• Journal of Mechanical Science and Technology
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• v.15 no.2
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• pp.232-238
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• 2001

Fast Fourier Transformation is employed to convert the head variation of a pipeline in the time domain to the amplitude of the frequency domain. Applying method of characteristics to a pipeline provides a significant frequency range for a surge introduced from the valve modulation. Inverse Fast Fourier Transformation and a Finite Impulse Response Filter can be used to remove any possible noise existing from the significant frequency range of an unsteady condition. A filtered signal shows higher potential for the inverse calculation of leakage detection than the noise-added signal does. The respective performances of Inverse Fast Fourier Transformation and a Finite Impulse Response Filter are compared in terms of leakage detection capability. Characteristics of the frequency range for multiple leakages were investigated to validate the effectiveness of the noise control method in the frequency domain.

• 한국전산유체공학회:학술대회논문집
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• 2011.05a
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• pp.608-609
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• 2011

In this study, we tried to validate FLUENT solver model and domain setting for the problem of convective heat transfer in multiple tube bank under transitional zone. We have paid special attention to verify proper boundary conditions and the grid convergence. Through validation work, it is found that unsteady solution method with two-dimensional simulation domain can produce reasonable accurate results compared with existing experimental data. Simulation results with steady solution generates relatively large error. We found that both steady and unsteady method for three-dimensional domain shows acceptable accuracy. Further parametric study for deriving correlation from transverse and longitudinal pitch is currently underway.

• International Journal of Ocean System Engineering
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• v.1 no.3
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• pp.155-164
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• 2011

The second-order motion characteristics of a semi-submersible are investigated in regular waves. A higher-order boundary element method in a frequency domain and a finite element method in a time-domain were applied to the numerical analysis of the nonlinear hydrodynamic force and motion characteristics of semi-submersibles in view point of potential flow. Various aspects of nonlinear effects on the heave and roll of a semi-submersible were numerically investigated and some selected cases were compared with the model test data.

• 한국전산유체공학회:학술대회논문집
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• 2003.10a
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• pp.86-87
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• 2003

Unstructured grid system is suitable for flows of complex geometries. For problems with moving boundary walls, the grid system must be changed and deformed with time if we use a body fitted grid system. In this paper, a new moving-grid finite-volume method on unstructured grid system is proposed and developed for unsteady compressible flows with shock waves. To assure geometric conservation laws on moving grid system, a control volume on the space-time unified domain is adopted for estimating numerical flux. The method is described and applied for two-dimensional flows.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.9 no.3
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• pp.595-600
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• 2005

A micro flow sensor on silicon substrate allows the fabrication of small components where many different functions can be integrated so that the functionality of the sensors can be increased. Further more, the small size of the elements these sensors can be quite fast. A thermal mass flow sensor measures the asymmetry of temperature profile around the heater which is modulated by the fluid flow. In normal, a mass flow sensor is composed of a central heater and a pair of temperature sensing elements around the heater A new 2-D wide range micro flow sensor structure with three pairs of temperature sensors and a central heater was proposed and numerically simulated by Finite Difference formulation to confirm the feasibility of the flow sensor structure in time domain.

• International Journal of Naval Architecture and Ocean Engineering
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• v.11 no.2
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• pp.923-938
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• 2019

Surge motion of top-end platform induced by periodic wave makes marine flexible riser encounter equivalent sheared-oscillatory flow, under which the Vortex-induced Vibration (VIV) response will be more complicated than pure sheared flow or oscillatory flow cases. Based on a time domain force-decomposition model, the VIV response characteristics under sheared-oscillatory flows are investigated numerically in this paper. Firstly, the adopted numerical model is validated well against laboratory experiments under sheared flow and oscillatory flow. Then, 20 sheared-oscillatory flow cases with different oscillation periods and top maximum current velocities are designed and simulated. Under long and short oscillation period cases, the structural response presents several similar features owing to the instantaneous sheared flow profile at each moment, but it also has some different patterns because of the differently varying flow field. Finally, the effects and essential mechanism of oscillation period and top maximum current velocity on VIV response are discussed systematically.

