• Journal of Life Science
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• v.30 no.8
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• pp.731-741
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• 2020

Coronavirus disease 19 (COVID-19) is caused by SARS-CoV-2 (Severe Acute Respiratory SyndromeCoronavirus 2). To date, seven coronaviruses that can infect humans were reported. Among them, infections with four coronavirus strains (HCoV-229E, HCoV-OC43, HCoV-NL63, and HCoV-HKU1) resulted in mild symptoms such as common cold, whereas SARS-CoV and MERS-CoV caused severe symptoms and epidemics in 2002 and 2012, respectively. In the most recent, SARS-CoV-2 was first reported in Wuhan, China in December 2019 and became a notorious cause of the ongoing global pandemics. To diagnose, treat, and prevent COVID-19, the development of rapid and accurate diagnostic tools, specific therapeutic drugs, and safe vaccines essentially are required. In order to develop these powerful tools, it is prerequisite to understand a phenotype, a genotype, and life cycle of SARS-CoV-2. Diagnostic techniques have been developing rapidly around world and many countries take the fast track system to accelerate approval. Approved diagnostic devices are rapidly growing facing to urgent demand to identify carriers. Currently developed commercial diagnostic devices are divided into mainly two categories: molecular assay and serological & immunological assay. Molecular assays begins the reverse transcription step following polymerase chain reaction or isothermal amplification. Immunological assay targets SARS-CoV-2 antigen or anti-SARS-CoV-2 antibody of samples. In this review, we summarize the phenotype, genome structure and gene expression of SARS-CoV-2 and provide the knowledge on various diagnostic techniques for SARS-CoV-2.

• Proceedings of the Korean Society for Bioinformatics Conference
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• 2006.02a
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• pp.83-89
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• 2006

Cellular functions are carried out by a concerted action of biochemical pathways whose components have genetic interactions. Abnormalities in the activity of the genes that constitute or modulate these pathways frequently have oncogenic implications. Therefore, identifying the upstream regulatory genes for major biochemical pathways and defining their roles in carcinogenesis can have important consequences in establishing an effective target-oriented antitumor strategy We have analyzed the gene expression profiles of human liver cancer samples using cDNA microarray chips enriched in liver and/or stomach-expressed cDNA elements, and identified groups of genes that can tell tumors from non-tumors or normal liver, or classify tumors according to clinical parameters such as tumor grade, age, and inflammation grade. We also set up a high-throughput cell-based assay system (cell chip) that can monitor the activity of major biochemical pathways through a reporter assay. Then, we applied the cell chip platform for the analysis of the HCC-associated genes discovered from transcriptome profiling, and found a number of cancer marker genes having a potential of modulating the activity of cancer-related biochemical pathways such as E2F, TCF, p53, Stat, Smad, AP-1, c-Myc, HIF and NF-kB. Some of these marker genes were previously blown to modulate these pathways, while most of the others not. Upon a fast-track phenotype analysis, a subset of the genes showed increased colony forming abilities in soft agar and altered cell morphology or adherence characteristics in the presence of purified matrix proteins. We are currently analyzing these selected marker genes in more detail for their effects on various biological Processes and for Possible clinical roles in liver cancer development.

• Korean Chemical Engineering Research
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• v.43 no.2
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• pp.236-242
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• 2005

Membrane fouling by protein mixtures during microfiltration has been investigated for binary mixtures of bovine serum albumin (BSA), casein, lysozyme, pepsin, and ovalbumin. Filtration experiments were carried out using $0.2{\mu}m$ polycarbonate track-etched (PCTE) membrane in a stirred cell under constant transmembrane pressure (14 kPa) and concentration of hydrogen ion (pH=11) to study the effect of mixture composition on filtrate flux decline. Flux decline data were analyzed using a pore blockage-cake formation model developed recently. It was found that the model is in a good agreement with the experimental data. Fouling parameters such as the rate of pore blockage(${\alpha}$), the initial resistance of the protein deposit ($R_{po}$) and the increasing rate of the protein layer resistance(${\beta}$) were used to evaluate the rate of filtrate flow by membrane fouling in the binary mixture system. Generally, the trend of ${\alpha}$ is comparable with that of filtrate flux decline. It was also found that fast flux decreasing was observed over the binary mixture containing casein. The result is due to high value of the initial resistance of the protein deposit ($R_{po}$) over casein.

