• Title/Summary/Keyword: field efficacy

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SPF 닭에서 재조합 H9N3 조류 인플루엔자 백신의 효능과 안전성 평가

  • Sin, Jeong-Hwa;Mo, In-Pil
    • Proceedings of the Korea Society of Poultry Science Conference
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    • 2006.11a
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    • pp.90-91
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    • 2006
  • To reduce the economic impact and control Low pathogenic avian influenza (LPAI), vaccination with inactivated vaccine has been considered in this country. We tried to develop inactivated vaccine with reassorted H9N3 AI virus which has different type of neuraminidase compare to those of field AI virus. Before reassorted vaccine was produced, we confirm the virus as master seed by limiting dilution, RT-PCR and sequencing method. Also, we evaluate the biological characteristics of the virus to find out the possibility of prevention against field infection of AI virus. Finally, we evaluate the safety and efficacy of the vaccine made of reassorted AI virus in the specific pathogen free (SPF) chickens. After limiting dilution, we choose RV7CE4 as a vaccine candidate and compare the gene sequence of this vaccine strain to those of AI05GA which is parents strain. Compared to amino acid sequences of specific gene of AI05GA and RV7CE4, exhibited a high degree of amino acid sequence homology. In the safety and efficacy test, there were no specific clinical signs or mortality. Reassorted H9N3 viruses were reisolated in cloaca swab on 5 days post inoculation. In the vaccine study, once or twice vaccination was performed and challenged with H9N2 field virus (01310). Vaccine has no adverse effect on birds and formed good immune capability which reduce viral shedding in the birds infected with 01310. Based on the above result, we developed reassorted H9N3 vaccine which will efficiently prevent the low pathogenic AIV (H9N2) infection in the poultry farms.

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A Potential Biological Weed Control by Golden Apple Snail(Pomacea canaliculata) in Wet Hill Seeded Rice with Iron-coated Seeds (벼 무논점파(철분코팅종자)재배에서 친환경 잡초관리를 위한 왕우렁이 이용 기술개발)

  • Park, Kwang-Ho
    • Korean Journal of Weed Science
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    • v.32 no.3
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    • pp.273-279
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    • 2012
  • This experiment was conducted to determine a potential effective biological weed control and/or rice young seedling injury by golden apple snail (Pomacea canaliculata) at wet hill seeded rice field. The rice seeds used were treated by iron-coating. The efficacy of weed control as affected by golden apple snail has been tested with twice applications of young golden apple snails of 12 kg (24,000 young snails, $0.5g{\pm}10%$ per young snail, 30~40 days after hatching) per ha at the same day after harrowing and applied with rate of 10 kg (20,000 young snails) per ha at 15days after seeding, respectively. The comparison of this experiment was of the conventional machine transplanted rice paddy field in terms of weed control and rice plant injury as a visual grade. The weed efficacy was of 100% similar with the conventional paddy field which was applied by systematic herbicides of pre-emergence and post-emergence chemical herbicides and there was 1~3% significant rice young seedling injury but no yield losses and grain quality due to the input of golden apple snail.

Field evaluation of Enterotoxigenic Escherichia coli-specific bacteriophage (ΦCJ19) as a feed additive (Enterotoxigenic Escherichia coli 특이 박테리오파지 (ΦCJ19)의 사료 첨가제로서의 사양 평가)

  • Yoo, Anna;Cha, Seung Bin;Shin, Min Kyoung;Park, Hong Tae;Seo, Hyo Sil;Kim, Jae Won;Yoo, Han Sang
    • Korean Journal of Veterinary Research
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    • v.53 no.2
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    • pp.83-88
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    • 2013
  • Field efficacy of enterotoxigenic Escherichia coli-specific phage (${\Phi}CJ19$) as a feed additive was evaluated in weaning piglets. Fifty-four piglets at 3-4 weeks old were allocated in three different groups and two of them were fed with bacteriophage at different concentrations ($10^6PFU/kg$ feed and $10^8PFU/kg$ feed, respectively) for 30 days. Body weight and feed intake were measured at 10 days interval and body condition and fecal score were inspected every day. Based on the measurement, feed conversion rate (FCR) and average daily gain (ADG) of each group during 30 days were analyzed. The analysis suggests that the bacteriophage may help the improvement of FCR and ADG at $10^8PFU/kg$ of bacteriophage feeding group in 30 days. A result from analysis of fecal score indicates that the bacteriophage also may help to relieve the intermittent diarrhea in post-weaning stage. Those results suggest that bacteriophage might help the growth of piglets in post-weaning stage.

