• 대한감각통합치료학회지
• /
• 제16권2호
• /
• pp.36-49
• /
• 2018

목적 : 본 연구는 한국판 삶의 균형 척도(Korean version of Life Balance Inventory; K-LBI)의 타당도 및 신뢰도를 검증하고, 삶의 균형과 감각 처리 간 관련성을 제시하고자 하였다. 연구방법 : K-LBI는 번역 및 역번역 과정을 통해 구성되었다. 후기 청소년기 대학생을 대상으로 K-LBI와 한국판 지각된 스트레스 척도, 한국판 삶의 만족도 척도, 성인 행동 평가 척도를 실시하여 수렴 타당도를 검증하였고, 내적 일관성 및 검사-재검사 신뢰도를 측정하였다. 감각 처리와 삶의 균형 간의 관련성을 알아보기 위해 한국판 청소년/성인 감각 프로파일과 K-LBI 간 상관 분석을 실시하였다. 결과 : K-LBI와 수렴 타당도를 위한 척도 간 유의미한 상관관계(r = .337~.449, p < .01), 양호한 반분 신뢰도(r = .906, p < .01) 및 검사-재검사 신뢰도(ICC = .669, p < .01)가 산출되었다. 감각민감 혹은 감각회피 성향과 관계 삶의 균형 영역 간 정적 상관(r = .422~.443, p < .01) 및 등록저하와 도전 삶의 균형 영역 간 부적 상관(r = -.373, p < .05)이 나타났다. 결론 : 본 연구는 후기 청소년을 대상으로 K-LBI의 타당도와 신뢰도를 제시하였고 삶의 균형과 감각 처리 간의 관련성에 대한 이해를 제공한다.

• Journal of Animal Science and Technology
• /
• 제63권3호
• /
• pp.475-490
• /
• 2021

An experiment was conducted to determine the effects of two levels of rumen undegradable protein (RUP) without or with whole or extruded flaxseed on milk yield, milk component, milk fatty acids (FAs) profile and plasma metabolites in transition ewes. Three weeks before and after lambing, seventy-two Baluchi ewes were used in a completely randomized design with a 3 × 2 factorial arrangement of treatments. The treatments contained 1) no flaxseed + 20% RUP (no flaxseed, low RUP [NFLR]); 2) no flaxseed + 40% RUP (no flaxseed, high RUP [NFHR]); 3) 10% whole flaxseed + 20% RUP (whole flaxseed, low RUP [WFLR]); 4) 10% whole flaxseed + 40% RUP (whole flaxseed, high RUP [WFHR]); 5) 10% extruded flaxseed + 20% RUP (extruded flaxseed, low RUP [EFLR]), and 6) 10% extruded flaxseed + 40% RUP (extruded flaxseed, high RUP [EFHR]). Ewes fed 10% extruded flaxseed exhibited higher (p < 0.001) dry matter intake (DMI) and colostrum yield (p < 0.1) compared to other treatments. Two types of flaxseed and RUP levels had no significant effect on milk yield, but milk fat and protein contents decreased and increased in diets containing 40% RUP, respectively. Ewes fed extruded flaxseed produced milk with lower concentrations of saturated fatty acids (SFA) and higher α-linolenic and linoleic acids and also polyunsaturated fatty acids (PUFA) compared to other groups (p < 0.05). During post-lambing, the ewes fed diets containing flaxseed exhibited higher concentration of serum non-esterified FAs (NEFA) compared to diets without flaxseed (p < 0.01). The concentration of serum β-hydroxybutyric acid (BHBA) decreased in the diets containing flaxseed types at pre-lambing, but increased in diets containing extruded flaxseed at post-lambing (p < 0.01). The serum glucose concentration of ewes (pre and post-lambing) which consumed diets containing extruded flaxseed or 40% RUP increased, but blood urea concentration was elevated following supplementation of diet with whole flaxseed or 40% RUP (p < 0.001). In conclusion, utilization of 10% extruded flaxseed in the diets of transition ewes had positive effects on animal performance with favorable changes in milk FAs profile. However, there is no considerable advantage to supply more than 20% RUP level in the diet of transition dairy sheep.

