• Journal of Korean Neurosurgical Society
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• 제52권1호
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• pp.1-6
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• 2012

Objective : The purpose of this study was to evaluate the different patterns of bone loss between the lumbar spine and the femur after ovariectomy in rats. Methods : Twenty-four female Sprague-Dawley rats underwent a sham operation (the sham group) or bilateral ovariectomy (the ovariectomized group). Four and eight weeks after operation, six rats from each of the two groups were euthanized. Serum biochemical markers of bone turnover including osteocalcin and alkaline phosphatase (ALP), which are sensitive biochemical markers of bone formation, and the telopeptide fragment of type I collagen C-terminus (CTX), which is a sensitive biochemical marker of bone resorption, were analyzed. Bone histomorphometric parameters of the 4th lumbar vertebrae and femur were determined by micro-computed tomography. Results : Ovariectomized rats were found to have higher osteocalcin, ALP and CTX levels than sham controls. Additionally, 8 weeks after ovariectomy in the OVX group, serum levels of osteocalcin, ALP and CTX were significantly higher than those of 4 weeks after ovariectomy. Bone loss after ovariectomy was more extensive in the 4th lumbar spine compared to the femur. Bone loss in the 4th lumbar spine was mainly caused by trabecular thinning, but in the femur, it was mainly caused by trabecular elimination. Conclusion : The present study demonstrates different patterns of bone loss between the 4th lumbar spine and the femur in ovariectomized rats. Therefore, when considering animal models of osteoporosis, it is important that bone sites should be taken into account.

• 대한방사선기술학회지:방사선기술과학
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• 제22권2호
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• pp.41-46
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• 1999

Osteoporosis, which causes mainly fracture of the spine, proximal femur and distal radius by minimal trauma, is a major public health problem and its prevalence is steadily increasing in Korea according to the development of public health care. There are reliable methods for diagnosis based on bone densitometry. Early detection and intervention are important for reducing the incidence of fractures. A consensus definition of osteoporosis, based on bone density measurement, has been developed by the World Health Organization(WHO). In this study, bone mineral density(RMD) was measured by dual energy x-ray absorptiometry(DEXA) at the proximal femur and lumbar spine in 132 post-menopausal women. The purpose of this study is to find influential factors on the BMD of the proximal femur and the lumbar spine and to analyze correlation between BMD and the problematic factors. We obtained the following results : 1. Mean BMD score, T-score and Z-score of the proximal femur were $0.81(g/cm^2)$, -2.45(S.D.) and -2.09(S.D.) respectively and in the lumbar spine were $0.83(g/cm^2)$, -2.02(S.D.), -2.43(S.D.) respectively. 2. In correlation analysis between BMD and many factors, correlation coefficients were -0.467, 0.212, -0.321 and 0.241 in age, height, duration after menopause respectively. BMI and the residuals were comparatively small. 3. Correlation coefficients to age matched BMD, in height and body weight were 0.222 and 0.241, in age and duration after menopause were -0.268, -0.282. 4. The fracture threshold of proximal femur BMD to the 90th percentile was $0.845(g/cm^2)$. 5. At the result of multiple regression analysis, age, body weight, $BMI(kg/m^2)$ and duration after menopause described as significant variables.

• Journal of Nutrition and Health
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• 제34권5호
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• pp.532-540
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• 2001

This study explored the effect of calcium levels and/or ovariectomy on bone composition and its related factors using the female Sprague-Dawley rats which achieved peak bone mass in normal(0.5%) calcium intake during growth period. The rats were randomly divided into six groups and fed 0.1%, 0.5% and 1.5% calcium diets for 8 weeks after ovariectomized and sham operation. The results indicated that body weight gain was higher in ovariectomized groups than sham groups, regardless of dietary calcium levels and food intakes. Serum Ca and P concentrations were normal level regardless of dietary calcium levels and operation. Estrogen concentration was decreased in ovariectomized rat groups. Serum alkaline phosphatase activity and urinary hydroxyproline were increased in ovariectomized groups. When rats were fed normal Ca diet during growing period, weight, length and breaking force of femur were not significantly different in all groups but increased the same level. Generally, lipid contents in lumbar and femur were lower in low calcium groups and this effect was more pronounced in femur. In case of femur, the significant decrease in Ca contents of bone was observed in a relatively short period of feeding low Ca diet, even though it appeared th desirable peak bone mass had achieved through the growing period by supplementing the adequate amount of calcium. The marked decrease of estrogen levels after ovariectomy did not seem to influence greatly bone parameters measured except bone wet weight. Therefore, this study indicated that lower intake of Ca might be more important determinating factor against osteoporosis than postmenopausal state stimulated by ovariectomy in female rats. With normal or high intake of Ca it appears possible to prevent bone loss in postmenopausal period, and this might apply only in case of achieving peak bone mass in the growing with the adequate intake of calcium. (Korean J Nutrition 34(5) : 532∼540, 2001)