Development and Application Performance of a Granular Herbicide Applicator Attached to Rice Transplanter (승용 이앙기 부착형 제초입제 살포기 개발과 살포성능)

  • 김진영;박석호;최덕규;구연충
    • Journal of Biosystems Engineering
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    • v.23 no.4
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    • pp.319-326
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    • 1998
  • A herbicide applicator attached to a rice transplanter was developed to perform herbicide application and transplanting simultaneously. The prototype machine was composed of herbicide tank, discharge device, spinner, scattering plate and power drive. The application rate of the machine could be adjusted from 10 to 30 kg/㏊ and the application swath was 1.8m. According to the field test, application uniformity showed the range of 13.6~43.9% in terms of CV(coefficient of variation) depending on the spinner speed, application height and shape of diffuser. The best uniformity could be achieved with the spinner speed of 30.8m/s and application height of 20cm. Field efficiency of the prototype was 4.7hr/㏊. Transplanting machine has field efficiency of 4.6hr/㏊ in Korea. By attaching the herbicide applicator, field efficiency became lowed only by 0.1hr/㏊, which was counted for filling time of herbicide. Simultaneous operation of transplanting and herbicide application had a of labor saying. The weed control efficacy was measured to be 96% in field when AC140 + Stomp and Londax + YRC was applied at the 65th day after transplanting. Nonanmae was treated by manual application to be compared to.

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Biocidal effect to fish pathogens of Aqua farmsafe® composed of yucca extract and didecyldimethylammonium chloride (유카추출물과 didecyldimethylammonium chloride를 주성분으로 하는 살균소독제 아쿠아 팜세이프의 어류병원체에 대한 살균 효과)

  • Seo, Jung Soo;Jeon, Eun Ji;Hwang, Jee Youn;Jung, Sung Hee;Park, Myoung Ae;Lee, Sung Min;Lee, Eun Hye
    • Journal of fish pathology
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    • v.26 no.2
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    • pp.111-116
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    • 2013
  • In this study, the disinfectant efficacy of Aqua farmsafe$^{(R)}$, composed of didecyldimethylammonium chloride (DDAC) and yucca extract was evaluated against Salmonella typhimurium and fish pathogens. Determination of the anti-microbial or anti-viral efficacy of the disinfectant was based on Animal, Plant and Fisheries Quarantine and Inspection Agency Regulation No. 2011-26, Korea. Anti-bacterial efficacy test by broth dilution method was used to determine the lowest effective dilution of the disinfectant following exposure to test bacteria for 30 min at $4^{\circ}C$. Aqua farmsafe and test bacteria or virus were diluted with distilled water (DW), standard hard water (SW) or organic matter dilution (OM) according to treatment condition. Under the our results, disinfectant efficacy of Aqua farmsafe$^{(R)}$ possesses 30~40 fold against fish pathogens including bacteria and virus compared to that on animal pathogenic bacteria, S. typhimurim. As the efficacy of Aqua farmsafe$^{(R)}$ against fish pathogen was investigated in vitro, a controlled field trial is required to determine whether the use of Aqua farmsafe$^{(R)}$ will be able to reduce fish diseases.

Centering Effect of the Transactional Leadership between the Social Worker Empowerment and Social Work Self-Efficacy in Social Work Practice (사회복지실천에서 리더의 변혁적 리더십이 사회복지사의 역량강화와 자기효능감에 미치는 조절효과에 관한 연구)