• Bulletin of the Korean Chemical Society
• /
• 제33권3호
• /
• pp.911-916
• /
• 2012

Ion selectivity in a simple cyclic peptide nanotube, composed of four cyclo[-(D-Ala-Glu-D-Ala-Gln)$_2-$] units, is investigated by calculating the PMF profiles of $Na^+$, $K^+$, and $Cl^-$ ions permeating through the peptide nanotube in water. The final PMF profiles of the ions obtained from the umbrella sampling (US) method show an excellent agreement with those from the thermodynamic integration (TI) method. The PMF profiles of $Na^+$ and $K^+$ display free energy wells while the PMF curve of $Cl^-$ features free energy barriers, indicating the selectivity of the cyclic peptide nanotube to cations. Decomposition of the total mean force into the contribution from each component in the system is also accomplished by using the TI method. The mean force decomposition profiles of $Na^+$ and $K^+$ demonstrate that the dehydration free energy barriers by water molecules near the channel entrance and inside the channel are completely compensated for by attractive electrostatic interactions between the cations and carbonyl oxygens in the nanotube. In the case of $Cl^-$, the dehydration free energy barriers are not eliminated by an interaction between the anion and the peptide nanotube, leading to the high free energy barriers in the PMF profile. Calculations of the coordination numbers of the ions with oxygen atoms pertaining to either water molecules or carbonyl groups in the peptide nanotube reveal that the stabilization of the cations in the midplane regions of the nanotube arises from the favorable interaction of the cations with the negatively charged carbonyl oxygens.

• Restorative Dentistry and Endodontics
• /
• 제27권4호
• /
• pp.411-420
• /
• 2002

The aim of this study is to compare the adaptability of thermoplasticized injectable gutta-percha technique to the canal walls in ribbon-shaped canals. Thirty resin models simulated ribbon-shape canals were instrumented to #40 using .06 taper Profile systems. Three groups of each 10 resin models were obturated by the lateral condensation technique(LC) and the two thermoplasticized injectable gutta-percha technique; Ultrafil Endoset+Obtura II(EO) and Ultrafil Firmset(UF), respectively. After resin model were kept at room temperature for 4 days, they were resected horizontally with micro-tome at 1, 2, 3, 4 and 5mm levels from apex. At each levels. image of resected surface were taken using CCD camera under a stereomicroscope at $\times$40 magnification and stored. Ratio of the area of gutta-percha was obtained by calculating area of gutta-percha cone to the total area of canal using digitized image-ana-Iyzing program. The data were collected then analyzed statistically using One-way ANOVA. The results were as follows. 1 At 1mm levels, there was no statistically significant difference in the mean ratio of gutta-percha among the groups. 2. At 2mm level, EO showed the highest mean ratio of gutta-percha (p<0.05) and there was no significant difference between LC and UF. 3. At 3, 4, 5mm levels, EO and UF had significantly greater mean ratio of gutta-percha than LC(p<0.05) and there was no significant difference between EO and UF. In conclusion, the thermoplasticized injectable gutta-percha techniques demonstrated relatively favorable adaptability to canal walls than lateral condensation technique in ribbon-shaped canals except for 1mm level.

