• 대한지역사회영양학회지
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• 제1권1호
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• pp.41-46
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• 1996

This study was undertaken to determine talc fatty acid intakes of lactating women and breast fed infants. Food consumptions of lactating women were measured at 3 4nd 9 days find 4, 8 and 12 weeks postpartum, respectively and diet samples were collected at the same time. Breast milk and blood samples were collected at 12 weeks postpartum. Fatty acid profiles of diet and breast milk were analyzed with GC. Total fatty acid intakes, fat percentage of energy, P/M/S and n-6/n-3 ratios of lactating women were 50.7 g/d, 20.9$\%$, 0.6/0.9/1 and 4.0/l, respect timely, over the first 12 weeks of postpartum and were not significantly different according to the lactating stages. Total fatty acid intakes and fat percentage of energy of the infects aged 12 weeks through the breast milk alone were 18.9 g/d and 44.8. This study shows that the linoleic acid percentage of energy intake in infants was 6.7$\%$, which was in optimum and/or high level to generally recommended guideline. DHA intakes of lactating women were positively correlated with those of infants from breast mil.

• Journal of Nutrition and Health
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• 제31권4호
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• pp.756-766
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• 1998

The objectives of this study were to examine the growth pattern and hair trace element contents of healthy infants who were fed breast milk(BF infant) and formula (FF infant) during the first 6 months and its relationship to intake of trace elements. Bimonthyl anthropometric measurements were obtained on 32 infants through 6 months of age. Mean calculated energy, iron, zinc and copper intake from breast milk at 2 months of age were 432.4kcal/d, 0.19mg/d, 1.18mg/d and 0.22mg/d. The values obtained from formular were543.7kcal/d, 6.68mg/d , 2.82mg/d and 0.33mg/d , respectively. In spite of the significantly lower intake of energy and trace elements in BF infants than in FF infants, BF infants showed growth above the average Kroean infant standard growth rate and showed no significant growth rate difference or hair trace element content. Hair iron content in the BF infants at 6 mo. of age was positively related to birth weight and iron intake at 2 mo. of age. In contrast, hair zinc and copper content in the FF infants at 6 mo. of age as negatively related to height increment and weight increment during 6 months, respectively. These results support the suggesting that BF infant's higher iron, zinc and copper intake is attributed to the superior bioabailability of these trace elements from breast milk.

• Journal of Microbiology and Biotechnology
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• 제30권7호
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• pp.1067-1071
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• 2020

To understand the formation of initial gut microbiota, three initial fecal samples were collected from two groups of two breast milk-fed (BM1) and seven formula milk-fed (FM1) infants, and the compositional changes in gut microbiota were determined using metagenomics. Compositional change analysis during week one showed that Bifidobacterium increased from the first to the third fecal samples in the BM1 group (1.3% to 35.1%), while Klebsiella and Serratia were detected in the third fecal sample of the FM1 group (4.4% and 34.2%, respectively), suggesting the beneficial effect of breast milk intake. To further understand the compositional changes during progression from infancy to childhood (i.e., from three weeks to five years of age), additional fecal samples were collected from four groups of two breast milk-fed infants (BM2), one formula milk-fed toddler (FM2), three weaning food-fed toddlers (WF), and three solid food-fed children (SF). Subsequent compositional change analysis and principal coordinates analysis (PCoA) revealed that the composition of the gut microbiota changed from an infant-like composition to an adult-like one in conjunction with dietary changes. Interestingly, overall gut microbiota composition analyses during the period of progression from infancy to childhood suggested increasing complexity of gut microbiota as well as emergence of a new species of bacteria capable of digesting complex carbohydrates in WF and SF groups, substantiating that diet type is a key factor in determining the composition of gut microbiota. Consequently, this study may be useful as a guide to understanding the development of initial gut microbiota based on diet.

• Journal of Nutrition and Health
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• 제35권7호
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• pp.771-778
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• 2002

