• Fire Science and Engineering
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• v.18 no.1
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• pp.42-48
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• 2004

The deterministic modeling techniques like Zone model and Field model are mainly used for thermal distribution and smoke flow at fire case in multi use facilities. While Zone model analyse fire simulation by dividing spaces by 2 section, the Field model dividing many cells. However, the difficultly follows to prove efficiency between the two models when it applys. Therefore new modeling development is required which in closes to real situation by verify number algorithm and related data for fire modeling. The paper analyses the efficiency of two different fire modeling at interior spaces of multiplex cinema theater. It is found that the zone model for average distribution and the field model for detail space phenomenon are relevant to apply. Also, Filed model is useful to the result that fire analysis and position of detector and review for smoke control system.

• Nutrition Research and Practice
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• v.7 no.4
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• pp.249-255
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• 2013

In this study, the protective effects of EGCG on L-3,4-dihydroxyphenylalanine (L-DOPA)-induced oxidative cell death in catecholaminergic PC12 cells, the in vitro model of Parkinson's disease, were investigated. Treatment with L-DOPA at concentrations higher than $150{\mu}M$ caused cytotoxicity in PC12 cells, as determined using the 3-(4,5-dimetylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and flow cytometry detection. The apoptotic ratio was similar in cells treated with $100{\mu}M$ EGCG plus $150{\mu}M$ L-DOPA (5.02%) and the control (0.96%) (P > 0.05), and was lower than that of cells treated with L-DOPA only (32.24%, P < 0.05). The generation level of ROS (% of control) in cells treated with EGCG plus L-DOPA was lower than that in cells treated with L-DOPA only (123.90% vs 272.32%, P < 0.05). The optical density in production of TBARS in cells treated with L-DOPA only was higher than that in the control ($0.27{\pm}0.05$ vs $0.08{\pm}0.04$, P < 0.05), and in cells treated with EGCG only ($0.14{\pm}0.02$, P < 0.05), and EGCG plus L-DOPA ($0.13{\pm}0.02$, P < 0.05). The intracellular level of GSH in cells treated with EGCG plus L-DOPA was higher than that in cells treated with L-DOPA only ($233.25{\pm}16.44$ vs $119.23{\pm}10.25$, P < 0.05). These results suggest that EGCG protects against L-DOPA-induced oxidative apoptosis in PC12 cells, and might be a potent neuroprotective agent.

• Journal of The Geomorphological Association of Korea
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• v.19 no.2
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• pp.69-79
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• 2012

The aim of this study is to analyze the mid-term changes of beach and dune morphology at Sohwang beach, Korea using by Total Station. Measurements executed 4 times during two year. Based on ArcInfo as point cloud obtained through precise measurement data by Total Station, alteration of beach and dune was analyzed at DEM, of which cell size is about 1m. Since these artificial constructions have influenced current systems of this region, the large-scale sand movements above mentioned have occurred around the jetty and the sea-wall. There occurred sedimentation in the north of the Jetty and erosion in the south of the Jetty, which is installed at the central part of object area. The direction of recent topographic development does not coincide with that of wind, and, rather, topographic changes occurred mainly at beaches and dunes due to the transformation of coastal water flow caused by artificial structure nearby. If precise measurement is conducted periodically, and long term monitoring is carried out by installing equipment measuring movement pattern of sediment around artificial structure, cause of topographic change around the object area could be discovered.

• Journal of the Korean Society of Propulsion Engineers
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• v.17 no.2
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• pp.9-15
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• 2013

An effect of a spiral turbulent ring, so-called Shchelkin spiral, on a detonation performance was studied experimentally for acetylene and oxygen mixture. A couple of dynamic pressure transducers were used to calculate a detonation wave velocity by a time difference between two pressure peaks. In addition, impulse was measured by a load cell and the impulse was used to analyze the spiral effect on the detonation performance. A CFD analysis was adopted to calculate mass flow rates of the propellants and the minimum filling time. The maximum velocity and pressure were measured at the equivalence ratio of 2.4, and the measured values showed similar trend to C-J conditions calculated from CEA. For the shorter chamber with the short spiral, the maximum detonation velocity was appeared. In contrast, the longer chamber without the spiral showed the maximum thrust performance.