• Molecules and Cells
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• v.43 no.7
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• pp.662-670
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• 2020

We have investigated the involvement of the pre-mRNA processing factor 4B (PRP4) kinase domain in mediating drug resistance. HCT116 cells were treated with curcumin, and apoptosis was assessed based on flow cytometry and the generation of reactive oxygen species (ROS). Cells were then transfected with PRP4 or pre-mRNA-processing-splicing factor 8 (PRP8), and drug resistance was analyzed both in vitro and in vivo. Furthermore, we deleted the kinase domain in PRP4 using Gateway™ technology. Curcumin induced cell death through the production of ROS and decreased the activation of survival signals, but PRP4 overexpression reversed the curcumin-induced oxidative stress and apoptosis. PRP8 failed to reverse the curcumin-induced apoptosis in the HCT116 colon cancer cell line. In xenograft mouse model experiments, curcumin effectively reduced tumour size whereas PRP4 conferred resistance to curcumin, which was evident from increasing tumour size, while PRP8 failed to regulate the curcumin action. PRP4 overexpression altered the morphology, rearranged the actin cytoskeleton, triggered epithelial-mesenchymal transition (EMT), and decreased the invasiveness of HCT116 cells. The loss of E-cadherin, a hallmark of EMT, was observed in HCT116 cells overexpressing PRP4. Moreover, we observed that the EMT-inducing potential of PRP4 was aborted after the deletion of its kinase domain. Collectively, our investigations suggest that the PRP4 kinase domain is responsible for promoting drug resistance to curcumin by inducing EMT. Further evaluation of PRP4-induced inhibition of cell death and PRP4 kinase domain interactions with various other proteins might lead to the development of novel approaches for overcoming drug resistance in patients with colon cancer.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.17 no.3
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• pp.916-937
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• 2023

Most of the existing Distributed Denial-of-Service mitigation schemes in Software-Defined Networking are only implemented in the network domain managed by a single controller. In fact, the zombies for attackers to launch large-scale DDoS attacks are actually not in the same network domain. Therefore, abnormal traffic of DDoS attack will affect multiple paths and network domains. A single defense method is difficult to deal with large-scale DDoS attacks. The cooperative defense of multiple domains becomes an important means to effectively solve cross-domain DDoS attacks. We propose an efficient multi-domain DDoS cooperative defense mechanism by integrating blockchain and SDN architecture. It includes attack traceability, inter-domain information sharing and attack mitigation. In order to reduce the length of the marking path and shorten the traceability time, we propose an AS-level packet traceability method called ASPM. We propose an information sharing method across multiple domains based on blockchain and smart contract. It effectively solves the impact of DDoS illegal traffic on multiple domains. According to the traceability results, we designed a DDoS attack mitigation method by replacing the ACL list with the IP address black/gray list. The experimental results show that our ASPM traceability method requires less data packets, high traceability precision and low overhead. And blockchain-based inter-domain sharing scheme has low cost, high scalability and high security. Attack mitigation measures can prevent illegal data flow in a timely and efficient manner.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.35 no.5
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• pp.299-308
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• 2022

This study was conducted to predict the tendency for heat exchange and boil-off gas (BOG) in a liquefied hydrogen tank under sloshing excitation. First, athe fluid domain excited by sloshing was modeled using a multiphase-thermal flow domain in which liquid hydrogen and hydrogen gas are in the saturated state. Both the the volume of fluid (VOF) and Eulerian-based multi-phase flow methods were applied to validate the accuracy of the pressure prediction. Second, it was indirectly shown that the fluid velocity prediction could be accurate by comparing the free surface and impact pressure from the computational fluid dynamics with those from the experimental results. Thereafter, the heat ingress from the external convective heat flux was reflected on the outer surfaces of the hydrogen tank. Eulerian-based multiphase-heat flow analysis was performed for a two-dimensional Type-C cylindrical hydrogen tank under rotational sloshing motion, and an inflation technique was applied to transform the fluid domain into a computational grid model. The heat exchange and heat flux in the hydrogen liquid-gas mixture were calculated throughout the analysis,, whereas the mass transfer and vaporization models were excluded to account for the pure heat exchange between the liquid and gas in the saturated state. In addition, forced convective heat transfer by sloshing on the inner wall of the tank was not reflected so that the heat exchange in the multiphase flow of liquid and gas could only be considered. Finally, the effect of sloshing on the amount of heat exchange between liquid and gas hydrogen was discussed. Considering the heat ingress into liquid hydrogen according to the presence/absence of a sloshing excitation, the amount of heat flux and BOG were discussed for each filling ratio.

• Journal of computational fluids engineering
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• v.19 no.3
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• pp.20-23
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• 2014

The flow pattern inside the inlet chamber of the tube side is one of the key parameters influencing on the performances of the shell-and-tube type of heat exchangers(STHE). In order to improve the flow distribution, the baffle shaped as the porous plate is installed in the inlet chambers. In the present study, numerical simulation has been performed to investigate the flow features of the tube side of the STHE in sense of the hydraulic performances. The flow fields have been analysed by the three-dimensional Navier-Stokes solvers with the proper turbulent models. Computational domain is ranged in the whole of the tube side of the STHE. The numerical results showed that the presence of the baffles improves the redistribution of the flow injecting to the tube bundels. The good agreements of the numerical results with the experimental results of PIV measurements have been shown for the validation of the numerical methods adopted in the present papers.