The purpose of this study is to investigate the contents of protein, fat, lactose and energy in the human milk and the intake of human milk and those nutrients in breast-fed infants from 16 lactating women in Seoul area during the first 5 months postpartum. Daily human milk intake was determined by test-weighing method and the milk from 16 mothers was analyzed for protein (semimicro Kjeldahl, N $\times$ 6.38), fat (milk checker), lactose (HPLC). Energy was calculated by Atwater and milk factor. The mean intake of human milk to the 5th month of lactation was 668 $\pm$ 186 $m\ell$/day. Mean protein contents of the human milk at 0.5, 12, 3, 4 and 5 months postpartum showed 1.48, 1.35, 1.17, 1.11, 1.15 and 1.10 g/100 $m\ell$ respectively. Lipid and lactose contents of the human milk during the first S months postpartum averaged 3.38 g/100 $m\ell$ and 6.79 g/100 $m\ell$. Energy contents at 0.5, 12, 3, 4 and 5 months postpartum showed 64.2, 66.1, 68.3, 60.1, 58.9 and 61.2 g/100 $m\ell$ respectively. Protein intake of infants from the human milk was 8.22 g/day which was 54.8% of Korean RDA. Lipid and lactose intake of infants were 23.0 and 45.6 g/day. Energy intake of infants was 422.3 kcal/day which was 84.4% of Korean RDA. Total energy content was almost same value regardless of Atwater or milk factor but the energy ratio was some different. Protein and solid contents decreased the course of lactation but lactose content was less changed. These results suggest that more research were required for the RDA.

• Clinical and Experimental Pediatrics
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• 제50권9호
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• pp.912-918
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• 2007

목 적 : 산모의 알레르기 질환 병력 유무와 초유와 모유 간에 차이가 있는지 살펴보고, 또한 이들의 모유수유 기간에 따른 자녀의 알레르기 질환 발생 유무의 차이를 보고, 생후 2세까지 발생한 알레르기 질환과 모유 내의 면역학적 인자간의 연관성을 알아보고자 하였다. 방 법 : 2002년 5월부터 2003년 2월까지 참여를 희망한 총 138명의 산모에서 알레르기 질환이 있는 산모 88명과 알레르기 질환이 없는 산모 50명으로 나누어 조사하였다. 생후 2일경 초유와 생후 4주경의 모유를 채취하여, 초유와 모유 내 IL-4, IL- 6, IL-8, IL-10, IL-13, RANTES, $TGF-{\beta}1$과 $TGF-{\beta}2$를 측정하였다. 이후 소아는 생후 2세까지 알레르기 질환의 발생에 대한 추적관찰을 하였으며, 초유와 모유 내의 사이토카인과의 연관성을 비교하였다. 결 과 : 알레르기 질환이 있는 산모 군에서 6개월 이상 모유 수유하는 경우가 34.4%(n=21)였고, 3개월 미만으로 수유한 경우가 55.6%(n=15)로 두군 간에 통계학적 차이는 보이지 않았다(P>0.05). 초유 내의 IL-8 농도만이(P=0.021) 알레르기 질환이 있는 산모에서 더 높게 측정되었다. 반면 초유 내의 $TGF-{\beta}1$와 $TGF-{\beta}2$ 농도는 알레르기 질환이 없는 산모에서 더 높게 측정되었다(P=0.013, P=0.001). 초유나 모유 내 사이토카인과 생후 2세까지 알레르기 질환이 발생한 소아 간에 통계학적인 차이를 보이지 않았다. 결 론 : 생후 2세까지 발생한 알레르기 질환과의 연관성 있는 사이토카인은 발견하지는 못했다. 알레르기 질환이 있는 산모와 알레르기 질환이 없는 산모 간에 차이를 보인 $TGF-{\beta}1$, $TGF-{\beta}2$와 IL-8이 알레르기 질환의 병인에 연관성 조사를 위해, 추후 이들에서 장기간 추적 관찰이 필요할 것으로 생각된다.

• 대한간호학회지
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• 제5권2호
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• pp.74-91
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• 1975

