• 대한기계학회:학술대회논문집
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• 대한기계학회 2004년도 추계학술대회
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• pp.1510-1515
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• 2004

Aggregability of red blood cells (RBCs) was determined by a laser backscattering light analysis in a microfluidic channel. Available techniques for RBC aggregation often adopt a rotational Couette-flow using bob-and-cup system for disaggregating RBCs, which causes the system to be complex and expensive. A disposable microfluidic channel and vibration generating mechanism were used in the proposed new detection system for RBC aggregation. Prior to measurement, RBC aggregates in a blood sample were completely disaggregated by applying vibration-induced shear. With the present apparatus, the aggregation indexes of RBCs can be easily measured with small quantities of blood sample. The measurements with the present aggregometer were compared with those of LORCA and showed a strong correlation between them. The aggregability of the defibrinogenated blood RBCs is markedly lower than that of the normal RBCs. The noble feature of this design is the vibration-induced disaggregation mechanism, which enables to incorporate disposable element that holds the blood sample.

• 한국초전도ㆍ저온공학회논문지
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• 제20권2호
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• pp.11-15
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• 2018

In this study, a cancer treatment by accumulating and aggregating ferromagnetic particles in newborn blood vessels was examined. It is necessary for this treatment to control dispersion-aggregation property of ferromagnetic particles. Ferromagnetic particles required in this method disperse at low magnetic field, aggregate at high magnetic field and maintain the aggregation even after removal of the magnetic field. In order to control the dispersion-aggregation property, the surface of magnetite particles was modified with higher fatty acids having different lengths. As a result, we succeeded to prepare propionic acid-modified magnetite particles that form irreversible aggregation by magnetic field. The model experiments simulating newborn blood vessels showed that these particles can block the flow by the magnetic field, and the blockage was maintained after removal of the magnetic field.

• 전기학회논문지
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• 제56권8호
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• pp.1367-1372
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• 2007

The modem large electric power system has made power system analysis much more complex and difficult. For effective analysis of the power system, model reduction and aggregation is required. In this paper, a new relation index to identify the coherency among the generators is presented and also a new aggregation method is presented to aggregate the coherent generators in the large scale power system while matching the power flow. In order to demonstrate the effects of this aggregation method, it is applied to the IEEE 39 bus test power system and to the 2006 summer power system of Korea Electric Power Corporation, and the simulation results are compared with those of the original system.

• Toxicological Research
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• 제14권3호
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• pp.333-339
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• 1998

Sambutoxin, a newly purified mycotoxin in Koea, caused hemorrhage in the stomach and intestine of rats. To elucidate the mechanism of hemorrhage, effects of sambutoxin on rabbit platelet aggregation were investigated. First of all, the effects of sambutoxin on the platelet aggregation response and ATP release from platelet by various appregating factors were investigated. And then the role of $Ca^{2+}$ on the platelet aggregation was investigated by flow cytometer. Finally, morphological effect of sambutoxin on platelet ultrastructure was examined by transmission electron microscope. Sambutoxin inhibited aggregation induced by ADP, collagen, thrombin, and arachidonic acid and decreased platelet activating factor-induced disaggregation time in a dose dependent manner. Sambutoxin also decreased thrombin and arachidonic acid-induced ATP release, but increased all factors induced $Ca^{2+}$ release. Sambutoxin showed severe ultrastructural changes of platelet such as appearance of disorganization debri of cellular organelle in intercellular space. Our results indicate that sambutoxin inhibitis rabbit platelet aggregation, and it may be party due to the decrease of ATP release. However, it is not clear whether the antiaggregating effect of sambutoxin is related to $Ca^{2+}$ increase.