• Spatial Information Research
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• v.15 no.3
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• pp.237-249
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• 2007

There are about 22,000 national control points throughout this nation. However, in order to identify the location data of a national control point, a control point result table is needed. And although the control points are important national facilities, due to the fact that these points located at remote areas such as on top of mountains, the facilities are being maintained via on-site inspection without any protections around them. In this research, by taking the locations where the control points are placed into consideration, a specialized RFID tags that can be attached to the national control point's marker has been developed, and CDMA-ready PDA based mobile Web System and national control point control system are developed as well. With help of these systems, control point data can be checked at the seen, and national control point maintenance personnel can find out about maintenance status and keep track of usage record. When these systems are taken into effect, access to the national control point data becomes easy, fast response to the change in data can be possible, and management efficiency will go up. When the Ubiquitous society becomes reality, the importance of location information will be high. Therefore, national control points using above mentioned RFID tags will not only be useful to the control point users and maintenance personnels such as professional land surveyors, but also useful when providing location based services to people, and it will become an important national infrastructure in terms of providing absolute location information.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.11 no.3
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• pp.1059-1065
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• 2010

Very-early strength latex-modified concrete (VES-LMC) was developed for the purpose of fast-track overlay of a concrete bridge deck under heavy traffic, concentrated on the workability, durability, and strength gain so that it can be opened to the traffic only three hours after its placement. The mixture of VES-LMC might accompany very high heat of hydration at early-age because of its inherent rapid hardening property and could have susceptibility to autogenous shrinkage because of its relatively low water-cement ratio. This study evaluated the effect of the latex-cement ratio(L/C) both of the constant and variable slumps on the autogenous shrinkage of VES-LMC by carrying out simple temperature rise test and early-age shrinkage experiment. Test results are as follows: The latex contributes on the enhancement of the concrete durability but has little effect on its hydration and the accompanied heat of hydration in VES-LMC. Autogenous shrinkage increased with the increase in latex-cement ratio at variable slumps and its pattern followed regularly a logarithmic increase. However, the influence of water-cement ratio and latex-cement ratios for the test specimens at constant slump on early-age autogenous shrinkage property was found to be minor due to the simultaneous effect of the two experimental variables.

• The KIPS Transactions:PartB
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• v.15B no.3
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• pp.197-204
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• 2008

It is well known that the tracking a certain person is a vary needed technic in the humanoid robot. In robot technic, we should consider three aspects that is cloth color matching, face recognition and motion analysis. Because a robot technic use some sensors, it is many different with the robot technic to track a certain person through the CCTV images. A system speed should be fast in CCTV images, hence we must have small calculation numbers. We need the statistical variable for color matching and we adapt the eigen-face for face recognition to speed up the system. In this situation, motion analysis have to added for the propose of the efficient detecting system. But, in many motion analysis systems, the speed and the recognition rate is low because the system operates on the all image area. In this paper, we use the moving energy only on the face area which is searched when the face recognition is processed, since the moving energy has low calculation numbers. When the proposed algorithm has been compared with Girondel, V. et al's method for experiment, we obtained same recognition rate as Girondel, V., the speed of the proposed algorithm was the more faster. When the LDA has been used, the speed was same and the recognition rate was better than Girondel, V.'s method, consequently the proposed algorithm is more efficient for tracking a certain person.

• Resources Recycling
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• v.21 no.1
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• pp.30-40
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• 2012

Electric arc furnace slag is made in ironworks during steel refining, it is been increasing chemical and physical resistibility using ageing method of unstable state of melting steel slag for using concrete's fine aggregates. Which is been changing stable molecular structure of aggregates, it restrains moving of ion and molecule. In Korea, KS F 4571 has been prepared for using the electric arc furnace oxidizing slag to concrete aggregates(EFS). In this study, Electric arc furnace oxidizing slag is used in the PRCC(Polymer Rapid setting Cement Concrete) which is applied a bridge pavement of rehabilitation, largely. The results showed that the increment of compressive strength development by 10- 20%. The flexural strength of EFS-Con increased greatly as the electric arc furnace oxidizing slag changed. The compressive strength and flexural strength developed enough for opening the overlayed EFS-Con to the traffic after 4 hours of EFS-Con placement. The permeability of EFS-Con was evaluated as negligible due to its very low charge passed. Thus, EFS-Con could be used at repairing or overlaying the concrete at fast-track job sites.

