Peroxiredoxin 6 Overexpression Induces Anxiolytic and Depression-Like Behaviors by Regulating the Serotonergic Pathway in Mice |
Gu, Sun Mi
(College of Pharmacy and Medical Research Center, Chungbuk National University)
Yu, Eunhye (College of Pharmacy and Medical Research Center, Chungbuk National University) Kim, Young Eun (College of Pharmacy and Medical Research Center, Chungbuk National University) Yoon, Seong Shoon (College of Korean Medicine, Daegu Haany University) Lee, Dohyun (Laboratory Animal Center, Osong Medical Innovation Foundation) Hong, Jin Tae (College of Pharmacy and Medical Research Center, Chungbuk National University) Yun, Jaesuk (College of Pharmacy and Medical Research Center, Chungbuk National University) |
1 | Stockmeier, C. A. (2003) Involvement of serotonin in depression: evidence from postmortem and imaging studies of serotonin receptors and the serotonin transporter. J. Psychiatr. Res. 37, 357-373. DOI |
2 | Oliviero, G., Munawar, N., Watson, A., Streubel, G., Manning, G., Bardwell, V., Bracken, A. P. and Cagney, G. (2015) The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis. Sci. Rep. 5, 18388. DOI |
3 | Porsolt, R. D., Le Pichon, M. and Jalfre, M. (1977) Depression: a new animal model sensitive to antidepressant treatments. Nature 266, 730-732. DOI |
4 | Rosenzweig-Lipson, S. (2011) New horizons for selective 5-HT2C receptor ligands in psychiatric/neurological disorders. Neuropsychopharmacology 36, 363-364. DOI |
5 | Vaccarino, V., Brennan, M. L., Miller, A. H., Bremner, J. D., Ritchie, J. C., Lindau, F., Veledar, E., Su, S., Murrah, N. V., Jones, L., Jawed, F., Dai, J., Goldberg, J. and Hazen, S. L. (2008) Association of major depressive disorder with serum myeloperoxidase and other markers of inflammation: a twin study. Biol. Psychiatry 64, 476-483. DOI |
6 | Yun, H. M., Choi, D. Y., Oh, K. W. and Hong, J. T. (2015) PRDX6 exacerbates dopaminergic neurodegeneration in a MPTP mouse model of Parkinson's disease. Mol. Neurobiol. 52, 422-431. DOI |
7 | Cryan, J. F., Mombereau, C. and Vassout, A. (2005) The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice. Neurosci. Biobehav. Rev. 29, 571-625. DOI |
8 | Birzniece, V., Johansson, I. M., Wang, M. D., Backstrom, T. and Olsson, T. (2002) Ovarian hormone effects on 5-hydroxytryptamine (2A) and 5-hydroxytryptamine (2C) receptor mRNA expression in the ventral hippocampus and frontal cortex of female rats. Neurosci. Lett. 319, 157-161. DOI |
9 | Canal, C. E. and Morgan, D. (2012) Head-twitch response in rodents induced by the hallucinogen 2,5-dimethoxy-4-iodoamphetamine: a comprehensive history, a re-evaluation of mechanisms, and its utility as a model. Drug Test. Anal. 4, 556-576. DOI |
10 | Colpaert, F. C. and Janssen, P. A. (1983) The head-twitch response to intraperitoneal injection of 5-hydroxytryptophan in the rat: antagonist effects of purported 5-hydroxytryptamine antagonists and of pirenperone, an LSD antagonist. Neuropharmacology 22, 993-1000. DOI |
11 | Hillhouse, T. M. and Porter, J. H. (2015) A brief history of the development of antidepressant drugs: from monoamines to glutamate. Exp. Clin. Psychopharmacol. 23, 1-21. DOI |
12 | Mchedlidze, O., Dzadzamia, S., Butskhrikidze, M., Tsomaia, V. and Nachkebia, N. (2011) Changes of locomotor, exploratory and emotional behavior in animal model of depression induced by deficiency of brain monoamine content. Georgian Med. News 198, 76-82. |
