• 한국방사성폐기물학회:학술대회논문집
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• 한국방사성폐기물학회 2005년도 춘계 학술대회
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• pp.513-517
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• 2005

This study examined the possibility of using striped field mice as a biological dosimeter or indicator for the environmental radio-surveillance. For this study, the external morphological characteristics and isoenzymic types of dark-striped field mice were studied after they were captured. Among the morphological external characteristics, the dark-brown coat, dark back stripe, head-to-tail length, tail length, and ear length matched the taxonomical characteristics of dark-striped field mice. The analyses on L-lactate dehydrogenase, aspartate aminotransferase, and malate dehydrogenese revealed that one species of dark-striped field mice, called Apodemus agrarius, was inhabitated throughout a wide range of Korea. On the other hand, A. agrarius and ICR mice to analyze their survival rate and frequency of micronuclei in peripheral polychromatic erythrocytes after irradiation (0, 0.5, 1, 3, 5, 7, 9 Gy). The $LD_{50/30}$ of A. agrarius and ICR mice were approximately 5 Gy and 7Gy, respectively. The results of the study reveal that wild A. agrarius have a high potential as a biological monitoring system to determine the impact of radiation effect in areas such as those within the vicinity of nuclear power plants.

• 한국환경생물학회:학술대회논문집
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• 한국환경생물학회 2003년도 학술대회
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• pp.38-47
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• 2003

Relationships between accumulations of endocrine disruptors and abnormalities in the reproductive organs in the adult male striped field mice, Apodemus agrarius, were reviewed. High levels of phenolic compounds were detected in the mice collected at an agricultural village in Gaduck island and at a place having a sewage problem in Samdong-myeon, Namhae. High levels of organo tin compounds were found in the mice collected at Jiri Mt. a tourist resort. Considerably high levels of phenolic or organo tin compounds were detected in mice with shrunken reproductive organs accounting for 14∼42% of the mice examined in each area, which suggests that the abnormality of reproductive organs may be induced by the endocrine disruptors. This hypothesis is strongly supported by histological observations of shrunken reproductive organs, such as necrosis of testicular germ and epithelial cells. This was found not only in the mice with shrunken reproductive organs but also in the mice with enlarged reproductive organs, both had accumulated high levels of endocrine disruptors in general.

• The Korean Journal of Ecology
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• 제25권4호
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• pp.213-216
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• 2002

Main attackers on pine seeds on the forest floor were investigated in Korea. Damage on pine cones begins in early stage of cone formation, especially by squirrel and Korean squirrel. The above animals left Kayak-like hulls of seed on rocks and fallen tree trunk. Field mice also left the same shape of Kayak-like hulls. But birds including doves and peasants left large shreds with longitudinal cracks or seed cup trace. Most of seeds on the leaf litters as well as under the fallen leaf were consumed by field mice and birds. Especially field mice found the seeds under fallen leaves and consumed all of them.

• 대한수의학회지
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• 제40권3호
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• pp.543-549
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• 2000

The pathogenicity of Br abortus RB51 strains, producted by commercial vaccine companies in Republic of Korea and USA, were evaluated in mouse and guinea pig. BALB/c and ICR mice were intraperitoneally inoculated with RB51 vaccines or virulent field strain and the existence of RB51 including its ratio of spleen to weights and persistence in spleens were examined. Groups of guinea pigs on day 55-58 of received subcutaneously with various RB51 vaccines, RB51 field isolates (Daehungjin) or virulent field isolates(Sangju) to compare the histopathogenicity in uterus. All the mice received RB51 vaccines or RB51 field isolates survived for 10 days, but the groups of mice received virulent field isolates died 5 from 11 (45.5%) in case of BALB/c mice and 12 from 12 (100%) in ICR mice, respectively. The number of RB51 in the groups of mice given with vaccine strains and RB51 field isolates were declined rapidly were in spleens between 12 and 20 days after inoculation. In contrast the mice given with the virulent field isolates rose in number of bacteria up to 20 days after inoculation. In the groups of mice infected with virulent field isolates, the ratio of spleen weights to body weight were significantly higher than those in control or in the groups inoculated with RB51 strain, including RB51 field isolates, at 12 and 20 days after inoculation. At ten days after inoculation, placentas of both the pregnant and non-pregnant guinea pigs were conducted for histopathological examination. Although any abnormal lesions were not observed in non-pregnant guinea pigs, all the strains caused the inflammation of the placenta, implying pathogenecity of RB51 in pregnant guinea pigs.

