• Smart Structures and Systems
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• 제14권5호
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• pp.811-830
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• 2014

A numerical study has been carried out to simulate an innovative monitoring procedure to detect and localize damage in reinforced concrete beams retrofitted with carbon fiber reinforced polymer (CFRP) unidirectional laminates. The main novelty of the present simulation is its ability to conduct the electromechanical admittance monitoring technique by considerably compressing the amount of data required for damage detection and localization. A FEM simulation of electromechanical admittance-based sensing technique was employed by applying lead zirconate titanate (PZT) transducers to acquire impedance spectrum signatures. Response surface methodology (RSM) is finally adopted as a tool for solving inverse problems to estimate the location and size of damaged areas from the relationship between damage and electromechanical admittance changes computed at PZT transducer surfaces. This statistical metamodel technique allows polynomial models to be produced without requiring complicated modeling or numerous data sets after the generation of damage, leading to considerably lower cost of creating diagnostic database. Finally, a numerical example is carried out regarding a steel-reinforced concrete (RC) beam model monotonically loaded up to its failure which is also retrofitted by a CFRP laminate to verify the validity of the present metamodeling monitoring technique. The load-carrying capacity of concrete is predicted in the present paper by utilizing an Ottosen-type failure surface in order to better take into account the passive confinement behavior of retrofitted concrete material under the application of FRP laminate.

• 대한의용생체공학회:의공학회지
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• 제34권3호
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• pp.111-116
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• 2013

Finite element analysis(FEA) has been extensively applied in the analyses of biomechanical properties of stents. Geometrically, a closed-cell stent is an assembly of a number of repeated unit cells and exhibits periodicity in both longitudinal and circumferential directions. This study concentrates on various parameters of the FEA models for the analysis of drug-eluting biodegradable polymeric stents for application to the treatment of coronary artery disease. In order to determine the mechanical characteristics of biodegradable polymeric stents, FEA was used to model two different types of stents: tubular stents(TS) and helicoidal stents(HS). For this modeling, epigallocatechin-3-O-gallate (EGCG)-eluting poly[(L-lactide-co-${\varepsilon}$-caprolactone), PLCL] (E-PLCL) was chosen as drug-eluting stent materials. E-PLCL was prepared by blending PLCL with 5% EGCG as previously described. In addition, the effects of EGCG blending on the mechanical properties of PLCL were investigated for both types of stent models. EGCG did not affect tensile strength at break, but significantly increased elastic modulus of PLCL. It is suggested that FEA is a cost-effective method to improve the design of drug-eluting biodegradable polymeric stents.

• Smart Structures and Systems
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• 제21권1호
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• pp.53-64
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• 2018

Nondestructive testing methods are required to assess the condition of civil structures and formulate their maintenance programs. Axial force identification is required for several structural members of truss bridges, pipe racks, and space roof trusses. An accurate evaluation of in situ axial forces supports the safety assessment of the entire truss. A considerable redistribution of internal forces may indicate structural damage. In this paper, a novel compressive force identification method for prismatic members implemented using static deflections is applied to steel beams. The procedure uses the Euler-Bernoulli beam model and estimates the compressive load by using the measured displacement along the beam's length. Knowledge of flexural rigidity of the member under investigation is required. In this study, the deflected shape of a compressed steel beam is subjected to an additional vertical load that was short-term measured in several laboratory tests by using fiber Bragg grating-differential settlement measurement (FBG-DSM) sensors at specific cross sections along the beam's length. The accuracy of midspan deflections offered by the FBG-DSM sensors provided excellent force estimations. Compressive load detection accuracy can be improved if substantial second-order effects are induced in the tests. In conclusion, the proposed method can be successfully applied to steel beams with low slenderness under real conditions.

• Nutrition Research and Practice
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• 제9권4호
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• pp.358-363
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• 2015

