III(p<0.001). Conclusions: Fluoride varnish should be recommended and applied to the children of high risk caries group in every three months.

• Clinical and Experimental Pediatrics
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• v.51 no.2
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• pp.129-133
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• 2008

Dental caries is the first disease to cause the pathological extraction of teeth in children. The complete prevention of dental caries is not achieved by toothbrushing alone. The use of fluoride and pit and fissure sealant is regarded as key tools to prevent dental caries. Fluoride-containing tablets or multi-vitamins and community water fluoridation can be used as systemic application techniques. Professional fluoride application, fluoride iontophoresis on teeth, fluoride mouth rinsing and fluoride-containing toothpaste can be used as local application techniques. Pit and fissure sealant is mainly used to prevent dental caries on occlusal surfaces of premolars and molars. Sweeteners not to occur dental caries has been developed to substitute sucrose. Dental erosion increases according to the high consumption of acidic soft drink or beverages. The appropriate use of fluoride and pit and fissure sealant are recommended to prevent dental caries effectively and the education is required to reduce the consumption of acidic soft drinks or beverages to decrease dental erosion.

• Journal of the korean academy of Pediatric Dentistry
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• v.24 no.1
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• pp.148-172
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• 1997

Sixty human premolar teeth were used for this in vitro study. After each tooth was sectioned mesiodistally, one half was used for the experimental group and the other half for the control. Three groups were made for each fluoride applying method and twenthy teeth were assigned to each group. Ten teeth were used for evaluating total fluoride amount and the other ten were used for firmly-bound fluoride. Fluorshield was used for fluoride-releasing sealant and 1.23% APF, 0.05% NaF were used for topical application fluorides. Each tooth was cleaned with a tooth brush using nonfluoride containing pumice before the experiment. In the sealant group, fluoroshield was applied to the enamel surface without etching procedure and stored in $37^{\circ}C$ saline for 30 days. After 30 days, sealant was removed with explorer without scratching the enamel surface and washed with distilled water and dried. In the APF group, each tooth was immersed in 1.23% APF for 30 min then washed and dried in the same manner. In the NaF group, each tooth was immersed in 0.05% NaF for 24 hours then washed and dried as described above. After each fluoride regimen was applied, ten teeth were randomly selected from each group and immersed in 1M KOH solution for 24 hours to remove loosely-bound fluoride possibly deposited by the three different fluorides applied. In each group, total fluoride amount deposited and the amount of enamel removed by acid biopsy were calculated. After loosely-bound fluoride was removed, firmly-bound fluoride deposited and the amount of enamel removed by acid biopsy were also calculated. Total fluoride amount deposition was significantly increased in the APF and NaF groups, but not in the sealant group. Amount of enamel removed by acid-biopsy was also significantly diminished in the APF and NaF groups, but not in the sealant groups. After loosely-bound fluoride was removed from each groups, no statistical difference was found in the amount of firmly-bound fluoride in any groups. Also no effect of firmly-bound fluoride on enamel dissolution was shown in any groups after loosely-bound fluoride was removed from each group. In conclusion, topical application method of APF or NaF is more effective than fluoride-releasing sealant application to make $CaF_2$ coating on enamel surface and $CaF_2$ coating is the main source for anticariogenic effect of fluoride. However, longterm anticariogenic effect of fluoride-releasing sealant should be further evaluated.

• Journal of the korean academy of Pediatric Dentistry
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• v.36 no.3
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• pp.377-384
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• 2009

The purpose of this study is to investigate the residual fluoride concentration of fluoride tape in oral cavity which made by spraying NaF on carboxymethylcellulose base. After 1, 3, 5, 7 hours and 1, 2, 3 days of applicating APF gel(60seconds $taste^{(R)}$, 1.23% APF gel, Group I), Fluoride varnish($CavityShield^{TM}$, 5% NaF, Group II) and Fluoride tape(SCMC-T-5, 5% NaF, Trial product, Group III) in oral cavity of 27 healthy adults in their twenties, the result of fluoride concentration in unstimulated whole saliva which measured by using fluoride sensitive electrode made up to following conclusion. 1. Until 7 hours after application in every group, it showed significantly higher fluoride concentration in saliva than baseline value but at 1, 2, 3 days after application, there were no significant differences between measurements and baseline value(p>0.05). 2. Until 7 hours after application at every time, mean fluoride concentration in saliva was higher in the order of Group II, I and III. 3. 1 hour and 3 hours after application, Group II revealed significantly higher fluoride concentration than Group III(p<0.05), but there were no significant differences between Group Ⅰ and Group III in every time.