• 한국환경과학회지
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• 제23권2호
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• pp.313-322
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• 2014

To investigate the effects of octylphenol and nonylphenol on the reproduction of the striped field mouse, the mice were subcutaneousely injected with 4-t-octylphenol 800 mg/kg (OP800), nonylphenol 900 mg/kg (NP900) or OP800 + NP900 (OPNP), respectively, in two times a week for 2 months. As the results, there were no differences between the control and the compound-treated groups in the body weight in both sexes, and the GSI (gonadosomatic index) and SVI (seminal vesicles index) in the adult males. But histological abnormalities of the reproductive organs in the mice seems to be related to the compound. This suggestion is supported by the facts that most mice treated with the compounds had only a small number of spermatozoa in the shrunken epididymal tubules. In addition, the shrunken reproductive organ in one mouse treated with the NP, suggests that the abnormalities in the wild striped field mice might be induced by the compound. Furthermore, it is indicated that the compounds must be toxicants to inhibit pregnancy, judging from the fact that all the mice treated with the compounds had failed to deliver.

• The Korean Journal of Physiology and Pharmacology
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• 제15권6호
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• pp.415-422
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• 2011

Previously, we reported that besides retinal ganglion cell (RGC) spike, there is ~10 Hz oscillatory rhythmic activity in local field potential (LFP) in retinal degeneration model, rd1 mice. The more recently identified rd10 mice have a later onset and slower rate of photoreceptor degeneration than the rd1 mice, providing more therapeutic potential. In this study, before adapting rd10 mice as a new animal model for our electrical stimulation study, we investigated electrical characteristics of rd10 mice. From the raw waveform of recording using $8{\times}8$ microelectrode array (MEA) from in vitro-whole mount retina, RGC spikes and LFP were isolated by using different filter setting. Fourier transform was performed for detection of frequency of bursting RGC spikes and oscillatory field potential (OFP). In rd1 mice, ~10 Hz rhythmic burst of spontaneous RGC spikes is always phase-locked with the OFP and this phase-locking property is preserved regardless of postnatal ages. However, in rd10 mice, there is a strong phase-locking tendency between the spectral peak of bursting RGC spikes (~5 Hz) and the first peak of OFP (~5 Hz) across different age groups. But this phase-locking property is not robust as in rd1 retina, but maintains for a few seconds. Since rd1 and rd10 retina show phase-locking property at different frequency (~10 Hz vs. ~5 Hz), we expect different response patterns to electrical stimulus between rd1 and rd10 retina. Therefore, to extract optimal stimulation parameters in rd10 retina, first we might define selection criteria for responding rd10 ganglion cells to electrical stimulus.

• 한국동물학회지
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• 제14권2호
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• pp.57-74
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• 1971