• Journal of Ship and Ocean Technology
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• v.12 no.3
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• pp.36-54
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• 2008

A jet stream applied tangential to a curved surface in fluid increases lift force by strengthening circulation around the surface and this phenomenon is known as the Coanda effect. Many experimental and numerical studies have been performed on the Coanda effect and the results found to be useful in various fields of aerodynamics. Recently, preliminary studies on Coanda control surface are in progress to look for practical application in marine hydrodynamics since various control surfaces are used to control behaviors of ships and offshore structures. In the present study, the performance of a Coanda control surface with different geometries of the jet injection nozzle was surveyed to assess applicability to ship rudders. A numerical simulation was carried out to study flow characteristics around a section of a horn type rudder subjected to a tangential jet stream. The RANS equations, discretized by a cell-centered finite volume method were used for this computation after verification by comparing to the experimental data available. Special attentions have been given to the sensitivity of the lift performance of a Coanda rudder to the location of the slit (outlet) and intake of the gap between the horn and rudder surface at the various angles of attack. It is found that the location of the water intake is important in enhancing the lift because the gap functions as a conduit of nozzle generating a jet sheet on the rudder surface.

• Journal of the Korean Magnetics Society
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• v.24 no.1
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• pp.28-33
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• 2014

The change of rouleau formation of red blood cells in the hand stimulated by pulse magnetic field having a maximum intensity of 0.27 Tesla and pulse duration of 0.102 msec was investigated. Before pulse magnetic field stimulus, the red blood cells of test subject were adjoined over ten and the flow of cells was slowed. However after the stimulus in the hand during 10 minutes, the red blood cells adjoined over tens was spreaded out each other and its motion was fast. Also the red blood cells of left hand unstimulated by pulse magnetic field were spreaded out each other, even though the right hand was stimulated during 10 minute. It prove that the rouleau formation of red blood cells can be improve in the whole body in spite of stimulus in the hand because the blood is flowing a whole body.

• The Journal of Korean Obstetrics and Gynecology
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• v.20 no.3
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• pp.45-64
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• 2007

Purpose: This study was performed to evaluate anti-thrombotic and anti-inflammatory effects of NeungaSoJeokTang water extract (NSJT). Methods: In the study of anti-inflammatory effects, NSJT was investigated using cultured cells and murine models. As for the parameters of inflammation, levels of several inflammatory cytokines and chemical mediators which are known to be related to inflammation were determined in mouse lung fibroblast cells(mLFC) and RAW 264.7 cells. Results: Prior to the experiment, we evaluated sGOT, sGPT, BUN and creatine after the treatment. As a result, NSJT was innoxious on liver and kidney. In experiment of anti-thrombotic effect, NSJT inhibited the platelet aggregation induced by ADP and epinephrine, and inhibited pulmonary embolism induced by collagen and epinephrine. NSJT did not affect significantly the blood flow rate both in vitro and in vivo. NSJT increased platelet number and fibrinogen amount, and NSJT shortened PT and APTT in thrombus model induced by dextran. In experiment of anti-inflammatory effect, NSJT inhibited $IL-1{\beta}$, IL-6, $TNF-{\alpha}$, COX-2 and NOS-II mRNA expression in a concentration-dependent manner in RAW 264.7 cell line, and inhibited significantly NO production at 50, 100 ${\mu}g/ml$, and also inhibited ROS production in a concentration-dependent manner. NSJT inhibited $IL-1{\beta}$, IL-6 and $TNF-{\alpha}$ production significantly in serum of acute inflammation-induced Balb/c mice, and decreased $IL-1{\beta}$, IL-6 and $TNF-{\alpha}$ production in spleen tissue, but increased $IL-1{\beta}$, IL-6 and $TNF-{\alpha}$ production in liver tissue. NSJT increased survival rate at the 3th day in ICR mice with lethal endotoxemia induced by LPS. Conclusion: These results suggest that NSJT can be used for treating diverse female diseases caused by thrombosis and inflammation such as pelvic pain, pelvic inflammatory disease as well as vulvar pain due to vulvitis, vulvar vestibulitis and so on.