13 | Mouri, A., Sasaki, A., Watanabe, K., Sogawa, C., Kitayama, S., Mamiya, T., Miyamoto, Y., Yamada, K., Noda, Y. and Nabeshima, T. (2012) MAGE-D1 regulates expression of depression-like behavior through serotonin transporter ubiquitylation. J. Neurosci. 32, 4562-4580. DOI |
14 | Canal, C. E., Olaghere Da Silva, U. B., Gresch, P. J., Watt, E. E., Sanders-Bush, E. and Airey, D. C. (2010) The serotonin 2C receptor potently modulates the head-twitch response in mice induced by a phenethylamine hallucinogen. Psychopharmacology (Berl.) 209, 163-174. DOI |
15 | Owens, M. J. and Nemeroff, C. B. (1994) Role of serotonin in the pathophysiology of depression: focus on the serotonin transporter. Clin. Chem. 40, 288-295. DOI |
16 | Schreiber, R., Brocco, M., Audinot, V., Gobert, A., Veiga, S. and Millan, M. J. (1995) (1-(2,5-dimethoxy-4 iodophenyl)-2-aminopropane)-induced head-twitches in the rat are mediated by 5-hydroxytryptamine (5-HT) 2A receptors: modulation by novel 5-HT2A/2C antagonists, D1 antagonists and 5-HT1A agonists. J. Pharmacol. Exp. Ther. 273, 101-112. |
17 | Lister, R. G. (1987) The use of a plus-maze to measure anxiety in the mouse. Psychopharmacology (Berl.) 92, 180-185. DOI |
18 | Ng, J., Heales, S. J. and Kurian, M. A. (2014) Clinical features and pharmacotherapy of childhood monoamine neurotransmitter disorders. Paediatr. Drugs 16, 275-291. DOI |
19 | Tomida, S., Mamiya, T., Sakamaki, H., Miura, M., Aosaki, T., Masuda, M., Niwa, M., Kameyama, T., Kobayashi, J., Iwaki, Y., Imai, S., Ishikawa, A., Abe, K., Yoshimura, T., Nabeshima, T. and Ebihara, S. (2009) Usp46 is a quantitative trait gene regulating mouse immobile behavior in the tail suspension and forced swimming tests. Nat. Genet. 41, 688-695. DOI |
20 | Can, A., Dao, D. T., Arad, M., Terrillion, C. E., Piantadosi, S. C. and Gould, T. D. (2012) The mouse forced swim test. J. Vis. Exp. (59), e3638. |
21 | Chae, H. Z., Robison, K., Poole, L. B., Church, G., Storz, G. and Rhee, S. G. (1994) Cloning and sequencing of thiol-specific antioxidant from mammalian brain: alkyl hydroperoxide reductase and thiol-specific antioxidant define a large family of antioxidant enzymes. Proc. Natl. Acad. Sci. U.S.A. 91, 7017-7021. DOI |
22 | Corne, S. J., Pickering, R. W. and Warner, B. T. (1963) A method for assessing the effects of drugs on the central actions of 5-hydroxytryptamine. Br. J. Pharmacol. Chemother. 20, 106-120. DOI |
23 | Kasahara, T., Kubota, M., Miyauchi, T., Noda, Y., Mouri, A., Nabeshima, T. and Kato, T. (2006) Mice with neuron-specific accumulation of mitochondrial DNA mutations show mood disorder-like phenotypes. Mol. Psychiatry 11, 577-593. DOI |
24 | Lopatina, O., Yoshihara, T., Nishimura, T., Zhong, J., Akther, S., Fakhrul, A. A., Liang, M., Higashida, C., Sumi, K., Furuhara, K., Inahata, Y., Huang, J. J., Koizumi, K., Yokoyama, S., Tsuji, T., Petugina, Y., Sumarokov, A., Salmina, A. B., Hashida, K., Kitao, Y., Hori, O., Asano, M., Kitamura, Y., Kozaka, T., Shiba, K., Zhong, F., Xie, M. J., Sato, M., Ishihara, K. and Higashida, H. (2014) Anxiety- and depression-like behavior in mice lacking the CD157/BST1 gene, a risk factor for Parkinson's disease. Front. Behav. Neurosci. 8, 133. DOI |
25 | Manevich, Y., Feinstein, S. I. and Fisher, A. B. (2004) Activation of the antioxidant enzyme 1-CYS peroxiredoxin requires glutathionylation mediated by heterodimerization with pi GST. Proc. Natl. Acad. Sci. U.S.A. 101, 3780-3785. DOI |