• 대한골관절종양학회지
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• 제3권2호
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• pp.112-118
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• 1997

Multicentric chondrosarcoma other than the mesenchymal subtype is rare separate entity. We experienced a case with nonmonomelic synchronous multicentric chondrosarcoma without any preexisting lesions of Oilier's disease or Maffucci's syndrome. To our knowledge, there was no report of synchronous nonmonomelic multicentric chondrosarcoma. A thirty-three year old man had right distal thigh pain of one and half year. Bone scan showed hot lesions on medial condyle of right femur and shaft of left femur. Plain X-ray showed osteolytic lesion on right femur and slight cortical thickening and calcific lesion was observed on left femoral shaft. Curettage and bone cement filling was done on both lesions. The pathology reports were grade I chondrosarcoma on both side of femur. At one month from operation, pathologic fracture of left femur occurred on bone cement-host bone junction. Conservative treatment and radiotherapy of 60Gy was done. At 8 months from operation, nonunion was evident. Segmental resection of left femur with contralateral fibula graft and second look operation on right condyle lesion were done. At 6 months from revision, fracture occurred at host-graft bone junction. We removed previous hardware and applied long DCP and massive autogenous bone graft. Afterwards, the patient looks good and union was progressing. But at 4 years from last operation, hypertrophic nonunion occurred. Another revision was done with condylar plate and bone graft and now he is well without any sign of local recurrence or metastasis.

• Journal of Magnetics
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• 제21권2호
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• pp.298-302
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• 2016

In bone density examinations, a change in the measured BMD occurs owing to the differences between the measured areas. To address this problem, we aimed to develop a new auxiliary device that could be rotated by $15^{\circ}$ by fixing the ankle to the distal femur neck. Dual energy X-ray absorptiometry (DXA) of BMD examinations were performed once a year, but 10 patients were examined over three sessions to analyze the area for measuring the femur neck BMD. The goal of this test was to determine the device's reliability, and the results were expressed in terms of the standard deviation of measurements. After performing bone density measurements using the new auxiliary device on 10 normal patients, with three measurements for each patient, the obtained standard deviation was 0.03. The standard deviation of the measured BMD was 0.19 when using the currently existing auxiliary device, while the standard deviation of the measured BMD was 0.03 when using the new auxiliary device. By using the new auxiliary device, the standard deviation could be reduced by ~80%. Accurate rotation of the femur neck was possible in all examinations, and the standard deviation of BMD measurements could be reduced by up to 80% compared with the measurements performed using the currently existing auxiliary device. We hope that this advantageous new design can be used as a standard auxiliary device for measuring the femur neck BMD.

• 대한의용생체공학회:의공학회지
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• 제31권3호
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• pp.199-209
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• 2010

The locking compression plates-distal femur(LCP-DF) are being widely used for surgical management of the extra-articular complex fractures of the distal femur. They feature locking mechanism between the screws and the screw holes of the plate to provide stronger fixation force with less number of screws than conventional compression bone plate. However, their biomechanical efficacies are not fully understood, especially regarding the number of the screws inserted and their optimal configurations. In this study, we investigated effects of various screw configurations in the shaft and the condylar regions of the femur in relation to structural stability of LCP-DF system. For this purpose, a baseline 3-D finite element (FE) model of the femur was constructed from CT-scan images of a normal healthy male and was validated. The extra-articular complex fracture of the distal femur was made with a 4-cm defect. Surgical reduction with LCP-DF and bone screws were added laterally. To simulate various cases of post-op screw configurations, screws were inserted in the shaft (3~5 screws) and the condylar (4~6 screws) regions. Particular attention was paid at the shaft region where screws were inserted either in clustered or evenly-spaced fashion. Tied-contact conditions were assigned at the bone screws-plate whereas general contact condition was assumed at the interfaces between LCP-DF and bone screws. Axial compressive load of 1,610N(2.3 BW) was applied on the femoral head to reflect joint reaction force. An average of 5% increase in stiffness was found with increase in screw numbers (from 4 to 6) in the condylar region, as compared to negligible increase (less than 1%) at the shaft regardless of the number of screws inserted or its distribution, whether clustered or evenly-spaced. At the condylar region, screw insertion at the holes near the fracture interface and posterior locations contributed greater increase in stiffness (9~13%) than any other locations. Our results suggested that the screw insertion at the condylar region can be more effective than at the shaft during surgical treatment of fracture of the distal femur with LCP-DF. In addition, screw insertion at the holes close to the fracture interface should be accompanied to ensure better fracture healing.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제26권4호
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• pp.363-368
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• 2000