  • Park, Bong-Gil;Jeong, Sun-Young
    • Korean Journal of Social Welfare
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    • v.58 no.4
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    • pp.341-369
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    • 2006
  • This study attempts to explain how the social-worker empowerment in the field of social work relates to social-work self-efficacy and whether or not the transactional leadership of the leader moderates the relationship between these two variables. Data from 390 social workers working with public and private sector agencies in Seoul were collected. For the questionnaire and analysis, this research uses the Social Worker Empowerment, Social Work Self-Efficacy, and Transactional Leadership scales. This research utilizes a wide range of statistical analyses, such as descriptive analysis, Pearson's correlation, reliability analysis, factor analysis, multiple regression, and general linear modeling. The calculations employed the use of SPSS/PC+ 12.0. This research indicates, among other things, that social workers with a high level of social worker empowerment and transactional leadership of the leader show a tendency toward higher social work self-efficacy and that the leader's transactional leadership level plays a moderating function in the relationship between social-worker empowerment and transactional leadership of the leader. In conclusion, a social worker with a low level of leader's transactional leadership shows a relatively greater tendency toward social work self-efficacy when compared to a social worker having a high level of leader's transactional leadership. Social workers and social-work organizations seeking professional practice can benefit from these findings on the relationship between professional behavior and social work self-efficacy with perceived transactional leadership about a team leader as a moderator.

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Effects of Educational Training and Psychosocial Characteristics on Job Involvement in Dental Hygienists (치과위생사의 교육훈련, 자기효능감 및 사회적 지지가 직무몰입에 미치는 영향)

  • Jeung, Da-Yee;Chang, Sei-Jin;Noh, Hie-Jin;Chung, Won-Gyun
    • Journal of dental hygiene science
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    • v.15 no.4
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    • pp.465-471
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    • 2015
  • The purpose of this study was to investigate the effects of educational training and psychosocial characteristics such as self-efficacy and social support on job involvement in dental hygienists. A total of 418 dental hygienists who were working in S, I and G area were recruited in this study. A self-administered questionnaire was used to evaluate individual and job characteristics, educational training, self-efficacy and social support of the study subjects. Hierarchical regression analysis was performed to examine the relationship of individual and job characteristics, educational training, self-efficacy and social support to job involvement. All statistical analyses were performed using the IBM SPSS Statistics ver. 20.0 for Windows, and p<0.05 was considered significant. The results show that learning experiences of liberal arts or social sciences as a part of college curriculum (t=-2.406), self-efficacy (t=3.728) and social support at work (t=4.391) were significantly associated with job involvement in dental hygienists. Dental hygienists who were having experiences of liberal arts or social sciences as a part of college curriculum, showing higher levels of self-efficacy, and receiving adequate social support from supervisors or coworkers at work were more likely to feel job involvement. They explained 17.4% of total variance of job involvement. This result suggests that experiences of liberal arts or social sciences as a part of college curriculum, higher levels of self-efficacy, and adequate social support from supervisors or coworkers at work might play an important role in increasing job involvement of dental hygienists. It is strongly required to develop individual and organizational program or training to promote a positive attitude to their job as a key professionals in the field of dental health, and to increase job involvement of dental hygienists.

Development of hypothermic preservation solution for the human dermal fibroblast using protein hydrolysates (단백질 가수분해 물을 이용한 인간 피부 섬유아세포의 저온 보존액 개발)

  • Byoun, Soon-Hwi;Choe, Tae-Boo
    • KSBB Journal
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    • v.24 no.3
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    • pp.312-320
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    • 2009
  • Stable cell preservation is an essential factor in the regenerative medicine for cell therapies and transplantation of biologic materials. In this study, we studied to provide more stable hypothermic preservation by protection of cell damage during the preservation at $4^{\circ}C$. The result of searching for key components that have excellent efficacy in hypothermic preservation of cells, we have identified the fact that the hypothermic preservation adding protein hydrolysates such as yeast hydrolysate is far superior to others. All protein hydrolysates that are derived from animal, plant and microbe sources have superior efficacy, especially the peptides which have molecular weights under 10 kDa have the best efficacy among the components of protein hydrolysate. The protein hydrolysates prevented the decrease of ATP level in the cells caused by hypothermic environment and they inhibited the generation of ROS. Adding antioxidants and control agents of osmotic pressure were showed to have more superior efficacy in hypothermic preservation. Finally, KUL261 solution (DMEM/F12 1 : 1 medium, yeastolate 1%, $\alpha$-tocopherol $100{\mu}M$, dextran 2.5%), the preservation solution developed in this study, showed the best efficacy in both cell viability and cell growth more than other conventional preservation solutions. In conclusion, the improved hypothermic preservation solution that contains the protein hydrolysates as a key component provide the best preservation efficacy. It provides better efficacy than other preservation solutions and will contribute to both the development of regenerative medicine and global commercialization in this therapeutic field.

