• Journal of Nutrition and Health
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• v.27 no.5
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• pp.429-441
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• 1994

The difference in lipid metabolism between breast-fed(BF) and formula-fed(FF) infants were studied in 31 Korean infants at 1, 2 and 3 months postpartum. The formulas had more total lipids(TL), triglycerides(TG) and phospholipids and less cholesterol(CHOL) and free fatty acids(FFA) than the breast milk. The milk consumption of the FF infants was significantly greater than that of the BF infants with a wide individual variation. As a result, the FF infants appeared to consume more TL, TG and PL and less CHOL and FFA than the BF infants during 3 months. The lipid contents of the breast milk tended to decrease in due course of lactation, therefore the intake of lipids of BF infants was reduced during the first three month of lactation. The plasma TG and CHOL levels of infants at 3 month were not significantly different between the BF and FF infants, but the PL level of the BF infants was higher then that of the FF infants. The plasma levels of TG and CHOL were not significantly correlated with the intakes of TL, TG, CHOL, PL and FFA, respectively. The PL level, however, was positively correlated with the intakes of CHOL and FFA, respectively and negatively correlated with PL intake as well as 18 : 2w6 fatty acid content of the breast milk or the formulas. The fecal weight and fecal loss of TL of the FF infants were greater than those of the BF infants during 3 months, however, apparent lipids digestibility was not significantly different between the BF and FF infants. The fecal excretions of CHOL and bile acids of FF infants were substantially higher than those of BF infants during 3 months. New sterol balance showed a particularly large difference between the BF and FF infants. The value of the net sterol balance of the BF infants was negative, but that of the FF infants was positive. This study shows that the consumption pattern of various lipid components of BF and FF infants were different as a result of different lipid compositions between breast milk and formula. The significantly lower sterol balance of the BF infants than the FF infants may have been derived from the unique dietary characteristic of breast milk.

• Journal of Nutrition and Health
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• v.36 no.7
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• pp.743-748
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• 2003

This study was longitudinally conducted to evaluate vitamin A intake of exclusively breast-fed infants compared with the Recommended Dietary Allowances (RDA) for Korean infants. Twenty-seven Korean lactating women and their infants during the first 6 months of lactation in Cheongju and Anseong areas were participated. Retinol and $\beta$-carotene contents in the milk were determined using HPLC and also the milk consumption of the infants was measured by the test-weighing methods. Vitamin A (retinol and $\beta$-carotene) contents of the milk were 65.7, 57.2, 48.1, 43.9, 38.2, 38.7 and 44.0 R.E./100 ml, and vitamin A intakes of the breast-fed infants were 361, 402, 348, 331, 304, 305 and 322 R.E./day at 0.5, 1, 2, 3, 4, 5 and 6 month of lactation, respectively. The average intake of vitamin A was 339.1 R.E./day and the percentage to RDA was 96.9% during 6 months. Vitamin A intakes per body weight of the breast-fed infants were 96.7, 88.3, 62.1, 50.0, 41.8, 39.3 and 39.6 R.E./kg/day at 0.5, 1, 2, 3, 4, 5 and 6 month. The body weight increased normally from 3.4 $\pm$ 0.5 kg at birth during lactation. It is suggested that the breast-fed infants in Cheongju and Anseong areas consumed adequately vitamin A from the milk compared with RDA for Korean infants.

• Journal of Nutrition and Health
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• v.29 no.2
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• pp.143-152
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• 1996

The surveys of food intakes were carried out on 49 healthy infants aged 4-9 months at the first interview and repeated 3 more times at the interval of 2 months by using food diary recorded by their mothers. Of the subjects 12 were breast-fed, 28, formula-fed, and 9, mixed type-fed. Foods introduced first as the weaning food were commercial weaning foods, fruit juices, yoghurt, egg and rice. Supplemental food was introduced at the age of 4 months in 57% of the infants, but it amounted to a significant proportion of overall food consumption from the age of 6 months. The levels of nutrients except energy, iron and niacin were similar or in excess of RDA, and breast-fed infants tended to have lower intakes of energy and protein compared to infants formula-fed or mixed type-fed. Average intakes of vitamin A, vitamin B1, vitamin B2, vitamin C and calcium were above RDA, but iron intake did not meet RDA of infants of all ages. In conclusion, the average status of nutrient intakes of infants was fairly good, however, food consumption besides milk was less in breast-fed infants than in formula-fed infants, and iron status seemed to be poor, Although it is well-known that breast-milk compared to formulas is more beneficial for infants, mothers feeding breast-milk to their infants should be educated for the importance of supplemental food and its practice to support good nutrition.