불화나트륨의 전신적인 투여가 백서골의 기계적, 조직학적인 특성에 미치는 영향을 알아보고자 0, 1, 5 및 50ppm의 불소를 6주간 투여한 다음 백서 대퇴골을 채취하여 대퇴골 전체의 압축 강도, 대퇴골 경부의 전단 강도를 만능압축시험기로 측정하고 대퇴골 횡단면 조직 슬라이드를 제작하여 피질골 및 골수강의 두께와 면적을 광학현미경과 image analyzer 등으로 측정한 결과는 다음과 같다. 1. 실험 6주간 불소 투여에 의한 백서 체중에 있어서 각 군간에 통계적으로 유의한 차이는 나타나지 않았다. 2. 6주간의 불소 투여시 대퇴골 전체의 압축강도는 대조군에 비해 1 및 5ppm 투여군에서 증가하다가 50ppm 투여군에서는 오히려 현저하게 감소하였다. 3. 대퇴골 경부의 전단 강도역시 대조군에 비해 1 및 5ppm군에서는 증가되다가 50ppm군에서는 감소되었으나 통계적으로 유의한 차이는 나타나지 않았다. 4. 피질골의 두께와 면적 역시 대조군에 비해 5ppm 투여군까지는 증가하다가 50ppm 투여군에서는 현저히 감소되었다. 5. 골수강의 두께와 면적은 대조군에 비해 불소투여군 모두에서 통계적으로 유의하게 증가되었다. 이상의 결과로 미루어 볼 때 상수도수불소화에 사용되는 1ppm의 불소 농도에서는 백서 대퇴골의 기계적인 압축강도가 증진되고 조직형태학적으로도 피질골의 두께가 증가됨으로 인하여 동일한 하중에서도 골의 파절에 대한 저항 능력을 향상시킬 수 있음을 확인하였다.

• 한국방사선학회논문지
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• 제14권5호
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• pp.651-660
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• 2020

본 연구에서는 보급형 3D 프린터를 이용하여 인체 Femur와 유사한 HU 값을 가진 팬텀을 제작하여 기존 돼지 뼈를 대체할 수 있는지 분석하고자 하였다. 인체 Femur의 HU 값을 알아보기 위해 연령별 총 372명의 데이터를 분석하였다. 보급형 3D 프린터를 이용하여 PLA-Cu 20%를 이용하여 인체 뼈 모형 팬텀을 제작하여 CT 검사하였다. 돼지 뼈는 생후 6개월 된 돼지로 도축된 지 2일이 지난 뼈를 이용하였다. 검사결과 내부채움 80%로 제작한 3D 프린팅 팬텀이 인체의 모든 데이터와 유사한 값이 나타났고(p<0.05) 돼지뼈와는 차이가 있었다(p>0.05). 또한 연령대별 Femur의 HU 값의 경우 연령대가 증가할수록 HU의 값은 줄어드는 것으로 확인 되었다(p<0.05). 3D 프린팅과 HU 값은 적층 높이에 대해서는 약한 음의 상관성을 확인 하였지만 내부 채움에서는 182.13±1.290으로 강한 양의 상관성(R²=0.996)을 확인하였다(p<0.05). 결론적으로 3D 프린팅을 이용한 인체 모형 팬텀이 기존 돼지뼈 팬텀에 비해 인체와 유사한 정도의 HU 값을 나타낼 수 있음을 확인할 수 있었으며 이에 본 연구가 3D 프린터를 이용한 인체 모형 팬텀의 제작에 기초자료를 제공할 수 있을 것이라 사료된다.

