• Journal of the Korean Society of Industry Convergence
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• v.6 no.4
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• pp.379-386
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• 2003

The goal of this research is to develop a Heel/Side Laster and control GUI(Graphic User Interface) for adaptive manufacturing. For this purpose, we have analyzed the working sequences of heel/side laster, and developed a control program that will facilitate the machineries with functions that are suitable for adaptive manufacturing. We also made it possible to modify the gluing path with simple manipulation of CAD data. By providing a user-friendly GUI, we made it possible for unskilled workers use the system without difficulty. In addition, we have developed a flexible environment where the already available CAD data can be modified and saved with ease. Automatic feeding and path control algorithms for thermoplastic cement were also implemented. By using the Heel/Side Laster for adaptive manufacturing, we are able to achieve increased productivity and work efficiency while improving the quality of the product with self-diagnosis and fine adjustment function.

• International Journal of Control, Automation, and Systems
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• v.2 no.4
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• pp.494-500
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• 2004

The wing rock phenomenon is a high angle of attack aerodynamic motion manifested by limit cycle roll oscillations. Experimental studies reveal that direct control and manipulation of leading edge vortices, through the use of 'blowing' techniques is effective in the suppression of wing rock. This paper presents the design of a robust controller for the experimental implementation of one such 'blowing' technique - recessed angle spanwise blowing (RASB), to achieve wing rock suppression over a range of operating conditions. The robust controller employs Takagi - Sugeno fuzzy system, which is fine-tuned by experimental simulations. Performance of the controller is assessed by real-time wind tunnel experiments with an 80 degree swept back delta wing. Robustness is demonstrated by the suppression of wing rock at a range of angles of attack and free stream velocities. Numerical simulation results are used to further substantiate the experimental findings.

• Journal of Microbiology and Biotechnology
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• v.31 no.7
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• pp.903-911
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• 2021

Previous studies have modified microbial genomes by introducing gene cassettes containing selectable markers and homologous DNA fragments. However, this requires several steps including homologous recombination and excision of unnecessary DNA regions, such as selectable markers from the modified genome. Further, genomic manipulation often leaves scars and traces that interfere with downstream iterative genome engineering. A decade ago, the CRISPR/Cas system (also known as the bacterial adaptive immune system) revolutionized genome editing technology. Among the various CRISPR nucleases of numerous bacteria and archaea, the Cas9 and Cas12a (Cpf1) systems have been largely adopted for genome editing in all living organisms due to their simplicity, as they consist of a single polypeptide nuclease with a target-recognizing RNA. However, accurate and fine-tuned genome editing remains challenging due to mismatch tolerance and protospacer adjacent motif (PAM)-dependent target recognition. Therefore, this review describes how to overcome the aforementioned hurdles, which especially affect genome editing in higher organisms. Additionally, the biological significance of CRISPR-mediated microbial genome editing is discussed, and future research and development directions are also proposed.

• Journal of Ship and Ocean Technology
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• v.5 no.4
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• pp.44-50
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• 2001

Large container carriers are suffering from lack of knowledge on reliable correlation allowances between model tests and full-scale trials, especially at fully loaded condition, Careful full-scale sea trial with a full loading of containers both in holds and on decks was carried out to clarify it. Model test results were analyzed by different methods but with the same measuring data to figure out appropriated correlations factors for each analysis methods, Even if it is no doubt that model test technique is one of the most reliable tool to predict full scale powering performance, its assumptions and simplifications which have been applied on the course of data manipulation and analysis need a feedback from sea trial data for a fine tuning, so called correlation factor. It can be stated that the best correlation allowances at fully loaded condition for both 2-dimensional and 3-dimensional analysis methods are fecund through the careful sea trial results and relevant study on the large size container carriers.

• IMMUNE NETWORK
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• v.20 no.1
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• pp.4.1-4.17
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• 2020

Tregs have a role in immunological tolerance and immune homeostasis by suppressing immune reactions, and its therapeutic potential is critical in autoimmune diseases and cancers. There have been multiple studies conducted on Tregs because of their roles in immune suppression and therapeutic potential. In tumor immunity, Tregs can promote the development and progression of tumors by preventing effective anti-tumor immune responses in tumor-bearing hosts. High infiltration of Tregs into tumor tissue results in poor survival in various types of cancer patients. Identifying factors specifically expressed in Tregs that affect the maintenance of stability and function of Tregs is important for understanding cancer pathogenesis and identifying therapeutic targets. Thus, manipulation of Tregs is a promising anticancer strategy, but finding markers for Treg-specific depletion and controlling these cells require fine-tuning and further research. Here, we discuss the role of Tregs in cancer and the development of Treg-targeted therapies to promote cancer immunotherapy.

• Journal of Biomedical Engineering Research
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• v.40 no.5
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• pp.206-214
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• 2019

Surgical methods and associated precision systems have been developed, but surgical procedures that require precise location and fine manipulation of the lesion remain a limitation. The combination of precision robot manipulation technology and 3D medical image navigation technology overcomes the limitations of minimally invasive surgery (MIS) and enables a more stable and successful operation. Surgical robots are surgical robots such as da Vince, and surgical robots using industrial robotic arms. There are various developments and researches of medical robots. In recent medical robot development, a new type of surgical robot based on an industrial robot arm capable of easily replacing the end effector according to the user's needs is being actively developed at home and abroad. Therefore, in this study, we developed safety and performance evaluation guideline for micro - surgical robots based on open robot platform using general purpose robot arm to help quality control of the medical device.

