• Journal of the Korea Convergence Society
• /
• v.11 no.8
• /
• pp.323-330
• /
• 2020

A purpose of this study is to investigate the effects of 12-Weeks regular physical activities on female senior adults aging related hormone(HGH, DHEA-S, estrogen) levels and a risk factor in cardiovascular disease(adiponectin, hs-CRP). Twenty female senior adults participated in this study and divided intoexercise group(n=10) and control group(n=10). The Korean traditional dance program was conducted three times a week(60min) for 12-weeks. Paired t-test was used to examone the differences within experimental groups and independent t-test was used to changes the differences between groups. The followings are the results of this study. Estrogen(p=0.025), HGH(p=0.009), DHEA-S(p=0.009), adiponectin(p=0.014) was significantly increased after 12-weeks program for exercise group, And hs-CRP(p=0.010) was significantly decreased for exercise group. Estrogen(p=0.006), DHEA-S(p<.0.002), adiponectin(p=0.008), hs-CRP(p=0.004) was significantly changed between exercise group and control group.

• Journal of Gastric Cancer
• /
• v.16 no.3
• /
• pp.191-194
• /
• 2016

Hypercalcemia of malignancy due to metastatic gastric adenocarcinoma is extremely rare; in fact, to the best of our knowledge, only three case reports of hypercalcemia associated with metastatic gastric adenocarcinoma have been published in the literature to date. Herein, we report a rare case involving a 61-year-old African-American female who had hypercalcemia at initial presentation and who was later diagnosed with poorly differentiated gastric adenocarcinoma with extensive liver metastases, without bone involvement. She was found to have elevated parathyroid hormone-related peptide and normal parathyroid hormone levels. Despite aggressive treatment, she died within a few months of diagnosis.

• Fashion & Textile Research Journal
• /
• v.5 no.1
• /
• pp.77-81
• /
• 2003

The purpose of this study was to investigate the effect of multi-functional fabric on EEG and growth hormone (GH) during sleep and quality of sleep with the 9 young female athletes. The subjects participated in separated experimental procedure; sleeping in multi-functional fabric wear (experimental group) and cotton wear (control group) for 450min. During the night (22:00-05:30), we recorded the changes of nocturnal polysomnographic sleep recording and GH were measured every 60min. The results show that there are significant differences in percentage of stage 1, 2 and slow wave sleep (SWS) between two groups(S1, p<.05; S2, SWS, p<.01). The SWS percentage of experimental group is 1.89 times higher than control group. The changes of GH secretion varied depending on two experimental procedures. The peak of GH secretion in experimental group is more than controls by 2.4time (p<.001). The quality of sleep in experimetal group is significantly higher than control (p<.01). These results suggest muti-functional fabric wear is effective in inducing the deep sleep and increasing GH and quality of sleep.

• Archives of Pharmacal Research
• /
• v.28 no.5
• /
• pp.566-572
• /
• 2005

The aim of this study was to determine if the isoflavones from Sophorae fructus (SISO) have potential clinical benefit in hormone replacement therapy (HRT) for the treat ment of menopausal signs, such as the levels of total cholesterol (TC), high density lipoprotein (HDL), low density lipoprotein (LDL) and follicle stimulating hormone (FSH). An additional aim was to present the potential antioxidant effect of SISO in a microglial cell line. For the animal model, the ovaries were removed from adult rats and the indicators of menopause were measured at the pre- and post-administration time points. Although no statistically significant correlation was found, SISO tended to decrease the TC level (p=0.15) and the FSH level (p=0.36), but to increase the HDL level (p=0.303).SISO (< 5${\mu}g$/mL) also exerted antioxidant activity on BV-2 microglial cells by inhibiting lipopolysaccharide-induced nitric oxide. This cytoprotective effect was confirmed by trypan blue staining, which was used to test for cellular damage from H$_2O_2$. In conclusion, this study highlights the anti-menopausal and antioxidant effect of SISO in an ovariectomized rat model, as well as in microglial cells, and provides new clinical targets for the screening of phytoestrogens as potential candidates for HRT in menopausal women.

• The Journal of Korean Obstetrics and Gynecology
• /
• v.36 no.2
• /
• pp.1-19
• /
• 2023

Objectives: The purpose of this health promotion project for Korean medicine is to promote the health of climacteric women in Boeun-gun. Methods: During the project, pressure needle acupuncture treatment, herbal medicine treatment, meditation pore therapy, and health education were conducted. To evaluate the results, basic health surveys (body height, body composition test, blood pressure etc.), female hormone tests, Kupperman's index (KI), Menopause-specific quality of life questionnaire (MENQOL), and Perceived stress scales (PSS) were conducted. Results: No significant change was observed in the body composition test and blood pressure after the project. Follicle stimulating hormone (FSH) was significantly increased after the project, but Luteinizing Hormone (LH) and total estrogen levels were not significantly changed. KI and MENQOL scores significantly decreased after the project, and significantly decreased in 4 out of 11 items of KI and 3 out of 4 domains of MEMQOL. No significant change was observed in the PSS score after the project. Conclusions: From the results of this project, it can be seen that the Korean medicine health promotion project can help alleviate symptoms of climacteric syndrome and postmenopausal syndrome.