• Structural Engineering and Mechanics
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• v.60 no.6
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• pp.939-952
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• 2016

A compression to tensile load transforming (CTT) device was developed to determine indirect tensile strength of concrete material. Before CTT test, Particle flow code was used for the determination of the standard dimension of physical samples. Four numerical models with different dimensions were made and were subjected to tensile loading. The geometry of the model with ideal failure pattern was selected for physical sample preparation. A concrete slab with dimensions of $15{\times}19{\times}6cm$ and a hole at its center was prepared and subjected to tensile loading using this special loading device. The ratio of hole diameter to sample width was 0.5. The samples were made from a mixture of water, fine sand and cement with a ratio of 1-0.5-1, respectively. A 30-ton hydraulic jack with a load cell applied compressive loading to CTT with the compressive pressure rate of 0.02 MPa per second. The compressive loading was converted to tensile stress on the sample because of the overall test design. A numerical modeling was also done to analyze the effect of the hole diameter on stress concentrations of the hole side along its horizontal axis to provide a suitable criterion for determining the real tensile strength of concrete. Concurrent with indirect tensile test, the Brazilian test was performed to compare the results from two methods and also to perform numerical calibration. The numerical modeling shows that the models have tensile failure in the sides of the hole along the horizontal axis before any failure under shear loading. Also the stress concentration at the edge of the hole was 1.4 times more than the applied stress registered by the machine. Experimental Results showed that, the indirect tensile strength was clearly lower than the Brazilian test strength.

• Journal of the Korean Society of Hazard Mitigation
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• v.11 no.3
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• pp.157-163
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• 2011

In this study, after the target basin was divided into both overland and channel grids, the travel time from center of each grid cell to watershed's outlet was calculated based on the manning equation. Through this process, volumetric discharge was calculated according to the isochrones and finally, the direct runoff hydrograph was estimated considering watershed's hydrodynamic characteristics. Sanseong subwatershed located in main stream of Bocheong basin was selected as a target basin. The model parameters are only two: area threshold and channel velocity correction factor; the optimized values were estimated at 3,800 and 3.3, respectively. The developed model based on the tuned parameters led to well-matching results between observed and calculated hydrographs (mean of absolute error of peak discharge: 3.41%, mean of absolute error of peak time: 0.67 hr). Moreover, the analysis results regarding histogram of travel time-contribution area demonstrates that the proposed model characterizes relatively well hydrodynamic characteristics of the catchment due to effective rainfall.

• Journal of Microbiology and Biotechnology
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• v.31 no.10
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• pp.1331-1342
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• 2021

In this study, we evaluated the mechanism of long non-coding RNA MIR22 host gene (LncRNA MIR22HG) in osteosarcoma cells. Forty-eight paired osteosarcoma and adjacent tissues samples were collected and the bioinformatic analyses were performed. Target genes and potential binding sites of MIR22HG, microRNA (miR)-629-5p and tet methylcytosine dioxygenase 3 (TET3) were predicted by Starbase and TargetScan V7.2 and confirmed by dual-luciferase reporter assay. Cell Counting Kit-8, colony formation and flow cytometry assays were utilized to determine the viability, proliferation and apoptosis of transfected osteosarcoma cells. Pearson's analysis was introduced for the correlation analysis between MIR22HG and miR-629-5p in osteosarcoma tissue. Relative expressions of MIR22HG, miR-629-5p and TET3 were measured by quantitative real-time polymerase chain reaction or Western blot. MiR-629-5p could competitively bind with and was negatively correlated with MIR22HG, the latter of which was evidenced by the high expression of miR-629-5p and low expression of MIR22HG in osteosarcoma tissues. Overexpressed MIR22HG repressed the viability and proliferation but enhanced apoptosis of osteosarcoma cells, which was reversed by miR-629-5p upregulation. TET3 was the target gene of miR-629-5p, and the promotive effects of upregulated miR-629-5p on the viability and proliferation as well as its repressive effect on apoptosis were abrogated via overexpressed TET3. To sum up, overexpressed MIR22HG inhibits the viability and proliferation of osteosarcoma cells, which was achieved via regulation of the miR-629-5p/TET3 axis.