A purpose of this study was to compare the breast massage and manual expression of the breast before engagement after delivery with the time of engagement, the throbbing pain in breast, the first amount of breast milk and involution of the uterus. The subjects selected for this study were 138 women (experimental group;69, control group :69) who were admitted to the Dept. of Obtest. and Gyneco. of Kyung Hee University Hospital from Jan. 5 to June 5, 1975. The results of study were as follows; 1 The average age of the women 26.9 years old in the experimental group and 27.6 years old in the control group. As to religion, the number of those who had no religion was 58.0 percent and 62.4 percent respectively. Classified according to occupation, there were 87.0 percent in house wives of the booths group. Educational background; 87.0 percent of high school graduates or above, 78.3 percent respectively. The occupation of husband 53.7 percent of company employees stood highest and 42.0 percent respectively. In according to the grade of wards, 55.1 percent and 52.2 percent of four-men room stood highest. 2. Physical condition: Body weight before this Pregnancy(T=0.4962, N.S.), the size of breast(X²df2 = 0.1728, N.S.), the shape of nipple(X²df3 =1.3804, N.S.), hemoglobin's level of the first day after delivery(T=1.2572, N.S.), the above were showed non significant between the experimental group and control group The investigator found any difference between the two groups of the health condition during the pregnancy, 3. The rate of no experience of breast massage during pregnancy was 85 percent and 75.4 percent (X²df1=2.2562, N.S.). 4. As to the meal during hospitalization after delivery: The booth of the groups in ordinary food took usually of meyer soup and milk(X²df8=2.5957, N.S.). 5. The relation between the first step of breast massage, second step of the manual expression of breast before engagement after delivery and time of engagement : average time of engagement in the experimental group (2.1 days±0.8) was shortened than the control group (3.3 days±1.2). (T=-6.9045, P< 0.005). It toot less time in the experimental group of primipara(2.2days±0.7) than in the control group (3.1day±1.2) and it also took less time in the experimental group of multipara (2.0 days±0.9) than in the control group (3.5days±1.4). (Primipara T=-3.9266, 0< 0.005. Multipara T= 5.2356, P<0.005). 6. The relationship between the first step of the massage and second step of manual expression and the throbbing pain at the time of engagement: The experimental group showed less effect than control group (X²df4= 27.3342 P<0.005). The separate study of primipara and multipara showed remarkable difference in the group of primipara)X²df4=20.7285, p<0.005) and little difference in the multipara group (X²df4=8.8351, p< 0. 10). 7. The relationship between the first step of the breast massage, second stop of the manual expression and first amount of breast milk: The average amount of breast milk increased more conspicuously in the experimental group (33.8㎖±23.4) than in the control(29.8㎖±25.3) (T=0.8262, N.S.). No remarkable difference was found in the respective groups that investigated in the groups of primipara and of multipara. (Primipara T=1.1467, N.S., Multipara T=-0.0354, N.S.). 8. The relationship between the first step of breast massage and second step of manual expression of breast and involution of uterus : Average time needed for uttering involution was sooner in the experimental group of primipasa(-3.3 F.B.±1.1), than the control group of primipara (-2.5F. B.±1.2), and it was sooner in the experimental group of muitipara (-3.0 F. B.±l..3), than the control group of multipara(-2.3 F.B±0.9). Primipara T=-2.9272, p< 0.005, Multipara T=2.5557, p< 0.01).

• 대한지역사회영양학회지
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• 제1권3호
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• pp.335-345
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• 1996

The solids(supplementary food) consumption of 200 healthy infants aged from 4 to 6 months have been measured. Five groups were assigned to different feeding patterns. Breastfed group(BF, n=38), formula-fed group(FF, n=102) and mixed-fed group(MF, n=14) were fed breast milk, formula and mixed(breast mile+formula) from birth until 6 months of age respectively. Convert 1 group(C1F, n=14) and convert 2 group(C2F, n=32) were fed breast milk and mixed milk at 2 months of age respectively and were switched to formula thereafter. All infants received solids form 4 months of age. The energy intake from solids at 4 and 6 months averaged 59.1 and 110.3㎉/d among BF groups vs 151.9 and 239.3㎉/d among FF groups respectively. Intakes of protein, calcium and iron were 38-46$\%$, 34-44% and 25-37$\%$ higher in the FF than in the Bf group during the first 6 months. However, no significant differences were found in the intakes of energy and nutrient intakes from solids in all 4 groups excluding BF group(39$\%$). Although BF infant's nutrient intakes from solids were lower than other group's intakes, they intaked evenly solids from various food groups. As the age of infant had increased, the energy intake ratio from solids was cereals and dairy products was increased whereas energy intake ratio from meats, eggs, fruits and vegetables was decreased. TSC4, TSC6(the frequency score for the kinds of weaning food taken) showed no significant difference among 5 feeding groups but CIF-and C2F group's scores tended to be high. Consequently, these results suggest that BF group's solid intake pattern is more desirable and that Korean lactating Mother's dependence on commercial weaning food is too high.

• Journal of Nutrition and Health
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• 제22권2호
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• pp.84-90
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• 1989

Allergic disorders may be defined as the abnormal reactions to proteins. Cow milk is the first foreign protein which the human being would contact postnatally. Serveral studies suggested that this contact had certain effects on the development o allergic disorders with great controlversies. Seven hundred seventy eight students from middle class in Seoul, aged 6 to 17 wears, were surveyed to delineate the relationshpis between the cow's milk contacts in infancy and the subsequent development of allergic disorders in Koran population. Questionaire were included the nursing patterns in infancy, the past medical history of asthma or wheezy bronchitis and the presence of infantile eczema. Skin tests to three common resporatory allergens in Korea(house dust, house dust mite; D. farinae, D. ptoeronssinus) were performed. The positivity was determined by the wheal size larger than that to histamine. 70.2% of whole mateials was fed by breast milk, 13.1% by cow's milk and 16.7% by mixed nutsing. From the obsevation of nursing patterns by (table 2), we find that the number of breast milk group has been decreasing in 1970's. 10.1% of breast milk group(BMG) had wheezy bronchitis, 8.8% of cow's milk group(CMG) and 11.5% of mixed nursing group(MNG). Infantile eczema history was positive in 27.8% of BMG, in 26.5% of CMG and in 29% of MNG. Skin test positivity was 23.8% in BMG, 25.5% in CMG and 26.2% in MNG. There prevalences of allergic disorders in each nursing group did not reveal any statistically significant differences. In conclusion, nursing patterns in infancy do not seem to have certain effects on the development of allergic disorders such as infantile eczema. wheezv bronchitis or skin test positivity.