BACKGROUND/OBJECTIVES: Previous studies have indicated that when compared to young mice, old mice have lower global DNA methylation and higher p16 promoter methylation in colonic mucosa, which is a common finding in colon cancer. It is also known that a Western-style diet (WSD) high in fat and calories, and low in calcium, vitamin D, fiber, methionine and choline (based on the AIN 76A diet) is tumorigenic in colons of mice. Because DNA methylation is modifiable by diet, we investigate whether a WSD disrupts DNA methylation patterns, creating a tumorigenic environment. SUBJECTVIES/METHODS: We investigated the effects of a WSD and aging on global and p16 promoter DNA methylation in the colon. Two month old male C57BL/6 mice were fed either a WSD or a control diet (AIN76A) for 6, 12 or 17 months. Global DNA methylation, p16 promoter methylation and p16 expression were determined by LC/MS, methyl-specific PCR and real time RT-PCR, respectively. RESULTS: The WSD group demonstrated significantly decreased global DNA methylation compared with the control at 17 months (4.05 vs 4.31%, P = 0.019). While both diets did not change global DNA methylation over time, mice fed the WSD had lower global methylation relative to controls when comparing all animals (4.13 vs 4.30%, P = 0.0005). There was an increase in p16 promoter methylation from 6 to 17 months in both diet groups (P < 0.05) but no differences were observed between diet groups. Expression of p16 increased with age in both control and WSD groups. CONCLUSIONS: In this model a WSD reduces global DNA methylation, whereas aging itself has no affect. Although the epigenetic effect of aging was not strong enough to alter global DNA methylation, changes in promoter-specific methylation and gene expression occurred with aging regardless of diet, demonstrating the complexity of epigenetic patterns.

• 한국정보처리학회논문지
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• 제4권6호
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• pp.1589-1600
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• 1997

광케이블에 의한 가입자 엑세스 망의 구성은 투자비면에서 볼 때 40~50% 이상의 많은 비용이 소요되는 부분으로 이 분야의 최적화는 광대역 종합정보통신망 구축의 핵심 분야이다. 따라서 선진 각국에서는 이에 대한 연구를 활발히 진행하고 있다. 그러므로 본 논문에서는 가장 보편적으로 이용될 수 있는 이중 성형 구조의 광가입자 엑세스 망 구조 중 HFC, ATM-PON/FTTC 그리고 Super PON 구조를 가지고 경제성 분석을 하였다. 경제성 분석을 위한 비교인자로는 투자비, 유지 보수비, 내용 년수 및 잔존가 등 광가입자 엑세스 망을 구축하기 위해 소요되는 여러가지 장비들을 선택하여 정적 비교 분석법을 TITAN 모델에 적용시켜 소요비용을 산출한 결과 ATM-PON/FTTC 구조가 가장 경제적인 구조로 판명되었다. 이것은 통신망 사업자의 가입자망 구조 결정시에 가이드 라인이 될 수 있다.

• 한국광학회지
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• 제14권5호
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• pp.504-508
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• 2003

최근 전자산업계에 새롭게 널리 생산되는 마이크로 전자부품들은 왜곡이 최소화된 정밀한 외관 형상을 갖도록 제조되고 관리되지만, 측정 대상의 표면이 가시광 영역에서 광산란되는 특징을 가짐으로 인해, 기존의 피죠나 마이켈슨 형태의 비교간섭법으로는 고정밀의 삼차원 형상측정이 용이하지 아니하였다. 본 논문에서는 광섬유를 이용한 새로운 개념의 점회절 간섭계를 제안하고, 이를 광산란 거친표면의 대표적인 제품인 칩패키지와 실리콘 웨이퍼의 삼차원 형상 측정에 적용하였다. 측정결과 66 mm 측정영역에서 측정 형상오차 PV(peak-to-valley value) 5.6 $\mu\textrm{m}$, 분산값($\sigma$) 1.5 $\mu\textrm{m}$를 획득함으로써 기존의 비교 간섭 측정법에 비해 더욱 향상된 측정 정밀도를 획득하였다.

• Journal of the Optical Society of Korea
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• 제20권2호
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• pp.269-275
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• 2016

This study has investigated the feasibility of 980-nm low-energy pulsed near-infrared laser stimulation to evoke auditory responses, as well as the effects of radiant exposure and pulse duration on auditory responses. In the experiments, a hole was drilled in the basal turn of the cochlea in guinea pigs. An optical fiber with a 980-nm pulsed infrared laser was inserted into the hole, orientating the spiral ganglion cells in the cochlea. To model deafness, the tympanic membrane was mechanically damaged. Acoustically evoked compound action potentials (ACAPs) were recorded before and after deafness, and optically evoked compound action potentials (OCAPs) were recorded after deafness. Similar spatial selectivity between optical and acoustical stimulation was found. In addition, OCAP amplitudes increased with radiant exposure, indicating a photothermal mechanism induced by optical stimulation. Furthermore, at a fixed radiant exposure, OCAP amplitudes decreased as pulse duration increased, suggesting that optical stimulation might be governed by the time duration over which the energy is delivered. Thus, the current experiments have demonstrated that a 980-nm pulsed near-infrared laser with low energy can evoke auditory neural responses similar to those evoked by acoustical stimulation. This approach could be used to develop optical cochlear implants.