A Study on the Relationship between Franchise Firm's Supervisors Job Insecurity and Organizational Effectiveness: The Moderating Effect of Self-Efficacy and Trust in Manager (슈퍼바이저의 고용불안정성이 조직유효성에 미치는 영향에 관한 연구: 자기효능감과 신뢰의 조절효과)

  • Cho, Joon-Sang
    • Journal of Distribution Science
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    • v.13 no.1
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    • pp.35-46
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    • 2015
  • Purpose - This paper attempted to investigate the relationships among the perception of job insecurity and organizational effectiveness, and it examines these relationships while considering the moderating effect of trust in the manager and self-efficacy. Job insecurity is an independent variable, organizational effectiveness aspects (job satisfaction, organizational commitment, and turnover intention) are dependent variables, and trust and self-efficacy are moderators. Research design, data, and methodology - Regression analysis was used to verify the effects. The measurement items were already deemed as reliable and valid in the previous study, but for this purpose, some modifications were made. To examine the model, this study relied on the samples chosen from Korean employees in the six franchise business firms. The survey was conducted on 288 workers. Each question is based on a 5-point Likert type scale. The data were analyzed using SPSS 18.0. Results - The results of the study are summarized as follows. First, job insecurity has an influence on organizational effectiveness aspects (negatively on job satisfaction, negatively on organizational commitment, and positively on turnover intention). Second, analyzing the moderating effect of trust, trust in manager is mediated between job insecurity and organizational effectiveness aspects (on organizational commitment and on turnover intention). However, employees' trust in manager had no significant moderating effect on the job insecurity-job satisfaction relationship. Third, self-efficacy is mediated between job insecurity and organizational effectiveness aspects (on job satisfaction, on organizational commitment, and on turnover intention). Conclusions - First, it is necessary to be aware of the seriousness of employees' job insecurity in franchise firms, which have played a pivotal role in national economic growth, and to create a detailed plan for reducing insecurity and actively implementing it. To this end, the franchise companies should implement efficiency efforts such as obtaining an appropriate capacity of equipped personnel and a training program. Second, there are moderating effects of self-efficacy and trust in the relationship between job insecurity and organizational effectiveness. Depending on business conditions, stability and instability can only be experienced in the organizations of franchise companies. This can give rise to instability in employment. Therefore, it is necessary to develop and utilize a system that can be minimized with a change in the new awareness of employment instability. After all, a good leader (manager) must accumulate personal trust and build up a core competence that is necessary to become competent in the field himself. Even if you lack the material resources to improve performance, if the leader with the core competencies (e.g., technical/management /organization/marketing/design) can gain the trust of the supervisor, you can get a good organizational performance. Therefore, you should foster a healthy organizational culture through education such as leadership training and employee training to be built on trust between the leaders and the employees. In addition, you need to focus on HRD&M training in order to increase the self-efficacy of the supervisor.

Effects of Health Perceptions and Social Support on Health Promotion Behaviors among College Students: the Mediating Effect of Self-efficacy (대학생의 건강지각, 사회적 지지가 건강증진행위에 미치는 영향: 자기효능감의 매개효과)

  • Su Jeong Park;A Reum Lee;Byoung Gil Yoon;Jung Hee Park
    • The Journal of the Convergence on Culture Technology
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    • v.9 no.6
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    • pp.461-469
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    • 2023
  • We attempted to identify the mediating effect of self-efficacy on the relationship between health perception, social support, and health promotion behaviors among university students and to provide basic data to improve health promotion behaviors. Data were collected using a structured questionnaire from a sample of 173 university students in City C. Health promotion behaviors according to general characteristics were found to have statistically significant differences in gender(t=3.892, p<.001) and major satisfaction(F=5.867, p=.003) .There was no statistically significant difference in age, grade, major field, hospitalization or surgery experience in the last three years, and economic activity. Health promotion behavior was positively correlated with health perception (r=.439, p<.001), social support (r=.532, p<.001), and self-efficacy (r=.533, p<.001) and was statistically significant. It was found that self-efficacy had a partial mediating effect (Z=3.964, p<.001) on the effect of health perception on health promotion behavior, and self-efficacy had a partial mediating effect (Z=4.24, p<.001) on the effect of social support on health promotion behavior. Therefore, it is necessary to identify the factors affecting health support, social support, and self-efficacy among college students and prepare intervention measures to improve health promotion behavior.