• 대한지역사회영양학회지
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• 제8권4호
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• pp.584-594
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• 2003

The lactose, total nitrogen and total lipid contents of human breast milk were determined longitudinally after protein and term deliveries. Milk samples were obtained from day 2 to 5, on weeks 1, 2, 4, and 6 after preform (PM : n = 24) and term (TM : n = 22) deliveries. The lactose contents of PM and TM increased from 5.28 g/dl and 5.93 g/dl at days 2 to 5, to 7.95 g/dl,7.87 g/dl at 6 weeks, respectively. The total nitrogen contents of PM and TM decreased significantly during the first 6 weeks after birth (from 374 to 220 mg/dl versus 382 to 220 mg/dl respectively). However the total lipid contents of the PM and TM increased during the same periods. Significant differences in the total lipid contents between the PM and TM were 2.15 versus 3.27 g/dl at 2 weeks, and 3.26 versus 2.52 g/dl at 6 weeks, respectively. The energy intakes of preform infants was 134.8 ㎉/kg/d during the 6 weeks of lactation, which satisfied with energy requirements (85-130 ㎉/kg/d) of the preform infants. (Korean J Community Nutrition 8(4) : 584-594, 2003)

• Clinical and Experimental Pediatrics
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• 제53권4호
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• pp.488-494
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• 2010

서 론 : 모유은행이란 모집한 기증자들로부터 모유를 수집하고, 처리하고, 부적절한 것은 폐기하며, 저장하는 일을 하고, 모유를 필요로 하는 사람들에게 모유를 제공하는 일을 한다. 전국규모의 모유은행을 운영하기 시작하여 2년의 경험에 대해 보고하고자 한다. 방 법 : 2007년 8월부터 2009년 8월까지 2년 동안, 동서신의학병원 모유은행의 기증자 분석, 기증량, 가공량, 수혜자 분석, 수혜량 등을 조사하였다. 결 과 : 총 기증자는 신규자 131명, 지속 기증자 39명이었고, 기증 횟수는 신규자가 341회, 지속 기증자가 127회 이었으며, 1달 평균 기증 횟수는 신규자 2.6회, 지속 기증자 3.3회이었다. 기증자의 지역분포는 서울 경기 지역이 79% 이었고, 연령은 20대 37%, 30대 60%, 기증자의 직업은 주부 60%, 회사원 35%, 기증자의 기증 동기는 인터넷 66%, TV 방송 매체가 14%, 분만 후 기증 개시 시기는 3개월 이내: 57%, 4-6개월이 29%이었다. 총 수집 2,736 L, 가공양은 1,979 L이었다. 누적 수혜자는 미숙아 신생아를 포함한 영아가 160명, 성인이 21명이었고 수혜 횟수는 영아가 337회, 성인이 41회 이었다. 총 수혜량은 영아에서 1,663 L, 성인이 179 L 이었다. 수혜자의 특징은 지역적으로 서울 경기가 82%, 수혜자의 연령에서 영아인 경우 3개월 미만이 50%, 4-6개월이 30% 이었고, 성인에서는 20-39세 40%, 60세 이상이 40%, 이었다. 수혜 이유로 아동 측에서는 환경여건, 영아질환, 아토피, 모유수유 거부 등이 있었고, 산모 측의 이유로는 모성질환, 모유량 감소 등이 있었다. 성인의 경우 전부 악성 종양에 의한 음식섭취 곤란에서 모유수유를 원하는 경우이었다. 동 병원의 NICU에서 필요한 환아 자신의 엄마 모유를 공급하는데 본 모유은행이 역할을 하였다. 결 론 : 타인의 남는 모유를 위생학적으로 안전하고, 의학적으로도 검정된 방법으로 수집, 가공, 보관하여 모유수유가 필요한 미숙아, 신생아, 영아와 일부 모유를 필요로 하는 성인에서 제공하는 모유은행의 역할을 인식할 수 있었으며, 전국적으로 규모를 확대하는 국가지원의 제도적 뒷받침이 필요하다고 사료된다.