• 대한간호학회지
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• 제41권6호
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• pp.834-842
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• 2011

Purpose: The purpose of this study was to determine the effect of dehydroepiandrosterone (DHEA) on recovery of muscle atrophy induced by Parkinson's disease. Methods: The rat model was established by direct injection of 6-hydroxydopamine (6-OHDA, 20 ${\mu}g$) into the left striatum using stereotaxic surgery. Rats were divided into two groups; the Parkinson's disease group with vehicle treatment (Vehicle; n=12) or DHEA treatment group (DHEA; n=22). DHEA or vehicle was administrated intraperitoneally daily at a dose of 0.34 mmol/kg for 21 days. At 22-days after DHEA treatment, soleus, plantaris, and striatum were dissected. Results: The DHEA group showed significant increase (p<.01) in the number of tyrosine hydroxylase (TH) positive neurons in the lesioned side substantia nigra compared to the vehicle group. Weights and Type I fiber cross-sectional areas of the contralateral soleus of the DHEA group were significantly greater than those of the vehicle group (p=.02, p=.00). Moreover, extracellular signal-regulated kinase (ERK) phosphorylation significantly decreased in the lesioned striatum, but was recovered with DHEA and also in the contralateral soleus muscle, Akt and ERK phosphorylation recovered significantly and the expression level of myosin heavy chain also recovered by DHEA treatment. Conclusion: Our results suggest that DHEA treatment recovers Parkinson's disease induced contralateral soleus muscle atrophy through Akt and ERK phosphorylation.

• 한국지구물리탐사학회:학술대회논문집
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• 한국지구물리탐사학회 2005년도 공동학술대회 논문집
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• pp.215-220
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• 2005

지뢰탐지에 효과적으로 적용하기 위해 광전계 센서를 이용한 GPR 시스템을 개발하였다. 측정되는 전기장의 왜곡을 최소화 하는 광전계 센서는 크기와 무게가 매우 적어 측정 장치로 운용하기가 용이하므로 지뢰탐지와 같이 세밀한 주의가 요구되는 곳에 적합하다. 송수신 장치 역할을 하는 벡터 네트웍 분석기와 광신호 발생기와 광검파기를 탑재한 광변조기, double ridge horn 송신 안테나와 광전계 센서로 구성된 stepped frequency radar 시스템이 개발되었으며, 이 시스템의 매우 긴 측정시간의 단점을 극복하기 위해 동일한 수준의 S/N 비를 가지는, 임펄스 발생기와 오실로스코프로 구성된 impulse radar 시스템이 또한 개발되었다. 비교 결과 자료 수준은 거의 동일하나 측정시간은 스텝 측정의 경우 8배 이상 빨라진 것을 알 수 있었으며, 동일한 자료를 연속 측정으로 획득한 결과 100 배 이상 빨라 질 수 있음을 확인하였다. 또한 이 임펄스 레이다 시스템을 PMN2 지뢰모형에 대해 현장과 비슷한 환경에서의 실험실 실험에 적용하여 지뢰모형의 영상을 획득하였다.

• 한국환경과학회지
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• 제24권7호
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• pp.927-937
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• 2015

This study was performed to identify and quantify the asbestos fibers released from two types of asbestos-cement slate roofs. One is a plant roof installed in 1987 which contained 15% chrysotile, and the other is a residential roof installed before 1983 which contained 12% chrysotile. The concentrations of asbestos fibers in air surrounding asbestos-cement slate roofs and in the falling water harvested from the same roofs on rainy days ranged from 0.0012 to 0.0018 f/mL and from 1,764 f/L to 10,584 f/L, respectively. The concentration of inorganic fibers in the soil around asbestos-cement slate roofs was from 217 to 348 f/g. With the above results, the excess lifetime cancer risk (ELCR) for the risk assessment of the asbestos fibers released from asbestos-cement slate based on US EPA IRIS (Integrated risk information system) model is within 5.5E-06 ~ 6.5E-06 levels which indicates that the levels do not exceed "the acceptable risk(1.0E-05)" recommended by WHO. The asbestos concentration in air, drained rainfall and soil around the plant slate roof was higher than that around residential slate roof, but the excess lifetime cancer risk (ELCR) from residential slate was higher than that from plant slate. This suggested that the enclose and encapsulation of residential roofs have priority in removal policy to minimize the exposure risk.