• Journal of the Korea Institute of Construction Safety
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• v.2 no.1
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• pp.36-44
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• 2019

$21^{st}$ century is digitally civilized era. Technologies such as AI, Iot, Big Data, Mobile and etc makes this era digitally advanced. These advancement of the technology greatly impacted detection range of the radar. Human's eye sight can see about 20Km and hear 20 ~ 20000 Hz. These limitations can be overcome using radar. This radar technology is used in military, aircraft, ship, vehicle and etc. to replace human eye. However, radar technology is capable of making False Alarm Rate. This document will propose the fix of these problems. Radar's distortion includes beam refraction, diffraction and reflection. These inaccurate data result in deterioration of human judgements and my cause various casualties and damages. Radar goes through annual testing to test how many false alarm is being produced. Normal radar usually makes 10 to 20 False alarms. In emergency situation, if operator were to follow this false alarm, this might result in following false object or take 12 more seconds to follow the right object. This problem can be overcome by using different radar data from different places and angles. This helps reduces False Alarm rate and track the object twice as fast.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.28 no.5D
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• pp.695-703
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• 2008

China water market has huge potential for increased use of BOT mode and one of the most attractive markets of doing business. However, the current China water BOT market shows that many foreign companies are retreating from the market while Chinese water companies fast growing. From the view no domestic companies have track records in China BOT water market, the research identified twenty market access barriers in terms of construction laws, regulations, BOT-related policy and the recent market situation. These are evaluated based on interview results with 10 professionals direct or indirect having a China water BOT experience. All the factors are found to be highly influential to foreign company's decision on the market participation. Among those, no fixed return policy and low water price, difficulty in water price adjustment and approval, and no government guarantees, all directly related to the project viability and under the control of government, were the most critical factors, implying government's role is the key in increasing the market competition by attracting more foreign participation on the market. In addition, new construction law regulating foreign EPC contractor's construction work, namely Decree 113, and requirement of applying competitive bidding in selecting EPC contractor in a BOT project are also considered signigicant barriers on foreign participation, which contradicts international norm and therefore necessitates an adjustment on current decision process in domestic companies.

• The Southeast Asian review
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• v.27 no.1
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• pp.95-129
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• 2017

This study surveys and reviews political change, economic performance, and regional cooperation that were carried out in 2016 by Southeast Asian countries and ASEAN. This paper reports that what has followed the inauguration of new governments in Myanmar, the Philippines, Vietnam, and Laos fails to live up to the expectation and optimism that arose in the aftermath of elections and party congresses that took place in the first half of the year. In other countries such as Malaysia, Thailand, and Cambodia, where authoritarian regimes are faced with strong oppositions, the prospects for democratic change worsened to a substantial degree, as schisms and internal strives complicated the opposition camp as a result of instigation and intervention by the authoritarian leaders and their followers. In stable political systems, both democratic and authoritarian, no significant changes that may entail serious political implications were noticed. In 2016, the national economy of almost each and every country continued its slow but steady recovery that had started in 2014 and grew by 5% on the average. For 2017 onward, however, the earlier optimism that it would grow at least as fast dimmed down as uncertainty about the world economy looms larger due to the unexpected win by Donald Trump as U.S. president and the expected 'hard landing' of the Chinese economy around 2018. ASEAN declared the launch of the ASEAN Economic Community (AEC) only one day before the New Year, but its track record looked already bad and unpromising by the end of 2016. ASEAN leaders were tied up by their domestic politics and affairs too tightly to take time off to work seriously to observe the schedule as laid out in the AEC Blueprint 2025. Korea's relationship with Southeast Asian countries and ASEAN was "as good as it gets" in 2016 as ever but could become subject to tough review in the near future, if the Ministry of Foreign Affairs is found out to have been implicated in the ongoing Choi Sun Sil scandal and if the opposition wins the next presidential election to be held by this year.