• Journal of Nutrition and Health
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• v.30 no.4
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• pp.425-433
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• 1997

Levels and distribution of five B-6 vitamers(PMP, PM, PLP, PL, and PN) and pyridoxine $\beta$-glucoside conjugates(PN-glucoside) were examined in milk of American women who received supplements of 2.5 or 10mg PN HCl/d and of unsupplemented Egyptian women during the first six months of lactation. B-6 vitamer and PN-glucoside levels in human milk were determined by reverse-phase HPLC. Pyridoxal(PL), which has been reported to be the most rapidly absorbed form of vitamin B-6 and may facilitate bioavailability, was the predominant vitamer in human milk of all three groups. Pyridoxal made up 72% of total vitamin B-6 for the 2.5mg supplemented group, 76% for the 10mg group, and 59% for the Egyptian group. Level and Percent PL were significantly lower for Egyptian women. Mean growth of the two American groups was similar to each other and within the normal range of the NCHS reference, however, Egyptian infants showed growth faltering at 6 months. The Percent of PN-glucoside, a less bioavailable form of vitamin B-6 in humans was 1% in milk of American women and was 11% in Egyptian women and these values were significantly different. for Egyptian women, total vitamin B-6 levels in breast milk correlated Positively with animal protein intake(r=0.91) and percent PN-glucosides(r=0.53) and negatively with plant protein intake(r=-0.55). These findings showed that high plant protein intake was associated with low concentrations of PL and total vitamin B-6 in human milk.

• 모자간호학회지
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• v.1
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• pp.45-58
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• 1991

The purpose of this descriptive study was to investigate the determinants of mother's choice of infant feeding method on immediate postpartum period & the breast feeding practice after 1, 2, 3, 4, 5months. The subjects were 170 mothers who were delivered at 2 hospital, 2 OBGY clinics, 1 midwifery in Jinju, the data were collected from Jan. 1 to Feb. 20 of 1991, form each subject at two periods of time ; postpartum 2 or 3 days via interview, 5months via telephone interview. The results were as fellows : 1. The propotion of mother planned exclusive breast-feeding was 66.5%, milk feeding 17.6%, mixed feeding 15.9%, End 38.9% of mothers planned to breast-feed their infants for 4-6moths, 25.7% for more than 12 months. The major reasons for selection of milk feeding method were the presence of mother's job(26.7%), the conditions of breast & milk production(23.7%). 2. There were significant relations between the choice of feeding method & the presence of s job(p<.01), & parity(p<.01). 3. The percentages of subjects that were received education about the advantages & method of breast feeding were 63.5%, 38.2%, respectively, & the informants were mass media, 89.8%, 81.5%. 4. The most of mothers had the knowledge about the advantages of breast feeding. 5. The percentage of mothers that practiced breast feeding on postpartum were 75.9%. 6. The rates of breast feeding practice by duration were more than 5months, 60.5%, 1 month, 27.1%, 2-4 months. 12.3%. 7. The reasons for the stop of breast feeding were the decrease of milk volume(22.9%), the presence of mother's job(17.4%). 8. The duration of breast feeding practice were differed significantly by the presence of mother's job, type of delivery, rooming-in, planned duration of breast feeding, the first feeding time.

• Nutrition Research and Practice
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• v.5 no.4
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• pp.308-312
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• 2011

This was a prospective cohort study of 976 infants from birth to 12 months of age. Infants were fed breast milk, goat infant formula, cow infant formula, or a combination of formula and breast milk during the first 4 months of age. Data on type of milk feeding and infant growth (weight and height) were collected at birth and at 4, 8, and 12 months during routine clinical assessment. The number and consistency of bowel motions per day were recorded based on observational data supplied by the mothers. Infants fed breast milk or goat or cow infant formula during the first 4 months displayed similar growth outcomes. More of the infants fed cow infant formula had fewer and more well-formed bowel motions compared with breast-fed infants. The stool characteristics of infants fed goat formula resembled those of infants fed breast milk.