• Toxicological Research
• /
• v.26 no.4
• /
• pp.237-243
• /
• 2010

Endocrine disrupting chemicals (EDCs) have been shown to interfere with physiological systems, i.e., adversely affecting hormone balance (endocrine system), or disrupting normal function, in the female and male reproductive organs. Although endocrine disruption is a global concern for human health, its impact and significance and the screening strategy for detecting these synthetic or man-made chemicals are not clearly understood in female and male reproductive functions. Thus, in this review, we summarize the interference of environmental EDCs on reproductive development and function, and toxicological mechanism(s) of EDCs in in vitro and in vivo models of male and female reproductive system. In addition, this review highlights the effect of exposure to multiple EDCs on reproductive functions, and brings attention to their toxicological mechanism(s) through estrogen receptors.

• Natural Product Sciences
• /
• v.1 no.1
• /
• pp.17-24
• /
• 1995

The effects of orchildectomy with/without testosterone replacement in wale rats, and ovarectomy with estrogen replacement in female rats on lipid peroxidation were studied in male and female rats fed with diets fortified with 20% w/w, soybean oil or palm oil for 4 months. Serum, liver and heart homogenates were assayed for malonaldehyde and conjugated diene levels. Orchidectomy was found to reduce levels of lipid peroxidation products in the serum, liver and heart. Testosterone replacement did not increase the lipid peroxidation products to levels in the non-orchildectomised rats, while estrogen did not influence lipid peroxidation significantly. Palm oil decreased, but soybean oil increased lipid peroxidation in the liver and heart of both the castrated and sex hormone-replaced male and female rats.

• Journal of Embryo Transfer
• /
• v.9 no.3
• /
• pp.229-234
• /
• 1994

This experiment was carried out to develop the model system for mass production of biomedical and nutritional proteins (human proteins) through mamraary gland of the transgenic cattle produced by gene manipulation and embryological technologies. Human growth hormone gene fused with rat $\beta$-casein gene promoter was microinjected into pronuclei of one cell bovine embryos produced by in vitro fertilization. After microinjection, embryos were cultured in vitro for 6 or 7 days. Twenty embryos reaching to blastocysts were transferred to 10 beef recipients, each receiving two embryos. Recipients were diagnosed for pregnancy by rectal palpation at 76 days after embryo transfer. One of them was pregnant to term and produced a female calf weighing 21 kg at 280 days following embryo transfer. DNA was extracted from umbilical cord tissue and blood of calf born for confirming gene insertion. As determined by Southern hybridization, the transgene was not found.

• Journal of Veterinary Clinics
• /
• v.18 no.4
• /
• pp.474-478
• /
• 2001

A female mixed miniature pinscher dog, about 5 years old, 4 kg, was referred to veterinary teaching hospital of Chungnam National University with chief complaint of excessive hemorrhagic vaginal discharge for a month, partial alopecia and hyperpigmentation. There are no specific change with CBC, blood chemistry and X-ray findings but we figured out high estrogen concentration with hormone analysis and detected a majority of the superficial epithelial cells with pyknotic nuclei by cytologic examination of vaginal smear preparation and multiple ovarian cysts on both ovaries by ultrasonography. Based on the clinical signs, hormone analysis, vaginal smear preparation and ultrasonography, the authors diagnosed this case as hyperestrogenism with ovarian cysts.

• The Journal of the Korean dental association
• /
• v.12 no.10
• /
• pp.773-776
• /
• 1974

The authors observed the effect of estrogen and progesterone on the submaxillary glands of female albino rabbits ovariectomized bilaterally. The animals were injected estrogen 25 ㎍ /kg, day intramuscullarly for 1 week, Progesterone was also injected intramuscullarly 0.5 ㎍/kg, day for five days after estrogen injection. After hormone injection, salivary glands were removed under ether anesthesia and the sections were stained with H-E stain for microscopic examination. In the estrogen injected-ovariectomized rabbits, glandular epithelial cells and a part of striated duct cells have high reactivity for hematoxylin and observed the proliferation or hypertrophy of interlobular connective tissues. In the estrogen-progesterone injected group, lesser significant changes than estrogen injected group were observed.