• 동의생리병리학회지
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• 제27권2호
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• pp.239-245
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• 2013

In in vitro study, the anti-platelet aggregation effect of Shiitake mushroom extract was examined by measuring the collagen induced platelet aggregation and the DPPH radical scavenging. In in vitro study, anti-thrombotic effect of Shiitake mushroom extract was examined using the carotid artery thrombosis rat model. Carotid artery thrombosis rat model was made by 35% $FeCl_3$ treatment. After that, we investigate thrombus weight and blood flow. In platelet aggregation test, the extract significantly inhibited platelet aggregation in a concentration dependent manner(p<.001). Also, extract increased DPPH radical scavenging activity in a concentration dependent manner. Extract significantly inhibited thrombus weight to compare with control group. And blood passage time were shorter in the Shiitake mushroom extract supplemented groups than in control group. These results provide experimental evidence that Shiitake mushroom can be used to prevent platelet aggregation and thrombosis, then could apply the clinical diseases such as cardiovascular disease, and so on.

• 대한한방내과학회지
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• 제16권1호
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• pp.181-196
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• 1995

The present experiments were designed to investigate the effects of BangPoongSan on the cardiovascular system in the experimental Animals. And thus the change of blood pressure, auricular blood flow, artery contraction, death rate, platelet aggregation repression, plasma coagulation factor activity, plasma antithrombin activity, whole blood viscosity and plasma viscosity were studied. The result were summarized as the followings: 1. BangPoongSan dropped the blood pressure in the spontaneous hypertensive rat. 2. The drug increased the auricular blood flow in rabbit. 3. The drug relaxed the artery contraction by pretreated norepinephrine in white rat. 4. The drug inhibited the death rate of mouse which was led to thromboembolism by serotonin and collagen. 5. The drug inhibited the platelet aggregation in rat. 6. The drug prolonged the prothrombin time and activated partial thromboplastin time on the test of plasma coagulation factor activity in rat, but was not valuable. 7. The drug presented the antithrombin activity in rat. 8. The drug reduced the whole blood viscosity and plasma viscosity in rat, but the latter was not valuable. According to the results, Bangpoongsan increased the blood flow and dropped the blood pressure by dilatation of blood vessel smooth muscle. And the drug presented the antithrombin acivity, inhibited the platelet aggregation and reduced blood viscosity. Therefore these effects are assumed to improve the cardiovascular circulation disorder and prevent thrombosis.

• 한국ITS학회 논문지
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• 제3권2호
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• pp.129-140
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• 2004

본 논문에서는 지방부 간선도로 단속류 구간(국도 42호선 양지$\~$용인구간 6km)의 통행시간정보에 관한 체계적인 수집 $\cdot$ 분석을 위해 현재 국도교통관리시스템(RTMS : Rural Trafc Management System)상에서 운영중인 차량 번호판 매칭방식 AVI 수집자료에 대한 신뢰성 검증 및 단속류 구간 통행시간 자료의 적정집락간격에 관한 연구가 수행되었다. 우선 AVI수집자료 신뢰성 검증을 위하여 번호판 매칭방식 AVI표본수집자료와 전수조사자료를 Kolmogorov-Smirnov 검증기법을 이용하여 분석한 결과 AVI 자료는 통과위주의 대표차로상에서 수집되는 관계로 전차로에 대한 수집자료와 교통특성에 차이가 있어 현재의 번호판 매칭방식 AW 표본수집자료를 통해 산출된 구간통행시간을 구간의 대표값으로 적용하는 문제는 추가 검토가 필요하다. 그리고 적정집락간격을 산출하기 위하여 통계적 추정 개념인 점추정과 구간추정을 적용하여 모형을 개발하여 적용한 결과 점추정기법이 구간추정기법보다 집락간격결정에 민감하고, 보다 정확한 적정집락간격 선정이 가능한 것으로 밝혀졌으며, 적정집락간격은 5분으로 산정되어 현재 적용되고 있는 5분 집락간격은 적정한 것으로 판단된다.