• 약학회지
• /
• 제42권3호
• /
• pp.265-274
• /
• 1998

In order to attain a sustained release at targeted organs in a prolonged time which can reduce the side effects and maximize the therapeutic effect, aclarubicin (ACL) was entrap ped into liposomes of different lipid compositions using Microfluidizer, and dry liposomes were prepared by lyophilization. The dry aclarubicin-entrapped liposomes were evaluated in terms of mean particle size and size distribution, entrapment efficiency and in vitro drug release profile. The Entrapment efficiency of liposome, when the concentration of aclarubicin and lipid were 0.5 to 1.0mg/ml and $200{\mu}mol$/ml, respectively, was over 80% using Microfluidizer, in contrast to 70% of entrapment efficiency using hand-shaking method. Mean particle size and size distribution of aclarubicin-entrapped liposomes of various lipid compositions did not change considerably by the freeze drying. The range of particle size was between 80 and 200nm. Among aclarubicin-entrapped liposomes, ACL-liposome of PC/DPPC/CH0L/TA displayed the most significant sustained release. The addition of DPPC appeared to be favorable for the control of release. In general, aclarubicin entrapped in liposomes was less stable than free aclarubicin either in pH 7.4 phosphate buffer or in human plasma. Formulation I($t_{1/2}$, 20.3 hr) devoid of lipid additive was the most unstable in the phosphate-buffer solution while formulation II($t_{1/2}$, 40.7 hr) with cardiolipin was the most stable. Half lives of aclarubicin-entrapped liposomes in human plasma were 43.2, 50.7, 35.9 and 35.3 hr for formulation I. II, III and IV, respectively, in contrast to 57.8 hr for free aclarubicin.

• 한국진공학회지
• /
• 제15권2호
• /
• pp.168-172
• /
• 2006

수소화물기상증착법을 이용하여 질화갈륨 핵화층을 성장시켰고, 성장 온도에 따라 상이한 구조적 특성을 갖는 핵화층이 질화갈륨 나노막대의 형성에 어떤 영향을 주는지 방사광 x-선 산란과 원자힘 현미경을 이용하여 연구하였다. 서로 다른 온도에서 성장시킨 질화갈륨 핵화층들의 (002) 브래그 봉우리에 대한 록킹 곡선(rocking curve)을 측정한 결과, 반폭치가 작은 주 봉우리와 반폭치가 넓은 작은 봉우리의 합으로 표현됨을 관측하였다. 이러한 현상은 핵화층의 표면 형상과 연관되어져서 설명될 수 있음을 정성적으로 보였고, AFM 결과와 비교해 볼 때 안정적인 나노막대 성장을 위해서는 핵화층이 저온에서 성장되어야 함을 확인하였다.

• 대한치과교정학회지
• /
• 제39권4호
• /
• pp.257-272
• /
• 2009

본 증례보고는 I급 견치 및 구치 관계를 보이나, 비강기도 협소에 따른 하안면 고경의 과도한 증가와 양 악궁의 폭경 감소 뿐만 아니라, 하악골의 후방위치 및 현저한 입술의 돌출로 인해 돌출된 안모를 지닌 성인 환자의 치료를 소개하고자 한다. 협착된 양 악궁은 수술을 동반한 급속 구개확장과 슈발츠 장치로써 확장되었으며, 마이크로임플란트를 이용한 directional force technology를 적용하여 상하악 구치부에서의 고정원 보강과 상악 전치부의 토크 조절 및 시계 반대 방향으로의 양호한 mandibular response를 얻음으로써 양호한 안모의 균형을 얻을 수가 있었다. 총 치료기간은 29개월 소요되었고, 장치 제거 후 13개월 유지 후에도 양호한 결과가 유지되었다.

• The Korean Journal of Pain
• /
• 제12권2호
• /
• pp.188-190
• /
• 1999

Background: The goal of this study was to evaluate the effects of gabapentin on postherpetic neuralgia. Gabapentin is a known anti-seizure medication, whose cellular mechanism of action is not well understood. Unlike other anticonvulsant, gabapentin has the advantage of a low toxicity and favorable side effect profile. If has been recently recommended for use in treatment of neuropathic pain. Methods: Twelve patients with a diagnosis of postherpetic neuralgia were prescribed gabapentin after failure of routine therapeutic regimens. The dose of gabapentin ranged 300~1800 mg per day, in three divided doses. If initial dose was ineffective and no side effects were noted, the dosages was increased by 300 mg a day in divided doses, to the maximum level for 2 weeks. Patients were evaluated for analgesia using visual analogue scale (VAS) pain score (0; no pain, 10; worst possible pain) and possible side effects. Results: A significant decrease in pain scores with gabapentin were noted. There were several mild side effects such as dizziness, somnolence, dry mouth, constipation and facial edema, without need of special treatment. Conclusions: Gabapentin may be a useful adjunct for treating intractable postherpetic neuralgia with a minimal side effects.