• Journal of Nutrition and Health
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• v.28 no.4
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• pp.331-344
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• 1995

The process of breast feeding was investigated from the 36th week of pregnancy to 12 weeks postnatal, in order to analyze the factors affecting breast feeding duration and provide the basic data on an education program for successful breast feeding. The general characteristics of study group had no marked effects on the breastfeeding duration. The young and highly condition during pregnancy and the degree of morning sickness affected the practice of breastfeeding. In the study of prenatal sociobehavioral factors, intended duration affected the breastfeeding duration, and the maternal perception that breastfeeding is good for weight loss after delivery as well as infant formula milk is not as good as breast milk, led to successful breast feeding. Among the postnatal biological factors, the duration of gestation affected the breast feeding. Among the postnatal biological factors, the duration of gestation affected the breastiffeding outcome. In the case of early parturition, breastfeeding rate was low. Among the postnatal biocultural factors, time of first feed, milk volume and maternal perception of infant's sucking ability affected the bresatfeeding duration. From these result, it is suggested that an education program such as participation of nursing class to the pregnant women should be provided for successful breastfeeding.

• Journal of Nutrition and Health
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• v.30 no.8
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• pp.1018-1024
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• 1997

In order to investigate calcium , phosphorous and magnesium intake of breast-fed infants, consumed volumes of human milk and those mineral contents of the milk were examined at 0.5, 1, 2, 3, 4 and 5 months of lactation. Calcium , phosphorus and magnesium contents of human milk during the first 5 months of lactation averaged 26.0, 13.7 and 3.70mg/100g, respectively. Calcium intake of infants averaged 192.3 and 171.0mg/day which represented 39.7 and 33.5% of the RDA for boys and girls, respectively. Phosphorus intake of infants averaged 100.7 and 85.2mg/day which represented 26.2% and 23.4 % of the RDA for boys and girls respectively. The calcium /phosphorus ratio of human milk averaged 2.00 during lactation. The results of this survey suggest that, the reevaluation of calcium , phosphorus and magnesium intake and recommended dietary allowance of these nutrients during infancy is merited.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.24 no.6
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• pp.501-509
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• 2021

Extensive studies have shown that breast milk is the best source of nutrition for infants, especially during the first six months, because it fulfills almost all of their nutritional needs. Among the many functional building blocks in breast milk, human milk oligosaccharides (HMOs) have been receiving more attention recently. Furthermore, it is the third most common group of compounds in human milk, and studies have demonstrated the health benefits it provides for infants, including improved nutritional status. HMOs were previously known as the 'bifidus factor' due to their 'bifidogenic' or prebiotic effects, which enabled the nourishment of the gastrointestinal microbiota. Healthy gastrointestinal microbiota are intestinal health substrates that increase nutrient absorption and reduce the incidence of diarrhea. In addition, HMOs, directly and indirectly, protect infants against infections and strengthen their immune system, leading to a positive energy balance and promoting normal growth. Non-modifiable factors, such as genetics, and modifiable factors (e.g., maternal health, diet, nutritional status, environment) can influence the HMO profile. This review provides an overview of the current understanding of how HMOs can contribute to the prevention and treatment of nutritional issues during exclusive breastfeeding.

• Clinical and Experimental Pediatrics
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• v.52 no.9
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• pp.1053-1058
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• 2009

Cytomegalovirus (CMV) is one of the most commonly encountered viral pathogens in newborn infants and is found in 0.3-2.4% of all live births. It has been demonstrated that 40-96% of seropositive mothers shed the virus via their breast milk. Breast milk containing CMV can cause almost one-third of CMV infections occurring in infants. A case of postnatal CMV infection in an extremely premature infant (gestational age $24^{+5}$ weeks, birth weight 750 g) transmitted via breast milk is presented. For neonatal intensive care unit (NICU) management of severe thrombocytopenia, anemia, and sepsis syndrome, the infant received repeated transfusions of platelets; intravenous (IV) immunoglobulins; and gamma- irradiated, filtrated packed red cells and was fed her mother's breast milk since the second week of life. CMV infection was diagnosed with positive CMV immunoglobulin M (IgM) and positive urine CMV culture at the second month of life. Considering the negative CMV IgM and urine CMV culture at birth, postnatally-acquired CMV infection was suspected and confirmed with completely identical nucleotide sequence alignments of the infantile blood isolate and the maternal breast milk isolate. To our knowledge, this is the first case of proven postnatal CMV infection transmitted via breast milk in an extremely premature infant in Korea.