• 핵의학기술
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• 제13권1호
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• pp.73-76
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• 2009

자주 사용하는 발에 상관없이 좌측 대퇴골밀도 측정만으로 골밀도 정보가 충분한지에 대해 알아보기 위해 발의 사용빈도가 운동과 관련이 있다는 가정하에 오른손잡이, 왼손잡이로 나누어 운동여부에 따른 양측 대퇴골밀도 차이에 관해 연구를 하였다. 2008년 7월부터 8월까지 본원건강증진센터를 내원한 30세 이상 70세 이하($51{\pm}6.7$세)의 수검자 229 명(여성 146명, 남성 83명)을 대상으로 자주 사용하는 손과 평상시 운동여부를 설문지 방식으로 조사하였고, 검사는 DXA (Dual energy X-ray absorptiometry) 방식 GE Lunar Prodigy advance장비를 이용해 양측 대퇴부위를 측정하였으며, 측정된 값의 평균을 구하여 차이를 비교해 SPSS 12.0 통계 프로그램을 이용하여 분석하였다. 운동여부를 고려하지 않고 양측 대퇴부위의 차이를 비교해 보았을 때 오른손잡이(n= 209)의 양측 대퇴골밀도 값의 차이는 neck (t=-0.15), total (t=-0.12), 왼손잡이(n=20)는 neck (t=-0.76), total (t=0.02)로 오른손잡이, 왼손잡이 모두 통계상양측의 차이는 없는 것으로 나타났다. 그리고 운동을 한 집단으로 나누어 조사해 보니 오른손잡이(n=114)는 neck (t=0.56), total (t=0.65), 왼손잡이(n=13)는 neck (t=-0.13), total (t=-0.39)로 두 그룹 모두 통계상 양측의 차이는 없는 것으로 나타났다. 마지막으로, 운동을 안 한 집단의 양측 대퇴부위의 차이 조사해 보니 오른손잡이(n=95)는 neck (t=-0.80), total (t=-0.78), 왼손잡이(n=7)는 neck (t=0.25), total (t=-0.64)로 세 집단에서 모두가 오른손잡이, 왼손잡이 상관없이 좌우측의 대퇴골밀도의 값이 통계상으로 차이는 없는 것으로 나타났다. 현대인들은 운동량이 부족한 생활방식에 익숙해져 있기도 하지만 평소 운동을 규칙적으로 행하는 사람들도 많기 때문에 두 집단의 차이에 대한 연구가 필요하였는데, 이들 모두 양측 대퇴골밀도의 차이는 오른손잡이, 왼손잡이냐에 상관없이 통계상 값의 의미 있는 차이는 없었다. 따라서 대퇴골밀도의 측정 시 자주 사용하는 손에 대한 위치나 운동여부에 상관없이 현재 방식대로 좌측 대퇴부를 측정하여 골밀도 검사를 실행하는 것이 옳을 것으로 생각된다. 다만 수술과 같은 특수한 경우에는 우측을 검사해야 할 것이다.

• 근관절건강학회지
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• 제7권1호
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• pp.89-101
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• 2000

This study was carried out to compare the bone mineral density and risk factors of osteoporosis between normal and rheumatoid arthritis in postmenopausal women. Sixty-eight postmenopausal patients with rheumatoid arthritis(RA) were compared with 124 postmenopausal normal women. Data were collected from october, 1998 to April, 1999 at Dong-a university hospital in Pusan. From all subjects, individual characteristics such as age, body weight, height, age of menarche, duration of menopause, gravity, parity, and breast feeding period and factors of life style such as milk consumption, exercise, alcohol intake, cigarette smoking, coffee consumption were identified as influencing factors of osteoporosis by questionnaire. From RA patients, health assessment score, Ritchie articular index, erythrocyte sedimentation rate, C-reactive protein and steroid dosage were measured by rheumatologist on measuring bone mineral density. Bone mineral density was measured at the Lumbar spine, femoral neck, femur Ward's triangle, and femur trochanter using dual x-ray absorptiometry. The data was analyzed by using a frequency, t-test, Chi-square, ANCOVA with SPSS PC program. The results could be summarized as follows : 1) There was a significant difference in age and breast feeding period between RA patients and normal women. 2) RA patients took less calcium in the past and practiced less regular exercise in past and present than normal women. 3) There was no difference in lumbar bone mineral density between RA patients and normal women. 4) There was a significant difference in femur Ward's triangle and femur trochanter between RA patients and normal women after adjustment for age and breast feeding period. 5) The prevalence of osteoporosis of all subjects was the highest in femur Ward's triangle. In summary, our findings suggest that the bone mineral densities of femur Ward's triangle and trochanter in postmenopausal women with RA is significantly lower than normal women. Also the exercise participation rate of postmenopausal women with RA is lower than normal women. For the further study, we recommend to develop exercise program that improve the bone mineral density in femur Ward's triangle and trochanter and to test the effect of that exercise program.