들쥐의 被害를 막기위한 基礎로 들쥐의 生態學的 硏究를 서울大 農大農場에서 한바 들쥐의 大部分이 등줄쥐 이어서 結果的으로 등줄쥐의 硏究가 되고 말았으나 要約하면 다음과 같다. (1) 들쥐무리 4屬(Apodemus, Cricetulus, Rattus, Micromys) 155마리를 採集했으며 그중 등줄쥐(A. agrarius coreae)가 95%(148마리)를 차지했다. (2) 등줄쥐의 옥수수밭에 있어서의 棲息密度는 활동 범위를 감안하여 1970年8月6日 $\\sim$ 8日까지 55/ha는 日本 菅平地方의 900/ha에 비교하면 대단히 낮았다. (3) 體重에 의한 年齡構造는 成體에 대한 幼鼠 및 亞鼠의 합계가 13%에 이르렀고 性比는 ♂ : ♀ = 1.8 : 1 이었다. (4) 쥐굴(쥐집)이 構造는 한 개의 쥐굴에 구멍(出入口)이 3個以上, 貯藏庫 1個以上, 둥지(寢所) 1個에 한 마리가 살고 있으며 저장식량은 가을의 農作物인데 特히 벼가 主가 되고 벼보다는 玄米로 저장해 둔다. (5) 活動時刻은 日沒後 1 $\\sim$ 2時間, 子正前後, 및 日出前 1時間 內外가 왕성하나 낮에라도 주위가 조용하여 安全하고 먹이가 필요하거나 求愛行動이 필요하면 활동 한다. (6) 옥수수의 被害相은 高株에서 30 $\\sim$ 40%, 低株 에서 80 $\\sim$ 90%의 被害率이었다. 벼에 있어서는 논(1,200坪)에서 벼로 11,400g가 被害되었으니 全國的으로 349.695kg, 그리고 이것을 白米로 推算하면 8,268입 가 등줄쥐에 提供되었다. (7) 등줄쥐의 分娩仔數는 平均體重 30g 의 암컷이 5마리를 낳고 3週후에 離乳했으며 멧밭쥐(16g)도 5마리를 낳았다. (8) 天敵은 食肉目(족제비, 고양이, 살쾡이, 여우, 너구리, 수달, 개) 猛禽目(독수리, 부엉이, 말똥가리, 소리개, 매) 및 뱀이며 시궁쥐와 비단털쥐도 등줄쥐의 天敵이다. (9) 등줄쥐의 食性(嗜好性)은 옥수수, 콩, 밀, 고구마, 밤, 들깨등을 좋아하며 보리, 조, 수수, 팥, 녹두등은 그렇게 좋아하지 아니한다. 그리고 하루에 한 마리의 成鼠의 攝食量은 벼라면 5.5g, 밀 인 경우 4.9g, 여기에 물 5ml 가량을 먹는 경우이다. (10) 물만 提供하고 다른 먹이를 주지 아니한 饑餓實驗에 의하면 營養좋게 飼育된 등줄쥐는 71 $\\sim$ 79時間後에, 그렇지 못한 쥐는 32 $\\sim$ 39時間後에 죽었다.

• 방사성폐기물학회지
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• 제4권1호
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• pp.25-32
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• 2006

이 연구에서는 원자력발전소 주변 환경 방사선이 생태에 미치는 영향을 감시할 수 있는 생물학적 지표로서 야생 등줄쥐의 활용 가능성을 평가하였다. 국내 5지 역을 선정하여 10월에 한정하여 등줄쥐를 채집하였는데, 농경지에서 산중턱에 이르기까지 폭 넓게 서식하였다. 채집한 쥐들에 대하여 황갈색 피모와 검은색 등줄무늬를 관찰하였는데, 외부형태 특성 가운데 몸통의 길이, 꼬리의 길, 귀의 길이를 계측한 결과, 등줄쥐의 분류기준과 일치하였다. 아울러, 간장내 효소형을 분석한 결과 국내에 서식하는 대부분의 등줄쥐가 Apodemus agrarius라는 것을 알 수 있었다. 또한, 야외에서 생포한 등줄쥐를 암수 한 마리씩 동거시키고 생산된 새끼가 5주령에 도달하였을때 방사선을 조사하고, ICR 마우스를 비교로 생존율과 적혈구내 미소핵 출현빈도를 분석한 결과, 반치사 선량$(LD_{50/30})$은 5와 7.9Gy였다. 이 연구결과로 야생 등줄쥐가 원자력 발전소 주변 수준의 방사선이 인간생환에 미치는 영향을 판단할 수 있는 생물학적 인 지표로서 잠재적 활용성이 높다는 것을 알 수 있었다.

