• Transactions of the Korean Society of Mechanical Engineers A
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• v.36 no.10
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• pp.1139-1146
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• 2012

An alternative approach for topology optimization of steady incompressible Navier-Stokes flow problems is presented by using P1 nonconforming finite elements. This study is the extended research of the earlier application of P1 nonconforming elements to topology optimization of Stokes problems. The advantages of the P1 nonconforming elements for topology optimization of incompressible materials based on locking-free property and linear shape functions are investigated if they are also valid in fluid equations with the inertia term. Compared with a mixed finite element formulation, the number of degrees of freedom of P1 nonconforming elements is reduced by using the discrete divergence-free property; the continuity equation of incompressible flow can be imposed by using the penalty method into the momentum equation. The effect of penalty parameters on the solution accuracy and proper bounds will be investigated. While nodes of most quadrilateral nonconforming elements are located at the midpoints of element edges and higher order shape functions are used, the present P1 nonconforming elements have P1, {1, x, y}, shape functions and vertex-wisely defined degrees of freedom. So its implentation is as simple as in the standard bilinear conforming elements. The effectiveness of the proposed formulation is verified by showing examples with various Reynolds numbers.

• Archives of Pharmacal Research
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• v.25 no.6
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• pp.770-780
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• 2002

The airway surface liquid (ASL), often referred to as mucus, is a thin layer of fluid covering the luminal surface of the airway. The major function of mucus is to protect the lung through mucociliary clearance against foreign particles and chemicals entering the lung. The mucus is comprised of water, ions, and various kinds of macromolecules some of which possess the protective functions such as anti-microbial, anti-protease, and anti-oxidant activity. Mucus glycoproteins or mucins are mainly responsible for the viscoelastic property of mucus, which is crucial for the effective mucociliary clearance. There are at least eight mucin genes identified in the human airways, which will potentially generate various kinds of mucin molecules. At present, neither the exact structures of mucin proteins nor their regulation are understood although it seems likely that different types of mucins are involved in different functions and might also be associated with certain airway diseases. The fact that mucins are tightly associated with various macromolecules present in ASL seems to suggest that the defensive role of ASL is determined not only by these individual components but rather by a combination of these components. Collectively, mucins in ASL may be compared to aircraft carriers carrying various types of weapons in defense of airborne enemies.

• Proceedings of the KSME Conference
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• 2007.05b
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• pp.3383-3388
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• 2007

To compare the sensor performance of AE leak diagnosis system which can measure valve leak conditions, AE activities such as RMS voltage level, AE signal trend, leak rate degree according to AE database, FFT spectrum were measured on valve of the simulated test system for power plant. AE activities were recorded and analyzed from various operating conditions including different temperature, pressure difference, valve size and fluid using both piezoelectric acoustic emission sensor and Pb-Free acoustic emission sensor. The results of this study are utilized to select the type of sensors, the frequency band for filtering and thereby to improve the signal-to-noise ratio for diagnosis or monitoring of valves in operation. As the final result of application study above, portable type leak diagnosis system by AE was developed. The outcome of the study can be definitely applied as a means of the diagnosis or monitoring system for energy saving and prevention of accident for power plant valve.

• Korean Journal of Veterinary Research
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• v.5 no.1
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• pp.27-30
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• 1965

In a cattle which had died of extreme emaciation caused by cachexic condition, a huge cyst of $45{\times}35{\times}20$cm, in size was found at the rumen. The cyst having with the narrow stalk which ended in blind sac attached firmly to the rumen by fibrinous or fibrous adhesion and, contained the lightly yellowish, clear exudative fluid of about 20 l, in volume. Grossly, the thickness of the cyst wall was 10~14mm, and its inner portion of the half was very rigid and colored with milky white in contrast with soft and edematous outer portion of the half. Microscopically the inner portion of the cyst wall was consisted of scarred fibrous tissue and possessed at its inner margin a little amount of the muscle fibers which had degenerated passably. These were confirmed as the muscle fibers in specific staining property by Van-Gieson's and Mallory-Azan stain. On regarding to above findings of gross and microscopic pictures, it was considered to be a pseudo-diverticulous cyst composed of the serosa and the muscle layer deriving from the wall of the rumen. And it was suggested that the cyst had been growing up to big size by storage of the plenty exudate arisen from its wall and was separated from the rumen at the end of its stalk.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.32 no.2
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• pp.158-165
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• 2008

The carbon dioxide properties change sharply near the critical or pseudo-critical point in the heat transfer processes. The reduction in turbulent, convective heat transfer parameters observed in some supercritical data and in experiments with common gases can be due to property variation, acceleration, buoyancy or combinations of these phenomena, depending on the conditions of the applications. In this study, the measurement for the secondary flow driven by buoyancy was carried out on the supercritical carbon dioxide turbulent flows in the different boundary condition with the constant mass flow rate. The available measuring techniques were used to clarify the behaviour of any supercritical fluid. Laser Doppler Velocimeter (LDV) and a special device was used to measure the secondary velocity and turbulent characteristics of the supercritical flows.