• 한국멀티미디어학회논문지
• /
• 제12권5호
• /
• pp.677-687
• /
• 2009

모바일 환경은 데이터 콘텐츠 이용에 유리한 조건을 갖고 있음에도 불구하고, MPEG-4 BIFS 기반 환경에서는 진보된 데이터 콘텐츠 구현이 쉽지 않다. BIFS는 VRML을 모태로 하여 방송 콘텐츠와는 타켓 콘텐츠 및 콘텐츠 개발 어프로치가 다르며, 모바일 방송환경에서 이용하기에는 표준이 너무 복잡하여 구현이 쉽지 않기 때문이다. 따라서 본 논문에서는 시청자가 방송 콘텐츠와 상호작용할 수 대화형 3D 객체 및 GUI를 제공하는 진보된 모바일 TV 콘텐츠 모델을 제시하고자 하며, 이를 실제 DMB 환경에 적용함으로써 향후 모바일 방송 콘텐츠의 발전 방향을 제시하고자 한다. 모바일 방송 콘텐츠에서의 3D 객체 표현을 위해 MPEG-4 BIFS 3D 노드를 분석하여 VRML 프로파일의 서브셋을 구성하였으며, GUI 표현을 위한 노드틀을 새로 정의하여 콘벤츠 개발 단계에서 활용할 수 있도록 하였다. 이와 같은 연구를 통해 모바일 데이터 콘텐츠 구성 시 3D 그래픽스와 인터랙션 표현이 쉬워진다면, 콘텐츠 개발의 효율성을 증대되어 모바일 방송 환경에 적합한 다양한 콘텐츠 개발이 활성화 될 수 있을 것이라 기대된다.

• 동의생리병리학회지
• /
• 제26권3호
• /
• pp.306-313
• /
• 2012

Herbal medicines are medicinal products containing a single or a mixture of two or more different herbal substances or herbal preparations as active principles. Recently, much attention has been paid to developing various kinds of fermented herbal extracts, a new type of traditional herbal medicine in the field of Korean traditional medicine. The fermentation of medicinal herbs is intended to exert a favorable influence on bioestability, bioavaliablilty and pharmacological activity of herbal extract in the gastrointestinal tract as well as intensifying the nutritional and pharmacological aspects of the medicinal herbs. The purpose of this study was to investigate biological activities of fermented Rehmanniae Radix by lactic acid bacteria at $30^{\circ}C$ for 3 days in comparison with those for Rehmanniae Radix The fermented Rehmanniae Radix exhibited different chemical profile to Rehmanniae Radix generated with HPLC, indicating production of new ingredients during fermentation. Rehmanniae Radix served as good nutritional sources for the growth of lactic acid bacteria showing increased number of bacteria during fermentation. Toxic effect of the fermented Rehmanniae Radix to cells were not seen judged by the MTT assay. The fermented Rehmanniae Radix exhibited better antioxidant effect than non-fermented Rehmanniae Radix analyzed by a SOD-likely assay. Both hypoglycemic and hypotensive effects of the fermented Rehmanniae Radix were also detected and better than those for Rehmanniae Radix in showing dose-dependent inhibitory effects on alpha-glucosidase and ACE, respectively. In conclusion, fermented Rehmanniae Radix appears to have more biological activities than non-feremented Rehmanniae Radix showing not only antioxidant effect but also cardiovascular protection.