• Journal of Korean Society of Forest Science
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• v.86 no.3
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• pp.399-404
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• 1997

This paper is presenting a practical result of environmental manipulation effect on pine mushroom Tricholoma matsutake yield and a discussion of key factor seeking for improving pine mushroom production by analyzing the effects on mushroom yield for 10 years with applying five kinds of environmental control at the pine stands located in Namwon, Chollabuk-do, Korea. The environmental controls included density control and forest floor manipulations, and the treatments were applied during early summer of 1983. The mushroom yield itself did not show statistically significant differences among the treatments. But, we could manifest the treatment effects by calculating the relative yield in percent on the basis of pretreatment yield collected in 1982. The forest floor manipulation with density control may affect pine mushroom yield in short term, and continuous management should be applied to keep and improve the mushroom production. The fine root activity was the most important factor of pine mushroom production at the Namwon research site since the floor raking resulted in the largest effect on the mushroom yield although the environmental condition for the growth of fungi is important for pine mushroom production. In addition, the pine mushroom forest with sandy soils demands adequate litter layer since the litter removal showed relatively detrimental effects on pine mushroom yield compared to that in litter covered plot at the research site. That is, soil texture should be considered for forest floor manipulation, and it is reconfirmed that the environmental control to improve pine mushroom production should be applied differently by each region.

• Journal of KIISE:Software and Applications
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• v.26 no.12
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• pp.1482-1496
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• 1999

기존의 스테레오 정합 알고리즘은 크게 명암기반기법과 특징기반기법의 두 가지로 나눌 수 있다. 그리고, 각 기법은 그들 나름대로의 장단점을 갖는다. 본 논문은 이 두 기법을 결합하는 새로운 알고리즘을 제안한다. 본 논문에서는 물체모델링을 목적으로 하기 때문에 배경을 제거하여 정합하는 방법을 사용한다. 이를 위해, 정합요소들과 정합유사함수가 정의되고, 정합유사함수는 두 기법사이의 장단점을 하나의 인수에 의해 조절한다. 그 외에도 거리차 지도의 오류를 제거하는 coarse-to-fine기법, 폐색문제를 해결하는 다중윈도우 기법을 사용하였고, 물체의 표면형태를 알아내기 위해 morphological closing 연산자를 이용하여 물체와 배경을 분리하는 방법을 제안하였다. 이러한 기법들을 기반으로 하여 여러가지 영상에 대해 실험을 수행하였으며, 그 결과들은 본 논문이 제안하는 기법의 효율성을 보여준다. 정합의 결과로 만들어지는 거리차 지도는 3차원 모델링을 통해 가상공간상에서 보여지도록 하였다.Abstract Classical stereo matching algorithms can be classified into two major areas; intensity-based and feature-based stereo matching. Each technique has advantages and disadvantages. This paper proposes a new algorithm which merges two main matching techniques. Since the goal of our stereo algorithm is in object modeling, we use images for which background is removed. Primitives and a similarity function are defined. The matching similarity function selectively controls the advantages and disadvantages of intensity-based and feature-based matching by a parameter.As an additional matching strategy, a coarse-to-fine method is used to remove a errorneous data on the disparity map. To handle occlusions, multiple windowing method is used. For finding the surface shape of an object, we propose a method that separates an object and the background by a morphological closing operator. All processes have been implemented and tested with various image pairs. The matching results showed the effectiveness of our method. From the disparity map computed by the matching process, 3D modeling is possible. 3D modeling is manipulated by VRML(Virtual Reality Manipulation Language). The results are summarized in a virtual reality space.

• International Journal of Control, Automation, and Systems
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• v.3 no.3
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• pp.461-468
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• 2005

This paper proposes a wheel-assembly automation system, which assembles a wheel into a hub of a vehicle hung to a moving hanger in a car manufacturing line. A macro-micro manipulator control strategy is introduced to increase the system bandwidth and tracking accuracy to ensure insertion tolerance. A camera is equipped at the newly designed wheel gripper, which is attached at the center of the end-effector of the macro-micro manipulator and is used to measure position error of the hub of the vehicle in real time. The redundancy problem in the macro-micro manipulator is solved without complicated calculation by assigning proper functions to each part so that the macro part tracks the velocity error while the micro part regulates the fine position error. Experimental results indicate that tracking error satisfies the insertion tolerance of assembly $({\pm}1mm)$, and thus it is verified that the proposed system can be applied to the wheel assembly task on a moving hanger in the manufacturing line.

• Archives of Reconstructive Microsurgery
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• v.15 no.2
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• pp.117-122
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• 2006

The function of the thumb is critical to overall hand function. The thumb enables motions such as pinch, grip, fine manipulation and allows to circumduction and opposition. It's loss is a serious problem not only from cosmetic point of view but also functional. Therefore, we should make every effort on thumb reconstruction. Many methods of thumb reconstruction from simple osteoplasty to complex microsurgical reconstruction have been reported. We should understand merits and demerits of each method and choose proper method on case by case. When both hands are injured and there is no option but to amputate one hand and the thumb of another hand is lost, spare part flap from the thumb of the amputated hand to another hand can solve cosmetic problem, functional problem and donor morbidity. We report a case of amputated thumb which has been reconstructed with amputated ring finger of the contralateral hand using spare part flap concept.