• 유체기계공업학회:학술대회논문집
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• 2002.12a
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• pp.258-263
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• 2002

A numerical analysis using 2-D unsteady compressible program is conducted to explain characteristics of rotating stall such as rotating speed and number of stall cells in an one-stage axial compressor. Unlike an axial compressor which has only a rotor, in one-stage axial compressor a rotating stall is generated by rotor/stator interaction and tack pressure rising without any artificial disturbance and modeling. As a back pressure is raised, the separation of suction side at blades is increased uniformly, but because of the discrepancy of blockage effect by stator, the disturbances are generated to form a stall cell. Once the stall cell is formed, regularly the stall cell are rotating through rotor blades. When the speed of rotor is design speed the rotating speed of stall cell is $83.3\%$ of rotor rotating speed. When the speed of rotor is $80\%$ of design speed, the speed of rotating stall is $88.2\%$ of rotor speed. The number of generated stall cell are also varied for rotor speed and back pressure.

• The Journal of the Korea institute of electronic communication sciences
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• v.15 no.5
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• pp.949-958
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• 2020

The functions of shock absorbers are to dampen body, suspend motions, dissipate impact energy, and control tire force variation. During the operation, hydraulic oil is passed between the chambers via a flow restrictions. Therefore the damping force characteristics of shock absorber is determined by the characteristics of orifices and flow restrictions. The uncertainty in design variable affects the performance of suspension system strongly. But, the researches about the influence of uncertainty in design variable such as a fluid restriction's property of shock absorber, on the suspension system performance was hardly ever proposed. In this paper, we used statistical method of Latin Hypercube sampling, and the effects of design variables uncertainty on the performance of suspension system was presented.

• Journal of the Korean Magnetic Resonance Society
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• v.24 no.3
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• pp.91-95
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• 2020

Transthyretin (TTR) is an abundant protein in blood plasma and cerebrospinal fluid (CSF), working as a homo-tetrameric complex to transport thyroxine (T₄) and a holo-retinol binding protein. TTR is well-known for its amyloidogenic property; several types of systemic amyloidosis diseases are caused by aggregation of either wild-type TTR or its variants, for which more than 100 mutations were reported to increase the amyloidogenicity of TTR. The rate-limiting step of TTR aggregation is the dissociation of a monomeric subunit from a tetrameric complex. A wide range of biochemical and biophysical techniques have been employed to elucidate the TTR aggregation processes, among which nuclear magnetic resonance (NMR) spectroscopy contributed much to characterize the structural and functional features of TTR during its aggregation processes. The present review focuses on discussing the recent advances of our understanding to the amyloidosis mechanism of TTR and to the structural features of its monomeric aggregation-prone state in solution. We expect that the present review provides novel insights to appreciate the molecular basis of TTR amyloidosis and to develop novel therapeutic strategies to treat diverse TTR-related diseases.

• Wind and Structures
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• v.12 no.1
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• pp.63-76
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• 2009

The vortex-induced vibration of an ${\sqcap}$-shaped bridge deck sectional model is studied in this paper via the wind tunnel experiment. The vibratory behavior of the model shows that there is a transition of the predominant vibration mode from the vertical to the rotational degree of freedom as the wind speed increases gradually or vice versa as the wind speed decreases gradually. The vertical vibration is, however, much weaker in the latter case than in the former. This is a phenomenon which is difficult to model by existing parametric models for vortex-induced vibrations. In order to characterize the aeroelastic property of the ${\sqcap}$-shaped sectional model, a time domain force identification scheme is proposed to identify the time history of the aeroelastic forces. After the application of the proposed method, the resultant fluid forces are re-sampled in dimensionless time domain so that reduced frequency response function (RFRF) can be obtained to explore the properties of the vortex-induced wind forces in reduced frequency domain. The RFRF model is proven effective to characterize the correlation between the wind forces and bridge deck motions, thus can explain the aeroelastic behavior of the ${\sqcap}$-shaped sectional model.

• Journal of Chest Surgery
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• v.23 no.6
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• pp.1152-1157
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• 1990

Colloid solution is commonly used to increase the oncotic pressures of priming solutions used in the cardiopulmonary bypass circuit. To study the effectiveness of this practice, we retrospectively evaluated 24 patients undergoing cardiac operations to receive isoelectric solution plus 50 gm of albumin[group A], isoelectric solution plus 25 gm of albumin[group B] and isoelectric solution without albumin[group C] as the prime solution for the bypass circuit. Various clinical parameters related to the perioperative fluid balance, cardiopulmonary function, and renal function were studied. There were no differences between the three groups with regard to postoperative clinical parameter of cardiopulmonary, liver function and renal function. But at the previous report by Cho et al. [38], there was a significant difference between groups with regard to hematologic property, especially in crenated red blood cells. These hematologic events did not affect the clinical outcome but thorough evaluations are needed in order to prove the clinical effect of crenated red blood cell. We conclude that there is no clinically detectable advantage for the routinely supplementing of albumin to the priming solution of bypass circuit in cardiac operations. Whether this practice can be of value in selected cases needs to be further studied.