26 | Darmani, N. A. (1996) Differential potentiation of L-tryptophan-induced head-twitch response in mice by cocaine and sertraline. Life Sci. 59, 1109-1119. DOI |
27 | Fisher, A. B., Dodia, C., Manevich, Y., Chen, J. W. and Feinstein, S. I. (1999) Phospholipid hydroperoxides are substrates for non-selenium glutathione peroxidase. J. Biol. Chem. 274, 21326-21334. DOI |
28 | Jacobsen, J. P., Medvedev, I. O. and Caron, M. G. (2012) The 5-HT deficiency theory of depression: perspectives from a naturalistic 5-HT deficiency model, the tryptophan hydroxylase 2Arg439His knockin mouse. Philos. Trans. R. Soc. Lond. B Biol. Sci. 367, 2444-2459. DOI |
29 | Nabeshima, T., Hiramatsu, M., Niwa, K., Fuji, K. and Kameyama, T. (1992) Effect of naftidrofuryl oxalate on 5-HT2 receptors in mouse brain: evaluation based on quantitative autoradiography and headtwitch response. Eur. J. Pharmacol. 223, 109-115. DOI |
30 | Millevoi, S., Thion, L., Joseph, G., Vossen, C., Ghisolfi-Nieto, L. and Erard, M. (2001) Atypical binding of the neuronal POU protein NOct3 to noncanonical DNA targets. Implications for heterodimerization with HNF-3 beta. Eur. J. Biochem. 268, 781-791. DOI |
31 | Murai, R., Noda, Y., Matsui, K., Kamei, H., Mouri, A., Matsuba, K., Nitta, A., Furukawa, H. and Nabeshima, T. (2007) Hypofunctional glutamatergic neurotransmission in the prefrontal cortex is involved in the emotional deficit induced by repeated treatment with phencyclidine in mice: implications for abnormalities of glutamate release and NMDA-CaMKII signaling. Behav. Brain Res. 180, 152-160. DOI |
32 | Zou, J., Weng, R. H., Chen, Z. Y., Wei, X. B., Wang, R., Chen, D., Xia, Y. and Wang, Q. (2016) Position emission tomography/single-photon emission tomography neuroimaging for detection of premotor Parkinson's disease. CNS Neurosci. Ther. 22, 167-177. DOI |
33 | Miyamoto, Y., Yamada, K., Noda, Y., Mori, H., Mishina, M. and Nabeshima, T. (2002) Lower sensitivity to stress and altered monoaminergic neuronal function in mice lacking the NMDA receptor epsilon 4 subunit. J. Neurosci. 22, 2335-2342. DOI |
34 | Siu, W. K. (2015) Genetics of monoamine neurotransmitter disorders. Transl. Pediatr. 4, 175-180. |
35 | Steru, L., Chermat, R., Thierry, B. and Simon, P. (1985) The tail suspension test: a new method for screening antidepressants in mice. Psychopharmacology (Berl.) 85, 367-370. DOI |
36 | Balasinor, N. H., D'souza, R., Nanaware, P., Idicula-Thomas, S., Kedia-Mokashi, N., He, Z. and Dym, M. (2010) Effect of high intratesticular estrogen on global gene expression and testicular cell number in rats. Reprod. Biol. Endocrinol. 8, 72. DOI |
37 | Buonora, J. E., Mousseau, M., Jacobowitz, D. M., Lazarus, R. C., Yarnell, A. M., Olsen, C. H., Pollard, H. B., Diaz-Arrastia, R., Latour, L. and Mueller, G. P. (2015) Autoimmune profiling reveals peroxiredoxin 6 as a candidate traumatic brain injury biomarker. J. Neurotrauma 32, 1805-1814. DOI |
38 | Nic Dhonnchadha, B. A., Bourin, M. and Hascoet, M. (2003) Anxiolyticlike effects of 5-HT2 ligands on three mouse models of anxiety. Behav. Brain Res. 140, 203-214. DOI |
39 | Crawley, J. N. (1999) Behavioral phenotyping of transgenic and knockout mice: experimental design and evaluation of general health, sensory functions, motor abilities, and specific behavioral tests. Brain Res. 835, 18-26. DOI |
![]() |