• Biomolecules & Therapeutics
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• 제30권4호
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• pp.334-339
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• 2022

Peroxiredoxin 6 (PRDX6) is a bifunctional protein with both glutathione peroxidase and calcium-independent phospholipase activity. Recently, we reported that PRDX6 plays an important role in dopaminergic neurodegeneration in Parkinson's disease. However, the relationship between PRDX6 function and emotional behavior remains elusive. In the present study, we examined depression- and anxiety-like behaviors in PRDX6-overexpressing transgenic (PRDX6-Tg) mice using the forced swim test, tail suspension test, open field paradigm, and elevated plus-maze. PRDX6-Tg mice exhibited depression-like behaviors and low anxiety. In particular, female PRDX6-Tg mice exhibited anxiolytic behavior in the open field test. Furthermore, the serotonin content in the cortex and 5-hydroxytryptophan-induced head twitch response were both reduced in PRDX6-Tg mice. Interestingly, levels of dopa decarboxylase expression in the cortex were decreased in male PRDX6-Tg mice but not in female mice. Our findings provide novel insights into the role of PRDX6 in 5-HT synthesis and suggest that PRDX6 overexpression can induce depression-like behaviors via downregulation of the serotonergic neuronal system.

• 한국산림과학회지
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• 제90권6호
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• pp.707-716
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• 2001

들쥐류(類)에 의한 삼림(森林)의 피해(被害)를 방지(防止)하기 위한 기초적 자료(資料)로서 활용할 목적(目的)으로 경남 양산시 소재 취서산(鷲棲山)지역을 대상으로 2000년 6월부터 2001년 3월까지 4차에 걸쳐 들쥐류의 생태조사(生態調査)를 실시한 결과(結果)는 다음과 같다. 1. 채집(採集)된 들쥐류(類)는 등줄쥐(Apodemus agrarius), 흰넓적다리붉은쥐(Apodemus peninsulae), 대륙밭쥐(Eothenomys regulus)등 3종과 식충류(食蟲類)인 땃쥐(Crocidura suaveolens) 1종이였다. 2. 조사지역(調査地域) 들쥐류(類)의 총채집율(總採集率)은 설치 Trap 758개중 61개체가 채집되어 8.1%였다. 3. 채집(採集)된 들쥐류(類)의 종구성율(種構成率)은 등줄쥐 45.9%(28개체), 대륙밭쥐 29.5%(18개체), 흰넓적다리 붉은쥐 19.7%(12개체), 땃쥐 4.9%(3개체)순이였다. 4. 채집(採集)된 들쥐류(類)의 체중조성(體重組成)은 등줄쥐 16~51.9g, 흰넓적다리붉은쥐 12~35.9g, 대륙밭쥐 16~45.9g, 땃쥐 12~15.9g이였다. 5. 채집(採集)된 들쥐류(類)의 성비구성(性比構成)은 등줄쥐 52.0% : 48.0%, 흰넓적다리붉은쥐 50.0% : 50.0%, 대륙밭쥐 44.4% : 55.6%, 땃쥐 33.3% : 66.7% 였다. 6. 채집(採集)된 들쥐류(類)의 평균 두동장(頭胴長)은 대륙밭쥐가 104.33mm로서 가장 길었으며, 등줄쥐 96.04mm, 흰넓적다리붉은쥐 94.50mm순이였고 땃쥐는 76.33mm였다. 7. 채집(採集)된 들쥐류(類)의 평균 미장(尾長)은 흰넓적다리붉은쥐가 92.75mm로서 가장 길었으며, 등줄쥐 80.65mm, 땃쥐 41.0mm, 대륙밭쥐 40.33mm순이였다. 8. 취서산(鷲棲山)에 서식(棲息)하는 들쥐류(類)의 번식기(繁殖期)는 3월부터 10월경까지로 추정되며, 특히 대륙밭쥐는 12월에도 번식하고 있음이 우리나라에서는 처음으로 본 조사(調査)에서 확인(確認)되었다. 9. 채집(採集)된 들쥐류(類)의 평균 태자수(胎仔數)는 등줄쥐 4.5마리, 흰넓적다리붉은쥐 4.7마리, 대륙밭쥐 3.4마리였다.