• Korea-Australia Rheology Journal
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• 제20권3호
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• pp.109-116
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• 2008

The effect of intermolecular aggregation induced by hydrophobic and electrostatic interactions on shear and elongational flow properties of aqueous acrylic thickener solutions is discussed. Complex shear modulus is determined at frequencies up to $10^4$ rad/s employing oscillatory squeeze flow. Extensional flow behavior is characterized using Capillary Break-up Extensional Rheometry. Aqueous solutions of poly(acrylic acid)(PAA)/poly(vinylpyrrolidone-co-vinylimidazole) (PVP-VI) mixtures exhibit unusual rheological properties described here for the first time. Zero-shear viscosity of the mixtures increases with decreasing pH and can exceed that of the pure polymers in solution by more than two orders of magnitude. This is attributed to the formation of complexes induced by electrostatic interactions in the pH range, where both polymers are oppositely charged. PAA/PVP-VI mixtures are compared to the commercial thickener Sterocoll FD (BASF SE), which is a statistical co-polymer including (meth) acrylic acid and ethylacrylate (EA) forming aggregates in solution due to "sticky" contacts among hydrophobic EA-sequences. PAA/PVP-VI complexes are less compact and more deformable than the hydrophobic Sterocoll FD aggregates. Solutions of PAA/PVP-VI exhibit a higher zero-shear viscosity even at lower molecular weight of the aggregates, but are strongly shear-thinning in contrast to the weakly shear-thinning solutions of Sterocoll FD. The higher ratio of characteristic relaxation times in shear and elongation determined for PAA/PVP-VI compared to Sterocoll FD solutions reflects, that the charge-induced complexes provide a much stronger resistance to extensional flow than the aggregates formed by hydrophobic interactions. This is most likely due to a break-up of the latter in extensional flow, while there is no evidence for a break-up of complexes for PAA/PVP-VI mixtures. These flexible aggregates are more suitable for the stabilization of thin filaments in extensional flows.

• International Journal of Vascular Biomedical Engineering
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• 제1권2호
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• pp.4-12
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• 2003

The present study investigated the effect of transverse vibration on the hemorheological characteristics of blood using a newly designed pressure-scanning capillary viscometer. As vibration was applied, aggregated blood cells (rouleaux) were disaggregated. The range of vibration frequency and amplitude are $0{\sim}100\;Hz$ and $0{\sim}0.8\;mm$, respectively for a capillary diameter 0.84 mm. As vibration increased, blood viscosity initially increased and tended to decrease. In order to delineate the unexpected results, the present study proposed two counteracting mechanisms of vibration related with red blood cell (RBC) aggregation affecting hemo-rheological properties. One is the reduction of RBC aggregation due to vibration causing an increase of blood viscosity. The other is forced cell migration due to the transverse vibration, which in turn forms a cell-free layer near the tube wall and causes a decrease of flow resistance.

• 대한공간정보학회지
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• 제15권2호통권40호
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• pp.33-42
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• 2007

원격탐사 자료를 이용한 토지피복도로부터 유역의 식생상황을 고려한 지표면 조도계수를 추정하기 위한 물리적 기반의 지표면 조도계수 추정방법을 제안하였다. 사전 연구로써 지표면 조도계수의 변화에 따른 첨두유량, 유출체적, 첨두시간에 대한 반응을 분석하기 위하여 NWS-PC 모형을 사용하였다. predominant, arithmetic mean, aggregation 방법으로 구해진 지표면 조도계수가 강우-유출 모형의 매개변수에 미치는 영향을 분석하였다. 지표면 조도계수에 대한 민감도 분석에서는 첨두유량이 약 10%의 변화를 나타내었고, 유출체적의 경우 약 2%의 변화를 나타내었다. 첨두시간은 지표면 조도계수에 비례하여 증가하는 것으로 나타났다. 물리적 기반의 aggregation 방법에 의해 구한 지표면 조도계수를 사용하였을 때의 강우-유출 모의결과는 STDEV, RMSE, NSE, PME 통계량에서 나은 결과를 보였지만, 각각의 통합 방법에 대해 크게 다른 결과를 보이지는 않았다. 그러나, 모형에서 지표면 조도계수의 설정에 따라 기저유량을 표현하는 하층부의 매개변수는 민감하게 변화하는 것으로 나타났다.